Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?

作     者：Hon Fai Chan Siying Ma Kam W.Leong 

作者机构：Department of Biomedical EngineeringDepartment of Systems BiologyColumbia UniversityNew YorkNY 10032USA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2016年第3卷第2期

页      面：87-98页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0802[工学-机械工程] 080201[工学-机械制造及其自动化] 

基　　金：This work was supported from NIH(4UH3TR000505,AI096305,HL109442) the NIH Common Fund for the Microphysiological Systems Initiative is acknowledged.H.F.C.is grateful for fellowship support from the Sir Edward Youde Memorial Fund Council(Hong Kong) 

主　　题：microfluidics biomanufacturing nanoparticle microencapsulation microfiber 

摘      要：Translation of any inventions into products requires *** of drug/gene/cell delivery systems will eventually face manufacturing challenges,which require the establishment of standardized processes to produce biologically-relevant products of high quality without incurring prohibitive *** technologies present many advantages to improve the quality of drug/gene/cell delivery *** also offer the benefits of *** remains unclear is whether they can meet the scale-up *** this perspective,we discuss the advantages of microfluidic-assisted synthesis of nanoscale drug/gene delivery systems,formation of microscale drug/cell-encapsulated particles,generation of genetically engineered cells and fabrication of macroscale drug/cell-loaded micro-/*** also highlight the scale-up challenges one would face in adopting microfluidic technologies for the manufacturing of these therapeutic delivery systems.