检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

《清代学者象传》传文史料考及其文献价值

古籍整理研究学刊 2010年第2期 40-45页

作者：何奕恺[新加坡] 南京大学文学院

《清代学者象传》第一集中的169人有传记,但一般人的主要兴趣偏重于其肖像,往往忽略这些传文,或为图像所掩,或为编著者叶衍兰之画名、词名所掩。其实此书作为一部如此规模图文并茂的传记文献非常稀见,为学人、读者带来了许多方便和可贵... 详细信息

《清代学者象传》第一集中的169人有传记,但一般人的主要兴趣偏重于其肖像,往往忽略这些传文,或为图像所掩,或为编著者叶衍兰之画名、词名所掩。其实此书作为一部如此规模图文并茂的传记文献非常稀见,为学人、读者带来了许多方便和可贵材料。如果可以更进一步地把握这些传文的文献价值,即可谓锦上添花,在实用性上又更上一层楼,把握其学术性。本文就是要通过近二百种史料文献之比对,考索《象传》诸传之资料来源及编著者的加工调整,从而评定其传文之文献价值。

关键词：清代学者象传史料来源文献价值

Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

在线全文

学校读者我要写书评

暂无评论

Bone Research 2022年第3期10卷 509-523页

作者： Yiqi Yang Yixuan Lin Minqi Wang kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang kai Huang Yugang Wang Hanjun Li Tingting Tang Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Bone and Joint Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics Shanghai Jiangong HospitalShanghaiChina Department of Trauma Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Stem Cell Research Center Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChin

Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. however, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(ho-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that ho-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or ho-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and ho-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment.

关键词： peroxidation osteoporosis diabetic

Efficient degradation of Rhodamine B by magnetically recoverable Fe_(3)O_(4)-modified ternary CoFeCu-layered double hydroxides via activating peroxymonosulfate

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2021年第10期33卷 188-200页

作者： Tong Li Xiange Du Jieqiong Deng kai Qi Jiandong Zhang Lili Gao Xiuping Yue College of Environmental Science and Engineering Taiyuan University of TechnologyShanxi 030024China Department of Biological and Pharmaceutical Engineering College of Biomedical EngineeringUniversity of TechnologyShanxi 030024China

Environment-friendly nano-catalysts capable of activating peroxymonosulfate(PMS)have received increasing attention ***,traditional nano-catalysts are generally well dispersed and difficult to be separated from reaction system,so it is particularly important to develop nano-catalysts with both good catalytic activity and excellent recycling *** this work,magnetically recoverable Fe_(3)O_(4)-modified ternary CoFeCu-layered double hydroxides(Fe_(3)O_(4)/CoFeCu-LDHs)was prepared by a simple co-precipitation method and initially applied to activate PMS for the degradation of Rhodamine B(Rh B).X-ray diffraction(XRD),fourier transform infrared spectrometer(FT-IR),scanning electron microscope(SEM),transmission electron microscopy(TEM),Brunauer-Emmett-Teller method(BET),and vibrating sample magnetometer(VSM)were applied to characterize morphology,structure,specific surface area and *** addition,the effects of several key parameters were *** Fe_(3)O_(4)/CoFeCu-LDHs exhibited high catalytic activity,and Rh B degradation efficiency could reach 100%within 20 min by adding 0.2 g/L of catalyst and 1 mmol/L of PMS into 50 mg/L of Rh B solution under a wide pH condition(3.0-7.0).Notably,the Fe_(3)O_(4)/CoFeCu-LDHs showed good super-paramagnetism and excellent stability,which could be effectively and quickly recovered under magnetic condition,and the degradation efficiency after ten cycles could still maintain 98.95%.Both radicals quenching tests and electron spin resonance(ESR)identified both ho·and SO_(4)^(·-) were involved and SO_(4)^(·-) played a dominant role on the RhB ***,the chemical states of the sample’s surface elements were measured by X-ray photoelectron spectroscopy(XPS),and the possible activation mechanism in Fe_(3)O_(4)/CoFeCu-LDHs/PMS system was proposed according to comprehensive analysis.

