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Influence of assisted reproductive technology and uterine leiomyoma on pregnancy outcomes in women with adenomyosis

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 56-59页

作者： Yi-Ling Wang Zhao Tian Xiao-hong Chang hong-lan zhu Heng Cui Department of Obstetrics and Gynecology People's HospitalPeking UniversityBeijing100044China

Aim To assess whether adverse pregnancy outcomes in women with adenomyosis are different according to the method of conception and the concurrent of uterine leiomyoma(UL).Methods We performed a retrospective ***-three singleton pregnancy cases complicated with adenomyosis were included in this *** the study group,15 women became pregnant with assisted reproductive technology(ART)and 21 women combined with *** outcomes were compared between ART and non-ART,UL and non-UL *** The prevalence for such complications as hypertensive disorder complicating pregnancy(HDCP)and postpartum hemorrhage(PPH)were significantly higher in the women conceived by ART(33.3%vs.5.3%,P=0.023)and(53.3%vs.23.7%,P=0.037),*** women concurrent with UL of which the diameter≥4cm were more likely to have severe PPH(44.4%vs.0%,P=0.021).Conclusion ART may increase the risk of adverse pregnancy outcomes such as HDCP and PPH in women with adenomyosis and UL of which the diameter≥4cm may further increase the risk of severe PPH.

关键词： Adenomyosis Adverse pregnancy outcomes Assisted reproductive technology Uterine leiomyoma

Influence of previous laparoscopic surgical and pathological diagnosis of endometriosis on pregnancy outcomes in women with adenomyosis

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Gynecology and Obstetrics Clinical Medicine 2022年第3期2卷 147-150页

作者： Zhao Tian Jin Lai Qing-Jie Zhai Yi Li Yue Wang Xiao-hong Chang hong-lan zhu Heng Cui Department of Obstetrics and Gynecology Peking UniversityPeople's HospitalBeijing100044China

Objectives:Previous studies demonstrated that endometriosis and adenomyosis are closely linked to lots of adverse pregnancy outcomes while the role of endometriosis in pregnant women with adenomyosis has not been explored *** present study aimed to evaluate the influence of previous laparoscopic surgical and pathological diagnosis of endometriosis on pregnancy outcomes in women with ***:A total of 60 pregnant women who were diagnosed with adenomyosis before or during pregnancy were included in this *** them,8 were also diagnosed with endometriosis by previous laparoscopic *** demographic characteristics and pregnancy outcomes were compared between women with adenomyosis only and those with the surgical history of ***:Compared with women with adenomyosis only,those concomitant with the surgical history of endometriosis had significantly higher age at delivery[37.5(36.25–39.75)vs.35(33.25–37),P=0.016]and an increased risk of postpartum hemorrhage(PPH)(adjusted OR:5.992,95%CI:1.03–34.857,P=0.046)while no significant differences were found in other adverse pregnancy outcomes between these two *** we further detected the risk factor of PPH in women with adenomyosis and found that the surgical history of endometriosis(OR:6.995,95%CI:1.16–42.171,P=0.034)and assisted reproductive technology(ART)(OR:5.062,95%CI:1.494–17.146,P=0.009)were the parameters closely associated with the occurrence of ***:The history of previous laparoscopic surgical and pathological diagnosis of endometriosis in pregnant women with adenomyosis may increase the risk of PPH,which still needs to be verified by future studies with a large sample ***,pregnancy through ART is also an increased risk factor for PPH in women with *** women with adenomyosis who conceived with the surgical history of endometriosis or by ART should be closely monitored for the reason of being at high risk of PPH.

关键词： Adenomyosis Endometriosis Adverse pregnancy outcomes Assisted reproductive technology

Current biomarkers for the detection of endometriosis

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Chinese Medical Journal 2020年第19期133卷 2346-2352页

作者： Zhao Tian Xiao-hong Chang Yan Zhao hong-lan zhu Department of Obstetrics and Gynecology People’s HospitalPeking UniversityBeijing 100044China.

