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Nano Research 2015年第5期8卷 1604-1614页

作者： Hui-Wang Cui Katsuaki Suganuma hiroshi uchida Institute of Scientific and Industrial Research Osaka University Mihogaoka 8-1 Ibaraki Osaka 567-0047 Japan Institute for Polymers and Chemicals Business Development Center Showa Denko K. K. 5-1 Yawata Kaigan Dori Ichihara Chiba 290-0067 Japan

In this study, we combined silver nanowires with cupro fabrics using a dipping- drying method to prepare electrically conductive fabrics. The silver nanowires were first adhered to and then absorbed by microfibers to form electrically conductive fibers. They also filled the gaps and spaces between the microfibers, and were stacked or piled together to form networks with high electrical conductivity. The electrically conductive fabric had low resistance and good stretchability, e.g., 0.0047-0.0091 Ωin the strain range of 0-190%. They also exhibited stable electrical conductivity, as well as excellent flexibility, which remained even when the fabric was stretched, shrunk, or bent. The results show that the electrically conductive fabric can be used as a smart textile, especially in fields associated with weaving, clothing, food products, lifestyle products, medicine, biology, electronics, aviation, and military equipment and accessories.

关键词： fabrics/textiles metals smart materials electrical properties

感耦等离子体发射光谱法测定硅酸盐岩石中少量和微量元素

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地球与环境 1981年第10期29卷 37-38页

作者： hiroshi uchida 盛兴土陈小暑湖南省地质局实验室

对于硅酸盐中大量、少量和微量元素的发射光谱化学分析,感耦等离子体(ICP)看来是最好的激发光源,因为它灵敏度高、动态范围宽、化学和电离干扰较少。虽然溶液粘度对分析结果有影响,但业已证明,在封闭聚四氟乙烯器皿中用盐酸与氢氟酸的... 详细信息

对于硅酸盐中大量、少量和微量元素的发射光谱化学分析,感耦等离子体(ICP)看来是最好的激发光源,因为它灵敏度高、动态范围宽、化学和电离干扰较少。虽然溶液粘度对分析结果有影响,但业已证明,在封闭聚四氟乙烯器皿中用盐酸与氢氟酸的混合物处理后。

关键词：微量元素痕量元素硅酸盐岩石原子吸收光谱法原子吸收分光光度法光谱干扰电离干扰氢氟酸氟化物

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《博士论文》作为《资本论》形成史的起点

晋阳学刊 2017年第6期 83-88页

作者：内田弘由阳日本专修大学吉林大学哲学基础理论研究中心长春130012

以往学者对《资本论》形成史的研究主要是从1843年马克思阅读经济学文献开始的。这一研究思路忽视了从马克思的《博士论文》到《资本论》始终贯穿的一个主题:批判康德。《博士论文》借助阐发德谟克利特与伊壁鸠鲁的自然哲学全面批判了... 详细信息

以往学者对《资本论》形成史的研究主要是从1843年马克思阅读经济学文献开始的。这一研究思路忽视了从马克思的《博士论文》到《资本论》始终贯穿的一个主题:批判康德。《博士论文》借助阐发德谟克利特与伊壁鸠鲁的自然哲学全面批判了康德的第一批判,并由此初步确立了《资本论》批判资本幻像、回归物质生产过程的理论基础。此外,《博士论文》中的宗教批判也暗含着对政治经济学的批判。正是在这个意义上,马克思的《博士论文》构成了《资本论》形成史的起点。

关键词：马克思《博士论文》《资本论》

Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

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Acta Pharmaceutica Sinica B 2014年第2期4卷 141-145页

作者： Ryuji uchida Seiko Ishikawa hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato UniversityTokyo 108-8641Japan School of Pharmacy Kitasato UniversityTokyo 108-8641Japan

2-Hydroxytyrosol(2-HT),originally reported as a synthetic compound,was isolated for the first time as a fungal metabolite.2-HT was found to inhibit mushroom tyrosinase with an IC_(50) value of 13.0 mmol/***,2-HT dose-dependently inhibited tyrosinase activity(IC_(50),32.5 mmol/L)in the cell-free extract of B16 melanoma cells andα-melanocyte stimulating hormone(α-MSH)-stimulated melanin formation in intact B16 melanoma cells.

