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orecast of peak infection and estimate of excess deaths in COVID-19 transmission and prevalence in Taiyuan City,2022 to 2023

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Infectious Disease Modelling 2024年第1期9卷 56-69页

作者： Jia-lin Wang Xin-Long Xiao Fen-Fen Zhang Xin Pei Ming-tao Li Ju-Ping Zhang Juan Zhang Gui-Quan Sun Complex Systems Research Center Shanxi UniversityTaiyuan030006China School of Mathematical Sciences Shanxi UniversityTaiyuan030006China School of Mathematics North University of ChinaTaiyuan030051China College of Mathematics Taiyuan University of TechnologyTaiyuan030024China Complex Systems and Data Science Key Laboratory of Ministry of Education Taiyuan030006China

In this paper,with the method of epidemic dynamics,we assess the spread and prevalence of COVID-19 after the policy adjustment of prevention and control measure in December 2022 in Taiyuan City in China,and estimate the excess population deaths caused by *** on the transmission mechanism of COVID-19 among individuals,a dynamic model with heterogeneous contacts is established to describe the change of control measures and the population's social behavior in Taiyuan *** model is verified and simulated by basing on reported case data from November 8th to December 5th,2022 in Taiyuan city and the statistical data of the questionnaire survey from December 1st to 23rd,2022 in Neijiang *** with reported numbers of permanent residents and deaths from 2017 to 2021 in Taiyuan city,we apply the dynamic model to estimate theoretical population of 2022 under the assumption that there is no effect of *** addition,we carry out sensitivity analysis to determine the propagation character of the Omicron strain and the effect of the control *** a result of the study,it is concluded that after adjusting the epidemic policy on December 6th,2022,three peaks of infection in Taiyuan are estimated to be from December 22nd to 31st,2022,from May 10th to June 1st,2023,and from September 5th to October 13th,2023,and the corresponding daily peaks of new cases can reach 400000,44000 and 22000,*** the end of 2022,excess deaths can range from 887 to 4887,and excess mortality rate can range from 3.06%to 14.82%.The threshold of the infectivity of the COVID-19 variant is estimated 0.0353,that is if the strain infectivity is above it,the epidemic cannot be control with the previous normalization measures.

关键词： Taiyuan city COVID-19 Dynamic model Epidemic scale Epidemic peak Excess death

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The haplotype-resolved genome assembly of autotetraploid rhubarb Rheum officinale provides insights into its genome evolution and massive accumulation of anthraquinones

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Plant Communications 2024年第1期5卷 196-214页

作者： hongyu Zhang Qiang He Longsheng Xing Ruyu Wang Yu Wang Yu Liu Qinghong Zhou Xuanzhao Li Zheng Jia Ze Liu Yuqing Miao tao lin Wei Li Huilong Du School of Life Sciences Institute of Life Sciences and Green DevelopmentBasic Science Center for Biotic Interaction in HebeiHebei UniversityBaoding 071000China College of Horticulture China Agricultural UniversityNo.2 Yuanmingyuan West RoadHaidian DistrictBeijing 100193China

Rheum officinale,a member of the Polygonaceae family,is an important medicinal plant that is widely used in traditional Chinese ***,we report a 7.68-Gb chromosome-scale assembly of *** with a contig N50 of 3.47 Mb,which was clustered into 44 chromosomes across four homologous *** genomics analysis revealed that transposable elements have made a significant contribution to its genome evolution,gene copy number variation,and gene regulation and expression,particularly of genes involved in metabolite biosynthesis,stress resistance,and root *** placed the recent autotetraploidization of *** at~0.58 mya and analyzed the genomic features of its homol-ogous *** no dominant monoploid genomes were observed at the overall expression level,numerous allele-differentially-expressed genes were identified,mainly with different transposable element insertions in their regulatory regions,suggesting that they functionally diverged after *** genomics,transcriptomics,and metabolomics,we explored the contributions of gene family amplification and tetraploidization to the abundant anthraquinone production of ***,as well as gene expression patterns and differences in anthraquinone content among *** report of-fers unprecedented genomic resources for fundamental research on the autopolyploid herb *** and guidance for polyploid breeding of herbs.

关键词： Rheum officinale genomics comparative genomics polyploid anthraquinone biosynthesis

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Laboratory studies on the infectivity of human respiratory viruses:Experimental conditions,detections,and resistance to the atmospheric environment

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Fundamental Research 2024年第3期4卷 471-483页

作者： Yaohao Hu Shuyi Peng Bojiang Su tao Wang Juying lin Wei Sun Xiaodong Hu Guohua Zhang Xinming Wang Ping'an Peng Xinhui Bi State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Guangdong-hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou 510640China

The environmental stability of infectious viruses in the laboratory setting is crucial to the transmission potential of human respiratory *** experimental techniques or conditions used in studies over the past decades have led to diverse understandings and predictions for the stability of viral infectivity in the atmospheric *** this paper,we review the current knowledge on the effect of simulated atmospheric conditions on the infectivity of respiratory viruses,mainly focusing on influenza viruses and coronaviruses,including severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome ***,we summarize the impact of the experimental conditions on viral stability;these involve the methods of viral aerosol generation,storage during aging and collection,the virus types and strains,the suspension matrixes,the initial inoculum volumes and concentrations,and the drying ***,we summarize and discuss the detection methods of viral infectivity and their ***,we integrate the results from the reviewed studies to obtain an overall understanding of the effects of atmospheric environmental conditions on the decay of infectious viruses,especially aerosolized ***,this review highlights the knowledge gaps in predicting the ability of viruses to maintain infectivity during airborne transmission.

