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Oncology Research 2024年第6期32卷 1021-1030页

作者： HYUNho KIM UIJU Cho SOOK HEE hoNG HYUNG SOON PARK IN-ho KIM ho JUNG AN BYOUNG YONG SHIM jin HYOUNG KANG Division of Medical Oncology Department of Internal MedicineSt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Department of Pathology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwonKorea Division of Medical Oncology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulKorea

Background:Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC),an endogenous mutator,induces DNA damage and activates the ataxia telangiectasia and Rad3-related(ATR)-checkpoint kinase 1(Chk1)*** cisplatin-based therapy is the mainstay for muscle-invasive bladder cancer(MIBC),it has a poor survival ***,this study aimed to evaluate the efficacy of an ATR inhibitor combined with cisplatin in the treatment of APOBEC catalytic subunit 3B(APOBEC3B)expressing ***:Immunohistochemical staining was performed to analyze an association between APOBEC3B and ATR in patients with *** APOBEC3B expression in MIBC cell lines was assessed using real-time polymerase chain reaction and western blot *** blot analysis was performed to confirm differences in phosphorylated Chk1(pChk1)expression according to the APOBEC3B *** viability and apoptosis analyses were performed to examine the anti-tumor activity of ATR inhibitors combined with ***:There was a significant association between APOBEC3B and ATR expression in the tumor tissues obtained from patients with *** with higher APOBEC3B expression showed higher pChk1 expression than cells expressing low APOBEC3B *** treatment of ATR inhibitor and cisplatin inhibited cell growth in MIBC cells with a higher APOBEC3B *** to cisplatin single treatment,combination treatment induced more apoptotic cell death in the cells with higher APOBEC3B ***:Our study shows that APOBEC3B’s higher expression status can enhance the sensitivity of MIBC to cisplatin upon ATR *** result provides new insight into appropriate patient selection for the effective application of ATR inhibitors in MIBC.

关键词： Apolipoprotein B mRNA editing catalytic polypeptide(APOBEC) Ataxia telangiectasia and Rad3-related(ATR) Bladder cancer DNA damage response DNA replication stress

Effect of organic mineral supplementation in reducing oxidative stress in holstein calves during short‑term heat stress and recovery conditions

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Journal of Animal Science and Biotechnology 2024年第2期15卷 812-825页

作者： A-Rang Son Seon-ho Kim Mahfuzul Islam Michelle Miguel Ye Pyae Naing Sang-Suk lee Ruminant Nutrition and Anaerobe Laboratory Department of Animal Science and TechnologySunchon National UniversitySuncheon 57922Korea Department of Microbiology and Parasitology Sher-e-Bangla Agricultural UniversityDhaka 1207Bangladesh

Background This study investigated the effects of inorganic and organic minerals on physiological responses,oxidative stress reduction,and rumen microbiota in holstein bull calves(123.81±9.76 kg;5 months old)during short-term heat stress(HS)and recovery *** holstein calves were randomly assigned to four treatment groups:no mineral supplementation(Con),inorganic minerals(IM),organic minerals(OM),and high-concentration organic minerals(hoM)and two thermal environments(HS and recovery)using 4×2 factorial arrangement in a crossover design of four periods of 35 *** were maintained in a temperature-controlled *** experimental period consisted of 14 d of HS,14 d of recovery condititon,and a 7-d washing *** Body temperature and respiration rate were higher in HS than in the recovery conditions(PhoM-supplemented calves in both HS(90.38μg/dL)and recovery periods(102.00μg/dL)(PhoM group,which was 5.60 ng/mL lower than in the control group(PhoM group during HS,whereas it was highest in the hoM group(2.58 mmol Trolox equivalent/L)during the recovery period(PhoM supplementation during the HS and recovery periods,whereas SOD and GPX levels were not significantly affected(P>0.05).The principal coordinate analysis represented that the overall rumen microbiota was not influenced by mineral supplementation;however,temperature-induced microbial structure shifts were indicated(PERMANOVA:P<0.05).At the phylum level,Firmicutes and Actinobacteria decreased,whereas Fibrobacteres,Spirochaetes,and Tenericutes increased(P<0.05),under HS *** genus Treponema increased under HS conditions,while Christensenella was higher in recovery conditions(P<0.05).Conc

关键词： Antioxidant status Heat stress holstein bull calves Organic mineral supplementation Oxidative stress

Dual-logic-in-memory implementation with orthogonal polarization of van der Waals ferroelectric heterostructure

