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Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?

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Regenerative Biomaterials 2016年第2期3卷 87-98页

作者： hon fai Chan Siying Ma Kam W.Leong Department of Biomedical Engineering Department of Systems BiologyColumbia UniversityNew YorkNY 10032USA

Translation of any inventions into products requires *** of drug/gene/cell delivery systems will eventually face manufacturing challenges,which require the establishment of standardized processes to produce biologically-relevant products of high quality without incurring prohibitive *** technologies present many advantages to improve the quality of drug/gene/cell delivery *** also offer the benefits of *** remains unclear is whether they can meet the scale-up *** this perspective,we discuss the advantages of microfluidic-assisted synthesis of nanoscale drug/gene delivery systems,formation of microscale drug/cell-encapsulated particles,generation of genetically engineered cells and fabrication of macroscale drug/cell-loaded micro-/*** also highlight the scale-up challenges one would face in adopting microfluidic technologies for the manufacturing of these therapeutic delivery systems.

关键词： microfluidics biomanufacturing nanoparticle microencapsulation microfiber

HFNC與NIV對I型呼吸衰竭患者的應用價值分析

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镜湖医学 2024年第1期24卷 49-51,41页

作者：石漢輝季銀樑陳劍龍澳門鏡湖醫院急診科中国

目的分析對於I型呼吸衰竭患者採用經鼻高流量氧療(HFNC)氧療對比無創通氣(NIV)治療的應用價值。方法選取2022年5月~2023年4月在鏡湖醫院急症室使用HFNC及NIV治療的I型呼吸衰竭患者,分析基礎資料、治療結局、呼吸困難評分、舒適度評分。... 详细信息

目的分析對於I型呼吸衰竭患者採用經鼻高流量氧療(HFNC)氧療對比無創通氣(NIV)治療的應用價值。方法選取2022年5月~2023年4月在鏡湖醫院急症室使用HFNC及NIV治療的I型呼吸衰竭患者,分析基礎資料、治療結局、呼吸困難評分、舒適度評分。結果HFNC組41例、NIV組26例。治療後的呼吸困難評分(VAS)、呼吸頻率的差異無統計學意義;治療後的氣合指數(PaO_(2)/FiO_(2))在NIV組改善更多,差異有統計學意義。在急症室通過HFNC或NIV治療2小時内的失敗率、入院後續用HFNC或NIV治療6小時内插管率、28天病死率,差異均無統計學意義。HFNC組舒適度評分更高,差異有統計學意義。結論對於I型呼吸衰竭患者,HFNC與NIV均可改善Ⅰ型呼吸衰竭患者生理指標及血氣分析指標,但與NIV比較,患者對HFNC的耐受性更好,更利於患者臨床治療。

关键词： I型呼吸衰竭經鼻高流量氧療無創通氣

Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure

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Bioactive Materials 2023年第10期28卷 112-131页

作者： Yuanyuan Jin Jiabin Zhang Yanteng Xu Ke Yi Fenfang Li Huicong Zhou Haixia Wang hon fai Chan Yeh-Hsing Lao Shixian Lv Yu Tao Mingqiang Li Laboratory of Biomaterials and Translational Medicine Center for NanomedicineThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou510630China Guangdong Provincial Key Laboratory of Liver Disease Research Guangzhou510630China School of Materials Science and Engineering Peking UniversityBeijing100871China Institute for Tissue Engineering and Regenerative Medicine School of Biomedical ScienceThe Chinese University of Hong Kong999077Hong KongChina Department of Pharmaceutical Sciences University at BuffaloThe State University of New YorkBuffaloNY14214USA

Reactive oxygen species(ROS)-associated oxidative stress,inflammation storm,and massive hepatocyte necrosis are the typical manifestations of acute liver failure(ALF),therefore specific therapeutic interventions are essential for the devastating ***,we developed a platform consisting of versatile biomimetic copper oxide nanozymes(Cu NZs)-loaded PLGA nanofibers(Cu NZs@PLGA nanofibers)and decellularized extracellular matrix(dECM)hydrogels for delivery of human adipose-derived mesenchymal stem/stromal cells-derived hepatocyte-like cells(hADMSCs-derived HLCs)(HLCs/Cu NZs@fiber/dECM).Cu NZs@PLGA nanofibers could conspicuously scavenge excessive ROS at the early stage of ALF,and reduce the massive accumulation of pro-inflammatory cytokines,herein efficiently preventing the deterioration of hepatocytes ***,Cu NZs@PLGA nanofibers also exhibited a cytoprotection effect on the transplanted ***,HLCs with hepatic-specific biofunctions and anti-inflammatory activity acted as a promising alternative cell source for ALF *** dECM hydrogels further provided the desirable 3D environment and favorably improved the hepatic functions of *** addition,the pro-angiogenesis activity of Cu NZs@PLGA nanofibers also facilitated the integration of the whole implant with the host ***,HLCs/Cu NZs@fiber/dECM performed excellent synergistic therapeutic efficacy on ALF *** strategy using Cu NZs@PLGA nanofiber-reinforced dECM hydrogels for HLCs in situ delivery is a promising approach for ALF therapy and shows great potential for clinical translation.

