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基因型A型(Aa和Ae亚型)与基因型D型HBV感染后的差异:一项病例对照研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 44-45页

作者： Tanaka Y. hasegawa I. Kato T. M. Mizokami 雒向宁 Dept. Clin. Molec. Info rmative Med. Nagoya City Univ. Grad. Sch. Med. S. Nagoya 467-8601 JapanDr.

There are two subtypes of hepatitis B virus genotype A (HBV/ A) and they are p rovisionally designated Aa (“a”standing for Africa/Asia) and Ae (“e”for Euro pe). In a case-control study, 78 HBV/Aa, 78HBV/Ae, and 78HBV/D carriers from several co untries were compared. The prevalence of HBe antigen (HBeAg) in serum was signif icantly lower in carriers of HBV/Aa than in carriers of HBV/Ae (31%vs. 49%; P = .033), with a difference more obvious in the carriers aged 30 years or younger (34%vs. 67%; P = .029). HBV DNA levels in the carriers of HBV/Aa (median, 3.4 6 log copies/mL; 95%CI, 2.93-3.95)were significantly lower than those of carri ers of HBV/Ae (6.09 log copies/mL; 95%CI, 4.24-7.64) or of carriers ofHBV/D (5 .48 log copies/mL; 95%CI, 4.06-7.02), regardless of the HBeAg status (P< .001) . The most specific and frequent substitutions in 54 HBV/Aa isolates were double substitutions for T1809 (100%) and T1812 (96%) immediately upstream of the pr ecore initiation codon, which would interfere with the translation of HBeAg in H BV/Aa infections. They were not detected in 57 HBV/Ae or 61 HBV/D isolates exami ned. The double mutation in the core promoter (T1762/A1764)was more frequent in both HBV/Aa (50%) and HBV/Ae (44%) than in HBV/D isolates (25%; P< .01), wher eas the precore mutation (A1896) occurred in HBV/D isolates only (48%; P < .000 1). In conclusion, the clearance of HBeAg from serum may occur by different mec hanisms in HBV/Aa, HBV/Ae, and HBV/D infections, which may influence clinical ma nifestations in the Western countries where both genotypes A and D are prevalent .

关键词： Aa Ae HBV感染病例对照研究核心启动子 DNA 启动密码子位点突变核心区西方国家

Body Characteristics of Professional Japanese Keirin Cyclists： Flexibility, Pelvic Tilt, and Muscle Strength

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Journal of Sports Science 2016年第6期4卷 341-345页

作者： Yuto Tashiro Satoshi hasegawa Shu Nishiguchi Naoto Fukutani Daiki Adachi Takayuki Hotta Saori Morino Hidehiko Shirooka Yuma Nozaki Hinako Hirata Moe Yamaguchi Seishiro Tasaka Tomohumi Matsushita Keisuke Matsubara Tomoki Aoyama Human Health Sciences Graduate School of Medicine Kyoto University Kyoto 606-8501 Japan Research Fellow of the Japan Society for the Promotion of Science Tokyo 102-0083 Japan

Prognostic factors in stage IB gastric cancer

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World Journal of Gastroenterology 2014年第21期20卷 6580-6585页

作者： Toru Aoyama Takaki Yoshikawa Hirohito Fujikawa Tsutomu Hayashi Takashi Ogata Haruhiko Cho Takanobu Yamada Shinichi hasegawa Kazuhito Tsuchida Norio Yukawa Takashi Oshima Mari S Oba Satoshi Morita Yasushi Rino Munetaka Masuda Department of Gastrointestinal Surgery Kanagawa Cancer CenterYokohama 241-0815Japan Department of Surgery Yokohama City UniversityYokohama 236-0004Japan Department of Biostatistics and Epidemiology Yokohama City UniversityYokohama 236-0004Japan

AIM:To identify the subset of patients with stage IB gastric cancer with an unfavorable ***:Overall survival(OS)rates were examined in 103 patients with stage IB(T1N1M0 and T2N0M0)gastric cancer between January 2000 and *** and multivariate analyses were performed to identify risk factors using a Cox proportional hazards ***:The OS rates of patients with T1N1 and T2N0 cancer were 89.2%and 94.1%at 5-years,*** univariate and multivariate analyses demonstrated that tumor location was the only significant prognostic *** OS rate was 81.8%at5-years when the tumor was located in the upper third of the stomach and was 95.5%at 5-years when the tumor was located in the middle or lower third of the stomach(P=0.0093).CONCLUSION:These data may suggest that tumor location is associated with survival in patients with stage IB gastric cancer.

