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Reappraisal of endoscopic papillary balloon dilation for the management of common bile duct stones

World Journal of Gastrointestinal Endoscopy 2015年第2期7卷 77-86页

作者： Kwok-hung Lai hoi-hung chan Tzung-Jiun Tsai Jin-Shiung Cheng Ping-I Hsu Division of Gastroenterology Department of Internal Medicine Kaohsiung Veterans General Hospital School of Medicine National Yang-Ming University

Although endoscopic sphincterotomy(EST) is still considered as a gold standard treatment for common bile duct(CBD) stones in western guideline, endoscopic papillary balloon dilation(EPBD) is commonly used by the endoscopists in Asia as the first-line treatment for CBD stones. Besides the advantages of a technical easy procedure, endoscopic papillary large balloon dilation(EPLBD) can facilitate the removal of large CBD *** indication of EPBD is now extended from removal of the small stones by using traditional balloon, to removal of large stones and avoidance of lithotripsy by using large balloon alone or after EST. According to the reports of antegrade papillary balloon dilatation, balloon dilation itself is not the cause of pancreatitis. On the contrary, adequate dilation of papillary orifice can reduce the trauma to the papilla and pancreas by the basket or lithotripter during the procedure of stone extraction. EPLBD alone is as effective as EPLBD with limited EST. Longer ballooning time may be beneficial in EPLBD alone to achieve adequate loosening of papillary orifice. The longer ballooning time does not increase the risk of pancreatitis but may reduce the bleeding episodes in patients with coagulopathy. Slowly inflation of the balloon, but not exceed the diameter of bile duct and tolerance of the patients are important to prevent the complication of perforation. EPBLD alone or with EST are not the sphincter preserved procedures, regular follow up is necessary for early detection and management of CBD stones recurrence.

关键词： Common bile duct stones Complications Endoscopic balloon dilation Endoscopic large balloondilation Endoscopic sphincterotomy

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Composition of common bile duct stones in Chinese patients during and after endoscopic sphincterotomy

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World Journal of Gastroenterology 2005年第27期11卷 4246-4249页

作者： Wei-Lun Tsai Kwok-hung Lai Chiun-Ku Lin hoi-hung chan Ching-Chu Lo Ping-I Hsu Wen-Chi Chen Jin-Shiung Cheng Gin-Ho Lo Division of Gastroenterology Department of InternalMedicine Kaohsiung Veterans General Hospital School of MedicineNational Yang Ming University Taiwan China

AIM： Endoscopic sphincterotomy （ES） is a well-established therapeutic modality for the removal of common bile duct （CBD） stones. Alter ES there are still around 10% of patients that experience recurrent CBD stones. The aim of this study is to investigate the composition of CBD stones before and alter ES and its clinical significance in Chinese ***： From January 1996 to December 2003, 735 patients with CBD stones received ES at Kaohsiung Veterans General Hospital and stone specimens from 266 patients were sent for analysis. Seventy-five patients had recurrent CBD stones and stone specimens from 44 patients were sent for analysis. The composition of the stones was analyzed by infrared （IR） spectrometry and they were classified as cholesterol or bilirubinate stones according to the predominant composition. Clinical data were ***： In the initial 266 stone samples, 217 （82%） were bilirubinate stones, 42 （16%） were cholesterol stones,3 were calcium carbonate stones, 4 were mixed cholesterol and bilirubinate stones. Patients with bilirubinate stones were significantly older than patients with cholesterol stones （66＋13 years vs 56＋17 years, P = 0.001）. In the 44 recurrent stone samples, 38 （86%） were bilirubinate stones, 3 （7%） were cholesterol stones, and 3 were mixed cholesterol and bilirubinate stones. In 27 patients, both initial and recurrent stone specimens can be obtained,23 patients had bilirubinate stones initially and 2 became cholesterol stones in the recurrent attack. In the four patients with initial cholesterol stones, three patients had bilirubinate stones and one patient had a cholesterol stone in the recurrent ***： Bilirubinate stone is the predominant composition of initial or recurrent CBD stone in Chinese patients, The composition of CBD stones may be different from initial stones afl：er ES,

关键词： Endoscopic sphincterotomy Common bile ductstone Bilirubinate stone Cholesterol stone

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Implications of anti-parietal cell antibodies and anti-Helicobacter pylori antibodies in histological gastritis and patient outcome

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World Journal of Gastroenterology 2005年第30期11卷 4715-4720页

