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美国国家安全局事件

美国国家安全局事件

Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

作者： (德)马塞尔·罗森巴赫(Marcel Rosenbach)，(德)霍尔格·斯塔克(holger stark)

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Nano Research 2024年第10期17卷 9141-9151页

作者： Jeong Yu Lee Shonit Nair Sharma Sung-Yu Hong Young-Guk Ko Yangsoo Jang Minjae Do Michael Christopher stark Qiwen Peng Benjamin Allen Mossburg Bo Chan Seo Yuhan Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea Division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

Hordedane diterpenoid phytoalexins restrict Fusarium graminearum infection but enhance Bipolaris sorokiniana colonization of barley roots

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Molecular Plant 2024年第8期17卷 1307-1327页

作者： Yaming Liu Dario Esposto Lisa K.Mahdi Andrea Porzel Pauline stark Hidayat Hussain Anja Scherr-Henning Simon Isfort Ulschan.Bathe Ivan F.Acosta Alga Zuccaro Gerd U.Balcke Alain Tissier Department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryHalleGermany institute for Plant Sciences Cluster of Excellence on Plant Sciences(CEPLAS)Cologne BiocenterUniversity of CologneCologneGermany Department of Bioorganic Chemistry Leibniz Institute of Plant BiochemistryHalleGermany Max Planck Institute for Plant Breeding Research CologneGermany Horticultural Sciences University of FloridaGainesvilleFLUSA.

Plant immunity is a multilayered process that includes recognition of patterns or effectors from pathogens to elicit defense *** include the induction of a cocktail of defense metabolites that typically restrict pathogen ***,we investigate the interaction between barley roots and the fungal pathogens Bipolaris sorokiniana(Bs)and Fusarium graminearum(Fg)at the metabolite *** identify hordedanes,a previously undescribed set of labdane-related diterpenoids with antimicrobial properties,as critical players in these *** of barley roots by Bs and Fg elicits hordedane synthesis from a 60o-kb gene *** reconstruction of the biosynthesis pathway in yeast and Nicotiana benthamiana produced several hordedanes,including one of the most functionally decorated products 19-β-hydroxy-hordetrienoic acid(19-OH-HTA).Barley mutants in the diterpene synthase genes of this cluster are unable to produce hordedanes but,unexpectedly,show reduced Bs *** contrast,colonization by Fusarium graminearum,another fungal pathogen of barley and wheat,is 4-fold higher in the mutants completely lacking ***,19-OH-HTA enhances both germination and growth of Bs,whereas it inhibits other pathogenic fungi,including *** of microscopy and transcriptomics data suggest that hordedanes delay the necrotrophic phase of *** together,these results show that adapted pathogens such as Bs can subvert plant metabolic defenses to facilitate root colonization.

关键词： barley Hordeum vulgare diterpenoid phytoalexins gene cluster pathogenic fungi Bipolaris sorokininiana Fusarium graminearum

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螺栓连接:设备安全背后的守护者

流程工业 2024年第9期 38-39页

作者： Alexander stark 不详

在工厂设备或装置的建设和安装过程中,细节往往起到了决定性的作用。例如,错误的螺栓连接可能会导致昂贵的停工事件和严重的安全事故。如何确保螺栓的装配和维护是按照标准进行的安全操作?本文提供了这些方式以飨读者。

关键词：螺栓连接工厂设备安全操作安全事故守护者

Evidence-Based Cesarean Section for Universal Use in China:The"stark(Misgav Ladach)Method"

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Maternal-Fetal Medicine 2019年第1期1卷 48-52页

作者： Michael stark New European Surgical Academy Unter den Linden 21Berlin 10117Germany Department ofObstetrics and Gynecology CharitéUniversity HospitalCharitépl.1Berlin 10117Germany ELSANHospital Group 58 Rue la BoétieParis 75008France

There are many ways to perform cesarean section,with many methods developing from local *** a 3-year study process,a modified,evidence-based method has bean developed,which is now in use in many *** abdomen incision is based on the Joel-Cohen incision,the peritoneum is opened by repeated stretching,and the uterus is opened transversely after pushing the bladder *** delivery the uterus is sutured with one layer using a large needle,and the abdomen is closed with only two layers,fascia and *** method was subject to scores of studies,with all upholding its superiority over traditional *** a result,the"stark(Misgav Ladach)method"is recommended to become a standard procedure across China.

关键词： Cesarean section stark cesarean Misgav Ladach

The ALMaQUEST Survey ⅩⅤ:The dependence of the molecular-to-atomic gas ratios on resolved optical diagnostics

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 174-196页

作者： Niankun Yu Zheng Zheng Chao-Wei Tsai Pei Zuo Sara L.Ellison David V.stark Di Li Jingwen Wu Karen L.Masters Ting Xiao Yinghui Zheng Zongnan Li Kai Zhang Hongying Chen Shu Liu Sihan Jiao Fanyi Meng National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Department of Physics&Astronomy University of VictoriaVictoriaV8P 1A1Canada Departments of Physics and Astronomy Haverford CollegeHaverford19041USA Space Telescope Science Institute San Martin Dr.Baltimore 21218USA Zhejiang Laboratory Hangzhou 311121China New Cornerstone Science Laboratory Shenzhen 518054China School of Physics Zhejiang UniversityHangzhou 310058China

