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Improvement in Surface Roughness and Hardness for Carbon Steel by Slide Burnishing Process

Materials Sciences and Applications 2021年第5期12卷 171-181页

作者： hirotaka kato Wataru Hirokawa Yoshikazu Todaka Kazufumi Yasunaga Department of Mechanical Engineering Fukui College National Institute of Technology Sabae Japan Department of Mechanical Engineering Toyohashi University of Technology Toyohashi Japan Research and Development Department The Wakasa Wan Energy Research Center Tsuruga Japan

Slide burnishing process, which is a surface severe plastic deformation technique, offers an attractive post-machining alternative due to its chip-less and relatively simple operations. The purpose of the present work is to investigate effects of initial turned surface roughness on the burnished surface roughness and hardness in slide burnishing. The carbon steel samples those have different roughness surfaces being treated were prepared by turning by varying the feed. Slide burnishing was then carried out by a silicon nitride ceramic ball that was loaded and fed on the turned surface of a rotating specimen using a lathe machine. It was found that the turned surfaces were smoothed drastically by the burnishing process, and that the Ra and Rz values were reduced at most by a factor of 52 and 21, respectively. However, the smoothing effect of burnishing has limit, and the limited maximum height roughness (Rz*) for burnishing smoothing increased under a higher burnishing force and with a larger ball diameter. When the Rz values of initial turned surfaces were less than the Rz*, the roughness of the burnished surfaces did not depend on the roughness of the initial turned surface and the burnishing force. There was no significant difference in the burnished microstructure and hardness under a specific burnishing force among the initial turned surface roughness, while a higher burnishing force caused a greater increase in surface hardness.

关键词： Burnishing Turning Surface Smoothing Roughness Hardness Carbon Steel

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4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

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Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei kato Daisuke Nishizaki hirotaka Miyashita Suzanna Lee Mary K.Nesline Sarabjot Pabla Jeffrey M.Conroy Paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer Medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States Medical College of Wisconsin Cancer Center and Genomic Sciences and Precision Medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure

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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

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Increase in thermal stability of proteins adsorbed on biomass charcoal powder prepared from plant biomass wastes

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Journal of Biomedical Science and Engineering 2011年第11期4卷 692-698页

作者： Hidetaka Noritomi Ryotaro Kai Daiki Iwai hirotaka Tanaka Reo Kamiya Masahiko Tanaka Kohichiroh Muneki Satoru kato 不详

Thermal stability of lysozyme adsorbed on biomass charcoal powder (BCP), which was prepared from plant biomass wastes such as dumped adzuki bean, bamboo, and wood by pyrolysis without combustion under nitrogen atmosphere and comminution with a jet mill, was examined. Adsorbing lysozyme on BCP could sufficiently prevent proteins from denaturing and aggregating in an aqueous solution at high temperatures, and enhanced the refolding of thermally denatured proteins by cooling treatment. The remaining activities of lysozyme adsorbed on BCP of adzuki bean exhibited 51% by cooling treatment after the heat treatment at 90?C for 30 min, although that of native lysozyme was almost lost under the same experimental conditions. The thermostabilization effect of BCP on the remaining activity of adsorbed lysozyme was markedly dependent upon the kind of plant biomass wastes.

关键词： Adsorption Biomass Charcoal Powder Lysozyme Refolding Remaining Activity Thermal Stability

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Case of arterial hemorrhage after endoscopic papillary large balloon dilation for choledocholithiases using a covered self-expandable metallic stent

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World Journal of Gastroenterology 2015年第16期21卷 5090-5095页

作者： Shuya Shimizu Itaru Naitoh Takahiro Nakazawa Kazuki Hayashi Katsuyuki Miyabe Hiromu Kondo Yuji Nishi Shuichiro Umemura Yasuki Hori Akihisa kato hirotaka Ohara Takashi Joh Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Department of Community-based Medical Education Nagoya City University Graduate School of Medical Sciences

