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微生物学通报 1997年第5期24卷 265-267页

作者：陈洁明高大维木村宏和园元谦二石崎文彬华南理工大学轻工食品学院轻化所广州510641 九州大学农学部微生物工学实验室

研究了足球菌ISK-1发酵中NaCl对足球菌素ISK-1活性的影响。在MRS培养基中添加8％的NaCl，发酵21～24h，足球菌素ISK-1活性达到最高，比无NaCl时提高250%。表明NaCl具有提高足球菌素ISK-1活性的作用。

关键词：足球菌素ISK-1 足球菌活性乳酸菌氯化钠

Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study

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World Journal of Gastrointestinal Endoscopy 2013年第6期5卷 281-287页

作者： Jiro Watari Toshihiko Tomita Fumihiko Toyoshima Jun Sakurai Takashi Kondo Haruki Asano Takahisa Yamasaki Takuya Okugawa Hisatomo Ikehara Tadayuki Oshima hirokazu Fukui Hiroto Miwa Division of Upper Gastroenterology Department of Internal Medicine Hyogo College of Medicine

AIM: To evaluate clinical outcomes and risk factors for endoscopic perforation during endoscopic submucosal dissection (ESD) in a prospective study. METHODS: We investigated the clinical outcomes and risk factors for the development of perforation in 98 consecutive gastric neoplasms undergoing ESD regarding. Demographic and clinical parameters including patient-, tumor-, and treatment-related factors, clinical parameters, and duration of hospital stay were analyzed for risk factors for perforation. In subgroup analysis, we also compared the clinical outcomes between perforation and "silent" free air without endoscopically visible perforation detected only by computed ***: Perforation was identified in 8.2% of patients. All patients were managed conservatively by the administration of antibiotics. The mean procedure time was significantly longer in patients with endoscopic perforation than in those without. According to the receiver-operating characteristic analysis, the resulting cutoff value of the procedure time for perforation was 115 min (87.5% sensitivity, 56.7% specificity). Prolonged procedure time (≥ 115 min) was associated with an increased risk of perforation (odds ratio 9.15; 95%CI: 1.08-77.54; P = 0.04). Following ESD, body temperature and C-reactive protein level were significantly higher in patients with perforation than in those without (P = 0.02), whereas there was no difference between these patient groups on the starting day of oral intake or of hospitalization. In subgroup analysis, the post-ESD clinical course was not different between endoscopic perforation and silent free air. CONCLUSION: Only prolonged procedure time (≥ 115 min) was significantly associated with perforation. The clinical outcomes of perforation are favorable and are comparable to those of patients with or without silent free air.

关键词： Gastric cancer Endoscopic submucosal dissection Perforation Risk factors Treatment outcome

日本北海道地区泡型包虫病的防控措施（英文）

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中国高原医学与生物学杂志 2017年第4期38卷 219-222页

作者：八木欣平孝口裕一郭志宏野中成晃日本北海道公共卫生学院传染病科医学动物研究室青海大学畜牧兽医学院人畜共患病研究室青海西宁810016 日本宫崎大学兽医科学部家畜寄生虫病学研究室

An alveolar echinococcosis(caused by Echinococcus multilocularis)patient was reported for the first time at the small island(Rebun Island)located in the northwest of Hokkaido,Japan in *** this,several patients were fo... 详细信息

关键词： cycle Figure

What types of early gastric cancer are indicated for endoscopic ultrasonography staging of invasion depth?

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World Journal of Gastrointestinal Endoscopy 2016年第16期8卷 558-567页

作者： Jiro Watari Shigemitsu Ueyama Toshihiko Tomita Hisatomo Ikehara Kazutoshi Hori Ken Hara Takahisa Yamasaki Takuya Okugawa Takashi Kondo Tomoaki Kono Katsuyuki Tozawa Tadayuki Oshima hirokazu Fukui Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine Department of Inflammatory Bowel Disease Hyogo College of Medicine

