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Review of the diagnosis of gastrointestinal lanthanum deposition

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World Journal of Gastroenterology 2020年第13期26卷 1439-1449页

作者： Masaya Iwamuro Haruo Urata Takehiro Tanaka hiroyuki okada Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 7008558Japan Central Research Laboratory Okayama University Medical SchoolOkayama 7008558Japan Department of Pathology Okayama University HospitalOkayama 7008558Japan

Lanthanum carbonate is used for treatment of hyperphosphatemia mostly in patients with chronic renal *** lanthanum carbonate is safe,recently,lanthanum deposition in the gastrointestinal mucosa of patients has been reported in the *** review provides an overview of gastroduodenal lanthanum deposition and focuses on disease's endoscopic,radiological,and histological features,prevalence,and outcome,by reviewing relevant clinical studies,case reports,and basic research findings,to better understand the endoscopic manifestation of gastrointestinal lanthanum *** possible relationship between gastric lanthanum deposition pattern and gastric mucosal atrophy is also illustrated;in patients without gastric mucosal atrophy,gastric lanthanum deposition appears as diffuse white lesions in the posterior wall and lesser curvature of the gastric *** the gastric mucosa with atrophy,lanthanum-related lesions likely appear as annular or granular whitish ***,these white lesions are probably more frequently observed in the lower part of the stomach,where intestinal metaplasia begins.

关键词： Lanthanum carbonate Hyperphosphatemia Gastrointestinal endoscopy Lanthanum phosphate Scanning electron microscopy Energy-dispersive X-ray spectrometry

Prediction of flare-ups of ulcerative colitis using quantitative immunochemical fecal occult blood test

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World Journal of Gastroenterology 2010年第9期16卷 1110-1114页

作者： Motoaki Kuriyama Jun Kato Koji Takemoto Sakiko Hiraoka hiroyuki okada Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical Sciences

AIM:To examine the feasibility of predicting the flareup of ulcerative colitis (UC) before symptoms emerge using the immunochemical fecal occult blood test (IFOBT).METHODS:We prospectively measured fecal hemoglobin concentrations in 78 UC patients using the I-FOBT every 1 or 2 ***:During a 20 mo-period,823 fecal samples from 78 patients were *** median concentration of fecal hemoglobin was 41 ng/mL (range:0-392 500 ng/mL).There were three types of patients with regard to the correlation between I-FOBT and patient symptoms;the synchronous transition type with symptoms (44 patients),the unrelated type withsymptoms (19 patients),and the flare-up predictive type (15 patients).In patients with the flare-up predictive type,the values of I-FOBT were generally low during the study period with stable *** to four weeks before the flare-up of symptoms,the I-FOBT values were ***,in these patients,I-FOBT could predict the flare-up before symptoms ***:Flare-up could be predicted by I-FOBT in approximately 20% of UC *** results warrant periodical I-FOBT in UC patients.

关键词： Flare-ups Immunochemical fecal occult blood test Inflammatory bowel disease Prediction Ulcerative colitis

Circulating tumor DNA dynamics analysis in a xenograft mouse model with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2021年第41期27卷 7134-7143页

作者： hiroyuki Terasawa Hideaki Kinugasa Kazuhiro Nouso Shumpei Yamamoto Mami Hirai Takehiro Tanaka Akinobu Takaki hiroyuki okada Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 7008558Japan Department of Pathology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 7008558Japan

BACKGROUND It remains unclear which factors,such as tumor volume and tumor invasion,influence circulating tumor DNA(ctDNA),and the origin of ctDNA in liquid biopsy is always *** use liquid biopsies clinically,it will be very important to address these *** To assess the origin of ctDNA,clarify the dynamics of ctDNA levels,assess ctDNA levels by using a xenograft mouse after treatment,and to determine whether tumor volume and invasion are related to ctDNA *** Tumor xenotransplants were established by inoculating BALB/c-nu/nu mice with the TE11 cell *** of mice were injected with xenografts at two or four sites and sacrificed at the appropriate time point after xenotransplantation for ctDNA *** of ctDNA was performed by droplet digital PCR,using the human telomerase reverse transcriptase(hTERT)*** Mice given two-site xenografts were sacrificed for ctDNA at week 4 and week *** hTERT was detected at week 4,but it was detected at week ***,in four-site xenograft mice,hTERT was detected both at week 4 and week *** experiments revealed that both tumor invasion and tumor volume were asso ciated with the detection of *** resection experiments,hTERT was detected at resection,but had decreased by 6 h,and was no longer detected 1 and 3 d after *** We clarified the origin and dynamics of ctDNA,showing that tumor volume is an important *** also found that when the tumor was completely resected,ctDNA was absent after one or more days.

