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Validation of novel Japanese indication criteria and biomarkers among living donor liver transplantation recipients with hepatocellular carcinoma - a single center retrospective study

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Hepatoma Research 2020年第8期6卷 101-111页

作者： Akihiko Ichida Nobuhisa Akamatsu Kiyoshi hasegawa Artificial Organ and Transplantation Surgery Division Department of SurgeryUniversity of TokyoTokyo 113-8655Japan.

Aim:To validate a novel Japanese indication criteria for liver transplantation(LT)for hepatocellular carcinoma(HCC),i.e.,the 5-5-500 criteria(nodule size≤5 cm in diameter,nodule number≤5,and alfa-fetoprotein(AFP)value≤500 ng/mL)and the Japanese double eligibility criteria(DEC)(patients meeting the Milan or the 5-5-500 criteria)in the University of Tokyo *** usefulness of biomarkers in predicting the recurrence of HCC was also ***:The overall survival and recurrence rates of patients meeting the Milan,5-5-500,and the Japanese DEC were compared among 153 patients who underwent living donor LT(LDLT)between 1996 and 2019.A receiver-operating characteristics curve analysis was conducted to evaluate the usefulness of AFP,lens culinaris agglutinin-reactive fraction of AFP,des-gamma-carboxy prothrombin,neutrophil-lymphocyte ratio,and the platelet-lymphocyte ratio to detect ***:The 5-year recurrence rate for all patients,those meeting the Japanese DEC,5-5-500 criteria,and the Milan criteria was 10.9%,9.2%,7.4%,and 7.6%,*** with the conventional Milan criteria,the 5-5-500 criteria and the Japanese DEC could increase the number of eligible LDLT candidates by 6.1%and 11.4%.Among five biomarkers,the area under the curve value of AFP was the highest(0.852).Conclusion:The results suggest that the 5-5-500 criteria and the Japanese DEC are the appropriate selection criteria for patients with HCC in *** five biomarkers investigated,AFP was most reliable to predict HCC recurrence,which justified the utilization of AFP in the 5-5-500 criteria and the Japanese DEC.

关键词： Indication criteria of liver transplantation for hepatocellular carcinoma the 5-5-500 criteria the Japanese double eligibility criteria alfa-fetoprotein the lens culinaris agglutinin-reactive fraction of alfa-fetoprotein the des-gamma-carboxy prothrombin the neutrophil-lymphocyte ratio the platelet-lymphocyte ratio

Contact Resistance Characteristics of Relays Operated in Vapors Evaporated from Non-Silicone-Type Acryl-Based Polymeric Products Cured in Various Manners

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Contact Resistance Characteristics of Relays Operated in Vap...

Complications of CAD/CAM Fabricated Surgical Template for Static Computer-Aided Implant Surgery

The 26th International Conference on Electrical contacts and the 4th International Conference on Reliability of Electrical Products & Electrical Contacts

作者： Makoto hasegawa Nanae Kobayashi Yoshiyuki Kohno hiroshi Ando Chitose Institute of Science and Technology Kaneka Corporation OsakaJapan

ISBN: (纸本)9781622763136

The authors have already reported that when relays were operated to break load currents in vapors evaporated from an acryl-based non-silicone-type polymeric cured product that can be used as replacement of conventional silicone-type products, the resultant contact resistance characteristics show no *** this paper,the acryl-based non-silicone-type product of UV-radiation-cured type was used,and influences of its vapors on contact resistance characteristics of relays at an ambient temperature of 120℃were ***,a commercially-available mechanical relay(AgSnIn contacts) was sealed into a metal can with the product,and placed in a heating chamber to operate,at an operating frequency of 1 Hz or 0.5 Hz, 40 000 break operations of an inductive DC 14V-1A or 14V-0.4A load *** resistance values were measured at every 50 *** a result,the relays showed no deterioration in contact resistances.

关键词： polyacrylate silicone siloxane contact resistance contact failure arc discharges

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Open Journal of Stomatology 2022年第4期12卷 103-107页

作者： Yu Kishimoto Yuka hasegawa Yasunori Kanemitsu Kuniteru Nagahara Tetsuji Nakamoto Department of Maxillofacial Implant Asahi University School of Dentistry Mizuho Japan Asahi University Medical and Dental Center Mizuho Japan

Purpose: Surgical templates produced by digital simulation and CAD/CAM allow for three-dimensional control of implant placement. However, due to clinical limitations, there are complications during the use of the template. The purpose of this study was to summarize the complications associated with the use of surgical templates for static computer-aided implant surgery. Methods: Complications were collected during the observation period, and then their implant sites were reanalyzed with simulation software. Results: There were 104 cases during the observation period, 5 cases had complications. Mechanical complications were observed in four cases, including three cases in which the frame of the template fractured during implant placement surgery and one case in which the sleeve fell off the surgical template. In one case, there was an error in the planned position. All cases were mandibular molar cases, and all cases of frame fracture were at the free end defect site. All cases had a Hounsfield unit of more than 700 at the implant site, and some of them had a significantly small jaw opening. Conclusion: Although the spread of CAD/CAM surgical templates has made it possible to avoid problems caused by the position of the implant, it has been difficult to avoid fractures in cases of mandibular free end defects with high Hounsfield unit.

