Stem cell aging in adult progeria

作     者：Hoi-Hung Cheung Duanqing Pei Wai-Yee Chan 

作者机构：CUHK-CAS GIBH Joint Research Laboratory on Stem Cell and Regenerative MedicineSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongShatinHong Kong S.A.R.China Chinese Academy of Sciences(CAS)Guangzhou Institutes of Biomedicine and Health(GIBH)GuangzhouChina The Chinese University of Hong KongRoom G03ALo Kwee-Seong Intergrated Biomedical Science BuildingShatinN.T.Hong Kong S.A.R.China 

出 版 物：《Cell Regeneration》 (细胞再生（英文）)

年 卷 期：2015年第4卷第1期

页      面：75-83页

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

基　　金：This work was partly supported by the Lo Kwee-Seong Biomedical Research Fund and the Chinese University of Hong Kong(CUHK)Vice Chancellor(VC)Discretionary Fund 

主　　题：Werner syndrome Stem cells Aging WRN 

摘      要：Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatricdiseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development ofcardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become thefocus in aging research. Natural aging is not regarded as a programmed process. However, accelerated agingdue to inherited genetic defects in patients of progeria is programmed and resembles many aspects ofnatural aging. Among several premature aging syndromes, Werner syndrome (WS) and Hutchinson–Gilfordprogeria syndrome (HGPS) are two broadly investigated diseases. In this review, we discuss how stem cellaging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigeneticlandscape in aged cells can be reversed to a “juvenile state. Lastly, we explore the potential application ofthe latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.