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Understanding and modifications on lithium deposition in lithium metal batteries

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Rare Metals 2022年第8期41卷 2800-2818页

作者： Qin-ya yang Zhao Yu yao Li Wang Zhang Hao-Wen Yuan Hong-Jie Li Wei Ma Shen-Min Zhu sa Li State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China School of Materials Science and Engineering Tongji UniversityShanghai201804China

Lithium metal has been considered as an ultimate anode choice for next-generation secondary batteries due to its low density,superhigh theoretical specific capacity and the lowest voltage ***,uncontrollable dendrite growth and consequently large volume change during stripping/plating cycles can cause unsatisfied operation efficiency and serious safety concern,restraining its commercial use for the last 40 *** widely used lithium-ion battery is approaching its theoretical limit at present,it is increasingly urgent to develop new energy storage equipment with sufficient practical ***,two important processes of lithium deposition,nucleation and growth on lithium metal anode are *** three-dimensional(3 d)porous anodes with unique structure and dynamic surface conditions,as one of the most efficient designs on dendrites suppression,are specifically discussed in terms of their beneficial adjustment on the dendrite *** on current designs and prospects on future advanced porous anode are explored in the end.

关键词： Lithium metal batteries Lithium nucleation dendrites growth Porous anodes

用高效液相色谱-同位素稀释质谱法测定川崎病患儿血浆中阿司匹林和水杨酸的药物浓度

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中国临床药理学杂志 2024年第8期40卷 1203-1207页

作者：马英华赵宜乐秦亚彬张英谦河北省儿童医院药学部河北石家庄050031 河北省儿童医院心内科河北石家庄050031

目的建立高效液相色谱-同位素稀释质谱(HPLC-idMS)法测定川崎病患儿血浆中阿司匹林(ASP)和水杨酸(sa)浓度的方法。方法血浆样品经有机溶剂沉淀蛋白后,分别以ASP-d4和sa-d4为内标,采用Phenomenex Kinetex XB C18色谱柱(2.6 mm×50.0 mm... 详细信息

目的建立高效液相色谱-同位素稀释质谱(HPLC-idMS)法测定川崎病患儿血浆中阿司匹林(ASP)和水杨酸(sa)浓度的方法。方法血浆样品经有机溶剂沉淀蛋白后,分别以ASP-d4和sa-d4为内标,采用Phenomenex Kinetex XB C18色谱柱(2.6 mm×50.0 mm, 3.0μm),以0.1%甲酸-水(A)和乙腈(B)作为流动相进行梯度洗脱,流速为0.5 mL·min^(-1),进样量为6μL。质谱检测方式为负离子模式,多反应监测扫描。结果 ASP在1.02~4 000 ng·mL^(-1)线性关系良好(r2=0.995 4),定量下限(LLOQ)为1.02 ng·mL^(-1)。sa在1.28~5 000 ng·mL^(-1)线性关系良好(r2=0.998 5),LLOQ为1.28 ng·mL^(-1)。准确度、精密度、基质效应和稳定性均符合《中国药典》(2020年版)规定。结论该方法操作简便快速稳定,灵敏度专属性高,可用于ASP和sa在川崎病患儿中的治疗药物监测和群体药代动力学-药效学研究。

关键词：阿司匹林水杨酸高效液相色谱-同位素稀释质谱法同位素内标治疗药物监测

Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PdE8 for the treatment of vascular dementia

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3103-3112页

作者： Xu-Nian Wu Qian Zhou ya.dan Huang Xi Xie Zhe Li Yinuo Wu Hai-Bin Luo School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health institute School of Pharmaceutical SciencesHainan UniversityHaikou 570228China

Our previous study demonstrated that phosphodiesterase 8(PdE8)could work as a potential target for vascular dementia(Va d)using a chemical probe ***,compound 3a is a chiral compound which was obtained by chiral resolution on HPLC,restricting its usage in ***,a series of non-chiral 9-benzyl-2-chloro-adenine derivatives were discovered as novel PdE8 *** 15 exhibited potent inhibitory activity against PdE8A(iC_(50)=11 nmol/L),high selectivity over other PdEs,and remarkable drug-like properties(worthy to mention is that its bioavailability was up to 100%).Oral administration of 15 significantly improved the c AMP level of the right brain and exhibited dosedependent effects on cognitive improvement in a Va d mouse ***,the X-ray crystal structure of the PdE8A—15 complex showed that the potent affinity and high selectivity of 15 might come from the distinctive interactions with H-pocket including T-shapedπ—πinteractions with Phe785 as well as a unique H-bond network,which have never been observed in other PdE-inhibitor complex before,providing new strategies for the further rational design of novel selective inhibitors against PdE8.