关键词： Acute liver failure Nanozyme Hepatocyte-like cells Human adipose-derived mesenchymal stem/stromal cells Electrospun nanofiber

Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

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Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： Jeremy Yuen-Chun Teoh Chi-Kwok Chan Maggie Haitian Wang Chi-Ho Leung Eddie Shu-Yin Chan Peter Ka-Fung Chiu Chi-Hang Yee hon-Ming Wong Simon See-Ming Hou Chi-fai Ng S.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTS)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and Statistics Department of the hong Kong Special Administrative Region(hong Kong,China).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTS group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** aged80 *** to the general population,younger patients in the LUTS group appeared to have better survival(80 years,survival was similar with the general population in both the LUTS and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTS may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate

Feasibility of gallbladder preservation during robotic left hepatectomy:A retrospective comparative study

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第3期5卷 100-105页

作者： Kit-fai Lee Andrew KY.Fung hon-Ting Lok Janet WC.Kung Eugene YJ.Lo Charing CN.Chong John Wong Kelvin KC.Ng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Objective:Traditionally,gallbladder is routinely removed during left hepatectomy even if there is no gallbladder ***,adverse consequence after cholecystectomy,though rare,still occa-sionally *** study aims to evaluate the feasibility of gallbladder preservation during robotic left ***:All consecutive robotic left hepatectomy cases between December 2010 and January 2022 in Prince of Wales Hospital,the Chinese University of hong Kong were retrieved from a prospectively collected *** gallbladder was preserved by moving the liver transection line just away from the gallbladder *** were divided into two groups:gallbladder preservation(GBP)and non-gallbladder preservation(NGBP).Operative results and long-term outcomes were compared between these two ***:There were 11 cases in the GBP group and 25 cases in the NGBP *** two groups were comparable in terms of the patient demographics and disease *** was no operative *** was no difference between the two groups in operative time(GBP 270 min *** 332 min,p=0.132),blood loss(GBP 50 mL *** 150 mL,p=0.115)or complication rate(GBP 27.3%*** 24.0%,p>0.999).There was also no difference in 5-year overall *** the GBP group,no patient developed specific symptoms or complications related to the preserved ***-up ultrasound or computed tomography revealed a normal appearance of the preserved gallbladders except in one patient who developed a 3-mm gallbladder *** the other hand,one(4%)patient in the NGBP group developed troublesome diarrhoea after ***:Gallbladder preservation is safe and feasible during robotic left *** preserved gallbladder does not lead to any symptoms,while postcholecystectomy diarrhoea can be avoided.

关键词： Robotic left hepatectomy Gallbladder preservation Cholecystectomy

Robot-assisted minimally invasive procedures for complicated biliary stone disease

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 185-188页

作者： Kit fai Lee Andrew K. Y. Fung hon Ting Lok Anthony K. W. Fong Charing C. N. Chong Paul B. S. Lai Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Introduction A big advancement in endoscopic management for biliary stone diseases was seen in the past three decades. Bile duct stones can be removed after sphincterotomy or balloon sphincteroplasty with stone basket... 详细信息

关键词： balloon biliary diseases

Pattern of disease recurrence and its implications for postoperative surveillance after curative hepatectomy for hepatocellular carcinoma: experience from a single center

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Hepatobiliary Surgery and Nutrition 2018年第5期7卷 320-330页

作者： Kit-fai Lee Charing C. N. Chong Anthony K. W. Fong Andrew K. Y. Fung hon-Ting Lok Yue-Sun Cheung John Wong Paul B. S. Lai Department of Surgery Division of Hepatobiliary and Pancreatic Surgery Prince of Wales Hospital the Chinese University of Hong Kong Hong Kong China

Background: Hepatectomy is a widely accepted curative treatment for hepatocellular carcinoma (HCC). However, the disease frequently recurs after a curative hepatectomy. The objective of this study is to provide a better understanding of the pattern of disease recurrence and the risk factors involved so as to improve the postoperative surveillance. Methods: A retrospective study for all patients receiving hepatectomy for HCC between 2003 and 2014 was performed. Emphasis was made on the timing and pattern of recurrent disease, and type of treatment given. Results: There were 506 patients in the study. Median follow-up was 43.7 months. The 1-, 3-, 5-, 10-year overall and disease free survival were 89.5%, 74.1%, 63.9%, 49.0% and 69.5%, 54.3%, 43.4%, 30.9%respectively. Recurrent disease occurred in 267 patients, 47.2% occurred within 9 months of hepatectomy and 80.1% recurred only in liver. Median survival was shorter for recurrence occurring within 9 months compared with those occurring between 10 months and 2 years postoperatively (36.2 vs. 65.7 months, P3.5 cm and history of rupture were risk factors for recurrence within 9 months. Conclusions: These findings suggest that recurrent diseases are common after curative hepatectomy for HCC and most recurrences occur in the remnant liver. Since almost half of recurrences occurred within first 9 months after hepatectomy, a more stringent postoperative surveillance with target imaging of liver in this period is needed. Early diagnosis of recurrent disease and curative retreatment hopefully can bring about a longer survival.

