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Impact of old age on clinical and angiographic characteristics of coronary artery spasm as assessed by acetylcholine provocation test

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Journal of Geriatric Cardiology 2016年第10期13卷 824-829页

作者： Woong Gil Choi Soo Hyun Kim Seung-Woon Rha Kang-Yin CHEN Yong-Jian LI Byoung Geol Choi Se Yeon Choi Jin Won Kim Eung Ju Kim Chang Gyu Park hong seog seo Dong Joo Oh Department of Internal Medicine School of Medicine Kunkuk University Chungbuk South Korea Cardiovascular Center Korea University Guro Hospital Seoul South Korea Department of Cardiology the Second Hospital of Tianjin Medical University Tianjin China Department of Cardiology Nankai Hospital Tianjin Medical University Tianjin China

吸烟并且另外的风险因素作为变体咽峡炎或冠的动脉痉挛(CAS ) 的重要因素众所周知。然而，与冠的动脉痉挛上的年龄有关的临床的特征是 *** 很少与不足道的冠的动脉损害评估了 3155 个连续病人。病人们经历了醋胆素(Ach ) 为 CAS 的正式... 详细信息

吸烟并且另外的风险因素作为变体咽峡炎或冠的动脉痉挛(CAS ) 的重要因素众所周知。然而，与冠的动脉痉挛上的年龄有关的临床的特征是 *** 很少与不足道的冠的动脉损害评估了 3155 个连续病人。病人们经历了醋胆素(Ach ) 为 CAS 的正式就职的挑衅测试。CAS 是被定义 >70% 钠在 Ach 期间变窄冠的动脉挑衅测试。Ach 挑衅测试的结果在年龄组之中被比较；< 45 年(组 1 ) ， 45-54 年(组 2 ) ， 55-64 年(组 3 ) ，和 .ResultsOlder 病人有高血压，糖尿病，而是更低的发生的更高的发生的 65 年(组 4 ) 与更年轻的病人相比当前的吸烟、男性别评价。积极 Ach 挑衅测试发现经常与老化被显示出(47.36% 对 58.3% 对 62.6% 对 61.5% ；P < 0.001 ) 。Multivariate 逻辑分析证明年龄，男性，和心肌的桥牌是学习显示出的在场的 Ach 挑衅 *** 导致的 CAS 的独立预言者老年是为导致 Ach 的重要冠的动脉痉挛的独立预言者。

关键词：试验评估冠状动脉临床特征碱激发老年人乙酰痉挛血管造影

Five-year major clinical outcomes between first-generation and second-generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention

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Journal of Geriatric Cardiology 2018年第8期15卷 523-533页

作者： Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Ju Yeol Baek Woong Gil Choi Tae Soo Kang Ji Hoon Ahn Sang-Ho Park Ahmed Mashaly Jin Oh Na Cheol Ung Choi hong Euy Lim Eung Ju Kim Chang Gyu Park hong seog seo Dong Joo Oh Korea University Korea University Graduate School Cardiovascular Center Dankook University Hospital Soonchunhyang University Gumi Hospital Kangwon National University School of Medicine Division of Cardiology Soonchunhyang University Cheonan Hospital Guro Hospital Konkuk University Chungju Hospital Department of Cardiology Cardiovascular Division Department of Internal Medicine Cheong Ju St.Mary hospital Department of Medicine

Background There were limited data comparing the major clinical outcomes between first-generation(lG)-drug eluting stents(DES)and second-generation(2 G)-DES in patients with acute myocardial infarction(AMI) after percutaneous coronary intervention(PCI) during very long follow-up periods. We thought to investigate the comparative efficacy and safety of 2 G-DES compared with 1 G-DES in AMI patients during 5-year follow-up periods. Method A total of 1016 eligible AMI patients who underwent PCI with 1 G-DES [paclitaxel-,sirolimus-, lG-zotarolimus-eluting stent(endeavor?or endeavor sprint?), n = 554] or 2 G-DES [2 G-zotarolimus(endeavor resolute?)-or everolimus-eluting stent, n = 462] were enrolled. The primary endpoint was the occurrence of major adverse cardiac events(MACE) defined as total death, non-fatal mycx^ardial infarction(MI), target lesion revascularization(TLR), target vessel revascularization(TVR), non-target vessel revascularization(Non-TVR) and the secondary endpoint was stent thrombosis(ST) at 5 years. Results Two propensity score-ma?tched(PSM) groups(232 pairs, n = 464, C-statistic = 0.802) were generated. During the 5-year follow-up period, the cumulative incidence of TLR [hazard ratio(HR): 3.133; 95% confidence interval(Cl): 1.539-6.376; P = 0.002], TVR(HR: 3.144; 95% Cl: 1.596-6.192; P = 0.001)and total revascularization rate(HR: 1.874; 95% Cl: 1.086-3.140; P = 0.023) were significantly higher in 1 G-DES compared with 2 G-DES after PSM. However, the incidence of total death, non-fatal MI and ST were similar between the two groups. Conclusion In this sin?gle-center and all-comers registry, 2 G-DES,s superiorities for TLR, TVR and total revascularization in AMI patients suggested during 5-year clinical follow-up periods.

