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Low Loss Polarization Maintaining Photonic Crystal Fiber

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光学学报 2003年第S1期23卷 31-32页

作者： Masatoshi Tanaka Osamu Tohyama Syun-ichiro Yamaguchi hirokazu Kubota Satoki Kawanishi Mitsubishi Cable Industries LTD4-3 IkejiriItamiHyogoJapanMitsubishi Cable IndustriesLTD4-3 IkejiriItamiHyogoJapanMitsubishi Cable IndustriesLTD4-3 IkejiriItamiHyogoJapanNTT Network Innovation LaboratoriesNTTCorporation1-1Hikarino-okaYokosukaJapanNTT Network Innovation LaboratoriesNTTCorporation1-1Hikarino-okaYokosukaJapan

A low loss polarization maintaining photonic crystal fiber has been fabricated. The fiber loss was 1.3 dB/km at 1550 nm. The polarization crosstalk for a 100-m fiber was -35 dB at 1550 nm.

关键词： PCF of on nm in as Low Loss Polarization Maintaining Photonic Crystal Fiber 双加 PM for

Spontaneous regression of hepatocellular carcinoma: A mini-review

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World Journal of Gastroenterology 2017年第21期23卷 3797-3804页

作者： Akira Sakamaki Kenya Kamimura Satoshi Abe Atsunori Tsuchiya Masaaki Takamura hirokazu Kawai Satoshi Yamagiwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

Spontaneous tumor regression is an extremely rare phenomenon in the oncology field. However, there are several case reports resulted in the regression of hepatocellular carcinoma(HCC) and the accumulation of clinical information and analyses of the mechanism can contribute to the development of a novel therapy. For this purpose, we have carefully reviewed 23 cases of spontaneously regressed HCC published in recent 5 years and our case. The information regarding the tumor size, tumor marker, treatments, etc., have been summarized. The mechanism of spontaneous regression has been discussed to date and presumed to be due to many factors, including hypoxia and immunological reactions. In this careful review of the 24 cases based on the clinical information, hypoxia, systemic inflammation, and both upon spontaneous regression were seen in 3, 8, and 4 cases, respectively amo ng t he 15 c as e s f or w hic h t he inf o r mat io n regarding the proposed mechanisms are available. Recent development of immunotherapeutic approaches in oncology shows promising results, therefore, accumulation of additional cases and analysis of mechanisms underlying the spontaneous regression of HCC are essential and could lead to the development of a new generation of immunotherapies including antibodies directed against immune reactions.

关键词：自发的回归 Hepatocellular 癌免疫学的反应免疫疗法组织缺氧

Correlation between smoking habit and surgical outcomes on viral-associated hepatocellular carcinomas

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World Journal of Gastroenterology 2018年第1期24卷 58-68页

作者： Keita Kai Sho Komukai Hiroki Koga Koutaro Yamaji Takao Ide Atsushi Kawaguchi Shinichi Aishima hirokazu Noshiro Department of Pathology Saga University Hospital Clinical Research Center Saga University Hospital Department of Surgery Saga University Faculty of Medicine Department of Pathology and Microbiology Saga University Faculty of Medicine Center for Comprehensive Community Medicine Saga University Faculty of Medicine

AIM To investigate the association between smoking habits and surgical outcomes in hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)(B-HCC) and hepatitis C virus(HCV)-related HCC(C-HCC) and clarify the clinicopathological features associated with smoking status in B-HCC and C-HCC *** We retrospectively examined the cases of the 341 consecutive patients with viral-associated HCC(C-HCC,n = 273; B-HCC, n = 68) who underwent curative surgery for their primary lesion. We categorized smoking status at the time of surgery into never, exand current smoker. We analyzed the B-HCC and C-HCC groups' clinicopathological features and surgical outcomes, i.e., disease-free survival(DFS), overall survival(OS), and disease-specific survival(DSS).Univariate and multivariate analyses were performed using a Cox proportional hazards regression model. We also performed subset analyses in both patient groups comparing the current smokers to the other *** The multivariate analysis in the C-HCC group revealed that current-smoker status was significantly correlated with both OS(P = 0.0039) and DSS(P = 0.0416).In the B-HCC patients, no significant correlation was observed between current-smoker status and DFS, OS,or DSS in the univariate or multivariate analyses. The subset analyses comparing the current smokers to the other patients in both the C-HCC and B-HCC groups revealed that the current smokers developed HCC at significantly younger ages than the other patients irrespective of viral infection *** A smoking habit is significantly correlated with the overall and disease-specific survivals of patients with C-HCC. In contrast, the B-HCC patients showed a weak association between smoking status and surgical outcomes.