关键词： Advanced catalytic oxidation Fe_(3)O_(4)/CoFeCu-LDHs Peroxymonosulfate Rhodamine B(RhB) High degradation efficiency Heterogeneous catalyst

Fluid-induced corrosion behavior of degradable zinc for stent application

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第32期91卷 134-147页

作者： kai Chen Xuenan Gu Hui Sun hongyan Tang hongtao Yang Xianghui Gong Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Materials Science and Engineering The Ohio State UniversityColumbusOH43210USA

The influence of laminar flow on the corrosion of pure zinc(Zn) and cell response was investigated and compared with the static *** results revealed that laminar flow accelerated the corrosion and enhanced the localized corrosion of pure *** dynamic corrosion rate was 0.184 mm/yr after 168 h *** corrosion products were formed under flow condition,which were mainly composed of Zn_(3)(PO_(4))_(2)·4 H_(2) O,Ca_(3)(PO_(4))_(2),ZnO and Zn_(5)(OH)_(6)(CO_(3))_(2).Moreover,the adhered rat aortic endothelial cells(RAEC) on Zn samples exhibited notably cell loss and round configuration under laminar flow.

关键词： Zinc Laminar flow Dynamic degradation Endothelial cells Biocompatibility

High performance of HNaV_(6)O_(16)·4H2_(O) nanobelts for aqueous zinc-ion batteries with in-situ phase transformation by Zn(CF_(3)SO_(3))_(2) electrolyte

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第2期41卷 448-456页

作者： Chao Guan Fang Hu Xin Yu Hai-Lian Chen Gui-hong Song kai Zhu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China 202 Plant Shandong Xinhua Pharmaceutical CO.LTD.Zibo 255005China Key Laboratory of Superlight Materials and Surface Technology of Ministry of Education College of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150010China

Zn(CF_(3)SO_(3))_(2)as an electrolyte has been widely used to improve the electrochemical performance for ZIBs due to that the bulky CF_(3)SO_(3)-can reduce the solvation effect of Zn^(2+)and promote the ionic ***,we found that Zn(CF_(3)SO_(3))_(2)electrolyte can induce different electrochemical mechanisms from ZnSO_(4)*** to the ZnSO^(4)electrolyte,the HNaV_(6)O_(16)·4H2_(O)electrode with Zn(CF_(3)SO_(3))_(2)electrolyte exhibits a high capacity of 444 mAh·g^(-1)at 500 mA·g^(-1)with a capacity retention of 92.3%after 80 ***,at a high rate of 5 Ag-1,the HNaV_(6)O_(16)·4H_(2)O electrode delivers an initial discharge capacity of 328 mAh·g^(-1)with a capacity retention of 93.7%after 1000 *** from the mechanism with ZnSO4 electrolyte,the excellent cycle stability of HNaV_(6)O_(16)·4H_(2)Oelectrode can be attributed to the in-situ phase transformation to ZnxV_(2)O_(5)·nH_(2)O based on the co-intercalation of Zn^(2+)/H^(+).

关键词： HNaV_(6)O_(16)·4H2_(O) Zinc-ion batteries Zn(CF_(3)SO_(3))_(2) ZnSO_(4) Electrolyte

中医药联合靶向药物治疗驱动基因阳性晚期非小细胞肺癌的回顾性研究

在线全文

学校读者我要写书评

暂无评论

中医药联合靶向药物治疗驱动基因阳性晚期非小细胞肺癌的回顾性研...

作者：何启泰（ho kai Tai）广州中医药大学

学位级别：硕士

目的:采用回顾性研究方法,采集中医药联合EGFR-TKIs靶向治疗晚期非小细胞肺癌(NSCLC)患者信息,分析患者的临床病理、肿瘤分期、中医证型等因素对患者生存及预后的影响,探讨中医药联合EGFR-TKIs靶向治疗晚期非小细胞肺癌(NSCLC)的预后及... 详细信息