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InfoMat 2024年第2期6卷 107-117页

作者： jingjie Niu Sumin Jeon Donggyu Kim Sungpyo Baek Hyun ho Yoo Jie Li Ji-Sang Park Yoonmyung lee Sungjoo lee SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Nano Science and Technology Sungkyunkwan UniversitySuwonRepublic of Korea Department of Electrical and Computer Engineering Sungkyunkwan UniversitySuwonRepublic of Korea IMEC HeverleeBelgium Department of Nano Engineering Sungkyunkwan UniversitySuwonRepublic of Korea

The rapid advancement of AI-enabled applications has resulted in an increasing need for energy-efficient computing ***-in-memory is a promising approach for processing the data stored in memory,wherein fast and efficient computations are possible owing to the parallel execution of reconfigurable logic *** this study,a dual-logic-in-memory device,which can simultaneously perform two logic operations in four states,is demonstrated using van der Waals ferroelectric field-effect transistors(vdW FeFETs).The proposed dual-logic-in-memory device,which also acts as a twobit storage device,is a single bidirectional polarization-integrated ferroelectric field-effect transistor(BPI-FeFET).It is fabricated by integrating an in-plane vdW ferroelectric semiconductor SnS and an out-of-plane vdW ferroelectric gate dielectric material—CuInP_(2)S_(6).Four reliable resistance states with excellent endurance and retention characteristics were *** two-bit storage mechanism in a BPI-FeFET was analyzed from two perspectives:carrier density and carrier injection controls,which originated from the out-of-plane polarization of the gate dielectric and in-plane polarization of the semiconductor,*** conventional multilevel FeFETs,the proposed BPIFeFET does not require additional pre-examination or erasing steps to switch from/to an intermediate polarization,enabling direct switching between the four memory *** utilize the fabricated BPI-FeFET as a dual-logic-inmemory device,two logical operations were selected(XOR and AND),and their parallel execution was *** types of logic operations could be implemented by selecting different initial states,demonstrating various types of functions required for numerous neural network *** flexibility and efficiency of the proposed dual-logic-in-memory device appear promising in the realization of next-generation low-power computing systems.

关键词： ferroelectric field-effect transistor in-plane ferroelectricity logic-in-memory out-of-plane ferroelectricity

Real-world utility of serological tests in patients with suspected scrub typhus in the Republic of Korea:A single-center,retrospective,observational study

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 273-280,I0004,I0005页

作者： Seulki Kim A Reum Kim Seungjin Lim Su jin lee Moonsuk Bae Division of Infectious Diseases Department of Internal MedicinePusan National University Yangsan HospitalYangsanRepublic of Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsanRepublic of Korea Department of Internal Medicine Pusan National University School of MedicineBusanRepublic of Korea

Objective:Serological tests are widely used for scrub typhus diagnosis;however,their limitations are *** study aims to assess their practical value in clinical ***:We analyzed the data of adult patients with suspected scrub typhus who visited a tertiary care hospital in the Republic of Korea from September to December from 2019 to *** included patients had an acute fever and at least one of the following ten secondary findings:myalgia,skin rash,eschar,headache,thrombocytopenia,increased liver enzyme levels,lymphadenopathy,hepatomegaly,splenomegaly,and pleural *** diagnoses were grouped as scrub typhus or other diseases by two infectious disease ***:Among 136 patients who met the eligibility criteria,109 had scrub typhus and 27 had different *** and paired total antibodies using immunofluorescence assay(IFA),and total antibodies using immunochromatography-based rapid diagnostic testing(ICT)were measured in 98%,22%,and 75%of all patients,*** using paired samples for scrub typhus was established at a median of 11[interquartile range(IQR)10-16]days following the first *** the 82 admitted patients,the median admission time was 9(IQR 7-13)*** to IFA,58(55%)patients with scrub typhus had total immunoglobulin titers≥1:320,while 23(85%)patients with other disease had titershowed negative ICT ***:Serological testing for scrub typhus is currently insufficient for decision-making in clinical practice.

关键词： Scrub typhus Serological test Immunofluorescence assay Immunochromatography Rapid detecting test

Transparent high-performance piezoceramics through pressureless sintering

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Journal of Advanced Ceramics 2024年第5期13卷 561-567页

作者： Hye-Lim Yu Woo-Seok Kang Ju-Hyeon lee Temesgen Tadeyos Zate Young-jin lee Bo-Kun Koo Dong-jin Shin Min-Soo Kim Soon-Jong Jeong Young Ghyu Ahn Wook Jo Department of Material Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Energy Conversion Research Center Korea Electrotechnology Research InstituteChangwon 51543Republic of Korea MLCC Development Team Component Biz.UnitSamsung Electro-Mechanics Co.Ltd.Suwon 16674Republic of Korea

