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Caspase-11 mediated inflammasome activation in macrophages by systemic infection of *** exacerbates arthritis

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International Journal of Oral Science 2024年第3期16卷 499-514页

作者： Tokuju Okano Hiroshi Ashida Noriko Komatsu Masayuki Tsukasaki Tamako Iida Marie iwasawa Yuto Takahashi Yasuo Takeuchi Takanori Iwata Miwa Sasai Masahiro Yamamoto Hiroshi Takayanagi Toshihiko Suzuki Department of Bacterial Pathogenesis Infection and Host ResponseGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Lifetime Oral Health Care Science Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Periodontology Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan Department of Immunoparasitology Research Institute for Microbial DiseasesOsaka UniversityOsakaJapan

Clinical studies have shown that Aggregatibacter actinomycetemcomitans(***)is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis(RA).However,the mechanism is poorly ***,we show that systemic infection with *** triggers the progression of arthritis in mice anti-collagen antibody-induced arthritis(CAIA)model following IL-1βsecretion and cell infiltration in paws in a manner that is dependent on caspase-11-mediated inflammasome activation in *** administration of polymyxin B(PMB),chloroquine,and anti-CD11b antibody suppressed inflammasome activation in macrophages and arthritis in mice,suggesting that the recognition of lipopolysaccharide(LPS)in the cytosol after bacterial degradation by lysosomes and invasion via CD11b are needed to trigger arthritis following inflammasome activation in *** data reveal that the inhibition of caspase-11-mediated inflammasome activation potentiates aggravation of RA induced by infection with *** work highlights how RA can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with ***.

关键词： CD11b inflam infection

3D attitude measurement by means of spread spectrum modulated ultrasonic wave

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仪器仪表学报 2007年第4期28卷 590-596页

作者： Shinji Ohyama Hiroshi iwasawa Sang Il Ko Junya Takayama Graduate School of Science and Engineering Tokyo Institute of Technology2-12-1O-okayamaMeguro-ku Tokyo 152-8552Japan

Local position and attitude measurement methods are necessary for the navigation of autonomous robots and the other applications. In this paper, a 3D attitude measurement method is proposed. This method uses the spread spectrum modulated ultrasonic wave for the measurement of the pseudo-distance of each pathway between transmitter and receiver elements that are arranged in an array. The relative attitude between transmitter and receiver unit could be calculated from the relationship between these pseudo-distances. The use of spread spectrum modulation enables the high accuracy, noise tolerance, and coexistence of multiple transmitter devices by code division multiple access (CDMA) between transmitter and receiver elements. A pair of transmitter and receiver prototype for proposed method was manufactured, and the fundamental performance was examined in experiments. As a result, accuracy of σ=0.78 mm in the pseudo-distance measurement of each pathway between transmitter and receiver elements was confirmed, and about 0.01 rad resolution in the attitude measurement was also confirmed.

关键词：姿态测量准距离伸展光谱超声波

Acute development of collateral circulation and therapeutic prospects in ischemic stroke

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Neural Regeneration Research 2016年第3期11卷 368-371页

作者： Eri iwasawa Masahiko Ichijo Satoru Ishibashi Takanori Yokota Department of Neurology and Neurological Science Tokyo Medical and Dental University

In acute ischemic stroke,collateral circulation plays an important role in maintaining blood flow to the tissue that is at risk of progressing into ischemia,and in increasing the successful recanalization rate without hemorrhagic *** have reported that well-developed collateral circulation is associated with smaller infarct volume and better long-term neurological outcome,and it disappears promptly once the effective recanalization is *** to the belief that collateral vessels develop over time in chronic stenotic condition,there exists a phenomenon that collateral circulation develops immediately in acute stenosis or occlusion of the arteries and it seems to be triggered by fluid shear stress,which occurs between the territories of stenotic/occluded arteries and those fed by surrounding intact *** believe that this acute development of collateral circulation is a target of novel therapeutics in ischemic stroke and refer our recent attempt in enhancing collateral circulation by modulating sphingosine-1-phosphate receptor 1,which is a known shear-stress mechanosensing protein.