关键词： Respiratory viruses Viral infectivity Laboratory simulation Atmospheric environmental condition Airborne transmission

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Hepatoid adenocarcinoma of the lung:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4813-4819页

作者： Yi-Jun Mo Li-Na lin Jing-Li tao tao Zhang Jian-Hua Zhang Department of Thoracic Surgery Shenzhen HospitalSouthern Medical UniversityShenzhen 518104Guangdong ProvinceChina School of Nursing Guangzhou Xinhua UniversityGuangzhou 510520Guangdong ProvinceChina Department of Pathology Shenzhen HospitalSouthern Medical UniversityShenzhen 518104Guangdong ProvinceChina

BACKGROUND Hepatoid adenocarcinoma of the lung(HAL)is a rare type of non-small cell lung cancer(NSCLC),histologically similar to hepatocellular *** has high malignancy and poor prognosis,and a better treatment plan needs further *** SUMMARY In order to deeply understand the occurrence and development of HAL,here we report a case of HAL with extensive metastasis of alpha fetoprotein negative KRAS A146T *** patient refused chemotherapy and received one course of treatment(immune checkpoint inhibitors),and died three months later due to progressive *** HAL is a special type of *** surgical treatment of HAL in the limited stage can achieve long-term survival,but most of them were in the advanced stage when they were found,and the prognosis was poor,which requires multidisciplinary comprehensive treatment.

关键词： Hepatoid adenocarcinoma Histopathological characteristics Non-small cell lung cancer Hepatoid adenocarcinoma of the lung Case report

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蒙皮效应考虑开洞影响的研究

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建筑科学 2009年第1期25卷 52-54,51页

作者：戚豹康文梅陶红林徐州建筑职业技术学院江苏徐州221008

应用有限元分析方法对闭口和开口蒙皮体及整体轻钢结构的抗剪性能及受力状态进行了研究,分析了蒙皮效应对整体结构的影响。最终确定了轻钢结构中最佳的门窗洞口位置。

关键词：轻钢结构蒙皮效应有限元分析

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三种柑橘类精油的GC-MS分析及抑菌活性对比

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现代食品科技 2024年第5期40卷 84-91页

作者：陈彦潘晓薇陶红林恋竹华南理工大学食品科学与工程学院广东广州510641 广东中烟工业有限责任公司技术中心广东广州510385

选取陈皮、柠檬和金桔这三种柑橘类植物为原料,利用超临界CO_(2)萃取法高效提取精油。采用GC-MS分析样品成分,进而探究三种精油对金黄色葡萄球菌和烟曲霉菌的抑菌活性。研究表明:柠檬精油中的醇类(3.41%)、醛类(2.55%)、酮类(2.03%)、酯... 详细信息

选取陈皮、柠檬和金桔这三种柑橘类植物为原料,利用超临界CO_(2)萃取法高效提取精油。采用GC-MS分析样品成分,进而探究三种精油对金黄色葡萄球菌和烟曲霉菌的抑菌活性。研究表明:柠檬精油中的醇类(3.41%)、醛类(2.55%)、酮类(2.03%)、酯类(7.17%)和除柠檬烯以外的萜烯类化合物(34.06%)含量较高,D-柠檬烯含量是这三种精油中最低的(46.52%);陈皮精油中的萜烯类(86.34%)、酚类化合物(1.82%)含量较高;金桔精油中的酸类化合物(12.71%)和D-柠檬烯(72.69%)含量较高。精油对金黄色葡萄球菌和烟曲霉菌的抑菌活性均为柠檬精油>陈皮精油>金桔精油。在这三种柑橘类精油中D-柠檬烯并非是唯一的抑菌成分,精油的抑菌活性也与除D-柠檬烯以外的抑菌成分密切相关。其中柠檬精油中含量丰富的γ-松油烯和β-蒎烯等其他抑菌成分可与D-柠檬烯协同起到有效提高精油抑菌活性的作用。该方法所提取的精油可为相关天然抑菌产品研发提供一定帮助。

关键词：柑橘精油超临界萃取抑菌活性 GC-MS

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Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis

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Genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang Rui Dong Sze Wan Hung Yiran Li Yuezhen lin ling Wu tao Zhang Gene Chi Wai Man Hui Xu Jacqueline Pui Wah Chung Chi Chiu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Chinese University of hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

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A Prediction Model for Detecting Dysthyroid Optic Neuropathy Based on Clinical Factors and Imaging Markers of the Optic Nerve and Cerebrospinal Fluid in the Optic Nerve Sheath

