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Gut microbiome: a key player in cancer immunotherapy

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 479-480页

作者： Yasuyuki Shigematsu Kentaro inamura Division of Pathology The Cancer InstituteDepartment of PathologyThe Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyoJapan

Immune checkpoint inhibitors(ICIs)have revolutionized the therapeutic approaches used to treat *** checkpoint molecules located on tumor cells interact with receptors on cytotoxic CD8+T cells(a type of effector T lymphocyte)and consequently lead to evasion of tumor cells from the immune *** stimulate T cellmediated antitumor immunity by inhibiting the interactions between immune checkpoint molecules and inhibitory T cell receptors.

关键词： immunity Immune inhibiting

Irrigation system and land use effect on surface water quality in river, at lake Dianchi, Yunnan, China

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Journal of Environmental Sciences 2013年第6期25卷 1107-1116页

作者： Takashi Tanaka Takahiro Sato Kazuo Watanabe Ying Wang Dan Yang Hiromo Inoue Kunzhi Li Tatsuya inamura Graduate School of Agriculture Kyoto University Biotechnology Research Center Kunming University of Science and Technology Crop and Environmental Sciences Division International Rice Research Institute Center for Southeast Asian Studies Kyoto University

The surface water samples were collected in river Dahe and its tributaries, which flow into severely eutrophic lake Dianchi, Yunnan Province, China, in order to elucidate factors controlling water quality fluctuations. The temporal and spatial distribution of water quality tendency was observed. The water quality of each river is dependent on the hydrology effect such water gate and circulating irrigation system. We must consider the hydrology effect to accurately understand water quality variations of river in this study field. In river without highly circulating irrigation system or water gate effect, the downstream nitrate nitrogen （NO3-N） concentration increase occurred in area dominated by open field cultivation, whereas the NO3-N concentration was constant or decreased in area dominated by greenhouse land use. This result suggests that greenhouse covers the soil from precipitation, and nitrate load of greenhouse could be less than that of open field cultivation while the rainfall event. In the upper reaches of river, where is dominated by open field cultivation, there were no sharp increase dissolved molybdate reactive phosphorus and total phosphorus concentration, but P load was accumulated in the lower reaches of river, whose predominant land use is greenhouse. Although the P sources is unclear in this study, greenhouse area may have potential of P loads due to its high P content in greenhouse soil. Considering hydrology effect is necessary to determine what the major factor is influencing the water quality variation, especially in area with highly complicated irrigation system in this studying site.

关键词： lake Dianchi eutrophication surface water quality land use plastic greenhouse circulating irrigation

Comparison of Reconstruction System of the Queensland Flood and of the East Japan Great Earthquake

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Journal of Civil Engineering and Architecture 2016年第4期10卷 452-460页

作者： Hajime inamura Department of Civil Engineering and Management Tohoku Institute of Technology Sendai 982-8577 Japan

The natural disasters struck northeast Australia between November 2010 and February 2011. The QLD （Queensland） State Government has established the Queensland Reconstruction Authority within one month. Recovery works in QLD seem to be very smooth, and transfer phase to the normal civil works is going to start. Eastern Japan also attacked by the great earthquake and following Tsunami on March 11, 2011. Japanese Government, however, established the Reconstruction Agency almost one year after the event. The reconstruction of the disaster area is still on the halfway. This paper aims to find out the differences between two countries from the viewpoints of organization, planning process and financial conditions.

关键词： Disaster earthquake reconstruction works international comparison Japan and Australia.

Changes in Soil Physicochemical Properties Following Land Use Change from Paddy Fields to Greenhouse and Upland Fields in the Southeastern Basin of Dianchi Lake,Yunnan Province,China

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Pedosphere 2013年第2期23卷 169-176页

作者： N.MORITSUKA T.NISHIKAWA S.YAMAMOTO N.MATSUI H.INOUE LI Kun-Zhi T.inamura Laboratory of Plant Production Systems Graduate School of AgricultureKyoto University Kagoshima University KANSO Technos Kunming University of Science and Technology

Paddy fields in the southeastern basin of Dianchi Lake have rapidly changed to greenhouses since 1999. A total of 61 surface soil samples, including 43 greenhouse soils, 12 upland soils, and 6 paddy soils, were collected from a flat lowland area mainly used for agricultural production fields in the southeastern basin of Dianchi Lake. Analyses of the soil samples indicated that the greenhouse soils were characterized by a lower organic matter content, lower pH, and higher soluble nutrients than the paddy soils in the area. The lower organic matter content of the greenhouse soils was ascribed to environmental or management factors rather than the clay content of the soil. Accumulation of soluble nutrients, especially inorganic N, was due to over-application of fertilizers, which also caused soil acidification. The average amount of readily available N, P, and K accumulated in the greenhouse soils was estimated to be equal to or higher than the annual input of these nutrients as a fertilizer, indicating that a reduction in fertilizer application was possible and recommended. In contrast, a very low available Si content was observed in the paddy soils, suggesting the need for Si application for rice production.