关键词： 2-Hydroxytyrosol Metarhizium sp. Tyrosinase inhibitor Melanine formation B16 melanoma cells

Stereochemistries of monapinones produced by Talaromyces pinophilus FKI-3864

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Acta Pharmaceutica Sinica B 2013年第3期3卷 163-166页

作者： Ryuji uchida Mio Kawaguchi Noriko Sato hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato University5-9-1 ShirokaneMinato-kuTokyo 108-864Japan

Monapinones A(1)to E(5),half parts of dinapinones,were produced by fermentation of Talaromyces pinophilus FKI-3864 in seawater-containing medium and have a common dihydronaphthopyranone skeleton with a different long alkyl *** relative stereochemistries of 3–5 were elucidated by various NMR experiments including analysis of 1 H NMR coupling constants,ROESY and the dihedral *** absolute stereochemistries of 3–5 at C-3 were determined by the circular dichroism spectra in comparison to the data of(R)-and(S)-semivioxanthins(6 and 7).Accordingly,total absolute stereochemistries of 3–5 were concluded to be 3S,13R,15R,17R,19R,3S,13R,15R,17R and 3S,13R,15R,respectively.

关键词： Monapinone Stereochemistry Triacylglycerol synthesis inhibitor Dinapinone Talaromyces pinophilus

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

One-step palliative treatment method for obstructive jaundice caused by unresectable malignancies by percutaneous transhepatic insertion of an expandable metallic stent

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World Journal of Gastroenterology 2006年第15期12卷 2423-2426页

作者： hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Yoshiaki Mizuguchi Tetsuya Shimizu Shigeki Yokomuro Takayuki Aimoto Yoshiharu Nakamura Eiji uchida Yasuo Arima Manabu Watanabe Eiichi uchida Takashi Tajiri Department of Surgery 1 Nippon Medical School Japan uchida Hospital Japan

AIM： To describe a simple one-step method involving percutaneous transhepatic insertion of an expandable metal stent （EMS） used in the treatment of obstructive jaundice caused by unresectable malignancies. METHODS： Fourteen patients diagnosed with obstructive jaundice due to unresectable malignancies were included in the study. The malignancies in these patients were a result of very advanced carcinoma or old age. Percutaneous transhepatic cholangiography was performed under ultrasonographic guidance. After a catheter with an inner metallic guide was advanced into the duodenum, an EMS was placed in the common bile duct, between a point 1 cm beyond the papilla of Vater and the entrance to the hepatic hilum. In cases where it was difficult to span the distance using just a single EMS, an additional stent was positioned. A drainage catheter was left in place to act as a hemostat. The catheter was removed after resolution of cholestasis and stent patency was confirmed 2 or 3 d post-procedure. RESULTS： One-step insertion of the EMS was achieved in all patients with a procedure mean time of 24.4 min. Out of the patients who required 2 EMS, 4 needed a procedure time exceeding 30 min. The mean time for removal of the catheter post-procedure was 2.3 d. All patients died of malignancy with a mean follow-up time of 7.8 mo. No stent-related complication or stent obstruction was encountered. CONCLUSIONS： One-step percutaneous transhepaticinsertion of EMS is a simple procedure for resolving biliary obstruction and can effectively improve the patient＇s quality of life.

关键词： Expandable metallic stent Bile duct carcinoma Gall bladder carcinoma Pancreatic carcinoma Gastric carcinoma Obstructive jaundice

Multiple intrahepatic artery aneurysms during the treatment for IgG4-related sclerosing cholangitis:A case report

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World Journal of Hepatology 2024年第12期16卷 1505-1514页

作者： Hotaka Tamura Yoshinori Ozono Keisuke uchida Naomi Uchiyama hiroshi Hatada Souichiro Ogawa Hisayoshi Iwakiri hiroshi Kawakami Division of Gastroenterology and Hepatology Department of Internal MedicineFaculty of MedicineUniversity of MiyazakiMiyazaki 889-1692Japan

BACKGROUND The purpose of this case report is to describe a case of multiple intrahepatic artery aneurysms during treatment for IgG4-related sclerosing cholangitis(IgG4-SC)and to provide information for daily *** SUMMARY A 64-year-old Japanese woman was diagnosed with IgG4-SC five years prior and was receiving maintenance treatment with prednisolone 7.5-10 mg/*** developed abdominal pain and a sudden onset of black stool and was admitted to our *** contrast-enhanced computed tomography(CT)and ultra-sonography(US)revealed multiple intrahepatic artery aneurysms that developed during the treatment for *** transarterial embolization for mu-ltiple hepatic artery aneurysms was *** artery aneurysms disappeared on contrast-enhanced CT and US,the progression of anemia ceased,and the melena ***,hemostasis was *** Hepatic artery aneurysms should be considered poor prognostic complications of IgG4-SC.