AIM To clarify the diagnostic efficacy and limitations of endoscopic ultrasonography(EUS) and the characteristics of early gastric cancers(EGCs) that are indications for EUS-based assessment of cancer invasion *** We retrospectively investigated the cases of 153 EGC patients who underwent conventional endoscopy(CE) and EUS(20 MHz) before *** We found that 13.7% were "inconclusive" cases with low-quality EUS images, including all nine of the cases with protruded(0-I)-type EGCs. There was no significant difference in the diagnostic accuracybetween CE and EUS. Two significant independent risk factors for misdiagnosis by EUS were identified-ulcer scarring [UL(+); odds ratio(OR) = 4.49, P = 0.003] and non-indication criteria for endoscopic resection(ER)(OR = 3.02, P = 0.03). In the subgroup analysis, 23.1% of the differentiated-type cancers exhibiting SM massive invasion(SM2) invasion(submucosal invasion ≥ 500 μm) by CE were correctly diagnosed by EUS, and 23.1% of the undifferentiated-type EGCs meeting the expanded-indication criteria for ER were correctly diagnosed by *** There is no need to perform EUS for UL(+) EGCs or 0-I-type EGCs, but EUS may enhance the pretreatment staging of differentiated-type EGCs with SM2 invasion without UL or undifferentiated-type EGCs revealed by CE as meeting the expanded-indication criteria for ER.

关键词： Gastric cancer Endoscopic ultrasonography Invasion depth diagnosis Conventional endoscopy Endoscopic submucosal dissection

Comparison of Inspection Data by Difference in Odour Inspection Kit (Including Results of Young and Old Age)

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Journal of Health Science 2019年第3期7卷 160-165页

作者： Naomi Katayama Shoko Kondo Yui Nakayama Takafumi Nakada Seiya Goto Satofumi Sugimoto WakakoKinoshita Masaaki Teranisi Michihiko Sone Yasushi Fujimoto Hironao Otake hirokazu Suzuki NaokiSaji Seiichi Nakata Tsutomu Nakashima Nagoya Women's University Nagoya City 467-8610Japan Graduate School of Nagoya Women’s University Nagoya City 467-8610Japan Department of Otorhinolaryngology Nagoya University Graduate School of MedicineNagoya City 466-8550Japan Watanabe Hospital Mihama TownChita-gun 470-3235Japan National Center for Geriatrics and Gerontology Obu City 474-8511Japan Otake Otolaryngology Hospital Kariya CityAichi 448-0857Japan Department of Otolaryngology Second Hospital Fujita Health University School of MedicineNagoya City 545-8509Japan Ichinomiya Medical Treatment & Habitaiton Center Ichinomiya City 494-0081Japan

The present study examined the relationship between olfactory function for ten years. A personal function test was calculated from the Nagoya Women’s University study database, and the odor stick identification test and open essence identification test were administered to healthy young and elderly people. The participants were community dwellers who voluntarily participated in the Nagoya Women’s University Study and had managed everyday life by themselves. We combined data of 2018 and checked two kinds of the olfactometry result. These data were made from a consultation result list which was handed to a testee by hand. The test age was in his/her 80s from 40s and in his/her 20s from 10s. The data were compared according to the generation (young age is 20.1 ± 0.7 years old and old age is 74.5 ± 10.0 years old). We conducted two kinds of olfaction tests. The Odour Stick Identification Test (OSIT-J) was used to assess odour perception. This test possesses high reliability and validity. The OSIT-J includes 12 different odorants to be identified. The Odour Essence Identification Test was used to assess odour perception, too. It also includes 12 different odorants to be identified. We compared the answer of generation and compared the results of the two olfactory tests. As a result, there were no statistically significant differences in the total number of correct answers in young people and old people in the two olfactory test results. In addition, we compare young people and old people who increased the number of correct answer in the two kinds of olfactory examination, the same person, and those who decreased, but there was no statistically significant difference. However, there were statistically significant differences between India ink and perfume and Household (domestic) gas compared with young people and old people with two kinds of olfactory test results. From the results of this study, it was found that the results of two kinds of olfactory test can be used tog

关键词： Healthy elderly people healthy young people olfactory function the odor stick test the open essence test

为从乳癌的内部乳房的淋巴节点转移的新奇的根除的高剂量的率 brachytherapy

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World Journal of Radiology 2012年第11期4卷 443-449页