关键词： CAD/CAM Surgical Template Static Computer-Aided Implant Surgery

Curvature derived from LiDAR digital elevation models as simple indicators of debris-flow susceptibility

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Journal of Mountain Science 2019年第1期16卷 95-107页

作者： Atsuko NONOMURA Shuichi hasegawa Hideo MATSUMOTO Mari TAKAHASHI Mina MASUMOTO Kazuhito FUJISAWA Faculty of Engineering and design Kagawa University Institute of Education Research and Regional Cooperation for Crisis Management Shikoku Kagawa University Faculty of Engineering Graduate school of Engineering Kagawa University

To mitigate the damage caused by debris flows resulting from heavy precipitation and to aid in evacuation plan preparation, areas at risk should be mapped on a scale appropriate for affected individuals and communities. We tested the effectiveness of simply identifying debris-flow hazards through automated derivation of surface curvatures using LiDAR digital elevation models. We achieved useful correspondence between plan curvatures and areas of existing debris-flow damage in two localities in Japan using the analysis of digital elevation models(DEMs). We found that plan curvatures derived from 10 m DEMs may be useful to indicate areas that are susceptible to debris flow in mountainous areas. In residential areas located on gentle sloping debris flow fans, the greatest damage to houses was found to be located in the elongated depressions that are connected to mountain stream valleys. Plan curvaturederived from 5 m DEM was the most sensitive indicators for susceptibility to debris flows.

关键词： Digital elevation model LiDAR Gridspacing Debris flow Geological hazard Curvature

Determination of the Dzyaloshinskii-Moriya interaction using pattern recognition and machine learning

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npj Computational Materials 2021年第1期7卷 198-204页

作者： Masashi Kawaguchi Kenji Tanabe Keisuke Yamada Takuya Sawa Shun hasegawa Masamitsu Hayashi Yoshinobu Nakatani Department of Physics The University of TokyoTokyo 113-0033Japan Toyota Technological Institute Nagoya 468-8511Japan Department of Chemistry and Biomolecular Science Faculty of EngineeringGifu UniversityGifu 501-1193Japan University of Electro-Communications Tokyo 182-8585Japan

Machine learning is applied to a large number of modern devices that are essential in building an energy-efficient smart *** and face recognition are among the most well-known technologies that make use of such artificial *** materials research,machine learning is adapted to predict materials with certain functionalities,an approach often referred to as materials ***,we show that machine learning can be used to extract material parameters from a single image obtained in *** Dzyaloshinskii–Moriya(DM)interaction and the magnetic anisotropy distribution of thin-film heterostructures,parameters that are critical in developing next-generation storage class magnetic memory technologies,are estimated from a magnetic domain *** simulation is used to generate thousands of random images for training and model validation.A convolutional neural network system is employed as the learning *** DM exchange constant of typical Co-based thin-film heterostructures is studied using the trained system:the estimated values are in good agreement with ***,we show that the system can independently determine the magnetic anisotropy distribution,demonstrating the potential of pattern *** approach can considerably simplify experimental processes and broaden the scope of materials research.

关键词： pattern interaction system

Fat Poor Renal Angiomyolipoma Showing Collapsed Shape: A Case Report

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Open Journal of Radiology 2022年第3期12卷 86-91页

作者： Takahiro Fujii Makoto hasegawa Akiko Kajiyama Toshiaki Oharaseki Yasuharu Takeuchi Tatsuya Gomi Department of Radiology Toho University Ohashi Medical Center Tokyo Japan Department of Pathology Toho University Ohashi Medical Center Tokyo Japan Department of Urology Toho University Ohashi Medical Center Tokyo Japan

Fat-poor renal angiomyolipoma (fpAML) and renal cell carcinoma (RCC) are difficult to differentiate and misdiagnosis can lead to unnecessary nephrectomy. We experienced a case showing a “collapsed shape” which reflected a fpAML tissue type. A renal tumor was incidentally discovered in a 42-year-old female during an abdominal ultrasound. RCC was suspected according to CT and MRI imaging results, and a partial nephrectomy was performed. However, the pathologic diagnosis was fpAML. Upon reevaluation of preoperative images, morphological change to the tumor due to contact with surrounding tissues: the collapsed shape was observed and could be identified by CT, which is the gold standard test for differentiating renal tumors. In cases where the collapsed shape is observed in a renal tumor, fpAML should be considered.