关键词： Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Smoking Surgery Prognosis

Impact of smoking habit on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第8期23卷 1397-1405页

作者： Keita Kai Hiroki Koga Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda hirokazu Noshiro Department of Pathology Saga University Hospital Departments of Surgery Saga University Hospital Pathology and Microbiology Saga University Hospital Center for Comprehensive Community Medicine Saga University Faculty of Medicine

AIM To analyzed the correlation between smoking status and surgical outcomes in patients with non-B non-C hepatocellular carcinoma(NBNC-HCC), and we investigated the patients' clinicopathological characteristics according to smoking *** We retrospectively analyzed the consecutive cases of 83 NBNC-HCC patients who underwent curative surgical treatment for the primary lesion at Saga University Hospital between 1984 and December 2012. We collected information about possibly carcinogenic factors such as alcohol abuse, diabetes mellitus, obesity and smoking habit from medical records. Smoking habits were subcategorized as never, ex- and current smoker at the time of surgery. The diagnosis of nonalcoholic steatohepatitis(NASH) was based on both clinical information and pathological *** Alcohol abuse, diabetes mellitus, obesity and NASH had no significant effect on the surgical outcomes. Current smoking status was strongly correlated with both overall survival(P = 0.0058) and disease-specific survival(P = 0.0105) by multivariate analyses. Subset analyses revealed that the current smokers were significantly younger at the time of surgery(P = 0.0002) and more likely to abuse alcohol(P = 0.0188) and to have multiple tumors(P = 0.023).CONCLUSION Current smoking habit at the time of surgical treatment is a risk factor for poor long-term survival in NBNC-HCC patients. Current smokers tend to have multiple HCCs at a younger age than other patients.

关键词： Hepatocellular 癌 Non-B Non-C 吸烟外科预后

Ultraviolet-emitting ZnO thick layer grown by thermal oxidation with gallium

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Science China(Technological Sciences) 2014年第12期57卷 2500-2503页

作者： YANG Qing ZHOU Xiao Hong NUKUI Takao SAEKI Yu IZUMI Sotaro TACKEUCHI Atsushi TATSUOKA hirokazu LIANG Shu Hua Faculty of Material Science and Engineering Xi'an University of Technology Department of Applied Physics Waseda University Graduate School of Engineering Shizuoka University

The Zn O layer with thickness of 1.6 μm in Zn O/Zn Ga2O4 composite structure was grown by the thermal oxidation of Zn S substrate with gallium. The optical property of the Zn O thick layer was investigated by time-resolved photoluminescence. A single UV emission around 375 nm with short lifetime was observed at room temperature while the visible emission was absolutely quenched. The UV emission band was composed of the neutral donor bound exciton(D0X) and donor-acceptor pair(DAP) emission peaks with large full-width at half-maximums(FWHMs) at 3.367 and 3.318 e V, respectively, at 10 K. However, the intensity of the D0 X emission was stronger than that of the DAP emission at measuring temperatures of 10–300 K.

关键词：光致发光 ZnO 热氧化紫外线 ZnGa2O4 紫外发射镓复合结构

Araucarian cone-scale complexes,newly found in Aptian Kitadani Formation of Tetori Group in Fukui Prefecture,Central Japan

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Global Geology 2019年第4期22卷 280-288页

作者： hirokazu Yukawa Atsushi Yabe Fukui Prefectural Dinosaur Museum KatsuyamaFukui 911-8601Japan Department of Geology and Paleontology National Museum of Nature and ScienceTsukubaIbaraki 305-0005Japan

This study reports on two forms of Araucarian cone-scale complexes from the Aptian Kitadani Formation of the Tetori Group in Fukui Prefecture,Central *** of these has been identified as a new fossil species:Araucarites kitadaniensis Yabe et Yukawa *** is the first known occurrence of Araucarian macrofossils from the Tetori Group,indicating that this group was substantially diverse during that time *** finding concurs with previous palynological investigations at the site,supporting the hypothesis that Araucarian plants began to diversify during Aptian global warming.

关键词： Araucarian cone-scale complexes Araucarites kitadaniensis Yabe et Yukawa sp.nov. Aptian Early Cretaceous Japan

Remaining issues of recommended management in current guidelines for asymptomatic common bile duct stones

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World Journal of Gastroenterology 2021年第18期27卷 2131-2140页

作者： hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita Shuji Tada Department of Gastroenterology Kumamoto City HospitalKumamoto City 862-8505Japan Department of Gastroenterology Tsuruta HospitalKumamoto City 862-0925Japan Department of Gastroenterology Kumamoto Chuo HospitalKumamoto City 862-0965Japan Department of Gastroenterology Saiseikai Kumamoto HospitalKumamoto City 861-4193Japan Department of Gastroenterological Surgery Kumamoto Chuo HospitalKumamoto City 862-0965Japan

Current guidelines for treating asymptomatic common bile duct stones(CBDS)recommend stone removal,with endoscopic retrograde cholangiopan-creatography(ERCP)being the first treatment *** deciding on ERCP treatment for asymptomatic CBDS,the risk of ERCP-related complications and outcome of natural history of asymptomatic CBDS should be *** incidence rate of ERCP-related complications,particularly of post-ERCP pancreatitis for asymptomatic CBDS,was reportedly higher than that of symptomatic CBDS,increasing the risk of ERCP-related complications for asymptomatic CBDS compared with that previously reported for biliopancreatic *** studies have reported short-to middle-term outcomes of natural history of asymptomatic CBDS,its long-term natural history is not well *** date,there are no prospective studies that determined whether ERCP has a better outcome than no treatment in patients with asymptomatic CBDS or *** randomized controlled trial has evaluated the risk of early and late ERCP-related complications vs the risk of biliary complications in the wait-and-see approach,suggesting that a change is needed in our perspective on endoscopic treatment for asymptomatic *** studies examining long-term complication risks of ERCP and wait-and-see groups for asymptomatic CBDS are warranted to discuss whether routine endoscopic treatment for asymptomatic CBDS is justified or not.