关键词： Hepatectomy hepatocellular carcinoma (HCC) recurrence

Lithographic patterning of ferromagnetic FePt nanoparticles from a single-source bimetallic precursor containing hemiphasmidic structure for magnetic data recording media

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Science China Materials 2019年第4期62卷 566-576页

作者： Zhengong Meng Cheuk-Lam Ho hon-fai Wong Zhen-Qiang Yu Nianyong Zhu Guijun Li Chi-Wah Leung Wai-Yeung Wong College of Chemistry and Environmental Engineering Shenzhen University Institute of Molecular Functional Materials and Department of Chemistry Hong Kong Baptist University HKBU Institute of Research and Continuing Education Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Applied Physics The Hong Kong Polytechnic University

Patterning of L10 FePt nanoparticles(NPs) with high coercivity offers a promising route to develop bit-patterned media(BPM) for the next generation magnetic data recording system, but the synthesis of monodisperse FePt NPs and mass production of their nanopatterns has been a longstanding challenge. Here, highly efficient nanoimprint lithography was applied for large-scale universal patterning, which was achieved by imprinting the solution of a single-source bimetallic precursor. The rigid coplanar metallic cores and the surrounding flexible tails in the bimetallic complex permit the spontaneous molecular arrangements to form the highly ordered negative morphology replicated from the soft ***-situ pyrolysis study was then investigated by one-pot pyrolysis of the precursor under an Ar/H2 atmosphere, and the resultant NPs were fully characterized to identify the phase,morphology and magnetic properties. Finally, highly-ordered patterns on certain substrates were preserved perfectly after pyrolysis and could be potentially utilized in magnetic data recording media.

关键词： FePt nanoparticles single-source bimetallic precursors one-pot pyrolysis lithographic patterning magnetic data recording media

An unprecedented outbreak investigation for nosocomial and community-acquired legionellosis in hong Kong

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Chinese Medical Journal 2012年第23期125卷 4283-4290页

作者： CHENG Vincent Chi-chung WONG Samson Sai-yin CHEN Jonathan hon-kwan CHAN Jasper Fuk-woo TO Kelvin Kai-wang POON Rosana Wing-shan WONG Sally Cheuk-ying CHAN Kwok-hung TAI Josepha Wai-ming HO Pak-leung TSANG Thomas Ho-fai YUEN Kwok-yung Department of Microbiology Queen Mary Hospital Hong Kong China Infection Control Team Queen Mary Hospital Hong Kong China Centre for Health Protection Department of Health Hong Kong China

Background The environmental sources associated with community-acquired or nosocomial legionellosis were not always detectable in the mainland of China and hong Kong, China. The objective of this study was to illustrate the control measures implemented for nosocomial and community outbreaks of legionellosis, and to understand the environmental distribution of legionella in the water system in hong Kong, China. Methods We investigated the environmental sources of two cases of legionellosis acquired in the hospital and the community by extensive outbreak investigation and sampling of the potable water system using culture and genetic testing at the respective premises. Results The diagnosis of nosocomial legionellosis was suspected in a patient presenting with nosocomial pneumonia not responsive to multiple beta-lactam antibiotics with subsequent confirmation by Legionella pneumophila serogroup 1 antigenuria. High counts of Legionella pneumophila were detected in the potable water supply of the 70-year-old hospital building. Another patient on continuous ambulatory peritoneal dialysis presenting with acute community-acquired pneumonia and severe diarrhoea was positive for Legionella pneumophila serogroup 1 by polymerase chain reaction （PCR） testing on both sputum and nasopharyngeal aspirate despite negative antigenuria. Paradoxically the source of the second case was traced to the water system of a newly commissioned office building complex. No further cases were detected after shock hyperchlorination with or without superheating of the water systems. Subsequent legionella counts were drastically reduced. Point-of-care infection control by off-boiled or sterile water for mouth care and installation of water filter for showers in the hospital wards for immunocompromised patients was instituted. Territory wide investigation of the community potable water supply showed that 22.1% of the household water supply was positive at a mean legionella count of 108.56 CFU/ml （rang

关键词： outbreak nosocomial legionellosis community-acquired legionellosis