关键词： available Si greenhouse soils inorganic N phosphorus salinization

Dietary Factors Associated with Obesity in Patients with Schizophrenia Living at Home

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Food and Nutrition Sciences 2012年第10期3卷 1387-1396页

作者： Yukiko inamura Teiji Izumi Kouji Sakurai Takemi Katsui Nobuko Murayama Department of Health and Nutrition Niigata University of Health and Welfare Niigata Japan Kohdo Mental Hospital Niigata Japan Matsunami Clinic Niigata Japan

Since a fact-finding survey was conducted in 2005 all over Japan on the eating habits of psychiatric patients living at home, and the results showed that 44.6% of the patients were obese. We carried out a study of dietary factors associated with obesity in patients with schizophrenia living at home in order to develop a dietary education program. Twenty obese patients and 20 non-obese patients were randomly selected from 30 - 50s male patients with schizophrenia in one mental hospital. Dietary survey of 3-non-consecutive-day was conducted. Eighteen obese patients and 17 non-obese patients completed the survey. The obese patients had significantly higher intake of carbohydrate (P = 0.02), consumption of snacks with junk foods (P = 0.04), and intake of energy from snacks (P ) than those of non-obese patients. Based on this dietary survey, it becomes necessary to focus on snacks, in addition to basic focus on balanced diet to prevent further obesity in those schizophrenic patients.

关键词： Dietary Habits Food Records Obesity Outpatients Schizophrenia

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太阳热处理对小白菜根肿病防治效果的研究

浙江农业学报 2020年第1期32卷 98-107页

作者：沈璐李勤超田中贵稻村达也伊日布斯昆明理工大学生命科学与技术学院云南昆明650504 日本京都大学农学研究科日本京都606-8502

为探讨太阳热处理对小白菜根肿病的防治效果,以超级小黄白为供试材料,测定太阳热处理前后的土壤理化性质、根肿菌休眠孢子数量、土壤微生物多样性及发病率和病情指数,评价太阳热处理对小白菜根肿病的影响。研究表明:经太阳热处理后土壤0... 详细信息

为探讨太阳热处理对小白菜根肿病的防治效果,以超级小黄白为供试材料,测定太阳热处理前后的土壤理化性质、根肿菌休眠孢子数量、土壤微生物多样性及发病率和病情指数,评价太阳热处理对小白菜根肿病的影响。研究表明:经太阳热处理后土壤0~10 cm处pH由4.96提高至5.60,根肿菌休眠孢子的浓度由1.09×106 g-1减少至5.74×105 g-1。变性梯度凝胶电泳(DGGE)结果证明,太阳热处理提高了土壤细菌微生物多样性,其中0~10 cm处和10~20 cm处土壤细菌微生物群落的香浓维纳指数分别由1.51、0.91提高到1.98、1.53,0~10 cm处根肿病的发病率由87.10%降低到49.12%,病情指数由45.24降低到16.96,防治效果明显。本研究为太阳热处理在实际农业生产中的应用及对根肿病的防治提供了理论基础。

关键词：小白菜根肿病太阳热处理发病率细菌多样性

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出生前诊断的先天性膈疝的新治疗方案

世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 43-43页

作者： inamura N. Kubota A. Nakajima T. 郭战宏 Department of Pediatric C ardiology Osaka Medical Center Research Institute for Maternal and Child Healt h Osaka 594-1101 Japan

Purpose: The prognosis of antenatally diagnosed congenital diaphragmatic herni a (ADCDH) is still very poor despite of innovation of various therapeutics. The authors reviewed their new therapeutic strategy of ADCDH from a viewpoint of car diologic function. Methods: The cardiac function in 19 cases of ADCDH was review ed. The patients, at the age of 0 days, were divided into 2 groups, PG (+) and PG (-), according to the requirement of prostaglandin E1 (PGE1) to attenuate pu lmonary hypertension. The left ventricular (LV) end-diastolic dimension (LV dia stolic diameter index [LVDI]) and bilateral pulmonary arterial diameters (total pulmonary artery index [TPAI]) were measured on days 0 and 2. Result: Only 1 pat ient died of cardiac or respiratory failure, and the survivors’postoperative co urse was uneventful. Eleven patients needed inhalation of nitric oxide (NO), and in 9 of those, PGE1 was administered. The LVDI and TPAI of day 0 in PG (+) wer e significantly smaller than those in PG (-) and the controls. The LVDI increas ed from postnatal day 0 to day 2 in both PG (+) and PG (-). Although the LV wa s too small to output enough volume, the right ventricle successfully compensate d for the low output through the ductus arteriosus, kept patent by NO and PGE1. Conclusion: For ADCDH with sever pulmonary hypertension, keeping patent ductus a rteriosus with NO and PGE1 plays a critical role in obtaining excellent clinical outcome. Thus, the authors proposed a new therapeutic strategy for ADCDH based on a circulatory management.

关键词：出生前诊断先天性膈疝肺动脉指数肺动脉高压舒张末期内径心脏功能动脉直径舒张期前列腺素