关键词： Acute myocardial infarction Clinical outcomes Drug-eluting stent

Changes in microorganisms and metabolites during long-term fermentation of commercially manufactured anchovy sauce

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Food Science and Human Wellness 2024年

作者： Daehyeon Kim seong-Eun Park Eun-Ju Kim Seung-Ho seo Kwang-Moon Cho Sun Jae Kwon hong-seok Son Department of Biotechnology College of Life Sciences and Biotechnology Korea University Sonlab Inc. 3. AccuGene Inc.

This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce. Samples of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 years. The complex bacterial community was simplified to two genera， Tetragenococcus and Halanaerobium， after approximately 0.55 years of fermentation. Although genera， such as Saccharomyces， Cladosporium， Candida， and Aspergillus， were relatively dominant， no clear pattern was identified in fungal community analysis. The longitudinal metabolite profile demonstrated that approximately half (55.8%) of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid fermentation. Despite the static microbial community， the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy sauce. This study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.

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Calcium channel blocker monotherapy versus combination with reninangiotensin system inhibitors on the development of new-onset diabetes mellitus in hypertensive Korean patients

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Journal of Geriatric Cardiology 2019年第6期16卷 439-447页

作者： Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park hong seog seo Division of Cardiology Department of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea Cardiovascular Center Korea University Guro Hospital Seoul South Korea Department of Medicine Korea University Graduate School Seoul South Korea Cardiology Department Konkuk University Chungju Hospital Chungju South Korea Department of Internal Medicine Cardiovascular Division Dankook University Hospital Cheonan South Korea Department of Cardiology Soonchunhyang University Gumi Hospital Gumi South Korea Cardiology Department Soonchunhyang University Cheonan Hospital Cheonan South Korea Division of Cardiology Department of Internal Medicine Cardiovascular Center Nowon Eulji Medical Center Eulji University Seoul South Korea Department of Cardiology Soonchunhyang University College of Medicine Seoul South Korea

Background In real practice, two or more antihypertensive drugs are needed to achieve target blood pressure. We investigated the comparative beneficial actions of combination therapy of renin-angiotensin system inhibitors (RASI), with calcium channel blockers (CCB) over CCB monotherapy on the development of new-onset diabetes mellitus (NODM) in Korean patients during four-year follow-up periods. Methods A total of 3208 consecutive hypertensive patients without a history of diabetes mellitus who had been prescribed CCB were retrospectively enrolled from January 2004 to December 2012. These patients were divided into the two groups according to the additional use of RASI (the RASI group, n = 1221 and the no RASI group, n = 1987). Primary endpoint was NODM, defined as a fasting blood glucose ≥ 126 mg/dL or hemoglobin A1c ≥ 6.5%. Secondary endpoint was major adverse cardiac events (MACE) defined as total death, myocardial infarction (MI) and percutaneous coronary intervention (PCI). Results After propensity score-matched (PSM) analysis, two propensity- matched groups (939 pairs, n = 1878, C-statistic = 0.743) were generated. The incidences of NODM (HR = 1.009, 95% CI: 0.700–1.452, P = 0.962), MACE (HR = 0.877, 95% CI: 0.544–1.413, P = 0.589), total death, MI, PCI were similar between the two groups after PSM during four years. Conclusions The use of RASI in addition to CCB showed comparable incidences of NODM and MACE compared to CCB monotherapy in non-diabetic hypertensive Korean patients during four-year follow-up period. However, large-scaled randomized controlled clinical trials will be required for a more definitive conclusion.