关键词： Liquid biopsy Circulating tumor DNA Xenograft Esophageal squamous cell carcinoma Dynamics of circulating tumor DNA

Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma

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World Journal of Gastroenterology 2012年第43期18卷 6263-6268页

作者： Takehiro Tanaka Atsushi Fujimura Koichi Ichimura hiroyuki Yanai Yasuharu Sato Katsuyohi Takata hiroyuki okada Seiji Kawano Shunsuke Tanabe Tadashi Yoshino Department of Pathology Okayama University Hospital Okayama 700-8558 Japan Department of Physiology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Pathology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Endoscopy Okayama University Hospital Okayama 700-8558 Japan Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan

AIM:To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan. METHODS:We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions. We compared the clinicopathological characteristics of HER2-positive and HER2-negative ***:HER2 positivity was identified in 8 (27%) carcinoma samples. We found that HER2 expression was associated with p53 overexpression (100% vs 52.6% in pT1 tumor; 100% vs 54.5% in all stage tumor, P < 0.05) and protruding lesions at the early disease stage. There was no association between the mucin phenotype of the carcinomas and prognosis. HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients, but the macroscopic features may be associated with earlier diagnosis in these patients. CONCLUSION:Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage.

关键词： Barrett's adenocarcinoma Human epidermal growth factor receptor 2 p53 Mucin phenotype

Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement

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World Journal of Gastroenterology 2010年第37期16卷 4661-4669页

作者： Masaya Iwamuro hiroyuki okada Yoshiro Kawahara Katsuji Shinagawa Toshiaki Morito Tadashi Yoshino Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Department of Hematology and Oncology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Department of Pathology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

AIM: To evaluate the endoscopic manifestations and prognoses of gastrointestinal (GI) mantle cell lymphoma (MCL). METHODS: A database search at the Department of Pathology of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences revealed 57 MCL patients with GI involvement. Clinical records were available for 35 of the 57 patients from 21 institutions, and those 35 patients were enrolled in this study. We summarized the gross types of endoscopic features, event-free survival (EFS), and overall survival (OS) of those ***: Of the 35 patients, GI involvement in the esophagus, stomach, and duodenum was found in 2 (5.7%), 26 (74.3%), and 12 (34.3%) patients, respectively. Twenty-one of the 35 patients underwent colonoscopy; among them, GI involvement in the ileum, cecum, colon, and rectum was found in 10 (47.6%), 3 (14.3%), 12 (57.1%), and 10 (47.6%), respectively. Various lesions, such as superficial, protruded, fold thickening, or ulcerative, were found in the stomach, whereas multiple lymphomatous polyposis (MLP) was dominant from the duodenum to the rectum. Twelve patients were treated with a hyper-CVAD/MA regimen, and they had better OS (3-year rate, 88.3% vs 46.4%, P < 0.01) and better EFS (3-year rate, 66.7% vs 33.8%, P < 0.05) than the remaining 23 patients who were not treated with this regimen. CONCLUSION: MLP was a representative form of intestinal involvement, whereas a variety of lesions were found in the stomach. The hyper-CVAD/MA regimen may improve survival in these patients.

关键词： Chemotherapy Gastrointestinal lymphoma Mantle cell lymphoma Multiple lymphomatous polyposis Non-Hodgkin’s lymphoma

Proton pump inhibitor step-down therapy for GERD:A multi-center study in Japan

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World Journal of Gastroenterology 2011年第11期17卷 1480-1487页

作者： Takao Tsuzuki hiroyuki okada Yoshiro Kawahara Ryuta Takenaka Junichiro Nasu Hidehiko Ishioka Akiko Fujiwara Fumiya Yoshinaga Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Internal Medicine Tsuyama Central HospitalOkayama 708-0841Japan Ishioka clinic Hiroshima 721-0926Japan Department of Internal Medicine Okayama Saiseikai General HospitalOkayama 700-8511Japan Deparment of Internal Medicine Mihara Red Cross HospitalHiroshima 723-8512Japan

AIM:To investigate the predictors of success in stepdown of proton pump inhibitor and to assess the quality of life(QOL).METHODS:Patients who had heartburn twice a week or more were treated with 20 mg omeprazole(OPZ) once daily for 8 wk as an initial therapy(study 1).Patients whose heartburn decreased to once a week or less at the end of the initial therapy were enrolled in study 2 and treated with 10 mg OPZ as maintenance therapy for an additional 6 mo(study 2).QOL was in-vestigated using the gastrointestinal symptom rating scale(GSRS)before initial therapy,after both 4 and 8 wk of initial therapy,and at 1,2,3,and 6 mo after starting maintenance ***:In study 1,108 patients were *** characteristics were as follows;median age:63(range: 20-88)years,sex:46 women and 62 *** success rate of the initial therapy was 76%.In the patients with successful initial therapy,abdominal pain,indigestion and reflux GSRS scores were *** study 2,83 patients were *** of 83 patients completed the study 2 *** the per-protocol analysis,80%of 70 patients were successful for *** multivariate analysis of baseline demographic data and clinical information,no previous treatment for gastroesophageal reflux disease(GERD)[odds ratio (OR)0.255,95%CI:0.06-0.98]and a lower indigestion score in GSRS at the beginning of step-down therapy(OR 0.214,95%CI:0.06-0.73)were found to be the predictors of successful step-down *** improved GSRS scores by initial therapy were maintained through the step-down ***:OPZ was effective for most GERD ***,those who have had previous treatment for GERD and experience dyspepsia before stepdown require particular monitoring for relapse.