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Current Medical Science 2024年第4期44卷 827-832页

作者： hong-yu WU Ban LUO Gang YUAN Qiu-xia WANG Ping LIU Ya-li ZHAO lin-han ZHAI Wen-zhi LV Jing ZHANG Lang CHEN Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Medical Imaging Guangdong Second Provincial General HospitalGuangzhou510317China Department of Radiology Sir Run Run Shaw Hospital Affiliated with the School of Medicine of Zhejiang UniversityHangzhou310000China Department of Artificial Intelligence Julei Technology CompanyWuhan430030China

Objective This study aimed to develop and test a model for predicting dysthyroid optic neuropathy(DON)based on clinical factors and imaging markers of the optic nerve and cerebrospinal fluid(CSF)in the optic nerve *** This retrospective study included patients with thyroid-associated ophthalmopathy(tao)without DON and patients with tao accompanied by DON at our *** imaging markers of the optic nerve and CSF in the optic nerve sheath were measured on the water-fat images of each patient and,together with clinical factors,were screened by Least absolute shrinkage and selection ***,we constructed a prediction model using multivariate logistic *** accuracy of the model was verified using receiver operating characteristic curve *** In total,80 orbits from 44 DON patients and 90 orbits from 45 tao patients were included in our *** variables(optic nerve subarachnoid space and the volume of the CSF in the optic nerve sheath)were found to be independent predictive factors and were included in the prediction *** the development cohort,the mean area under the curve(AUC)was 0.994,with a sensitivity of 0.944,specificity of 0.967,and accuracy of ***,in the validation cohort,the AUC was 0.960,the sensitivity was 0.889,the specificity was 0.893,and the accuracy was *** A combined model was developed using imaging data of the optic nerve and CSF in the optic nerve sheath,serving as a noninvasive potential tool to predict DON.

关键词： dysthyroid optic neuropathy magnetic resonance imaging water-fat sequence optic nerve optic nerve subarachnoid space

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基于多模态大语言模型的攻击性模因解释生成方法

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计算机研究与发展 2024年第5期61卷 1206-1217页

作者：林萌戴程威郭涛中国科学院信息工程研究所北京100019 中国科学院大学网络空间安全学院北京100049

随着5G的发展,攻击性言论逐渐以多模态的方式在社交网络上广泛传播.因此,攻击性模因的检测与解释生成对于提高内容审核效果、维护和谐健康的舆论场环境有着重要的作用.现有的攻击性模因解释生成研究只关注于攻击对象和攻击内容,忽略了... 详细信息

随着5G的发展,攻击性言论逐渐以多模态的方式在社交网络上广泛传播.因此,攻击性模因的检测与解释生成对于提高内容审核效果、维护和谐健康的舆论场环境有着重要的作用.现有的攻击性模因解释生成研究只关注于攻击对象和攻击内容,忽略了模因包含的社会背景知识和隐喻表达手法,无法全面、准确地解释攻击性模因的含义,大大限制了解释的应用范围.为了应对这一挑战,提出一种基于多模态大模型的攻击性模因解释生成方法,通过增强攻击目标、攻击内容和隐喻识别等多种指令数据,利用其微调多模态大模型,以提升大模型对攻击性模因的解释生成能力.实验结果证实,该方法生成的解释具有3点优势:一是相比基线模型在BERTScore评估指标上提高了19%;二是解释中包含了攻击性隐喻表达的相关背景知识;三是在处理未见的模因数据时也表现出良好的泛化性能.

关键词：攻击性模因解释生成多模态大语言模型数据增强指令微调

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圆柱薄膜振动特性

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上海交通大学学报 2024年第4期58卷 428-437页

作者：黄涛何泽青宋林中国科学院空天信息创新研究院北京100094 中国科学院大学航空宇航学院北京100040

根据达朗贝尔原理建立圆柱状薄膜非线性振动方程并对其展开分析与试验验证.建立圆柱膜振动问题的控制方程组,依据薄膜振动物理方程与边界条件简化方程组并求解;得到圆柱膜非线性振动频率解析解,并通过有限元仿真对其线性解析解进行验证... 详细信息

根据达朗贝尔原理建立圆柱状薄膜非线性振动方程并对其展开分析与试验验证.建立圆柱膜振动问题的控制方程组,依据薄膜振动物理方程与边界条件简化方程组并求解;得到圆柱膜非线性振动频率解析解,并通过有限元仿真对其线性解析解进行验证.结果表明,理论计算与数值仿真结果误差较小,有限元方法适用于柔性薄膜结构模态分析.采用三维激光扫描式测振系统测试圆柱膜在空气环境中的振动频率,利用有限元分析软件获得圆柱膜干模态和湿模态振动频率并提取空气附加质量系数.结果表明,圆柱膜振动湿模态测试结果与数值分析结果具有良好的一致性,地面空气附加质量对圆柱膜振动的影响与薄膜自身质量处于同一量级.

关键词：非线性振动湿模态空气附加质量曲率薄膜

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