关键词： Calcium channel blocker Diabetes mellitus Renin-angiotensin system inhibitors

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Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon Hyung Il seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung Lee Seung Baek hong Ji Hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

Five-year clinical outcomes of first-generation versus second-generation drug-eluting stents following coronary chronic total occlusion intervention

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Journal of Geriatric Cardiology 2019年第8期16卷 639-647页

作者： Yong Hoon Kim Ae-Young Her Seung-Woon Rha Byoung Geol Choi Se Yeon Choi Jae Kyeong Byun Yoonjee Park Dong Oh Kang Won Young Jang Woohyeun Kim Ju Yeol Baek Woong Gil Choi Tae Soo Kang Jihun Ahn Sang-Ho Park Ji Young Park Min-Ho Lee Cheol Ung Choi Chang Gyu Park hong seog seo Division of Cardiology Department of Internal MedicineKangwon National University School of MedicineChuncheonSouth Korea Department of Cardiology Soonchunhyang University College of MedicineSeoulSouth Korea Cardiovascular Center Korea University Guro HospitalSeoulSouth Korea Department of Medicine Korea University Graduate SchoolSeoulSouth Korea Cardiovascular Center Seoul St. Mary’s Hospitalthe Catholic University of KoreaSeoulSouth Korea Cardiology Department Konkuk University Chungju HospitalChungjuSouth Korea Department of Internal Medicine Cardiovascular DivisionDankook University HospitalCheonanSouth Korea Department of Cardiology Soonchunhyang University Gumi HospitalGumiSouth Korea Cardiology Department Soonchunhyang University Cheonan HospitalCheonanSouth Korea Division of Cardiology Department of Internal MedicineCardiovascular CenterNowon Eulji Medical CenterEulji UniversitySeoulSouth Korea

Background There are limited data comparing long-term clinical outcomes between first-generation (1G) and second-generation (2G) drug-eluting stents (DESs) in patients who underwent successful percutaneous coronary intervention (PCI) for coronary chronic total occlusion (CTO) lesion. Methods A total of 840 consecutive patients who underwent PCI with DESs for CTO lesion from January 2004 to November 2015 were enrolled. Finally, a total of 324 eligible CTO patients received 1G-DES (Paclitaxel-eluting stent or Sirolimus-eluting stent, n = 157) or 2G-DES (Zotarolimus-eluting stent or Everolimus-eluting stent, n = 167) were enrolled. The clinical endpoint was the occurrence of major adverse cardiac events (MACE) defined as all-cause death, recurrent myocardial infarction (re-MI), total repeat revascularization [target lesion revascularization (TLR), target vessel revascularization (TVR), and non-TVR]. We investigated the 5-year major clinical outcomes between 1G-DES and 2G-DES in patient who underwent successful CTO PCI. Results After propensity score matched (PSM) analysis, two well-balanced groups (111 pairs, n = 222, C-statistic = 0.718) were generated. Up to the 5-year follow-up period, the cumulative incidence of all-cause death, re-MI, TLR, TVR and non-TVR were not significantly different between the two groups. Finally, MACE was also similar between the two groups (HR = 1.557, 95% CI: 0.820–2.959, P = 0.176) after PSM. Conclusions In this study, 2G-DES was not associated with reduced long-term MACE compared with 1G-DES following successful CTO revascularization up to five years.

关键词： Chronic total occlusion Drug-eluting stent Outcomes

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Magnetic field regression using artificial neural networks for cold atom experiments

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Chinese Physics B 2024年第2期33卷 46-51页

作者：陈子霆黃建陶 Bojeong seo 黄明琛 Mithilesh K.Parit 何逸飞甄浩廷 Jensen Li Gyu-Boong Jo Department of Physics The Hong Kong University of Science and TechnologyKowloon 999077China

Accurately measuring magnetic fields is essential for magnetic-field sensitive experiments in areas like atomic,molecular,and optical physics,condensed matter experiments,and other ***,since many experiments are often conducted in an isolated environment that is inaccessible to experimentalists,it can be challenging to accurately determine the magnetic field at the target ***,we propose an efficient method for detecting magnetic fields with the assistance of an artificial neural network(NN).Instead of measuring the magnetic field directly at the desired location,we detect fields at several surrounding positions,and a trained NN can accurately predict the magnetic field at the target *** training,we achieve a below 0.3%relative prediction error of magnetic field magnitude at the center of the vacuum chamber,and successfully apply this method to our erbium quantum gas apparatus for accurate calibration of magnetic field and long-term monitoring of environmental stray magnetic *** demonstrated approach significantly simplifies the process of determining magnetic fields in isolated environments and can be applied to various research fields across a wide range of magnetic field magnitudes.

