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Usefulness of serum lipase for early diagnosis of post-endoscopic retrograde cholangiopancreatography pancreatitis

World Journal of Gastrointestinal Endoscopy 2019年第9期11卷 477-485页

作者： Masayoshi Tadehara Kosuke Okuwaki hiroshi Imaizumi Mitsuhiro Kida Tomohisa Iwai hiroshi Yamauchi Toru Kaneko Rikiya hasegawa Eiji Miyata Yusuke Kawaguchi Hironori Masutani Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine

BACKGROUND Post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP)is new onset acute pancreatitis after *** complication is sometimes *** such,PEP should be diagnosed early so that therapeutic interventions can be carried *** lipase(s-Lip)is useful for diagnosing acute ***,its usefulness for diagnosing PEP has not been sufficiently *** This study aimed to retrospectively examine the usefulness of s-Lip for the early diagnosis of *** We retrospectively examined 4192 patients who underwent ERCP at our two hospitals over the last 5 *** primary outcomes were a comparison of the areas under the receiver operating characteristic(ROC)curves(AUCs)of s-Lip and serum amylase(s-Amy),s-Lip and s-Amy cutoff values based on the presence or absence of PEP in the early stage after ERCP via ROC curves,and the diagnostic properties[sensitivities,specificities,positive predictive values(PPV),and negative predictive value(NPV)]of these cutoff values for PEP *** Based on the eligibility and exclusion criteria,804 cases were *** the entire course,PEP occurred in 78 patients(9.7%).It occurred in the early stage after ERCP in 40 patients(51.3%)and in the late stage after ERCP in 38 patients(48.7%).The AUCs were 0.908 for s-Lip[95%confidence interval(CI):0.880-0.940,P<0.001]and 0.880 for s-Amy(95%CI:0.846-0.915,P<0.001),indicating both are useful for early *** comparing the AUCs,s-Lip was found to be significantly more useful for the early diagnosis of PEP than s-Amy(P=0.023).The optimal cutoff values calculated from the ROC curves were 342 U/L for s-Lip(sensitivity,0.859;specificity,0.867;PPV,0.405;NPV,0.981)and 171 U/L for s-Amy(sensitivity,0.859;specificity,0.763;PPV,0.277;NPV,0.979).CONCLUSION S-Lip was significantly more useful for the early diagnosis of *** s-Lip after ERCP could help diagnose PEP earlier;hence,therapeutic interventions can be provided earlier.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Pancreatitis Lipase Amylase

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In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography

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Light(Advanced Manufacturing) 2022年第3期3卷 150-159页

作者： Satoshi hasegawa Masatoshi Fujimoto Toshihisa Atsumi Yoshio Hayasaki Center for Optical Research and Education Utsunomiya University7-1-2 YotoUtsunomiya 321-8585Japan Hamamatsu Photonics K.K. 5000 HirakuchiHamakita-kuHamamatsu 434-8601Japan

A line-shaped beam is useful for increasing the processing speed in laser grooving and *** laser grooving,depth control of the processed structure is important for performing precise *** this paper,in-process monitoring of the depth of a structure formed by femtosecond laser processing with a line-shaped beam using swept-source optical coherence tomography(SS-OCT)was *** the evaluation of the SS-OCT system,the depth resolution,measurement accuracy,and axial measurable range were 15.8μm,±2.5μm and 5.3 mm,*** laser grooving,the structural shape and the distribution of deposited debris were successfully *** measured depth agreed well with the depth obtained using a laser confocal *** proposed method will be effective for precise laser processing with feedback control of the laser parameters based on in-process monitoring of the processed structure.