The atomic-to-molecular gas conversion is a critical step in the baryon cycle of galaxies,which sets the initial conditions for subsequent star formation and influences the multi-phase interstellar *** compiled a sample of 94 nearby galaxies with observations of multi-phase gas contents by utilizing public H_(Ⅰ),CO,and optical IFU data from the Ma NGA survey together with new FAST H_(Ⅰ)*** agreement with previous results,our sample shows that the global molecular-to-atomic gas ratio(R_(mol)≡log M_(H2)/M_(H_(Ⅰ)))is correlated with the global stellar mass surface densityμ_*with a Kendall'sτcoefficient of 0.25 and p<10^(-3),less tightly but still correlated with stellar mass and NUV-r color,and not related to the specific star formation rate(sSFR).The cold gas distribution and kinematics inferred from the H_(Ⅰ)and CO global profile asymmetry and shape do not significantly rely on R_(mol).Thanks to the availability of kpc-scale observations of MaNGA,we decompose galaxies into H_(Ⅱ),composite,and AGN-dominated regions by using the BPT *** increasing R_(mol),the fraction of H_(Ⅱ)regions within 1.5 effective radius decreases slightly;the density distribution in the spatially resolved BPT diagram also changes significantly,suggesting changes in metallicity and ionization *** with high R_(mol)tend to have high oxygen abundance,both at one effective radius with a Kendall'sτcoefficient of 0.37(p<10^(-3))and their central *** all parameters investigated here,the oxygen abundance at one effective radius has the strongest relation with global R_(mol).The dependence of gas conversion on gas distribution and galaxy ionization states is *** contrast,the observed positive relation between oxygen abundance(μ_(*))and R_(mol)indicates that the gas conversion is efficient in regions of high metallicity(density).

关键词： Galaxies baryon cycle radio lines H_(Ⅰ)21 cm atomic-to-molecular gas conversion

Protein-mediated interactions in the dynamic regulation of acute inflammation

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BIOCELL 2023年第6期47卷 1191-1198页

作者： RYAN stark Department of Pediatric Critical Care Medicine Vanderbilt University Medical CenterNashvilleTN37232-9075USA

Protein-mediated interactions are the fundamental mechanism through which cells regulate health and *** interactions require physical contact between proteins and their respective targets of *** targets include not only other proteins but also nucleic acids and other important molecules as *** proteins are often involved in multibody complexes that work dynamically to regulate cellular health and *** techniques have been adapted to study these important interactions,such as affinity-based assays,mass spectrometry,and fluorescent *** application of these techniques has led to a greater understanding of how protein interactions are responsible for both the instigation and resolution of acute inflammatory *** pursuits aim to provide opportunities to target specific protein interactions to alleviate acute inflammation.

关键词： Protein interactions Inflammation Sepsis RNA DNA Therapeutics

Apologos:A Lightweight Design Method for Sociotechnical Inquiry

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Journal of Social Computing 2021年第4期2卷 297-308页

作者： Luke stark the Faculty of Information and Media Studies Western UniversityLondonN6A 0A2Canada

While scholars involved in studying the ethics and politics flowing from digital information and communication systems have sought to impact the design and deployment of digital technologies,the fast pace and iterative tempo of technical development in these contexts,and the lack of structured engagement with sociotechnical questions,have been major barriers to ensuring values are considered explicitly in the R&D *** I introduce Apologos,a lightweight design methodology informed by the author’s experience of the challenges and opportunities of interdisciplinary collaboration between computational and social sciences over a five-year ***,which is inspired by“design apologetics”,is intended as an initial mechanism to introduce technologists to the process of considering how human values impact the digital design process.

关键词： values in design values sensitive design(VSD) artificial intelligence Values@Play design methods sociotechnical ethics values

The Mechanism of Ground Granulated Blastfurnace Slag Preventing Alkali Aggregate Reaction

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Journal of Wuhan University of Technology(Materials Science) 2010年第2期25卷 332-341页

作者： stark Jochen FREYBURG Ernst F A Finger-Institute for Building Material Science of Bauhaus-University Weimar

Three different methods were applied to study the alkali content of gelpores in cement. In the closed system, the concentration of K＋, Na＋ and OH - have not reduced with the increase of age. In the open system, the diffusion and transferring of K＋ and Na＋ towards free space leads to the de-crease of total alkali content. In the micro-analysis system, the contents of K＋ and Na＋ in the first hy- drated layer of ground granulated blastfurnace slag （GBFS） are very low, while the contents of calcium and magnesium are relatively high. This phenomenon shows that the mechanism of GBFS preventing alkali aggregate reaction （AAR） is： when GBFS is dissolved by alkali medium, SiO2 and Al2O3 are dissolved into the cement matrix, then around GBFS particles form reaction rings rich in Ca2＋ and Mg^2＋, and the C-S-H gel of positive charges formed in the area repulses K＋ and Na＋, which are forced to transfer to the mortar＇s matrix, pore or mortar sample surface. The transferred K ^＋ and Na^＋ form alkali gel products with other dissolved ions, then become evenly distributed in the mortar sample and react with Ca（OH）2 in pore solutions to form （Na,K）x-2z·zCa·（SiO2）y·（OH）x gel products; and thus changes the AAR gel products＇ structure. The gel products will not expand, and so they can delay expansion destruction.

关键词： granulated blastfurnace slag (GBFS) alkali aggregate reaction (AAR) alkali content preventing mechanism