关键词： ultracold gases trapped gases measurement methods and instrumentation

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Portable and Efficient Implementation of CRYSTALS-Kyber Based on WebAssembly

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Computer Systems Science & Engineering 2023年第8期46卷 2091-2107页

作者： seog Chung seo Heeseok Kim Department of Financial Information Security Kookmin UniversitySeoul02707Korea Department of Cyber Security College of Science and TechnologyKorea UniversitySejong30019Korea

With the rapid development of quantum computers capable of realizing Shor’s algorithm,existing public key-based algorithms face a significant security ***-Kyber has been selected as the only key encapsulation mechanism(KEM)algorithm in the National Institute of Standards and Technology(NIST)Post-Quantum Cryptography(PQC)*** this study,we present a portable and efficient implementation of a Crystals-Kyber post-quantum KEM based on WebAssembly(Wasm),a recently released portable execution framework for high-performance web *** now,most Kyber implementations have been developed with native programming languages such as C and *** there are a few previous Kyber implementations based on JavaScript for portability,their performance is significantly lower than that of implementations based on native programming ***,it is necessary to develop a portable and efficient Kyber implementation to secure web applications in the quantum computing *** Kyber software is based on JavaScript and Wasm to provide portability and efficiency while ensuring quantum ***,the overall software is written in JavaScript,and the performance core parts(secure hash algorithm-3-based operations and polynomial multiplication)are written in ***,we parallelize the number theoretic transform(NTT)-based polynomial multiplication using single instruction multiple data(SIMD)functionality,which is available in *** three steps in the NTT-based polynomial multiplication have been parallelized with Wasm SIMD intrinsic *** software outperforms the latest reference implementation of Kyber developed in JavaScript by×4.02(resp.×4.32 and×4.1),×3.42(resp.×3.52 and×3.44),and×3.41(resp.×3.44 and×3.38)in terms of key generation,encapsulation,and decapsulation on Google Chrome(***,and Microsoft Edge).As far as we know,this is the first software implementation of Kyber with Wasm technology in the web enviro

关键词： Crystals-kyber post-quantum cryptosystem(PQC) javascript WebAssembly SIMD web application internet of things(IoT) edge computing

Accelerating Falcon Post-Quantum Digital Signature Algorithm on Graphic Processing Units

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计算机、材料和连续体（英文） 2023年第4期75卷 1963-1980页

作者： seog Chung seo Sang Woo An Dooho Choi Kookmin University Seoul02707Korea Telecommunications Technology Association(TTA) Gyeonggi-do13591Korea Korea University Sejong30019Korea

Since 2016,the National Institute of Standards and Technology(NIST)has been performing a competition to standardize post-quantum cryptography(PQC).Although Falcon has been selected in the competition as one of the standard PQC algorithms because of its advantages in short key and signature sizes,its performance overhead is larger than that of other lattice-based *** study presents multiple methodologies to accelerate the performance of Falcon using graphics processing units(GPUs)for server-side *** GPU porting significantly degrades performance because the Falcon reference codes require recursive functions in its sampling ***,an iterative sampling approach for efficient parallel processing is *** this study,the Falcon software applied a fine-grained execution model and reported the optimal number of threads in a thread ***,the polynomial multiplication performance was optimized by parallelizing the number-theoretic transform(NTT)-based polynomial multiplication and the fast Fourier transform(FFT)-based ***,dummy-based parallel execution methods have been introduced to handle the thread divergence *** presented Falcon software on RTX 3090 NVIDA GPU based on the proposed methods with Falcon-512 and Falcon-1024 parameters outperform at 35.14,28.84,and 34.64 times and 33.31,27.45,and 34.40 times,respectively,better than the central processing unit(CPU)reference implementation using Advanced Vector Extensions 2(AVX2)instructions on a Ryzen 95900X running at 3.7 GHz in key generation,signing,and verification,***,the proposed Falcon software can be used in servers managing multiple concurrent clients for efficient certificate verification and be used as an outsourced key generation and signature generation server for Signature as a Service(SaS).

关键词： DSA Falcon GPU CUDA software optimization