Inhibition of tyrosinase activity and melanine pigmentation by 2-hydroxytyrosol

作     者：Ryuji Uchida Seiko Ishikawa Hiroshi Tomoda 

作者机构：Graduate School of Pharmaceutical SciencesKitasato UniversityTokyo 108-8641Japan School of PharmacyKitasato UniversityTokyo 108-8641Japan 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2014年第4卷第2期

页      面：141-145页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by Kitasato Research Project for Lactic Acid Bacteria from Kitasato University 

主　　题：2-Hydroxytyrosol Metarhizium sp. Tyrosinase inhibitor Melanine formation B16 melanoma cells 

摘      要：2-Hydroxytyrosol(2-HT),originally reported as a synthetic compound,was isolated for the first time as a fungal metabolite.2-HT was found to inhibit mushroom tyrosinase with an IC_(50) value of 13.0 mmol/***,2-HT dose-dependently inhibited tyrosinase activity(IC_(50),32.5 mmol/L)in the cell-free extract of B16 melanoma cells andα-melanocyte stimulating hormone(α-MSH)-stimulated melanin formation in intact B16 melanoma cells.