关键词： Optical coherence tomography Computer-generated hologram Femtosecond laser processing In-process monitoring

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The mechanism of axillary odor generation and its inhibition

The mechanism of axillary odor generation and its inhibition

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2006中国中西医结合皮肤性病学术会议

作者： Yutaka TAKAGI Shunichi AKIBA hiroshi KUSUOKU Yuusuke Shibuya hiroshi NOJIRI Toyoki HAGURA Akira FUJI Masayuki YABUKI Yoshihiro hasegawa Kao Corporation Biological Science Laboratories Kao(China)Research & Development Centre Co． Ltd． Kao Corporation SKin Care Products Research Laboratories Kao Corporation Perfumery Development Research Laboratories

One of odor component in the human axillary region is 3 -methyl -2 -hexenoic acid(3M2H). It is reported that this component is secreted from the apocrine gland as bound form to apolipoprotein D( Apo D) as odorless component and that the odor arise when3M2H release from Apo D. In this report,we have clarified that proteinase of Brevibacterium,which is derived from human skin,degrade the Apo D and arise the axillary odor in apocrine sweat. And we found that Amur cork extract has high efficacy to inhibit the degrading of Apo D by Brevibacterium resulting in suppressing of the generation of axillary odor.

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SnO-SnO_(2) modified two-dimensional MXene Ti3C2Tx for acetone gas sensor working at room temperature

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Journal of Materials Science & Technology 2021年第14期73卷 128-138页

作者： Zijing Wang Fen Wang Angga Hermawan Yusuke Asakura Takuya hasegawa Hiromu Kumagai Hideki Kato Masato Kakihana Jianfeng Zhu Shu Yin School of Material Science and Engineering Shaanxi Key Laboratory of Green Preparation and Functionalization for Inorganic MaterialsShaanxi University of Science and TechnologyXi'an710021China Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai980-8577Japan The Institute of Scientific and Industrial Research(ISIR) Osaka University Mihogaoka 8-1IbarakiOsaka567-0047Japan

Acetone,as widely used reagents in industry and laboratories,are extremely harmful to the *** the detection of acetone gas concentrations and leaks in special environments at room temperature is ***,the nanocomposite combining SnO-SnO_(2)(p-n junction)and Ti_(3)C_(2)T_(x) MXene was successfully synthesized by a one-step hydrothermal *** of the existence of a small amount of oxygen during the hydrothermal conditions,part of the p-type SnO was oxidized to n-type SnO_(2),forming in-situ p-n junctions on the surface of Sn *** hamburger-like SnO-SnO_(2)/Ti_(3)C_(2)T_(x) sensor exhibited improved acetone gas sensing response of 12.1(R_(g)/R_(a))at room temperature,which were nearly 11 and 4 times higher than those of pristine Ti_(3)C_(2)T_(x) and pristine SnO-SnO_(2),***,it expressed a short recovery time(9 s)and outstanding *** of the different work functions,the Schottky barrier was formed between the SnO and the Ti_(3)C_(2)T_(x) nanosheets,acting as a hole accumulation layer(HALs)between Ti_(3)C_(2)T_(x) and tin ***,the sensing mechanism based on the formation of hetero-junctions and high conductivity of the metallic phase of Ti_(3)C_(2)T_(x) MXene in SnO-SnO_(2)/Ti_(3)C_(2)T_(x) sensors was discussed in detail.

关键词： p-n junction Ti_(3)C_(2)T_(x)MXene Nanocomposites Acetone gas sensor Room temperature sensing

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A Case of Acute Cauda Equina Syndrome for Combined Lumbar Ossification of the Posterior Longitudinal and Yellow Ligament

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Open Journal of Orthopedics 2014年第6期4卷 145-149页

作者： Kazumasa Nakamura Yuichirou Yokoyama Akihito Wada Yasuhiro Inoue Keiji hasegawa Shintaro Tsuge hiroshi Takahashi Yasuaki Iida Department of Orthopaedic Surgery School of Medicine Toho University Tokyo Japan

Acute cauda equina syndrome is known as a symptom of lumbar disc herniation, but to date, there have been no reports of cases caused by lumbar vertebral ligament ossification. We encountered a 61-year-old female patient with acute cauda equina syndrome associated with lumbar vertebral OPLL and OLF. The symptoms were improved by emergency laminectomy. One year after the surgery, the disturbances of gait and urination have been resolved.

