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Chinese Journal of Biomedical Engineering(English Edition) 2024年第2期33卷 47-53,68页

作者： JIANG Hui-qiong hong yan-ling Quanzhou First Hospital Quanzhou Fujian 362000China

Objective:To discuss the effect of catechins on myocardial injury and inflammatory factors in rats with coronary heart disease under PI3K/Akt/eNOS signaling ***:A total of 50 healthy adult pathogen-free(SPF)-grade SD rats were divided into five groups by random number table *** for the blank group,the other four groups were fed with high fat to construct a rat model of coronary artery *** the model was successfully constructed,the blank group and the model group were given saline by gavage,the positive group was given 25 mg/kg aspirin by gavage,the low-dose group was given 20 mg/kg catechin by gavage,and the high-dose group was given 60 mg/kg catechin by *** expression levels of PI3K/Akt/eNOS signaling pathway-related proteins,myocardial injury markers,myocardial infarction and myocardial inflammatory factors were observed and compared in the five ***:Overall,there were significant differences in the expression levels of PI3K,p-Akt/Akt,and p-eNOS/eNOS in the five groups of rats(Pling pathway-related *** with aspirin,high-dose catechins have a more prominent protective effect on the myocardium of rats with coronary heart disease.

关键词： coronary heart disease catechins PI3K/Akt/eNOS signaling pathway myocardial injury inflammatory factors

高血压全科治疗中硝苯地平联合二甲双胍的疗效

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中国现代药物应用 2024年第13期18卷 88-91页

作者：洪燕玲厦门思明区梧村街道社区卫生服务中心全科 361000

目的分析高血压全科治疗过程中接受硝苯地平联合二甲双胍治疗的临床效果。方法20例高血压患者,均接受硝苯地平联合二甲双胍治疗。对比治疗前后的血压、血糖、血脂、血管内皮功能、血液流变学水平以及临床疗效、不良反应发生情况。结果... 详细信息

目的分析高血压全科治疗过程中接受硝苯地平联合二甲双胍治疗的临床效果。方法20例高血压患者,均接受硝苯地平联合二甲双胍治疗。对比治疗前后的血压、血糖、血脂、血管内皮功能、血液流变学水平以及临床疗效、不良反应发生情况。结果同治疗前的收缩压(162.38±5.17)mm Hg(1 mm Hg=0.133 kPa)、舒张压(101.25±2.74)mm Hg、空腹血糖(10.38±1.74)mmol/L、餐后2 h血糖(14.38±2.43)mmol/L、糖化血红蛋白(4.26±0.49)%、总胆固醇(5.42±1.39)mmol/L、甘油三酯(2.86±1.15)mmol/L、低密度脂蛋白胆固醇(3.74±0.39)mmol/L、高密度脂蛋白胆固醇(1.05±0.11)mmol/L相比,患者治疗后收缩压(137.15±3.49)mm Hg、舒张压(79.25±2.43)mm Hg、空腹血糖(6.27±0.63)mmol/L、餐后2 h血糖(9.25±0.76)mmol/L、糖化血红蛋白(3.12±0.16)%、总胆固醇(4.16±0.49)mmol/L、甘油三酯(1.42±0.36)mmol/L、低密度脂蛋白胆固醇(2.49±0.16)mmol/L均下降,高密度脂蛋白胆固醇(1.39±0.19)mmol/L增高,存在统计学差异(P<0.05)。同治疗前的一氧化氮(NO)(24.39±2.76)μmol/L、血管内皮生长因子(VEGF)(24.76±2.79)pg/ml、内皮素-1(ET-1)(79.26±11.25)ng/L、全血粘度(2.16±0.34)mPa·s、全血低切粘度(28.43±1.77)mPa·s、全血高切粘度(8.46±0.95)mPa·s、红细胞聚集指数(3.36±0.16)相比,患者治疗后的NO(28.36±4.19)μmol/L、VEGF(31.28±2.49)pg/ml均升高,ET-1(64.26±7.26)ng/L、全血粘度(1.82±0.16)mPa·s、全血低切粘度(20.36±1.43)mPa·s、全血高切粘度(6.25±0.49)mPa·s、红细胞聚集指数(3.26±0.13)均下降,存在统计学差异(P<0.05)。20例患者用药后显效12例(60.00%)、有效7例(35.00%),无效1例(5.00%),治疗总有效率为95.00%(19/20)。用药后有3例患者出现头痛、2例患者有面色潮红、1例患者出现轻度低血糖反应,所有患者经对症治疗后不良反应未有加重迹象,未因药物不良反应而停药。结论高血压患者在接受全科治疗中,将降压药物硝苯地平联合降糖药物二甲双胍应用,可有效改善患者血压及糖脂代谢情况,同时也能调节血管内皮功能及血液流变学,利于提高临床治疗效果,临床可进一步推广运用。