关键词： Hepatic artery aneurysm Pseudoaneurysm IgG4-related sclerosing cholangitis Embolization Melena Atherosclerosis Case report

Maintenance time of sedative effects after an intravenous infusion of diazepam: A guide for endoscopy using diazepam

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World Journal of Gastroenterology 2008年第33期14卷 5197-5203页

作者： Mitsushige Sugimoto Takahisa Furuta Akiko Nakamura Naohito Shirai Mutsuhiro Ikuma Shingen Misaka Shinya uchida hiroshi Watanabe Kyoichi Ohashi Takashi Ishizaki Akira Hishida First Department of Medicine Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Center for Clinical Research Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Department of Gastroenterology Enshu General Hospital1-1-1 Tyuou Naka-ku Hamamatsu 430-0929 Japan Department of Pharmacoki-netics and Pharmacodynamics School of Pharmaceutics Sciences University of Shizuoka52-1 Yada Suruga-ku Shizuoka 422-8526 Japan Department of Clinical Pharmacology and Therapeutics Hamamatsu University School of Medicine1-20-1 Handayama Higashi-ku Hamamatsu 431-3192 Japan Department of Clinical Pharmacology and Therapeutics Oita University1-1 Idaigaoka Hazama Yufu 879-5593 Japan

AIM: To examine whether the sedative effects assessed by psychomotor tests would depend on the cytochrome P450 (CYP ) 2C19 genotypes after an infusion regimen of diazepam commonly used forgastrointestinal endoscopy in Japan. METHODS: Fifteen healthy Japanese volunteers consisting of three different CYP2C19 genotype groups underwent a critical ? icker fusion test, an eye movement analysis and a postural sway test as a test for physical sedative effects, and a visual analog scale (VAS) symptom assessment method as a test for mental sedative effects during the 336 h period after the intravenous infusion of diazepam (5 mg). RESULTS: The physical sedative effects assessed by the critical flicker test continued for 1 h (t values of 5 min, 30 min and 60 min later: 4.35, 5.00 and 3.19, respectively) and those by the moving radial area of a postural sway test continued for 3 h (t values of 5 h, 30 h, 60 min and 3 h later: -4.05, -3.42, -2.17 and -2.58, respectively), which changed significantly compared with the baseline level before infusion (P < 0.05). On the other hand, the mental sedative effects by the VAS method improved within 1 h. The CYP2C19 genotype-dependent differences in the postinfusion sedative effects were not observed in any of the four psychomotor function tests. CONCLUSION: With the psychomotor tests, the objective sedative effects of diazepam continued for 1 h to 3 h irrespective of CYP2C19 genotype status and the subjective sedative symptoms improved within 1 h. Up to 3 h of clinical care appears to be required after the infusion of diazepam, although patients feel subjectively improved.

关键词： Diazepam Sedation cytochrome P450(CYP) 2C19 Endoscopy Complication Critical flicker fusion test Eye movement analysis Postural sway test Visual analog scale

Emergence of resistance to carbocyclic oxetanocin G in herpes simplex virus type 1 and genetic analysis of resistant mutants

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Acta Pharmacologica Sinica 2004年第7期25卷 75-80页

作者： hiroshi SHIOTA Department of Ophthalmology Japan School of Medicine The University of Tokushima Tokushima 770

AIM: To elucidate the potentiality of emergence of drug-resistance to carbocyclic oxetanocin G (***-G ), a new effective antiviral drug for herpetic keratitis during treatment and the mechanism of this drug resistance. METHODS: A ***-G resistant strain (***-Gr) was established by serially propagating the herpes simplex virus (HSV) -1 in African green monkey kidney (VERO) cells in the presence of ***-G. After the drug sensitiv- ity assay and the thymidine kinase (TK) activity assay, the molecular basis for the drug resistance was studied using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis and PCR direct se- quencing technology. RESULTS: After the 10th passage in 10 μm ***-G, the ED50 of the ***-Gr was 17.08-fold greater than that of the original strain on the average and the TK activities of these resistant strains were extremely reduced. PCR-SSCP analysis on TK gene of the wild HSV-1 and the ***-Gr showed altered migration patterns in part 3 and part 4, while PCR-SSCP analysis on DNA polymerase gene showed no difference among the viruses. Sequence analysis revealed a deletion of G at position of 430 that caused frameshift, resulting in premature termination in the TK gene. CONCLUSION: The drug resistance to ***-G may appear during the treatment due to the deficiency of TK activity caused by a single mutation in the TK gene of HSV-1.

关键词： carbocyclic oxetanocin G human herpesvirus 1 viral drug resistance thymidine kinase