关键词： Gastric cancer Stage IB Prognostic factor

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有机过氧化物安定性的差示扫描量热测定

分析化学 1999年第9期27卷 1112-1112页

作者：彭金华,长谷川和俊南京理工大学化工学院日本国立消防研究所テ181东京都三鹰市中原3-14-1 南京210094

1 引言有机过氧化物是一种自反应性物质.这类物质在制造、使用、贮存过程中或由于自分解发热、热积累导致燃烧、爆炸,或由于冲击、摩擦、电火花、明火等外部作用导致燃烧爆炸而造成人员伤亡.差示扫描量热法(DSC)、压力容器试验法(PVT)... 详细信息

1 引言有机过氧化物是一种自反应性物质.这类物质在制造、使用、贮存过程中或由于自分解发热、热积累导致燃烧、爆炸,或由于冲击、摩擦、电火花、明火等外部作用导致燃烧爆炸而造成人员伤亡.差示扫描量热法(DSC)、压力容器试验法(PVT)是评价这类物质安全性的基本方法.本文利用DSC法对7种有机过氧化物进行了加热分解试验研究,探讨其热安定性、发生热爆炸的难易程度及剧烈程度.

关键词：过氧化叔丁基物质过氧化物加热分解热爆炸恒温试验 BPO 贮存过程难易程度异丙苯枯烯分解反应

A topological metal at the surface of an ultrathin BiSb alloy film

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A topological metal at the surface of an ultrathin BiSb allo...

硝酸盐高亲和水稻品种的筛选与硝酸盐高亲和基因表达分析

第18届国际真空大会

作者： T. Hirahara Y. Sakamoto Y. Saisyu H. Miyazaki S. Kimura T. Okuda I. Matsuda S. Murakami S. hasegawa Department of Physics University of Tokyo UVSOR Facility Institute for Molecular ScienceOkazaki 444-8585Japan HSRC Hiroshima University Synchrotron Radiation Laboratory ISSP University of Tokyo Department of Physics Tokyo Institute of TechnologyTokyo 152-8551Japan

Recently there has been growing interest in topological insulators or the quantum spin Hall （QSH） phase, which are insulating materials with bulk band gaps but have metallic edge states that are formed topologically and robust against any non-magnetic impurity [1]. In a three-dimensional material, the two-dimensional surface states correspond to the edge states （topological metal） and their intriguing nature in terms of electronic and spin structures have been experimentally observed in bulk Bi1-xSbx single crystals [2,3,4]. However, if we want to know the transport properties of these topological metals, high purity samples as well as very low temperature will be needed because of the contribution from bulk states or impurity effects. In a recent report, it was also shown that an intriguing coupling between the surface and bulk states will occur [5]. A simple solution to this bothersome problem is to prepare a topological metal on an ultrathin film, in which the surface-to-bulk ratio is drastically enhanced.

关键词： Topoplogical insulators Surface states

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湖南农业大学学报（自然科学版） 2009年第6期35卷 593-596页

作者：赖灯妮彭克勤梁雄长谷川博湖南农业大学生命科学与技术学院湖南长沙410128 日本滋贺县立大学环境学部滋贺县彦根市 5228523

对19份不同基因型水稻进行苗期不同硝酸盐水平下的生长率、苗高分布及离子吸收值的测定,初步筛选出硝酸盐高亲和性水稻品种,并对其基因的表达进行了分析.筛选结果:Nipponbare为双氮高效型、Tongyi为低氮高效型、IR8和陆稻农林21为高氮... 详细信息

对19份不同基因型水稻进行苗期不同硝酸盐水平下的生长率、苗高分布及离子吸收值的测定,初步筛选出硝酸盐高亲和性水稻品种,并对其基因的表达进行了分析.筛选结果:Nipponbare为双氮高效型、Tongyi为低氮高效型、IR8和陆稻农林21为高氮高效型典型性品种,并发现OsNTR2.4和OsNAR2.1基因表达在0.5h时最弱,3h时最强;OsNTR2.1,OsNTR2.2随着诱导时间的延长而表达增强.Nipponbare与Tongyi在OsNRT2.1表达上存在差异,与Tongyi相比,Nipponbare的OsNRT2.1表达所需诱导时间短,并在3h时表达最强.