关键词：高血压全科治疗硝苯地平二甲双胍

两种鸡尾酒双染法评估乳腺癌HER2表达的应用对比

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诊断病理学杂志 2024年第8期31卷 811-813页

作者：洪艳玲武汉市第三医院/武汉大学附属同仁医院病理科武汉430060

目的对比两种鸡尾酒双染法在乳腺癌HER2表达评估中的应用效果。方法收集乳腺癌手术标本20例,每例标本切片7张,1张行HE染色,4张分别进行Calponin、p63、CK5/6和HER2抗体的免疫组化单染,2张切片分别进行Calponin-p63-HER2和CK5/6-p63-Her... 详细信息

目的对比两种鸡尾酒双染法在乳腺癌HER2表达评估中的应用效果。方法收集乳腺癌手术标本20例,每例标本切片7张,1张行HE染色,4张分别进行Calponin、p63、CK5/6和HER2抗体的免疫组化单染,2张切片分别进行Calponin-p63-HER2和CK5/6-p63-Her2鸡尾酒双染。对比分析单染组和双染组在HER2评估的时间差异。结果相比于传统单染组,Calponin-p63-Her2鸡尾酒双染组的评估时间缩短(2.7±0.98 min vs.16.9±3.82 min,P<0.001);CK5/6-p63-HER2鸡尾酒双染组的评估时间也明显缩短(2.1±0.55 min vs.16.6±3.95 min,P<0.001);CK5/6-p63-HER2比Calponin-p63-HER2鸡尾酒双染组染色更加清晰,时效性更高(P=0.01)。结论CK5/6-p63-HER2鸡尾酒双染法在乳腺癌HER2表达评估中的应用效果较好,值得推广。

关键词：乳腺癌 HER2 免疫组化双染

The Generalized Inverse of Singular Integral Operators on an Open Arc and Its Applications

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Wuhan University Journal of Natural Sciences 2001年第4期6卷 747-753页

作者： Li hong-yan Wang Xiao-ling School of Mathematics and Statistics Wuhan University Wuhan 430072 China

After choosing weight functions suitably, we define a Banach spaceH ω μ (L) and discuss the generalized inverse of singular integral operators on an open arc. Using the generalized inverse, we obtain the solutions f... 详细信息

关键词： open arc generalized inverse singular integral equations with kernel having singularities of order one

Optimized the vanadium electrolyte with sulfate-phosphoric mixed acids to enhance the stable operation at high-temperature

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Frontiers of Chemical Science and Engineering 2024年第2期18卷 13-26页

作者： ling Ge Tao Liu Yimin Zhang hong Liu School of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China State Environmental Protection Key Laboratory of Mineral Metallurgical Resources Utilization and Pollution Control Wuhan University of Science and TechnologyWuhan 430081China Hubei Collaborative Innovation Center for High Efficient Utilization of Vanadium Resources Wuhan University of Science and TechnologyWuhan 430081China Hubei Provincial Engineering Technology Research Center of High Efficient Cleaning Utilization for Shale Vanadium Resource Wuhan University of Science and TechnologyWuhan 430081China School of Resource and Environmental Engineering Wuhan University of TechnologyWuhan 430070China