关键词： Lumbar Spine Ossification of the Yellow Ligament Ossification of the Posterior Longitudinal Ligament Cauda Equina Syndrome

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Prediction of electromigration failure in passivated polycrystalline line

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光学精密工程 2003年第2期11卷 114-119页

作者： Kazuhiko Sasagawa Masataka hasegawa Masumi Saka Hiroyuki Abé Department of Intelligent Machines and System Engineering Hirosaki University 3 Bunkyo-cho Hirosaki 036-8561 JapanDepartment of Mechanical Engineering Tohoku University 01 Aoba Aramaki Aoba-ku Sendai 980-8579 JapanDepartment of Mechanical Engineering Tohoku University 01 Aoba Aramaki Aoba-ku Sendai 980-8579 JapanTohoku University 2-1-1 Katahira Aoba-ku Sendai 980-8577 Japan

Recently, a governing parameter for electromigration damage in passivated polycrystalline lines, AFD*gen, was formulated considering the effect of the atomic density gradient. In this study, a prediction method for electromigration failure in a passivated polycrystalline line was proposed using AFD*gen. The characteristics of film used for prediction is established in advance using a method based on AFD*gen. The film characteristics of metal lines with different lengths were determined experimentally by AFD*gen_based method. From the film characteristics obtained, both lifetime and location of failure in the passivated polycrystalline lines were predicted through numerical simulation of failure process. Good agreement has been shown between the predicted and the experimental results concerning both lifetime and location of failure.

关键词：多晶线钝化失效电迁移预报

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Significance of timing of therapeutic line on effectiveness of nivolumab for metastatic renal cell carcinoma

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Current Urology 2023年第1期17卷 52-57页

作者： Jun Teishima Daiki Murata Kazuma Yukihiro Yohei Sekino Shogo Inoue Tetsutaro Hayashi Koji Mita Yasuhisa hasegawa Masao Kato Mitsuru Kajiwara Masanobu Shigeta Satoshi Maruyama Hiroyuki Moriyama Seiji Fujiwara Akio Matsubara Department of Urology Graduate School of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan Department of Urology Hiroshima-City Asa Citizens HospitalHiroshimaJapan Department of Urology Fukuyama Medical CenterFukuyamaJapan Department of Urology Hiroshima General HospitalHatsukaichiJapan Department of Urology Hiroshima Prefectural HospitalHiroshimaJapan Department of Urology Kure Medical Center and Chugoku Cancer CenterKureJapan Department of Urology Miyoshi Central HospitalMiyoshiJapan Department of Urology Onomichi General HospitalOnomichiJapan Department of Urology Higashi-Hiroshima Medical Center Higashi-HiroshimaJapan

Objectives:This study aimed to clarify the significance of therapeutic timing on the effectiveness of nivolumab for treating metastatic renal cell *** and methods:Fifty-eight patients with metastatic renal cell carcinoma treated with nivolumab monotherapy were retrospectively *** who were treated with nivolumab as second-line therapy were included in the second-line group,while the others were included in the later-line *** clinicopathological characteristics,effects of nivolumab,and prognoses of these groups were ***:Twenty and thirty-eight patients were included in the second-line and later-line groups,*** were no significant differences in the distribution of International Metastatic Renal Cell Carcinoma Database Consotium risk and other clinicopathological characteristics between the 2 *** proportion of patients whose objective best response was progressive disease in the second-line group was significantly lower than that in the later-line group(15%vs.50%,p=0.0090).The 50%progression-free survival with nivolumab in the second-line group was significantly better than that in the later-line group(not reached and 5 months,p=0.0018).Multivariate analysis showed that the second-line setting was an independent predictive factor for better progression-free survival(p=0.0028,hazard ratio=0.108).The 50%overall survival after starting nivolumab in the second-line and later-line groups was not reached and 27.8 months,respectively(p=0.2652).Conclusions:The therapeutic efficacy of nivolumab as second-line therapy is expected to be better than that of later therapy.