Piezoelectricity offers an electromechanical coupling that is widely utilized in transducer *** has been a consistent demand for transparent piezoelectric materials for optoelectrical ***,despite the inherent tradeoff between the transparency and the piezoelectricity,numerous strategies have been explored to develop the transparent piezoelectric ***,the most transparent piezoelectric materials developed to date is either a single crystal or materials that achieve transparency via hot-press sintering,limiting its industrial ***,we introduce a novel piezoelectric material that ensures transparency through co-doping and pressureless sintering of polycrystalline *** this study,we employed a compositional optimization approach to enhance the synergistic effect between the transparency and the piezoelectric properties of 0.71Pb(Mg_(1/3)Nb_(2/3))O_(3)–0.29PbTiO_(3)(PMN–0.29PT)*** utilizing the tape casting process for mass production and large-area manufacturing,our Pb_(0.913)La_(0.0145)Sm_(0.0145)(Mg_(1/3)Nb_(2/3))_(0.71)Ti_(0.29)O_(3)(TP2.9)ceramics exhibited over 60%transparency and large piezoelectric coefficient(d33)of 1104 pC/*** material holds considerable promise for a wide range of industrial applications in both the optical and electronic domains.

关键词： piezoelectric ceramics transparency pressureless sintering co-doping tape casting

High Na-ion conductivity andmechanical integrity of anion-exchanged polymeric hydrogel electrolytes for flexible sodium ion hybrid energy storage

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SusMat 2024年第1期4卷 140-153页

作者： JungWoo hong Harpalsinh H.Rana Jeong Hee Park Jun Su Kim Sang Joon lee Gun Jang Tae hoon Kang Kang ho Shin Sang Ha Baek Wooseok Yang Kwang ho Kim Ju-Hyuk lee ho Seok Park School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Clean Energy Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)SuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea COSMOS LAB/92 Jomaru-ro 385beon-gilBucheon-siRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

The polymeric gel electrolytes are attractive owing to their higher ionic conductivities than those of dry polymer electrolytes and lowered water activity for enlarged potential ***,the ionic conductivity and mechanical strength of the Na-ion conducting polymeric gel electrolytes are limited by below 20 mS cm−1 and 2.2 ***,we demonstrate Na-ion conducting and flexible polymeric hydrogel electrolytes of the chemically coupled poly(diallyldimethylammonium chloride)-dextrin-N,N′-methylene-bisacrylamide film immersed in NaClO_(4) solution(ex-DDA-Dex+NaClO_(4))for flexible sodium-ion hybrid capacitors(f-NIHC).In particular,the anion exchange reaction and synergistic interaction of ex-DDA-Dex with the optimum ClO_(4)−enable to greatly improve the ionic conductivity up to 27.63 mS cm−1 at 25◦C and electrochemical stability window up to 2.6 V,whereas the double networking structure leads to achieve both the mechanical strength(7.48 MPa)and softness of hydrogel ***,the f-NIHCs with the ex-DDA-Dex+NaClO_(4) achieved high specific and high-rate capacities of 192.04 F g^(−1)at 500 mA g^(−1)and 116.06 F g^(−1)at 10000 mA g^(−1),respectively,delivering a large energy density of 120.03Wh kg^(−1)at 906Wkg^(−1)and long cyclability of 70%over 500 cycles as well as demonstrating functional operation under mechanical stresses.

关键词： anion exchange chemistry flexible energy storage hybrid energy storage hydrogel electrolytes renewable electrolytes sodium storage

Malignant triton tumor in the abdominal wall:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1467-1473页

作者： ho Jik Yang Donghyun Kim Won Suk lee Sang-Ha Oh Department of Plastic and Reconstructive Surgery Chungnam National University Sejong HospitalSejong 30099South Korea Department of Plastic and Reconstructive Surgery Chungnam National University HospitalDaejeon 35015South Korea Department of Emergency Eulji University HospitalDaejeon 35233South Korea Department of Plastic and Reconstructive Surgery Chungnam National University College of MedicineDaejeon 35015South Korea