A clinically reliable non-invasive test for endometriosis is expected to reduce the diagnostic *** varieties of biomarkers have been investigated for decades,and cancer antigen-125,cancer antigen-199,interleukin-6,and urocortin were the most studied ones among hundreds of biomarkers,no clinically reliable biomarkers have been confirmed so *** emerging technologies including“omics”technologies,molecular imaging techniques,and microRNAs are promising in solving these challenges,but their utility to detect endometriosis has yet to be *** combinations of researched indicators or other non-invasive methods and further exploration of the emerging technologies may be new targets and future research hotspots for non-invasive diagnosis of *** conclusion,researches of biomarkers for the detection of endometriosis are still ongoing and may benefit from novel molecular biology,bioinformatics methods and a combination of more diverse monitoring *** it will be a daunting task,the identification of a specific set of diagnostic biomarkers will undoubtedly improve the status of endometriosis.

关键词： Biomarkers Endometriosis Non-invasive diagnosis

Percutaneous transhepatic cholangioscopy-assisted biliary polypectomy for local palliative treatment of intraductal papillary neoplasm of the bile duct

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1821-1832页

作者： Xu Ren Yong-Ping Qu Chun-lan zhu Xiao-hong Xu hong Jiang Yi-Xia Lu hong-Peng Xue Digestive Disease Hospital of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Digestive Endoscopy Center of Heilongjiang Provincial Hospital Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Second Department of Gastroenterology Digestive Disease Hospital of Heilongjiang Provincial Hospitaland Heilongjiang Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Pancreaticobiliary DiseasesHarbin 150001Heilongjiang ProvinceChina Department of Pathology Heilongjiang Provincial HospitalHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a premalignant biliarytype epithelial neoplasm with intraductal papillary or villous *** reported local palliative therapeutic modalities,including endoscopic nasobiliary drainage,stenting and biliary curettage,endoscopic biliary polypectomy,percutaneous biliary drainage,laser ablation,argon plasma coagulation,photodynamic therapy,and radiofrequency ablation to relieve mechanical obstruction are limited with weaknesses and *** have applied percutaneous transhepatic cholangioscopy(PTCS)-assisted biliary polypectomy(PTCS-BP)technique for the management of IPNB including mucin-hypersecreting cast-like and polypoid type tumors since *** To assess the technical feasibility,efficacy,and safety of PTCS-BP for local palliative treatment of *** Patients with mucin-hypersecreting cast-like or polypoid type IPNB and receiving PTCS-BP between September 2010 and December 2019 were ***-BP was performed by using a half-moon type snare with a soft stainless-steel wire,and the tumor was snared and resected with *** primary outcome was its feasibility,indicated by technical *** secondary outcomes were efficacy,including therapeutic success,curative resection,and clinical success,and *** Five patients(four with mucin-hypersecreting cast-like type and one with polypoid type IPNB)were ***-and high-grade intraepithelial neoplasia(HGIN)and recurrent IPNB with invasive carcinoma were observed in one,two,and two patients,*** cholangitis and/or obstructive jaundice were presented in all four patients with mucin-hypersecreting cast-like type *** five patients achieved technical success of *** patients(three with mucin-hypersecreting cast-like type and one with polypoid type IPNB)obtained therapeutic success;one with mucin-hypersecreting cast-like type tumors in the intrahepatic small bile duct and HGIN h

关键词： Intraductal papillary neoplasm of the bile duct Percutaneous transhepatic cholangioscopy Biliary polypectomy Feasibility Efficacy

Pivotal role for long noncoding RNAs in zygotic genome activation in mice

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Science China(Life Sciences) 2024年第5期67卷 958-969页

