Practical Use of Transient Elastography in Screening for Nonalcoholic Steatohepatitis in a Japanese Population
作者机构：Department of Internal MedicineThe Nippon Dental University School of Life Dentistry at NiigataChuo-kuNiigataJapan
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2019年第7卷第2期
页 面：127-131页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：NAFLD Insulin resistance NASH Transient elastography CAP Fibrosis marker
摘 要：Background and Aims:Fatty infiltration of liver may induce insulin resistance(IR),and a proportion of patients with nonalcoholic fatty liver disease(NAFLD)is diagnosed with nonalcoholic *** elastography is gaining popularity as a means of non-invasively determining both liver stiffness(fibrosis level)and degree of fatty infiltration,expressed as controlled attenuation parameter(CAP)***:The aims of this study were to investigate the association between IR and level of fatty liver,and to identify the group at a greater risk of nonalcoholic steatohepatitis using transient elastography and other noninvasive fibrosis markers.A total of 169 patients without chronic hepatitis B and C were ***:The CAP value was significantly associated with IR(HOMA-IR≥2.5;AUROC=0.81),and the optimal cut-off to discriminate IR was 264 dB/*** liver stiffness measurement and aspartate aminotransferase-to-platelet ratio index values were significantly higher for CAP≥264 than in CAP*** 9 patients among the overall 169 patients(5.3%)and among the 102 NAFLD patients(8.8%)who showed≥264 dB and≥7.0 kPa in transient elastography could represent good candidates for liver ***:Evaluation of NAFLD based on CAP values was useful in diagnosing *** 9%of NAFLD patients in a Japanese outpatient clinic with a few metabolic complications might be considered good candidates for liver biopsy to confirm nonalcoholic steatohepatitis.
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