关键词：水稻硝酸盐吸收 OsNRT2和OsNAR2表达

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蝼蛄池塘和皮奇奥游客中心

风景园林 2020年第2期27卷 45-50页

作者：长谷川浩己庄杭武藏野美术大学 studio on site景观事务所不详

蝼蛄池塘位于日本长野县轻井泽星野地区,沿着从轻井泽野生鸟类保护区森林(文中称为"野鸟之森")里流淌出的溪流而建。起初人们打算通过截流溪水的方式把这里建成滑冰场,但最近几年放弃了这个想法。现在,这里已经被重新设计为一个"混合动... 详细信息

蝼蛄池塘位于日本长野县轻井泽星野地区,沿着从轻井泽野生鸟类保护区森林(文中称为"野鸟之森")里流淌出的溪流而建。起初人们打算通过截流溪水的方式把这里建成滑冰场,但最近几年放弃了这个想法。现在,这里已经被重新设计为一个"混合动力"滑冰场,通过制冷管道与天然结冰并用,延长冰场的使用时间。在夏天池塘是各种生物的栖息地,到了冬天池塘便成为在现代技术有效管理下的滑冰场。同时,设计方案也充分重视对现有自然过程的描绘,即冬天水池会自然结冰,而人们可以在冰面上滑冰。

关键词：轻井泽鸟类保护区滑冰场混合动力蝼蛄设计方案充分重视

The Mechanism of Flow Field around a Rotating Cylinder with Fins for High Performance Magnus Wind Turbine

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Journal of Energy and Power Engineering 2016年第1期10卷 23-31页

作者： Nobuhiro Murakami Hiroaki hasegawa Toshihiro Haniu Masahide Nakamura Dept. of Mechanical Engineering Tegatagakuen-machi 1-1 Graduate School of Engineering & Resource Science Akita Univ.Akita 010-8502 Japan Dept. of Mechanical and Intelligent Engineering Yoto Graduate School of Engineering Utsunomiya Univ. Utsunomiya-shi 7-1-2 Japan

Spiral Magnus is a unique wind turbine system that rotates with cylinders which have spiral-shaped fins coiled around them (instead of using the more common propeller-type blades). In the present study, three models (cylinder with no fins, cylinder with straight fins and cylinder with spiral fins) were installed, and fluid force measurements were performed by a strain gauge force balance. A PIV (particle image velocimetry) system was used to better understand the flow fields around the cylinder. Considering the results of the experiment, it was confirmed that, the aerodynamic performance of the rotating cylinder can be improved by the fin. However, the straight fin makes the flow close to the cylinder surface ineffective. The rotary cylinder with the spiral fins was able to generate the greatest lift among three models, because the spiral fin effectively influences the vicinity of the cylinder surface.

关键词：气动性能绕流场风力涡轮机旋转圆筒风力发电系统螺旋翅片机理鳍

Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E

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World Journal of Gastroenterology 2005年第41期11卷 6410-6415页

作者： Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami Department of Internal Medicine and Molecular Science Nagoya City University Graduate School of Medical Sciences NagoyaJapan Department of Clinical Molecular Informative Medicine Nagoya City University Graduate School of Medical Sciences NagoyaJapan AIDS Research Center National Institute of Infectious Disease TokyoJapan Agency for Cooperation in International Health Kumamoto Japan Clinical Pathology Department Faculty of Medicine Suez Canal UniversityIsmailiaEgypt Central National Blood Transfusion Center Cotonou Benin Hematology Lab-CNHUC Cotonou Benin

AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant ***: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct ***: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/*** comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/***: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E.

关键词：乙型肝炎病毒基因型病毒类型遗传因素