作者： Ching-Chu Lo Ping-I Hsu Gin-Ho Lo Kwok-hung Lai Hui-Hwa Tseng Chiun-Ku Lin hoi-hung chan Wei-Lun Tsai Wen-Chi Chen Nan-Jing Peng Division of Gastroenterology Department of Internal Medicine Kaohsiung Veterans General Hospital and St. Martin De Porres HospitalNational Yang-Ming University Kaohsiung Taiwan China Department of Pathology Kaohsiung Veterans General Hospital and National Yang-Ming University KaohsiungTaiwan China Department of Nuclear Medicine Kaohsiung Veterans General Hospital and National Yang-Ming University Kaohsiung Taiwan China

AIM： To develop a serum or histological marker for early discovery of gastric atrophy or intestinal metaplasia. METHODS： This study enrolled 44 patients with gastric adenocarcinoma, 52 patients with duodenal ulcer, 14 patients with gastric ulcer and 42 consecutive healthy adults as controls. Each patient received an endoscopy and five biopsy samples were obtained. The degrees of histological parameters of gastritis were categorized following the Updated Sydney System. Anti-parietal cell antibodies （APCA） and anti- Helicobacter pylori （ H pylori） antibodies （AHPA） were analyzed by immunoassays. Hpyloriinfection was diagnosed by rapid unease test and histological examination. RESULTS： Patients with gastric cancer and gastric ulcer are significantly older than healthy subjects, while also displaying higher frequency of APCA than healthy controls. Patients with positive APCA showed higher scores in gastric atrophy and intestinal metaplasia of corpus than patients with negative APCA. Patients with positive AHPA had higher scores in gastric atrophy, intestinal metaplasia, and gastric inflammation of antrum than those patients with negative AHPA. Elderly patients had greater prevalence rates of APCA. Following multivariant logistic regression analysis, the only significant risk factor for antral atrophy is positive AHPA, while that for corpus atrophy is positive APCA. CONCLUSION： The existence of positive APCA correlates with glandular atrophy in corpus and the presence of positive AHPA correlates with glandular atrophy in antrum. The existence of serum APCA and AHPA betokens glandular atrophy and requires further examination for gastric cancer.

关键词： Glandular atrophy Intestinal metaplasia Gastriccancer Anti-parietal cell antibody Anti-Helicobacter pylori antibodies

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Stem cell aging in adult progeria

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Cell Regeneration 2015年第1期4卷 75-83页

作者： hoi-hung Cheung Duanqing Pei Wai-Yee chan CUHK-CAS GIBH Joint Research Laboratory on Stem Cell and Regenerative Medicine School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong S.A.R.China Chinese Academy of Sciences(CAS)Guangzhou Institutes of Biomedicine and Health(GIBH) GuangzhouChina The Chinese University of Hong Kong Room G03ALo Kwee-Seong Intergrated Biomedical Science BuildingShatinN.T.Hong Kong S.A.R.China

Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatricdiseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development ofcardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become thefocus in aging research. Natural aging is not regarded as a programmed process. However, accelerated agingdue to inherited genetic defects in patients of progeria is programmed and resembles many aspects ofnatural aging. Among several premature aging syndromes, Werner syndrome (WS) and Hutchinson–Gilfordprogeria syndrome (HGPS) are two broadly investigated diseases. In this review, we discuss how stem cellaging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigeneticlandscape in aged cells can be reversed to a “juvenile” state. Lastly, we explore the potential application ofthe latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.

关键词： Werner syndrome Stem cells Aging WRN

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Heterogeneous Structure Design to Strengthen Carbon-Containing CoCrFeNi High Entropy Alloy

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Acta Metallurgica Sinica(English Letters) 2021年第11期34卷 1503-1510页

作者： Xiaomeng Qin chan hung Shek Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong SAR 999077China

A carbon-containing CoCrFeNi high entropy alloy(HEA)with heterogeneous structures was obtained through thermomechanical treatments,which induced concurrent recrystallization and carbide precipitation in the alloy.A combination of high yield strength(556 MPa)and large uniform elongation(45%)was achieved in the investigated *** enhancement of the strength is attributed to the combined effects of grain refinement,precipitation strengthening and microstructural *** work demonstrated that the heterogeneity design could be realized by thermomechanical processes,which provided a practical strategy for producing HEAs with high performance.