关键词： Phosphodiesterase 8(PdE8) Vascular dementia Structure-based drug design MM-GB/sa Free energy prediction Structure—activity relationship Binding potencies

Correlation of serum albumin level on postoperative day 2 with hospital length of stay in patients undergoing emergency surgery for perforated peptic ulcer

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World Journal of Gastrointestinal Surgery 2023年第7期15卷 1434-1441页

作者： dan Xie Ping-Lan Lu Wen Xu Jing-ya You Xiao-Gang Bi Ying Xian department of General intensive Care Unit Lingnan HospitalThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510530Guangdong ProvinceChina department of Surgical intensive Care Unit The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUNd Perforated peptic ulcer(PPU)is a common emergency surgical condition and a significant cause of morbidity and mortality *** advances in surgical techniques have improved outcomes for patients with PPU,many factors still affect postoperative hospital stay and overall *** potential factor is the serum albumin(sa)level,a widely utilized marker of nutritional status that has been associated with length of stay and complications in various surgical *** To clarify the correlation of sa level on postoperative day 2 with hospital length of stay(HLOS)in patients undergoing emergency surgery for perforated peptic ulcer(PPU).METHOdS We retrospectively collected and analyzed clinical baseline data,including blood routine and sa levels,of patients who underwent emergency PPU surgery and postoperative treatment at the Lingnan Hospital,the Third Affiliated Hospital of Sun yat-sen University between december 2012 and September *** were grouped according to HLOS with 7 d as the cut-off value,and relevant indicators were analyzed using SPSS *** Of the 37 patients undergoing emergency surgery for PPU referred to our department,33 had gastric and 4 had duodenal ulcer *** median HLOS was 10 *** were 8 patients in the≤7-d group(median HLOS:7 d)and 29 patients in the>7-d group(median HLOS:10 d).The≤7-d group had markedly higher sa on postoperative day 2 than the>7-d group(37.7 g/L vs 32.6g/L;Psa level on postoperative day 2 was a protective factor for patients with HLOS>7 d(Odds ratio=0.629,P=0.015).The cut-off of sa on postoperative day 2 was 30.6g/L,with an area under the curve of 0.86 and a negative predictive value of 100%for the prediction of HLOS≤7 *** The sa level on postoperative day 2 was associated with the HLOS in patients undergoing emergency surgery for *** pre-and post-operative albumin levels should be monitored,and infusion of human sa should be considered in a timely man

关键词： Perforated peptic ulcer Emergency surgery Serum albumin Hospital length of stay

配戴Paragon CRT角膜塑形镜后光学治疗区直径的相关因素

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国际眼科杂志 2023年第5期23卷 867-872页

作者：寇洒洒任亚茹庄歆予陈颖杰杨牧张晓峰苏州大学附属第一医院眼科江苏省苏州市215006 苏州大学附属独墅湖医院眼科江苏省苏州市215125

目的:探讨配戴Paragon CRT角膜塑形镜后光学治疗区直径的影响因素以及与眼轴增长量的关系。方法:回顾性临床研究。收集2020-04/2022-09配戴Paragon CRT角膜塑形镜近视患者资料226例226眼。分析戴镜后1mo光学治疗区直径的相关因素以及重... 详细信息

目的:探讨配戴Paragon CRT角膜塑形镜后光学治疗区直径的影响因素以及与眼轴增长量的关系。方法:回顾性临床研究。收集2020-04/2022-09配戴Paragon CRT角膜塑形镜近视患者资料226例226眼。分析戴镜后1mo光学治疗区直径的相关因素以及重叠光学治疗区面积/瞳孔面积比值与戴镜后1a眼轴增长量的关系。结果:戴镜后1mo,光学治疗区直径与中央角膜厚度呈负相关,与平坦角膜偏心率呈正相关。戴镜后1a,小直径光学区组眼轴增长量(0.25±0.18mm)显著小于大直径光学区组(0.34±0.24mm,P=0.002),小面积比值组眼轴增长量(0.24±0.19mm)显著小于大面积比值组(0.35±0.23mm,P<0.001)。多因素线性回归分析显示,年龄及重叠光学治疗区面积/瞳孔面积比值两个因素影响眼轴增长(均P<0.05)。结论:中央角膜越厚、平坦角膜偏心率越小的配戴者光学治疗区直径更小,且光学治疗区直径及重叠光学治疗区面积/瞳孔面积比值均与眼轴增长量相关。