目的:采用回顾性研究方法,采集中医药联合EGFR-TKIs靶向治疗晚期非小细胞肺癌(NSCLC)患者信息,分析患者的临床病理、肿瘤分期、中医证型等因素对患者生存及预后的影响,探讨中医药联合EGFR-TKIs靶向治疗晚期非小细胞肺癌(NSCLC)的预后及影响因素,为临床及科研提供参考。方法:根据拟定的纳排标准纳入2016年1月1日至2021年12月31日于广东省中医院肿瘤科住院治疗的晚期NSCLC患者,收集患者的年龄、性别、肿瘤分期、远处转移、并发症、基因突变类型、EGFR-TKIs靶向药物类型等临床相关信息,记录患者的无进展生存期(Progress Free Survival,PFS)、总生存期(Overall Survival,OS)、客观缓解率(Obj ective Response Rate,ORR)、靶向相关不良反应(immune-related adverse reactions,irAEs),通过后续随访记录及数据分析,应用SPSS18.0进行数据分析,单因素分析采用t检验、秩和检验、卡方检验,生存分析运用Kaplan-Meier(Log-Rank检验)及Cox 比例风险模型进行分析,再对其有意义的结果运用Kaplan-Meier法绘制生存曲线,以及探索各临床相关因素对PFS、OS及ORR的影响。结果:截止随访至2022年12月31日,共有效纳入150例晚期驱动基因阳性晚期肺癌的患者。疗效方面,中位PFS时间为15.00个月(95%CI:11.20-18.80个月),其中病理类型间存在相关性(经Lok-Rank检验,(P<0.05))可能是PFS的独立预后因素。总体中位生存期(mOS)为29.00个月(95%CI:25.65-32.35个月),总体半年、1年、2年、3年生存率分别为92.7%、78%、50%、24%,其中ECOG评分和肾转移存在相关性(经Lok-Rank检验,(P<0.05)),是OS的独立预后因素。在疗效评价方面,客观缓解率(ORR)=45.3%,疾病控制率(DCR)=93.3%,安全性方面,其不良反应率为41.3%。其中可见其不良反应为皮疹,其次是腹泻、肝毒性,再者口腔黏膜溃疡,最后是甲沟炎。皮疹其发生率16%,2级以上的皮疹其发生率4%。腹泻发生率为12.7%。肝毒性发生率低于5%。口腔黏膜溃疡发生率为2.7%,甲沟炎有1.3%。结论:1.我院晚期非小细胞肺癌的临床特征:中老年居多,大部分患者有吸烟史。从病理类型主要以腺癌为主。我院患者主要基因突变以19外显子缺失,21L858为主,其中位PFS和OS也更长。2.消积饮是广东省名老中医刘伟胜教授所治疗肺癌的经验方。可根据虚实偏重适当选择益气、养阴、化痰、行瘀之法。在往后临床日子进一步挖掘用药机理,在临床中推广使用。3.中医药联合一线方案OS更长,积极的治疗有利于延长患者寿命。更有效减缓其靶向药物带来的不良反应和增效。

关键词：中医药靶向药物驱动基因阳性晚期非小细胞肺癌回顾性研究

Proactive infection control measures to prevent nosocomial transmission of carbapenem-resistant Enterobacteriaceae in a non-endemic area

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第23期126卷 4504-4509页

作者： CHENG Vincent Chi-Chung CHAN Jasper Fuk-Woo WONG Sally Cheuk-Ying CHEN Jonathan hon-Kwan TAI Josepha Wai-ming YAN Mei-Kum KWAN Grace See-Wai TSE Herman TO Kelvin kai-Wang ho Pak-Leung YUEN Kwok-Yung Department of Microbiology Queen Mary Hospital Hong KongChina Infection Control Team Queen Mary Hospital Hong Kong China