关键词： High entropy alloy Heterogeneous structures Mechanical properties Interstitial

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Numerical characteristics of the full operator hybrid simulation method

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Earthquake Engineering and Engineering Vibration 2011年第3期10卷 453-463页

作者： Chung-chan hung Yong-Song Chen Department of Civil Engineering Central University （NCU） Chinese Taipei Department of Mechanical Engineering Chung Cheng University （NCCU） Chinese Taipei

The full operator method （FOM） has been proposed to overcome some of the shortcomings of the commonly used operator splitting method （OSM）. In particular, the FOM is improved by increasing the accuracy of both the predictor and corrector using the estimated tangent stiffness of the tested structure. The numerical characteristics of the FOM, including stability and accuracy, are investigated in this study. It is shown that FOM is conditionally stable. The stability and accuracy characteristics are dependent on the accuracy of the estimated tangent stiffness and the parameters associated with the acceleration variation in the time-stepping integration method. Mass-spring systems with different types of nonlinearity, including hardening, stiffening, and softening behavior, are used to evaluate the performance of the FOM. It is found that the FOM can capture these types of nonlinearity with satisfactory accuracy. Using a prototype 12-story composite coupled wall system, the influences of the strong nonlinearity of the system as well as the displacement control errors from hydraulic actuators on the performance of the FOM are explored. The results show that the FOM is capable of generating reasonably accurate results despite the presence of strong structural nonlinearity and displacement control errors.

关键词： hybrid simulation tangent stiffness numerical characteristic composite coupled wall system collapse behavior nonlinear behavior

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A computation design method for architectural artifacts adapted from traditional Kagome bamboo basketry techniques

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Frontiers of Architectural Research 2024年第2期13卷 249-264页

作者： Hiroyuki Shinohara Tung hoi Peter chan School of Architecture The Chinese University of Hong KongHong KongChina

This study is a digital form-finding and manual fabrication experiment in woven architectural design,with one traditional weaving style,Kagome,used to scale the craft up into an architectural-scale bamboo woven *** is a trihexagonal pattern employed in traditional bamboo basketry as a triaxial weaving system,resulting in an object with a self-bracing capacity without the use of fasteners owing to its interlacing *** existing studies and tools have addressed triaxial weaving design and representation,the current consideration of the advantages of weaving with bamboo is *** address this research gap,this study develops a computational design method based on studies on bamboo *** allows for the representation and exploration of design geometries using combinations of regular triangular meshes for the fabrication of Kagome woven bamboo artifacts.A full-scale mock-up was fabricated to evaluate the effectiveness of the *** mock-up demonstrated the self-bracing properties of Kagome,but there were discrepancies between the mock-up and the *** affecting bamboo weaving on an architectural scale have been identified within this study to inform future research on woven bamboo structures.

关键词： Traditionalbamboo craft Triaxialmaterial interlacing Bamboo Computational design methods Mesh block combinationsystem Architecturalwoven artifact

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Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho hung Cheung Wong hoi She Siu Lun Ho Albert Chi Yan chan Chung Mau Lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

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An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline(alkaloids) from Stephania tetrandra roots

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Journal of Integrative Medicine 2021年第4期19卷 311-316页

作者： Eric Wei Chiang chan Siu Kuin Wong hung Tuck chan Faculty of Applied Sciences UCSI UniversityKuala Lumpur 56000Malaysia School of Foundation Studies Xiamen University MalaysiaSelangor 43900Malaysia Secretariat of the International Society for Mangrove Ecosystems(ISME) Faculty of AgricultureUniversity of the RyukyusOkinawa 903-0129Japan

Tetrandrine(TET) and fangchinoline(FAN) are dominant bisbenzylisoquinoline(BBIQ) alkaloids from the roots of Stephania tetrandra of the family Menispermaceae. BBIQ alkaloids comprise two benzylisoquinoline units linked by oxygen bridges. The molecular structures of TET and FAN are exactly the same, except that TET has a methoxy(-OCH3) group, while FAN has a hydroxyl(-OH) group at C7. In this overview,the current knowledge on the chemistry, pharmacology and anticancer properties of TET and FAN have been updated. The focus is on colon and breast cancer cells, because they are most susceptible to TET and FAN, respectively. Against colon cancer cells, TET inhibits cell proliferation and tumor growth by inducing apoptosis and G1 cell cycle arrest, and suppresses adhesion, migration and invasion of *** breast cancer cells, FAN inhibits cell proliferation by inducing apoptosis, G1-phase cell cycle arrest and inhibits cell migration. The processes involve various molecular mechanisms and signaling pathways. Some insights on the ability of TET and FAN to reverse multi-drug resistance in cancer cells and suggestions for future research are provided.

关键词： Tetrandrine Fangchinoline Alkaloids Pharmacology Anticancer Multi-drug resistance

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