作者： Kang Chen Wenju Liu Jiang zhu Xiaochen Kou Yanhong Zhao hong Wang Cizhong Jiang Shaorong Gao lan Kang Institute for Regenerative Medicine Shanghai East HospitalShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200120China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji HospitalShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Frontier Science Center for Stem Cell Research Tongji UniversityShanghai 200092China Clinical and Translation Research Center of Shanghai First Maternity&Infant Hospital School of Life Sciences and TechnologyTongji UniversityShanghai 200092China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Vertebrate life begins with fertilization,and then the zygote genome is activated after transient silencing,a process termed zygotic genome activation(ZGA).Despite its fundamental role in totipotency and the initiation of life,the precise mechanism underlying ZGA initiation remains *** existence of minor ZGA implies the possible critical role of noncoding RNAs in the initiation of ***,we delineate the expression profile of long noncoding RNAs(lncRNAs)in early mouse embryonic development and elucidate their critical role in minor *** with protein-coding genes(PCGs),lncRNAs exhibit a stronger correlation with minor *** H3K9me3 profiles can be observed between lncRNA genes and PCGs,and the enrichment of H3K9me3 before ZGA might explain the suspended expression of major ZGA-related PCGs despite possessing PolII ***,we identified the presence of PolII-enriched MuERV-L around the transcriptional start site of minor ZGA-related lncRNAs,and these repeats are responsible for the activation of minor ZGA-related lncRNAs and subsequent embryo *** study suggests that MuERV-L mediates minor ZGA lncRNA activation as a critical driver between epigenetic reprogramming triggered by fertilization and the embryo developmental program,thus providing clues for understanding the regulatory mechanism of totipotency and establishing bona fide totipotent stem cells.

关键词： ZGA lncRNA MuERV-L

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High-entropy design boosts dielectric energy storage

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Rare Metals 2024年第8期43卷 4013-4015页

作者： Qiu-Ying Xia He zhu Si lan Yang Ren Herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Department of Physics City University of Hong KongHong Kong999077China

Dielectric capacitors are vital for advanced electronic and electrical power systems due to their impressive power density and ***,a persistent challenge has been enhancing their energy densities while maintaining high *** in Science,a novel high-entropy design for relaxor ferroelectric materials has been proposed,promising significant improvements in both energy density and efficiency for multilayer dielectric ceramic *** the crucial role of high-entropy design in energy storage materials and devices,this highlight focuses on interpreting the progress and significance of this innovative work.

关键词： ceramic dielectric energy

Clinicopathological Characteristics of Ten Patients with Atypical Glandular Hyperplasia Transformation of Adenomyosis

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Chinese Medical Journal 2016年第3期129卷 364-366页

作者： hong-lan zhu Songoyuan Gao Dan-Hua Shen Heng Cui Department of Obstetrics and Gynecology People's Hospital Peking University Beijing 100044 China Department of Pathology People's Hospital Peking University Beijing 100044 China

Although adenomyosis is a largely benign disease,malignant transformations do happen in rare cases,resulting in endometrioid adenocarcinoma or sarcoma in the ***, attention has been focused on the malignant transformation of the *** 1988, the concept of atypical endometriosis （aEM） was first proposed by LaGrenade and Silverberg,[1] who suggested that aEM might be a precursor of malignant transformations of ***, the majority of investigations of aEM focus on endometriosis, while adenomyosis remains *** this article, we report 10 cases of atypical glandular hyperplasia transformation of adenomyosis, of whom the clinical and pathological characteristics are observed.