作者： Kazushi Kishi hirokazu Tanino Tetsuo Sonomura Shintaro Shirai Yasutaka Noda Morio Sato Yoshitaka Okamura Department of Radiation Oncology Wakayama Medical UniversityWakayama 641-8510Japan Department of Surgery Naga HospitalUchi-da 1282Kinokawa CityWakayama Prefecture 649-6414Japan Department of Radiology Wakayama Medical UniversityWakayama 641-8510Japan 1st Department of Surgery Wakayama Medical University Wakayama 641-8510 Japan

AIM:To develop a method of delivering an eradicative high radiotherapeutic dose safely preserving the surrounding skin in the treatment of internal mammary lymph node metastasis (IMLNM) of breast cancer. METHODS:We report a 38-year-old female patient with a solo IMLNM showing no response to 60 Gy in 2.5 Gy fractions of external beam radiotherapy. To eradicate this tumor, a boost brachytherapy plan was created after percutaneous insertion of an applicator needle into the IMLNM lesion avoiding the pleura and vessels under ultrasound monitoring. According to the dose distribution, the required thickness of a spacer between the skin and the tumor was determined, and hyaluronic gel was injected up to this thickness under ultrasound monitoring. We evaluated skin doses, target doses and clinical outcome. RESULTS:All procedures were performed easily. Sixteen Gy (34.7 Gy equivalent in 2 Gy fractions calculated by the linear quadratic model at α/β = 10:EQ 2, α/β = 10 , cumulative total was 101.9 Gy EQ 10) to 100% of the target volume was irradiated with cumulative maximum skin dose of 70 Gy EQ 2, α/β = 3 which was 98.7 Gy EQ 2, α/β = 3 without spacer. No procedure related-or late complications and no local recurrence at the treated site were observed for three years until expiration. CONCLUSION:We consider that this procedure will provide an eradicative high-dose irradiation to IMLNM of breast cancer, preserving skin from overdose complications.

关键词： Brachytherapy Hyaluronate Internal mammary lymph node Metastasis Skin preservation Breast cancer Organ at risk

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中国古老月季及其后代的倍性分析(英文)

Agricultural Science & Technology 2013年第4期14卷 620-623,660页

作者：李莲花小笠原利恵马策庄得凤浅野阳一福井博一辽宁省农业科学院辽宁沈阳110161 岐阜大学大学院连合农学研究科花卉节纪念公园岐阜大学应用生物科学部

[目的]对中国古老月季及其后代进行倍性鉴定。[方法]利用细胞流式分析仪对38个月季品种进行了倍性鉴定。[结果]对现代月季的育成起决定性作用的4种中国古老月季是二倍体。这4种古老月季和四倍体欧洲古老月季的杂交后代几乎都是四倍体,... 详细信息

[目的]对中国古老月季及其后代进行倍性鉴定。[方法]利用细胞流式分析仪对38个月季品种进行了倍性鉴定。[结果]对现代月季的育成起决定性作用的4种中国古老月季是二倍体。这4种古老月季和四倍体欧洲古老月季的杂交后代几乎都是四倍体,表明后代的基因可能来自中国古老月季不减数配子。试验用的其余中国古老月季是3倍体。由此可推测十八世纪中国古老月季有2倍体和3倍体,但只有可育的2倍体月季传到了欧洲。来自中国的中国古老月季的16个杂交后代品种中,6个为2倍体,5个为三倍体,其余5个是四倍体。[结论]2倍体的中国月季可能来自中国古老月季间杂交,而3倍体和4倍体可以认为是中国古老月季和欧洲古老月季的杂交后代。

关键词：系谱欧洲古老月季流式细胞仪

Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study

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World Journal of Gastrointestinal Endoscopy 2015年第12期7卷 1070-1077页

作者： Jiro Watari Toshihiko Tomita Hisatomo Ikehara Masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima hirokazu Fukui Seiichi Hirota Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine NishinomiyaHyogo 663-8501 Japan Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Division of Gastroenterology Department of Internal Medicine Hyogo College of MedicineNishinomiyaHyogo 663-8501 Japan

AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD.