A 78-year-old male was admitted to our hospital because of *** demonstrated choledocholithiases with a maximum diameter of 13 mm, and we performed endoscopic papillary large balloon dilation(EPLBD) with a size of 15 *** following the balloon deflation, spurting hemorrhage occurred from the orifice of the duodenal *** we performed endoscopic hemostasis by compressing the bleeding point with the large balloon catheter, we could not achieve ***, we placed a 10 mm fully covered selfexpandable metallic stent(SEMS) across the duodenal papilla, and the hemorrhage stopped *** 1 wk of SEMS placement, duodenal endoscopy revealed ulcerative lesions in both the orifice of the duodenal papilla and the lower bile duct.A direct peroral cholangioscopy using an ultra-slim upper endoscope revealed a visible vessel with a longitudinal mucosal tear in the ulceration of the lower bile *** believe that the mucosal tear and subsequent ruptured vessel were caused by the EPLBD procedure.

关键词： Endoscopic papillary large balloon dilation Hemorrhage Covered self-expandable metallic stent Direct peroral cholangioscopy Endoscopic hemostasis

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最新铁路变电所设备新的环保产品

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西铁科技 2006年第2期 50-52页

作者： Naoki Kawamura Tetsuya kato Yoshimasa Eda hirotaka Takahashi 宋文伟

为了缩小铁路变电所装置的体积、降低损耗、便于维修，日立公司研制出了体积小、坚固耐用的SF6GIS（气体绝缘开关装置），噪声低、效率高的电气化铁路变压器和数控电源柜。为满足目前不断增长的环保、安全、高效、坚固、便于维修设备的... 详细信息

为了缩小铁路变电所装置的体积、降低损耗、便于维修，日立公司研制出了体积小、坚固耐用的SF6GIS（气体绝缘开关装置），噪声低、效率高的电气化铁路变压器和数控电源柜。为满足目前不断增长的环保、安全、高效、坚固、便于维修设备的需求，我们研制出了（1）环保型防故障硅变压器；（2）无SF6温室气体环保型GIS和坚固型叠放式SWGR（开关装置）；（3）一种新的不含PFCs（全氟化碳气体）冷却液的生态型低损耗整流器；（4）BBU（组合单元），通过采用标准单元的保护控制器，实现在线维修。

关键词：铁路变电所维修设备气体绝缘开关装置 SF6GIS 降低损耗电气化铁路保护控制器环保型日立公司温室气体

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Hayabusa2’s station-keeping operation in the proximity of the asteroid Ryugu

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Astrodynamics 2020年第4期4卷 349-375页

作者： Yuto Takei Takanao Saiki Yukio Yamamoto Yuya Mimasu Hiroshi Takeuchi Hitoshi Ikeda Naoko Ogawa Fuyuto Terui Go Ono Kent Yoshikawa Tadateru Takahashi hirotaka Sawada Chikako Hirose Shota Kikuchi Atsushi Fuji Takahiro Iwata Satoru Nakazawa Masahiko Hayakawa Ryudo Tsukizaki Satoshi Tanaka Masanori Matsushita Osamu Mori Daiki Koda Takanobu Shimada Masanobu Ozaki Masanao Abe Satoshi Hosoda Tatsuaki Okada Hajime Yano Takaaki kato Seiji Yasuda Kota Matsushima Tetsuya Masuda Makoto Yoshikawa Yuichi Tsuda Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan The Graduate University for Advanced Studies Sagarmihara 252-5210Japan NEC Aerospace Systems LtdFruchu 183-8502Japan NEC Corporation Puchu 183-8501Japan

The Japanese interplanetary probe Hayabusa2 was launched on December 3,2014 and the probe arrived at the vicinity of asteroid 162173 Ryugu on June 27,*** its 1.4 years of asteroid proximity phase,the probe successfully accomplished numbers of record-breaking achievements including two touchdowns and one artificial cratering experiment,which are highly expected to have secured surface and subsurface samples from the asteroid inside its sample container for the first time in *** Hayabusa2 spacecraft was designed not to orbit but to hover above the asteroid along the sub Earth *** orbital and geometrical configuration allows the spacecraft to utilize its high-gain antennas for telecommunication with the ground station on Earth while pointing its scientific observation and navigation sensors at the *** paper focuses on the regular station-keeping operation of Hayabusa2,which is called“home position”(HP)-keeping ***,together with the spacecraft design,an operation scheme called HP navigation(HPNAV),which includes a daily trajectory control and scientific observations as regular activities,is *** the description on the guidance,navigation,and control design as well as the framework of optical and radiometric navigation,the results of the HP-keeping operation including trajectory estimation and delta-V planning during the entire asteroid proximity phase are summarized and evaluated as a first ***,this paper states that the *** operation in the framework of HPNAV had succeeded without critical incidents,and the number of trajectory control delta-V was planned fficiently throughout the period.