BACKGROUND Malignant triton tumors(MTTs)comprise a subgroup of malignant peripheral nerve sheath tumors(MPNSTs)that exhibits rhabdomyosarcomatous differen-tiation and follow an aggressive *** are primarily located along peripheral *** of MTTs in the abdominal wall have not been *** has a poorer prognosis than classic MPNSTs,and accurate diagnosis necessitates a keen understanding of the clinical history and knowledge of its differential diagnosis *** for MTTs mirrors that for MPNSTs and is predominantly *** SUMMARY A 49-year-old woman presented with a subcutaneous mass in her lower abdo-minal wall and a pre-existing surgical scar that had grown slowly over 3-4 months before the *** had previously undergone radical hysterectomy and concurrent chemo-radiotherapy for cervical cancer approximately 5 years prior to the *** computed tomography(CT)showed a 1.3 cm midline mass in the lower abdomen with infiltration into the rectus abdominis *** was no sign of metastasis(T1N0M0).An incisional biopsy identified sporadic MTT of the lower abdomen.A comprehensive surgical excision with a 3 cm margin inclusive of the peritoneum was ***-quently,the general surgeon utilized an approach akin to the open peritoneal onlay mesh *** patient underwent additional treatment with an excision shaped as a mini-abdominoplasty for the skin *** complications arose,and annual follow-up CTs did not show signs of recurrence or *** An abdominal MTT was efficaciously treated with extensive excision and abdominal wall reconstruction,eliminating the need for postoperative radiotherapy.

关键词： Malignant triton tumor Abdominal wall Surgical excision Reconstruction Case report

Urban rail transit disruption management: Research progress and future directions

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Frontiers of Engineering Management 2024年第1期11卷 79-91页

作者： Lebing WANG Jian Gang jin Lijun SUN Der-horng lee School of Naval Architecture Ocean&Civil Engineeringand State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering McGill UniversityMontrealQuebec H3A 0C3Canada ZJU-UIUC Institute Zhejiang UniversityHaining 314400China

Urban rail transit (URT) disruptions present considerable challenges due to several factors: i) a high probability of occurrence, arising from facility failures, disasters, and vandalism;ii) substantial negative effects, notably the delay of numerous passengers;iii) an escalating frequency, attributable to the gradual aging of facilities;and iv) severe penalties, including substantial fines for abnormal operation. This article systematically reviews URT disruption management literature from the past decade, categorizing it into pre-disruption and post-disruption measures. The pre-disruption research focuses on reducing the effects of disruptions through network analysis, passenger behavior analysis, resource allocation for protection and backup, and enhancing system resilience. Conversely, post-disruption research concentrates on restoring normal operations through train rescheduling and bus bridging services. The review reveals that while post-disruption strategies are thoroughly explored, pre-disruption research is predominantly analytical, with a scarcity of practical pre-emptive solutions. Moreover, future research should focus more on increasing the interchangeability of transport modes, reinforcing redundancy relationships between URT lines, and innovating post-disruption strategies.

关键词： urban rail transit disruption management resilient network train rescheduling bus bridging services

Solar‑Driven Sustainability:Ⅲ–ⅤSemiconductor for Green Energy Production Technologies

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Nano-Micro Letters 2024年第11期16卷 445-478页

作者： Chandran Bagavath Jeong‑Kyun Oh Sang‑Wook lee Dae‑Young Um Sung‑Un Kim Veeramuthu Vignesh jin‑Seo Park Shuo Han Cheul‑Ro lee Yong‑ho Ra Division of Advanced Materials Engineering Engineering CollegeResearch Center for Advanced Materials Development(RCAMD)Jeonbuk National UniversityJeonju 54896Republic of Korea

Long-term societal prosperity depends on addressing the world’s energy and environmental problems,and photocatalysis has emerged as a viable *** the efficiency of photocatalytic processes is fundamentally achieved by optimizing the effective utilization of solar energy and enhancing the efficient separation of photogenerated *** has been demonstrated that the fabrication ofⅢ–Ⅴsemiconductor-based photocatalysts is effective in increasing solar light absorption,long-term stability,large-scale production and promoting charge *** focused review explores on the current developments inⅢ–Ⅴsemiconductor materials for solar-powered photocatalytic *** review explores on various subjects,including the advancement ofⅢ–Ⅴsemiconductors,photocatalytic mechanisms,and their uses in H2 conversion,CO_(2)reduction,environmental remediation,and photocatalytic oxidation and reduction *** order to design heterostructures,the review delves into basic concepts including solar light absorption and effective charge *** also highlights significant advancements in green energy systems for water splitting,emphasizing the significance of establishing eco-friendly systems for CO_(2)reduction and hydrogen *** main purpose is to produce hydrogen through sustainable and ecologically friendly energy *** review intends to foster the development of greener and more sustainable energy source by encouraging researchers and developers to focus on practical applications and advancements in solar-powered photocatalysis.

关键词： Green energy system Hydrogen evolution CO_(2)reduction Ⅲ-Ⅴsemiconductors Photo electrochemical water splitting