关键词： Asymptomatic common bile duct stone Endoscopic retrograde cholangiopancreatography Complication Natural history of asymptomatic common bile duct stone Guideline Recommendation

Endoscopic retrograde cholangiopancreatography for bile duct stones in patients with a performance status score of 3 or 4

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World Journal of Gastrointestinal Endoscopy 2022年第4期14卷 215-225页

作者： hirokazu Saito Yoshihiro Kadono Takashi Shono Kentaro Kamikawa Atsushi Urata Jiro Nasu Haruo Imamura Ikuo Matsushita Tatsuyuki Kakuma Shuji Tada Department of Gastroenterology Kumamoto City HospitalKumamoto City 862-8505Japan Department of Gastroenterology Tsuruta HospitalKumamoto City 862-0925Japan Department of Gastroenterology Kumamoto Chuo HospitalKumamoto City 862-0965Japan Department of Gastroenterology Saiseikai Kumamoto HospitalKumamoto City 861-4193Japan Department of Gastroenterological Surgery Kumamoto Chuo HospitalKumamoto City 862-0965Japan Department of Biostatics Kurume UniversityKurume City 8300011Japan

BACKGROUND As the aging population grows worldwide,the rates of endoscopic retrograde cholangiopancreatography(ERCP)for common bile duct stones(CBDS)in older patients with a poor performance status(PS)have been ***,the data on the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or 4 are lacking,with only a few studies having investigated this issue among patients with poor *** To examine the safety and efficacy of ERCP for CBDS in patients with a PS score of 3 or *** This study utilized a retrospective multi-centered design of three institutions in Japan for 8 years to identify a total of 1343 patients with CBDS having native papillae who underwent therapeutic *** a result,1113 patients with a PS 0-2 and 230 patients with a PS 3-4 were ***-to-one propensity-score matching was performed to compare the safety and efficacy of ERCP for CBDS between patients with a PS 0-2 and those with a PS *** The overall ERCP-related complication rates in all patients and propensity score-matched patients with a PS 0-2 and 3-4 were 9.0%(100/1113)and 7.0%(16/230;P=0.37),and 4.6%(9/196)and 6.6%(13/196;P=0.51),*** the propensity score-matched patients,complications were significantly more severe in the group with a PS 3-4 than in the group with a PS 0-2 group(P=0.042).Risk factors for complications were indications of ERCP and absence of antibiotics in the multivariate *** success rates,including complete CBDS removal and permanent biliary stent placement,in propensity score-matched patients with a PS 0-2 and 3-4 were 97.4%(191/196)and 97.4%(191/196),respectively(P=1.0).CONCLUSION ERCP for CBDS can be effectively performed in patients with a PS 3 or ***,the indication for ERCP in such patients should be carefully considered with prophylactic antibiotics.

关键词： Endoscopic retrograde Cholangiopancreatography Complication Performance status Risk factor

A combination treatment of entecavir and early-phase corticosteroid in severe exacerbation of chronic hepatitis B

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World Journal of Gastroenterology 2009年第13期15卷 1650-1652页

作者： Kazuyuki Matsumoto Yasuhiro Miyake hirokazu Miyatake Masahiro Takahara Takayuki Imada Satoru Yagi Tatsuya Toyokawa Morihito Nakatsu Masaharu Ando Mamoru Hirohata Department of Internal Medicine Mitoyo General Hospital Department of Molecular Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences

Of patients with severe exacerbation of chronic hepatitis B accompanied by jaundice and coagulopathy,20%-30%have a fatal *** this report,we describe 2 cases of severe exacerbation of chronic hepatitis B with jaundice and coagulopathy who were successfully treated with a combination of entecavir and *** both cases,rapid reductions in serum hepatitis B virus(HBV)-DNA levels were observed,and corticosteroid was stopped after serum HBV-DNA levels became *** treatment was ***,entecavir treatment reduced serum HBV-DNA levels rapidly,although the improvement in liver function was delayed by a few *** this time lag,liver cell injury continued and the disease *** suppressed the excessive host immune response and was useful for stopping progressive deterioration.A combination of entecavir and early-phase corticosteroid may be a useful treatment in severe exacerbation of chronic hepatitis B.

关键词：慢性乙型肝炎激素肝炎病毒临床分析