关键词：角膜塑形镜眼轴光学治疗区瞳孔

Combined application of Trichoderma harzianum SH2303 and difenoconazole-propiconazolein controlling Southern corn leaf blight disease caused by Cochliobolus heterostrophus in maize

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Journal of integrative Agriculture 2019年第9期18卷 2063-2071页

作者： WANG Shao-qing MA Jia WANG Meng WANG Xin-hua Li ya-qian CHEN Jie School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240P.R.China Key Laboratory of Urban Agriculture(South)Ministry of Agriculture Shanghai Jiao Tong UniversityShanghai 200240P.R.China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong UniversityShanghai 200240P.R.China Plant Genetic Engineering Center of Hebei Province Institute of Genetics and PhysiologyHebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051P.R.China

Southern corn leaf blight(SCLB)disease caused by Cochliobolus heterostrophus is one of the major threats to corn production *** synergistic application of low toxic chemical fungicide and biocontrol agents could improve biocontrol stability and efficiency against plant diseases,which ultimately reduce use of chemical *** spp.,well-known biocontrol fungi have been used to control some foliar ***,few works have been reported on synergistic application of chemical fungicide and Trichoderma against foliar *** study was aimed to investigate the control effect on the synergistic application of Trichoderma harzianum SH2303 and difenoconazole-propiconazole(dP)against *** showed that the synergistic application of dP and SH2303 reduced the leaf spot area compared to the *** efficacy of synergistic application of dP+SH2303 against SCLB could last for 15–20 d in pot trial under the greenhouse *** the natural field condition,maize treated with dP+dP and dP+SH2303 showed 60%control,which was higher than that of SH2303+dP(45%)and SH2303+SH2303(35%).All these treatments induced the synthesis of defense-related enzymes(phenylalanine ammonia lyase(PAL),catalase(CAT),and superoxide dismutase(SOd))and the defence-related gene expression of sa pathway(PR1).Taken together the in-vitro leaf test and field trial,the control of SCLB by synergistic application of dP+SH2303 was similar to that of dP+*** synergistic application,the sequential application of dP+SH2303 showed better control than the sequential application of SH2303+*** was concluded that the synergistic application of chemical fungicide(dP)and biocontrol agent(*** SH2303)could be used to reduce the chemical fungicide and to reduce the SCLB diseases in maize,which provided alternative approach to realize an eco-friendly controlling of the foliar disease.

关键词： synergistic bio-control chemical fungicide Trichoderma harzianum maize leaf spot disease

麻醉及手术创伤对老年大鼠认知功能及海马突触结构的影响

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中华医学杂志 2009年第17期89卷 1203-1206页

作者：丁力石翊飒朱雅斌马永丰兰州大学第二医院麻醉科 730030

目的探讨麻醉和手术创伤对老年大鼠认知功能及海马突触结构的影响。方法18月龄Sd大鼠56只随机分为3组：对照组（C组，n=8）、麻醉组（A组，n=24）、手术组（0组，n=24），A、0组根据麻醉和手术后1、3和7d分为3个亚组A1、A3、A7组和01、0... 详细信息

目的探讨麻醉和手术创伤对老年大鼠认知功能及海马突触结构的影响。方法18月龄Sd大鼠56只随机分为3组：对照组（C组，n=8）、麻醉组（A组，n=24）、手术组（0组，n=24），A、0组根据麻醉和手术后1、3和7d分为3个亚组A1、A3、A7组和01、03、07组，每亚组8只。在相应的时间点用Morris水迷宫测试老年大鼠的认知功能，电镜定量测量海马CA3区多形层的突触结构。结果与C组比较，A1、01、03组Morris水迷宫测试潜伏期及游泳距离明显延长（P〈0．05），01、03组通过原平台次数明显减少（P〈0．01）；与A1组比较，O1组潜伏期明显延长（P〈0．05），游泳距离无明显差异。与C组比较，O1、O3组海马CA3区多形层突触间隙宽度加大变宽（P〈0．01）、突触后膜致密物厚度变薄（P〈0．01）、突触活性区长度缩短（P〈0．05）、突触界面曲率减小（P〈0．01）、穿孔性突触百分率亦下降，O7组恢复正常；各麻醉组突触形态改变差异无统计学意义。结论麻醉和手术创伤可损害老年大鼠的认知功能，而海马突触的可塑性可能是术后认知功能障碍的结构基础。