关键词： Fat Poor Renal Angiomyolipoma Renal Cell Carcinoma Differential Diagnosis Computed Tomography

A Study of Plaque Adhesion during Implant Treatment of Missing Molars

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Open Journal of Stomatology 2022年第3期12卷 96-102页

作者： Yuka hasegawa Yu Kishimoto Yasunori Kanemitsu Toshiichiro Tanabe Kuniteru Nagahara Tetsuji Nakamoto Department of Maxillofacial Implant School of Dentistry Asahi University Mizuho Japan Medical and Dental Center Asahi University Mizuho Japan

Purpose: In implant treatment, the abutments and superstructures form a transmucosal area. In addition to providing appropriate cleaning instructions to patients, its material properties must be carefully considered. It is not clear how much plaque adhesion occurs at each site during treatment process, and the effect of materials on plaque adhesion. Methods: In this study, 33 patients, 13 maxillary cases and 20 mandibular cases, who had implants placed in the missing molars were evaluated for the plaque adhesion of provisional restorations made of acrylic resin and monolithic zirconia final restoration after a period of more than 4 weeks. In addition, oral hygiene instructions were thoroughly given for 12 cases at the time of staining after the provisional restorations, and re-evaluated in 4 weeks. Results: About 20% of the buccal-lingual area of the prosthetic device fabricated with acrylic resin showed plaque staining, whereas about 40% of the area of the mesial and distal. On the other hand, for the zirconia final restorations, the percentage of staining was about 5% for buccal and lingual surface and 10% for mesial and distal surface. The stained area ratio of the provisional restoration correlated with the zirconia superstructure area ratio. Even with careful oral hygiene, it became clear that the amount of plaque adhesion due to the difference in materials could not be overcome. Conclusion: The zirconia superstructure is extremely good from the viewpoint of plaque adhesion, but cases with a large stained area at the time of provisional restoration should be carefully followed up.

关键词： Superstructure Dental Plaque Yttria-Stabilized Zirconia Polymethyl Methacrylate

Self-Assembly of TBrPP-Co Molecules on an Ag/Si（111） Surface Studied by Scanning Tunneling Microscopy

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Chinese Physics Letters 2010年第2期27卷 224-227页

作者：李青 Shiro Yamazaki Toyoaki Eguchi 马旭村贾金锋薛其坤 Yukio hasegawa Institute of Physics Chinese Academy of Science Beijing 100190 The Institute for Solid State Physics The University of Tokyo 5-1-5 Kashiwa-no-ha Kashiwa 277-8581 Japan Department of Physics Tsinghua University Beijing 100084

Self-assembly of TBrPP-Co molecules on a Si（111）-√3t×√3 Ag substrate is studied by low-temperature scanning tunneling microscopy. With the same adsorbed amount （0.07 ML）, the molecules deposited by low-temperature evaporation show three kinds of ordered structures whereas those deposited by high-temperature evaporation have size-dependent ordered structures. The distinct differences in the self-assembly structures and in the electron density of states inside the molecule near the Fermi energy demonstrate that the Br atoms of the molecule desorb at the higher evaporation temperature.

关键词： Cold Temperature Timing Time Aging Evaporation Evaporating

Time to take another Iook at perceived disadvantages of robotic hepatectomy

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 208-210页

作者： Yasushi hasegawa Hiroyuki Nitta Takeshi Takahara Akira Sasaki Department of Surgery Iwate Medical University School of MedicineMorioka CityIwateJapan

Robotic hepatectomy remains controversial to date,despite continuous advances in the technology and more surgeons gaining experience with the *** et al.(1)recently published an interesting article in Hepatobiliary Surgery and Nutrition,titled"Selecting incision-dominant cases for robotic liver resection:towards outpatient hepatectomy with rapid recovery."The authors evaluated 97 cases of robotically-assisted liver resection(RLR)arguing that it is difficult to reach the superior-posterior liver segments with the straight instruments used in conventional laparoscopic liver resection(LLR).The articulated instruments of the surgical robot are better suited for hepatectomies in these difficult-to-reach areas of the *** concluded that cases where the incision of an open approach would be large and affect recovery results in the highest likelihood of patients benefitting from a robotic *** think that the authors present an interesting perspective by focusing on the strong points of RLR compared to LLR.

关键词： hepatectomy Surgery straight