关键词： Immune checkpoint inhibitor Metastatic renal cell carcinoma Nivolumab Prognostic factor Second-line treatment

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AQO办公室

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现代装饰 2023年第5期 74-79页

作者： Kenta hasegawa(摄影) 舒禹(编译) 不详

本案是一家建造公司,位于日本静冈,设计师在进行项目时,认为该办公室应与当地的社区建立联系.办公室建筑的一层有一面采光墙,可以吸纳外界的光线,让空间的轮廓明晰,缓解空间的压抑封闭感.

关键词：办公室采光建筑社区

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A Patient with Malignant Spinal Epidural Lymphoma with Initial Rapidly Aggravating Paraplegia

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Open Journal of Orthopedics 2017年第3期7卷 90-97页

作者： Taihei Go Yasuaki Iida Hideyuki Aoki Shintaro Tsuge Keiji hasegawa Yuichiro Yokoyama Akihito Wada Yuri Akishima-Fukasawa hiroshi Takahashi Department of Orthopedics Toho University Tokyo Japan

We report the case of a 51-year-old female with rapid neurological deterioration as an initial presentation of non-Hodgkin’s lymphoma. Paraplegia occurred suddenly after a 4-day history of weakness and numbness of the lower extremity. MRI revealed a dorsal epidural mass from T10 to T11 that compressed the spinal cord. There was neither bone destruction nor a paravertebral mass. Emergency decompressive laminectomy and tumor resection were performed. Histological analysis of the surgical specimen indicated diffuse large B cell lymphoma. The clinical stage was IV on CT and complete remission was achieved by subsequent chemotherapy. Spinal cord compression occurs in the course of non-Hodgkin’s lymphoma in 0.1% - 6.5% of cases, but this situation usually develops in the late phase with bone destruction and/or a paravertebral mass. Cord compression and especially the severe symptoms such as paraplegia are rare as the initial presentation of lymphoma.

关键词： Malignant Lymphoma Epidural Mass Paraplegia Thoracic Spine

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Corticospinal excitability during motor imagery is diminished by continuous repetition-induced fatigue

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Neural Regeneration Research 2021年第6期16卷 1031-1036页

作者： Akira Nakashima Takefumi Moriuchi Daiki Matsuda Takashi hasegawa Jirou Nakamura Kimika Anan Katsuya Satoh Tomotaka Suzuki Toshio Higashi Kenichi Sugawara Department of Rehabilitation Juzenkai HospitalNagasakiJapan Graduate School of Biomedical Sciences Nagasaki UniversityNagasakiJapan School of Rehabilitation Kanagawa University of Human ServicesYokosukaJapan

Application of continuous repetition of motor imagery can improve the performance of exercise ***,there is a lack of more detailed neurophysiological evidence to support the formulation of clear standards for interventions using motor ***,identification of motor imagery intervention time is necessary because it exhibits possible central ***,the purpose of this study was to elucidate the development of fatigue during continuous repetition of motor imagery through objective and subjective *** study involved two *** experiment 1,14 healthy young volunteers were required to imagine grasping and lifting a 1.5-L plastic bottle using the whole *** participant performed the motor imagery task 100 times under each condition with 48 hours interval between two conditions:500 mL or 1500 mL of water in the bottle during the demonstration *** fatigue and a decrease in pinch power appeared under the 1500-mL *** were changes in concentration ability or corticospinal excitability,as assessed by motor evoked potentials,between each set with continuous repetition of motor imagery also under the 1500-mL ***,in experiment 2,12 healthy volunteers were required to perform the motor imagery task 200 times under the 1500-mL *** concentration ability and corticospinal excitability *** is the first study to show that continuous repetition of motor imagery can decrease corticospinal excitability in addition to producing mental *** study was approved by the Institutional Ethics Committee at the Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121302)on January 30,2019.

关键词： central nervous system concentration continuous repetition of motor imagery corticospinal excitability mental fatigue motor evoked potential motor imagery muscle fatigue neurophysiology transcranial magnetic stimulation

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