关键词： Adenomyosis Atypical Glandular Hyperplasia Clinicopathological Characteristics

UAV-assisted cooperative offloading energy efficiency system for mobile edge computing

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Digital Communications and Networks 2024年第1期10卷 16-24页

作者： Xue-Yong Yu Wen-Jin Niu Ye zhu hong-Bo zhu Jiangsu Key Laboratory of Wireless Communications Nanjing University of Posts and Telecommunications Nanjing210003China Engineering Research Centerof Health Service System Based on Ubiquitous Wireless Networks Ministry of EducationNanjng Universityof Posts and Telecommunications Nanjing210003China

Reliable communication and intensive computing power cannot be provided effectively by temporary hot spots in disaster areas and complex terrain ground *** this has greatly developed the application and integration of UAV and Mobile Edge Computing(MEC)to the Internet of Things(loT).However,problems such as multi-user and huge data flow in large areas,which contradict the reality that a single UAV is constrained by limited computing power,still *** to allowing UAV collaboration to accomplish complex tasks,cooperative task offloading between multiple UAVs must meet the interdependence of tasks and realize parallel processing,which reduces the computing power consumption and endurance pressure of *** the computing requirements of the user terminal,delay constraint of a computing task,energy constraint,and safe distance of UAV,we constructed a UAV-Assisted cooperative offloading energy efficiency system for mobile edge computing to minimize user terminal energy ***,the resulting optimization problem is originally nonconvex and thus,difficult to solve *** tackle this problem,we developed an energy efficiency optimization algorithm using Block Coordinate Descent(BCD)that decomposes the problem into three convex ***,we jointly optimized the number of local computing tasks,number of computing offloaded tasks,trajectories of UAV,and offloading matching relationship between multi-UAVs and multiuser *** results show that the proposed approach is suitable for different channel conditions and significantly saves the user terminal energy consumption compared with other benchmark schemes.

关键词： Computation offloading Internet of things(IoT) Mobile edge computing(MEC) Block coordinate descent(BCD)

Effects of Previous Laparoscopic Surgical Diagnosis of Endometriosis on Pregnancy Outcomes

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Chinese Medical Journal 2017年第4期130卷 428-433页

作者： Hui Li hong-lan zhu Xiao-hong Chang Yi Li Yue Wang Jing Guan Heng Cui Gynecological Oncology Center Peking University People's Hospital Beijing 100044 China Department of Obstetrics and Gynecology Peking University People's Hospital Beijing 100044 China Reproductive Medicine Center Peking University People's Hospital Beijing 100044 China

Background： The association between the previous history ofendometriosis and obstetric outcomes is still ambiguous. This study aimed to evaluate the effects of previous history of operatively diagnosed endometriosis on pregnancy outcomes. Methods： A total of 98 primiparous women who had been diagnosed with endometriosis by previous laparoscopic surgery were included in this retrospective cohort study. Pregnancy outcomes were compared between these women （study group） who had a live birth and 300 women without endometriosis （control group） who had a live birth. In the study group, the pregnancy outcomes of 74 women who conceived naturally （no assisted reproductive technology [ART] subgroup） were simultaneously compared with 24 women who conceived by ART （ART subgroup）. Results： Miscarriage was observed in 23 of 98 women with endometriosis （23.5%）. There were 75 women who had a live birth after laparoscopic diagnosis ofendometriosis in the study group eventually. On multivariate analysis, the postpartum hemorrhage rate increased significantly in the study group when compared with the control group （adjusted odds ratio： 2.265, 95% confidence interval： 1.062, 4.872; P = 0.034）. There was an upward tendency of developing other pregnancy-related complications, such as preterm birth, placental abruption, placenta previa, cesarean section, fetal distress/anemia, and others in the study group than in the control group. However, the differences showed no statistical significance. Within the study group, the occurrence rate of postpartum hemorrhage and preterm birth was both higher in the ART subgroup than in the no ART subgroup. The differences both had statistical significance （44.4% vs. 17.5%, P = 0.024 and 27.8% vs. 1.8%, P = 0.010, respectively）. At the same time, median （interquartile range） for gestational age at delivery in the ART subgroup was significantly shorter than that in the no ART subgroup （38 weeks [36-39 weeks] vs. 39 weeks [38-40 weeks]; P = 0.005）. Conclus

关键词： Assisted Reproductive Technology Endometriosis Pregnancy Outcomes