关键词： small body mission station-keeping guidance,navigation,and control(GNC) optical and radiometric navigation

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抽吸获取的脂肪组织中活脂肪细胞、未成活脂肪细胞和其他细胞成分数量的测定

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中国美容整形外科杂志 2011年第7期22卷 I0022-I0023页

作者： hirotaka Suga Daisuke Matsumoto Keita Inoue Tomokuni Shigeura Hitomi Eto Noriyuki Aoi Harunosuke kato Hiroaki Abe Kotaro Yoshimura 魏峰(译) 高景恒(译) 张晨(译) 日本东京东京大学医学院整形外科 Biomaster公司研究所《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景分析脂肪组织中脂肪细胞和其他细胞成分生存能力和数量的方法仍需进一步评估。方法作者采用抽吸法获得1g脂肪组织，利用离心分离法将脂肪组织分层（顶层、中层和底层），利用烟酸己可碱33342和碘化丙啶为细胞染色，采用二甲氧唑黄... 详细信息

背景分析脂肪组织中脂肪细胞和其他细胞成分生存能力和数量的方法仍需进一步评估。方法作者采用抽吸法获得1g脂肪组织，利用离心分离法将脂肪组织分层（顶层、中层和底层），利用烟酸己可碱33342和碘化丙啶为细胞染色，采用二甲氧唑黄比色法（2，3-bis（2-methoxy-4-nitro-5-sulfophenyl）-5-[（phenyl-amino）carbonyl]-2H-tet-razoliumhydroxide，XTT）和甘油一3．磷酸脱氢酶试验（n=10）评估细胞生存能力和数量。分析配制细胞（脂肪细胞，脂肪基质细胞，和白细胞）数量与XTY和甘油-3-磷酸脱氢酶试验分析结果之间的关联（凡=5）。从相同脂肪组织中分离血管基质部分细胞，并利用多色流式细胞术检测其细胞成分（n=5）。结果烟酸己可碱33342和碘化丙啶染色法将活的脂肪细胞从脂肪粒，死亡脂肪细胞和其他细胞中区分开。作者从1g的抽吸脂肪组织中获得6．9×10^5个未破碎脂肪细胞；原脂肪细胞中有30％发生破碎。XTT和甘油-3-磷酸脱氢酶试验均显示了活脂肪细胞的数量与分析结果之间具有显著相关关系，但是只有甘油-3-磷酸脱氢酶试验结果对脂肪细胞有严格特异性。本研究还发现，脂肪基质细胞与脂肪细胞的比率大于之前研究的描述。结论本研究中单独使用一种或联合使用2种生存能力分析法，均能确定脂肪细胞和其他细胞的数量，但是不采用组织分离而直接评估原始细胞仍有困难。

关键词：脂肪细胞脂肪组织细胞成分抽吸法脂肪基质细胞细胞生存能力多色流式细胞术数

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人类脂肪来源干细胞经长期深低温保藏后保留的增殖能力和多能性

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中国美容整形外科杂志 2011年第7期22卷 I0013-I0021页

作者： Koichi Gonda Tomokuni Shigeura Takahiro Sato Daisuke Matsumoto hirotaka Suga Keita Inoue Noriyuki Aoi Harunosuke kato Katsujiro Sato Syoko Murase Isao Koshima Kotaro Yoshimura 魏峰(译) 高景恒(译) 张晨(译) 日本东京东京大学医学院整形外科 Biomaster公司研究所《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景人类脂肪来源干（问质）细胞作为间叶细胞谱系（包括脂肪、骨骼肌和心肌、骨、软骨、血管）组织缺损的再生疗法的工具，是很有应用前景的。同其他领域所发生的一样（包括造血干细胞和脐带血细胞在基于细胞的治疗方法中的应用），在... 详细信息