关键词：手术认知突触

电针长强穴对缺血缺氧脑损伤仔鼠学习记忆能力及海马Pi3K、Akt蛋白表达的影响

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中华中医药杂志 2022年第1期37卷 416-419页

作者：黄倩茹董亚琴潘晓华萨喆燕周丽莉许金森福建省中医药科学院福建省经络感传重点研究室福州350003

目的:观察电针长强穴对缺血缺氧脑损伤(HiBd)大鼠学习记忆能力及海马Pi3K、Akt蛋白表达的影响。方法:制备HiBd大鼠,随机分为电针长强组(长强组)、电针非穴组(非穴组)、模型组,各8只,另随机选取并制备假手术组大鼠8只。长强组取长强穴,... 详细信息

目的:观察电针长强穴对缺血缺氧脑损伤(HiBd)大鼠学习记忆能力及海马Pi3K、Akt蛋白表达的影响。方法:制备HiBd大鼠,随机分为电针长强组(长强组)、电针非穴组(非穴组)、模型组,各8只,另随机选取并制备假手术组大鼠8只。长强组取长强穴,电针刺激(连续波,频率为2 Hz,强度为2 mA)20 min,连续治疗10 d为1个疗程,共1个疗程;非穴组取大鼠右胁肋下缘一横指处,余操作同长强组;假手术组和模型组在相同环境下饲养,不予干预。治疗结束第2天予Morris水迷宫试验,取脑组织,应用免疫印迹技术观察大鼠海马Pi3K、Akt蛋白的表达。结果:与假手术组比较,模型组逃避潜伏期显著延长(Pi3K、Akt蛋白表达显著降低(Pi3K、Akt蛋白表达显著升高(Pi3K及Akt蛋白的表达,对神经元异常发育进行调节,进而改善其学习记忆能力。

关键词：电针长强穴缺血缺氧脑损伤学习记忆三磷酸肌醇激酶蛋白激酶B 机制

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陕西省成年人睡眠总时长与代谢综合征的关系

中国慢性病预防与控制 2022年第12期30卷 920-923,928页

作者：武萌王艳平王维华飒日娜胡志平刘蓉徐亚陇邱琳陕西省疾病预防控制中心慢性非传染性疾病预防控制所陕西省西安710054

目的探讨睡眠总时长与代谢综合征(MS)的关系,为陕西省MS的早期防控提供依据。方法数据来源于2018年陕西省成人慢性病及其危险因素监测,采用多阶段分层整群随机抽样方法,选取陕西省10个监测点18岁及以上常住居民6202人为研究对象,进行问... 详细信息

目的探讨睡眠总时长与代谢综合征(MS)的关系,为陕西省MS的早期防控提供依据。方法数据来源于2018年陕西省成人慢性病及其危险因素监测,采用多阶段分层整群随机抽样方法,选取陕西省10个监测点18岁及以上常住居民6202人为研究对象,进行问卷调查、体格检查和实验室检测。采用SPSS 25.0软件进行χ^(2)检验和多因素logistic回归分析。结果共纳入6031人,调查对象平均睡眠总时长为(7.67±1.76)h/d,睡眠总时长8 h/d组分别有613人(10.16%)、3785人(62.76%)和1633人(27.08%)。经加权后,调查对象MS患病率为36.16%。多因素logistic回归分析结果显示,睡眠总时长d与MS(OR=1.22,95%Ci:1.02~1.46)、血糖升高(OR=1.23,95%Ci:1.02~1.47)、血压升高(OR=1.38,95%Ci:1.13~1.69)及甘油三酯升高(OR=1.21,95%Ci:1.01~1.45)高风险相关,均有统计学意义(P8 h/d与MS(OR=0.85,95%Ci:0.76~0.97)低风险相关,有统计学意义(Pd与MS高风险相关,睡眠总时长>8 h/d与MS低风险相关,提示可将睡眠干预作为MS防控的一项措施。

关键词：代谢综合征睡眠时间成年人