Herein, the influence of the concentration design and comprehensive performance of the sulfate-phosphoric mixed acid system electrolyte is investigated to realize an electrolyte that maintains high energy density and stable operation at high temperatures. Static stability tests have shown that VOPO4 precipitation occurs only with vanadium(V) electrolyte. The concentration of vanadium ion of 2.0–2.2 mol·L^(–1), phosphoric acid of 0.10–0.15 mol·L^(–1), and sulfuric acid of 2.5–3.0 mol·L^(–1) are suitable for a vanadium redox flow battery in the temperature range from –20 to 50 ℃. The equations for predicting the viscosity and conductivity of electrolytes are obtained by the response surface method. The optimized electrolyte overcomes precipitation generation. It has 2.8 times higher energy density than the non-phosphate electrolyte, and a coulomb efficiency of 94.0% at 50 ℃. The sulfate-phosphoric mixed acid system electrolyte promotes the electrode reaction process, increases the current density, and reduces the resistance. This work systematically optimizes the concentrations of composition of positive and negative vanadium electrolytes with mixed sulfate-phosphoric acid. It provides a basis for the different valence states and comprehensive properties of sulfate-phosphoric mixed acid system vanadium electrolytes under extreme environments, guiding engineering applications.

关键词： all vanadium redox flow battery mixed-acid vanadium electrolyte concentration optimization response surface methodology high-temperature stability

Personalized and continuous care intervention affects rehabilitation,living quality,and negative emotions of patients with breast cancer

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World Journal of Psychiatry 2024年第6期14卷 876-883页

作者： ling-Xia Kong yan-hong Zhao Zhi-Lin Feng Ting-Ting Liu Department of Breast Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Operating Room The First Affiliated Hospital of Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Breast cancer is among the most common malignancies *** progress in treatment methods and levels,the overall survival period has been prolonged,and the demand for quality care has *** To investigate the effect of individualized and continuous care intervention in patients with breast *** Two hundred patients with breast cancer who received systemic therapy at The First Affiliated Hospital of Hebei North University(January 2021 to July 2023)were retrospectively selected as research *** them,134 received routine care intervention(routing group)and 66 received personalized and continuous care(intervention group).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),and Functional Assessment of Cancer Therapy-Breast(FACT-B)scores,including limb shoulder joint activity,complication rate,and care satisfaction,were compared between both groups after *** SAS and SDS scores were lower in the intervention group than in the routing group at one and three months after *** total FACT-B scores and five dimensions in the intervention group were higher than those in the routing group at three months of *** range of motion of shoulder anteflexion,posterior extension,abduction,internal rotation,and external rotation in the intervention group was higher than that in the routing group one month after *** incidence of postoperative complications was 18.18%lower in the intervention group than in the routing group(34.33%;P<0.05).Satisfaction with care was 90.91% higher in the intervention group than in the routing group(78.36%;P<0.05).CONCLUSION Personalized and continuous care can alleviate negative emotions in patients with breast cancer,quicken rehabilitation of limb function,decrease the incidence of complications,and improve living quality and care satisfaction.

关键词： Breast cancer Personalized care Continuous care Negative emotions Living quality Rehabilitation effect

Research on casing deformation prevention technology based on cementing slurry system optimization

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Petroleum Science 2024年第2期21卷 1231-1240页

作者： yan yan Meng Cai Wen-Hai Ma Xiao-Chuan Zhang Li-hong Han Yong-hong Liu State Key Laboratory for Performance and Structure Safety of Petroleum Tubular Goods and Equipment Materials CNPC Tubular Goods Research InstituteXi©an710077ShaanxiChina College of Mechanical and Electrical Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Gas Evaluation and Exploitation Key Laboratory of Sichuan Province Chengdu610095SichuanChina CNPC Daqing Oilfield Company Daqing163453HeilongjiangChina

The casing deformation prevention technology based on the optimization of cement slurry is proposed to reduce the casing deformation of shale oil and gas wells during hydraulic fracturing. In this paper, the fracture mechanism of hollow particles in cement sheath was firstly analyzed by discrete element method, and the effect of hollow particles in cement on casing deformation was investigated by laboratory experiment method. Finally, field test was carried out to verify the improvement effect of the casing deformation based on cement slurry modification. The results show that the formation displacement can be absorbed effectively by hollow particles inside the cement transferring the excessive deformation away from casing. The particles in the uncemented state provide deformation space during formation slipping. The casing with diameter of 139.7 mm could be passed through by bridge plug with the diameter of 99 mm when the mass ratio of particle/cement reaches 1:4. According to the field test feedback, the method based on optimization of cement slurry can effectively reduce the risk of casing deformation, and the recommended range of hollow microbeads content in the cement slurry is between 15% and 25%.