关键词： Gastroesophageal reflux disease Proton pump inhibitor Omeprazole Step-down therapy Gastrointestinal symptom rating scale

Partial stent-in-stent placement of biliary metallic stents using a short double-balloon enteroscopy

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World Journal of Gastroenterology 2012年第45期18卷 6674-6676页

作者： Koichiro Tsutsumi Hironari Kato Takeshi Tomoda Kazuyuki Matsumoto Ichiro Sakakihara Naoki Yamamoto Yasuhiro Noma Takayuki Sonoyama hiroyuki okada Kazuhide Yamamoto Department of Gastroenterology and Hepatology Dentistry and Pharmaceutical SciencesOkayama University Graduate School of MedicineOkayama 700-8558Japan

Endoscopic intervention is less invasive than percutaneous or surgical approaches and should be considered the primary drainage procedure in most cases with obstructive ***,therapeutic endoscopic retrograde cholangiopancreatography(ERCP) using double-balloon enteroscopy(DBE) has been shown to be feasible and effective,even in patients with surgically altered *** the other hand,endoscopic partial stent-in-stent(PSIS) placement of selfexpandable metallic stents(SEMSs) for malignant hilar biliary obstruction in conventional ERCP has also been shown to be feasible,safe and *** performed PSIS placement of SEMSs for malignant hilar biliary obstruction due to liver metastasis using a short DBE in a patient with Roux-en-Y anastomosis and achieved technical and clinical *** procedure can result in quick relief from obstructive jaundice in a single session and with short-term hospitalization,even in patients with surgically altered anatomies.

关键词： Double-balloon enteroscopy Malignant hi-lar biliary obstruction Self-expandable metallic stent Partial stent in stent Roux-en-Y anastomosis

Reference Design of ICRF Antenna for EAST

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Plasma Science and Technology 2006年第3期8卷 358-362页

作者：秦成明赵燕平 hiroyuki okada 张新军毛玉周 T.WATARI R.KUMAZAWA T.SEKI Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China National Institute for Fusion Science Furo-cho Chikusa-ku Nagoya 464-01 Japan Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China

An antenna array suitable for plasma heating and current drive has been designed for the ion cyclotron resonance frequency range （ICRF） heating on the EAST superconducting tokamak. The ICRF heating is planned to operate in a frequency range of 30 MHz to 80 MHz and hence the antenna geometry is optimized for 55 MHz. The design is based on the conventional strap antenna element. The coupling properties of the antenna are calculated with a slab model of the plasma for the antenna simulation. The coupling code is extended for the analysis of the toroidal antenna array separated by septa.

关键词： ICRF antenna design input impedance plasma coupling

Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse

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World Journal of Gastroenterology 2016年第21期22卷 5079-5087页

作者： Asuka Nakarai Jun Kato Sakiko Hiraoka Shiho Takashima Daisuke Takei Toshihiro Inokuchi Yuusaku Sugihara Masahiro Takahara Keita Harada hiroyuki okada Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Second Department of Internal Medicine Wakayama Medical University Department of Endoscopy Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

AIM: To assess the risk of relapse in ulcerative colitis (UC) patients in clinical remission using mucosal status and fecal immunochemical test (FIT) ***: The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores (MESs) and FIT ***: Patients with an MES of 0 (n = 94, 48%) showed a ten-fold lower risk of relapse than those with an MES of 1-3 (n = 100, 52%) (HR = 0.10, 95%CI: 0.05-0.19). A negative FIT result (fecal hemoglobin concentrations ≤ 100 ng/mL) was predictive of patients with an MES of 0, with a sensitivity of 0.94 and a specific of 0.76. Moreover, patients with a negative FIT score had a six-fold lower risk of clinical relapse than those with a positive score (HR = 0.17, 95%CI: 0.10-0.28). Inclusion of the distinguishing parameter, sustaining clinical remission > 12 mo, resulted in an even stronger correlation between negative FIT results and an MES of 0 with respect to the risk of clinical relapse (HR = 0.11, 95%CI: 0.04-0.23).CONCLUSION: Negative FIT results one year or more after remission induction correlate with complete mucosal healing (MES 0) and better prognosis. Performing FIT one year after remission induction may be useful for evaluating relapse risk.

关键词： Ulcerative colitis Clinical remission Mucosal healing Mayo endoscopic subscore Quantitative fecal immunochemical test