Background Identification of hospitalized carbapenem-resistant Enterobacteriaceae （CRE）-positive patient is important in preventing nosocomial *** objective of this study was to illustrate the implementation of proactive infection control measures in preventing nosocomial transmission of CRE in a healthcare region of over 3200 beds in hong Kong between October 1,2010 and December 31,*** The program included active surveillance culture in patients with history of medical tourism with hospitalization and surgical operation outside hong Kong within 12 months before admission,and ＂added test＂ as an opportunistic CRE screening in all fecal specimens submitted to the *** investigation and contact tracing were conducted for CRE-positive *** quantitative culture was performed on CRE-positive patients and the duration of fecal carriage of CRE was *** During the study period,a total of 6533 patients were screened for CRE,of which 76 patients were positive （10 from active surveillance culture,65 from ＂added test＂,and 1 secondary case from contact tracing of 223 patients with no nosocomial outbreak）,resulting in an overall rate of CRE fecal carriage of 1.2％.The median time of fecal carriage of CRE was 43 days （range,13-119 days）.Beta-lactam-beta-lactamase-inhibitors,cephalosporins,and fluoroquinolones were associated significantly with high fecal bacterial load when used 90 days before CRE detection,while use of cephalosporins,carbapenems,and fiuoroquinolones after CRE detection are significantly associated with longer duration of *** duration of fecal carriage of CRE also correlates significantly with the initial fecal bacterial load （Pearson correlation：0.53; P=0.02）.Conclusion Proactive infection control measures by enhanced surveillance program identify CRE-positive patients and data obtained are useful for the planning of and resource allocation for CRE control.

关键词： surveillance nosocomial transmission carbapenem-resistant Enterobacteriaceae

Analysis of Genetic Diversity and Differentiation of Seven Stocks of Litopenaeus vannamei Using Microsatellite Markers

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2014年第4期13卷 647-656页

作者： ZHANG kai WANG Weiji LI Weiya ZHANG Quanqi KONG Jie College of Marine Life Sciences Key Laboratory of Marine Genetics and Breeding (Ministry of Education) Ocean University of China Key Laboratory for Sustainable Utilization of Marine Fisheries Resources (Ministry of Agriculture) Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Shandong Marine Fishing and Production Management Station

Seven microsatellite markers were used to evaluate the genetic diversity and differentiation of seven stocks of Litopenaeus vannamei, which were introduced from Central and South America to China. All seven microsatellite loci were polymorphic, with polymorphism information content(PIC) values ranging from 0.593 to 0.952. Totally 92 alleles were identified, and the number of alleles(Na) and effective alleles(Ne) varied between 4 and 21 and 2.7 and 14.6, respectively. Observed heterozygosity(ho) values were lower than the expected heterozygosity(He) values(0.526–0.754), which indicated that the seven stocks possessed a rich genetic diversity. Thirty-seven tests were detected for reasonable significant deviation from Hardy-Weinberg equilibrium. Fis values were positive at five loci, suggesting that there was a relatively high degree of inbreeding within stocks. Pairwise Fst values ranged from 0.0225 to 0.151, and most of the stock pairs were moderately differentiated. Genetic distance and cluster analysis using UPGMA revealed a close genetic relationship of L. vannamei between Pop2 and Pop3. AMOVA indicated that the genetic variation among stocks(11.3%) was much lower than that within stocks(88.7%). Although the seven stocks had a certain degree of genetic differentiation and a rich genetic diversity, there is an increasing risk of decreased performance due to inbreeding in subsequent generations.

关键词： Litopenaeus vannamei microsatellite introduced stock genetic diversity genetic differentiation

Large Format Encapsulation

在线全文

学校读者我要写书评

暂无评论

Journal of Electrical Engineering 2016年第1期4卷 11-18页

作者： Eric Kuah Hao Ji Yuan Yuan Bin Chan Wei Ling Wu kai ho Shu Chuen ASM Technology Singapore Pte Ltd. 2 Yishun Avenue 7 Singapore 768924

This paper will review the challenges on large format encapsulation with respect to the control of mold cap thickness, and the encapsulant impact on moldability such as flow mark on final product. Control of mold co-planarity is best performed dynamically during molding, otherwise it would be challenging to obtain good co-planarity within 20 μm. Moldability demand such as encapsulant coverage with highly viscous material, flowability and flow mark will be discussed. Warpage control depends heavily on the formulation of the encapsulant and the form of encapsulant, i.e., granular/powder, liquid and sheet.

关键词： Co-planarity dynamic control encapsulant flowability flow mark and warpage.