关键词： Cement slurry Hollow ceramsite Casing deformation Formation slip Field test

The Multiple Roles of Autophagy in Neural Function and Diseases

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Neuroscience Bulletin 2024年第3期40卷 363-382页

作者： yan-yan Li Zheng-hong Qin Rui Sheng Department of Pharmacology and Laboratory of Aging and Nervous Diseases Jiangsu Key laboratory of Neuropsychiatric DiseasesCollege of Pharmaceutical Sciences of Soochow UniversitySuzhou 215123China

Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,where proteins,lipids,and organelles are degraded and *** to the way the cytoplasmic components are engulfed,autophagy can be divided into macroautophagy,microautophagy,and chaperone-mediated ***,many studies have found that autophagy plays an important role in neurological diseases,including Alzheimer's disease,Parkinson's disease,Huntington's disease,neuronal excitotoxicity,and cerebral *** maintains cell homeostasis in the nervous system via degradation of misfolded proteins,elimination of damaged organelles,and regulation of apoptosis and ***-mTOR,Beclin 1,TP53,endoplasmic reticulum stress,and other signal pathways are involved in the regulation of autophagy and can be used as potential therapeutic targets for neurological ***,we discuss the role,functions,and signal pathways of autophagy in neurological diseases,which will shed light on the pathogenic mechanisms of neurological diseases and suggest novel targets for therapies.

关键词： Autophagy Neurodegenerative diseases Cerebral ischemia AMPK mTOR Beclin 1 TP53 Endoplasmic reticulum stress

Extending Structures for Gel'fand-Dorfman Bialgebras

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Acta Mathematica Sinica,English Series 2024年第2期40卷 619-638页

作者： Jia Jia WEN yan Yong hong School of Mathematics Hangzhou Normal UniversityHangzhou 311121P.R.China

Gel'fand-Dorfman bialgebra,which is both a Lie algebra and a Novikov algebra with some compatibility condition,appeared in the study of Hamiltonian pairs in completely integrable *** also emerged in the description of a class special Lie conformal algebras called quadratic Lie conformal *** this paper,we investigate the extending structures problem for Gel'fand-Dorfman bialgebras,which is equivalent to some extending structures problem of quadratic Lie conformal ***,given a Gel'fand-Dorfman bialgebra(A,o,[.,.]),this problem is how to describe and classify all Gel'fand-Dorfman bialgebra structures on a vector space E(A⊂E)such that(A,o,[.,.])is a subalgebra of E up to an isomorphism whose restriction on A is the identity *** by the theories of extending structures for Lie algebras and Novikov algebras,we construct an object gH2(V,A)to answer the extending structures problem by introducing the notion of a unified product for Gel'fand-Dorfman bialgebras,where V is a complement of A in *** particular,we investigate the special case when dim(V)=1 in detail.

关键词： Gel'fand-Dorfman bialgebra Lie conformal algebra Extending structures problem Novikovalgebra

Sobolev Mapping of the Bergman Projections on Generalized Hartogs Triangles

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Acta Mathematica Sinica,English Series 2024年第2期40卷 451-466页

作者： hong yan LIU Zhen Han TU School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China

In this paper,we investigate Sobolev mapping properties of the Bergman *** domain we focus on is defined byΩm/n:={(z,w)∈C^(1+N):|w1|<|z|m1/n1<1,…|wN|<|z|/m_(N)/n_(N)<1},where m=(m1,…mN)∈(Z^(+))^(N),n=(n1,…nN)∈(Z^(+))N,N∈Z^(+).Sobolev irregularity of the Bergman projections on 2 is *** also prove some Sobolev regularity results of the Bergman projections onΩm/n for m=(1,…1).

关键词： Bergman projections generalized Hartogs triangles Sobolev spaces