关键词： Gastric cancer Signet ring cell carcinoma Narrow-b

Comparison of Survey Results on Subjective Dizziness,Hearing and Tinnitus and Stabilometry Test Results in Yakumo Inhabitant Examination Study (Comparison of 2005, 2007 and 2015, 2017)

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Journal of Health Science 2019年第3期7卷 151-159页

作者： Naomi Katayama Shoko Kondo Yui Nakayama Takafumi Nakada Naoki Saji Seiya Goto Satofumi Sugimoto Wakako kinoshita Masaaki Teranisi Michihiko Sone Yasushi Fujimoto Hironao Otake hirokazu Suzuki Seiichi Nakata Tsutomu Nakashima Yukiharu Hasegawa Nagoya Women’s University Nagoya City 467-8610Japan Graduate School of Nagoya Women’s University Nagoya City 467-8610Japan Department of Otorhinolaryngology Nagoya University Graduate School of MedicineNagoya City 466-8550Japan Watanabe Hospital Mihama TownChita-gun 470-3235Japan National Center for Geriatrics and Gerontology Obu City 474-851Japan Otake Otolaryngology Hospital Kariya City 448-0857Japan Department of Otolaryngology Second Hospital Fujita Health University School of MedicineNagya City 545-8509Japan Ichinomiya Medical Treatment &Habitaiton Center Ichinomiya City 494-0018Japan Department of Occupational Therapy Kansai University of Welfare SciencesOsaka fu 582-0026Japan

Abstract: The Nagoya University Hospital otolaryngology department is doing the prospective cohort study in Yakumo-cho, Hokkaido, Japan from 2005, because this place is a little transfer of the population. Most of inhabitants of Yakumo-cho engage in fishery and agriculture as work mainly. We perform questionary survey using an interview vote. The item is “having feeling of dizziness or not”,“quality of hearing” and “having tinnitus or not”. Furthermore, we go for the examination of stabilometry, too. We compared 2015, 2017 with 2005, 2007 among Yakumo-cho inhabitant examination data this time. As a result, participant with a feeling of conscious dizziness got a bad reputation of the hearing consciously. In addition, participant with a feeling of conscious dizziness had tinnitus consciously. Furthermore, the participant with a feeling of conscious dizziness had bad stabilometry result. As a result of having compared ten years later, we understood that stabilometry result worsened if 60s became in 70s with or without a feeling of dizziness consciously. When there is a feeling of conscious dizziness, it is necessary to perform an examination of stabilometry as routine work. In addition, it is necessary to inspect stabilometry if participants have the bad hearing or tinnitus with a feeling of dizziness in particularly.

关键词： Feeling of dizziness hearing tinnitus stabilometry Yakumo study

基于等厚干涉的轴向空间相干度分析及其在表面形状测量中的可行性探讨(英文)

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实验力学 2002年第4期17卷 403-411页

作者：段志辉 Golkher Mark Joseph Rosen 小琦宽和石进信生武田光夫张青川中国科学技术大学力学和机械工程系合肥230027 Department of Electrical and Computer Engineering Ben-Gurion University of the Negev Laboratory for Information Photonics and Wave Signal Processing Department of Information and Communication Engineering The University of Electro-Communications

从等厚干涉的解释出发,推导出了二维空间的相干方程.基于空间相干方程,利用SLM产生了一个新的空间非相干光源.同时提出了新的相移方案,并结合这个新的相移方案,实现了轴向空间距离的探测和干涉条纹的相移.分析了空间方向角对相干方程的... 详细信息

从等厚干涉的解释出发,推导出了二维空间的相干方程.基于空间相干方程,利用SLM产生了一个新的空间非相干光源.同时提出了新的相移方案,并结合这个新的相移方案,实现了轴向空间距离的探测和干涉条纹的相移.分析了空间方向角对相干方程的影响,并给出了实验验证.通过对非相干光源的参数和特定的空间距离以及空间方向角的匹配,重建了一个具有标准段差的实际物体的表面形状.为光学表面形状测量提供了新的思路.

关键词：表面形状测量轴向空间相干度等厚干涉空间非相干光源空间光调制器空间方向角相移