背景人类脂肪来源干（问质）细胞作为间叶细胞谱系（包括脂肪、骨骼肌和心肌、骨、软骨、血管）组织缺损的再生疗法的工具，是很有应用前景的。同其他领域所发生的一样（包括造血干细胞和脐带血细胞在基于细胞的治疗方法中的应用），在未来可能的临床应用中，脂肪来源干细胞深低温保藏也许是一项必不可少的基本技术。方法作者从18例患者抽吸获得的脂肪中分离出脂肪来源干细胞，并在干细胞深低温保藏6个月前后分别检测它们的增殖能力和多功能性，深低温保藏过程遵循他们已确定的方案。通过检测培养细胞的倍增时间对细胞增殖能力进行量化分析，通过分析脂肪来源干细胞向成软骨、成骨和成脂谱系细胞的分化确定细胞的多功能性。另外，通过流式细胞术确定细胞表面标记物的表达谱，并对新鲜的和经深低温保藏的脂肪来源干细胞表面标记物的表达谱进行对比。结果经深低温保藏的脂肪来源干细胞完全保存分化成脂肪细胞、成骨细胞、成软骨细胞的能力及增殖能力。流式细胞术分析结果显示深低温保藏前后细胞表面标记物表达谱保持不变。结论在现有的方案下，脂肪来源干细胞至少可深低温保藏6个月，且不损失任何增殖能力和分化潜能。这些结果保证了自体库存的脂肪来源干细胞在未来临床应用的可用性。

关键词：脂肪来源干细胞细胞增殖能力深低温保藏人类多能性表面标记物成软骨细胞流式细胞术

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非血管化的脂肪移植后脂肪细胞的命运：脂肪细胞早期死亡和替换的证据

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中国美容整形外科杂志 2013年第11期24卷 I0005-I0013页

作者： Hitomi Eto Harunosuke kato hirotaka Suga Noriyuki Aoi Kentaro Doi Shinichiro Kuno Kotaro Yoshimura 魏峰(译者) 高景恒(译者) 袁继龙(译者) 东京大学医学院整形外科日本东京《中国美容整形外科杂志》编辑部辽宁省人民医院整形外科

背景与目的脂肪移植的临床效果是一种可变因素，而且其依赖于所采用的技术，同时，移植组织怎样建立血管化是未知的。近来，我们通过对蛋白进行免疫组化染色，而非HE染色，对存活和死亡的脂肪细胞进行观察。方法利用如下方法对人类脂肪... 详细信息

背景与目的脂肪移植的临床效果是一种可变因素，而且其依赖于所采用的技术，同时，移植组织怎样建立血管化是未知的。近来，我们通过对蛋白进行免疫组化染色，而非HE染色，对存活和死亡的脂肪细胞进行观察。方法利用如下方法对人类脂肪组织中各细胞成分（脂肪细胞，脂肪干细胞／间质细胞／祖细胞，血管内皮细胞，造血细胞）的生存能力进行评价：①储存脂肪抽吸物；②培养细胞；③培养功能性脂肪组织。此外，将小鼠腹股沟脂肪垫（150～200mg）移植于头皮下，并在第0、1、2-,3、5、7、14天对移植物进行染色。结果体外研究显示，尽管脂肪来源间质干细胞可以保持3d的活性，但在缺血环境条件下脂肪细胞最易受影响而死亡。体内研究证实，大多数移植脂肪细胞在第1天开始死亡，仅有少部分距离组织边缘300μm的脂肪细胞存活。增殖细胞的数量在第3天开始增多，从第7天开始活性脂肪细胞区域增大，提示坏死组织的修复重建过程开始。结论我们展示了非血管化的脂肪移植后脂肪组织最大程度有活力模型的令人信服的证据。我们观察到移植组织由外围至内部分为3个区域：存活区域（脂肪细胞存活），再生区域（脂肪细胞死亡，脂肪来源间质干细胞存活，坏死脂肪细胞由新生的脂肪细胞替换），坏死区域（脂肪细胞核脂肪来源间质干细胞均死亡）。

关键词：脂肪细胞早期死亡非血管化移植后证据免疫组化染色细胞存活间质干细胞

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