关键词： ischemic stroke collateral S1PR1 shear stress leptomeningeal arteries PCA laterality hyperintensive vessels

The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts

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Signal Transduction and Targeted Therapy 2019年第1期4卷 34-48页

作者： Tianyi Liu Linli Zhou Kun Yang Kentaro iwasawa Ana Luisa Kadekaro Takanori Takebe Thomas Andl Yuhang Zhang Division of Pharmaceutical Sciences College of PharmacyUniversity of CincinnatiCincinnatiOH45267USA Division of Gastroenterology Hepatology&NutritionCincinnati Children’s Hospital Medical Center3333 Burnet AvenueCincinnatiOH45229-3039USA Division of Developmental Biology Cincinnati Children’s Hospital Medical Center3333 Burnet AvenueCincinnatiOH45229-3039USA Department of Dermatology College of MedicineUniversity of CincinnatiCincinnatiOH45267USA Center for Stem Cell and Organoid Medicine(CuSTOM) Cincinnati Children’s Hospital Medical Center3333 Burnet AvenueCincinnatiOH45229-3039USA Department of Pediatrics University of Cincinnati College of Medicine3333 Burnet AvenueCincinnatiOH45229-3039USA Institute of Research Tokyo Medical and Dental University 1-5-45 YushimaBunkyo-kuTokyo113-8510Japan Burnett School of Biological Sciences University of Central FloridaOrlandoFL32816USA

β-catenin is a multifunctional protein that plays crucial roles in embryonic development,physiological homeostasis,and a wide variety of human ***,we showed that in vivo targeted ablation ofβ-catenin in melanoma-associated fibroblasts after melanoma formation significantly suppressed tumor ***,when the expression ofβ-catenin was ablated in melanoma-associated fibroblasts before tumor initiation,melanoma development was surprisingly *** stromalβ-catenin deficiency leads to opposite biological effects in melanoma progression is not completely ***,we report thatβ-catenin is indispensable for the activation of primary human stromal fibroblasts and the mediation of fibroblast-melanoma cell *** coimmunoprecipitation and proximity ligation assays,we identified Yes-associated protein(YAP)as an importantβ-catenin-interacting partner in stromal *** is highly expressed in the nuclei of cancer-associated fibroblasts(CAFs)in both human and murine *** investigation revealed that YAP nuclear translocation is significantly modulated by Wnt/β-catenin activity in *** Wnt/β-catenin signaling in stromal fibroblasts inhibited YAP nuclear *** the absence of YAP,the ability of stromal fibroblasts to remodel the extracellular matrix(ECM)was inhibited,which is consistent with the phenotype observed in cells withβ-catenin *** studies showed that the expression of ECM proteins and enzymes required for remodeling the ECM was suppressed in stromal fibroblasts after YAP ***,our data provide a new paradigm in which theβ-catenin-YAP signaling axis regulates the activation and tumor-promoting function of stromal fibroblasts.

关键词： melanoma inhibited homeostasis

Optimization of Cu content for the development of high-performance T5-treated thixo-cast Al-7Si-0.5Mg-Cu(wt.%)alloy

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Journal of Materials Science & Technology 2021年第34期93卷 178-190页

作者： K.Yamamoto M.Takahashi Y.Kamikubo Y.Sugiura S.iwasawa T.Nakata S.Kamado Nagaoka University of Technology NagaokaJapan Asanuma Giken Co. Ltd.HamamatsuJapa Industrial Research Institute of Shizuoka Prefecture ShizuokaJapan

Cu content has been successfully optimized in a thixo-cast and directly aged(T5-treatment)Al-7 Si-0.5 Mg(wt.%)*** after the 0.5%Cu addition,plate-like Al_(2)Cu(θ’)phases,which contribute to high strengths and large plasticity,are *** formation of a large fraction of Cu-containing brittle phases could be suppressed as ***,the Al-7Si-0.5Mg-0.5Cu alloy exhibits high ultimate tensile strength,0.2%proof stress,and elongation to failure of 296 MPa,209 MPa,and 8.8%,*** results in a high quality index similar to that of solution-treated and subsequently aged(T6-treated)Al-7 Si-Mg alloys.A Cu addition over 1.0%further improves the strengths;however,this leads to poor ductility because of the high fraction of Cu-containing brittle phases.

关键词： Al-Si-Mg-Cu alloy Thixo-casting T5-treatment Mechanical property Microstructure

Childhood-onset inflammatory bowel diseases associated with mutation of Wiskott-Aldrich syndrome protein gene

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World Journal of Gastroenterology 2017年第48期23卷 8544-8552页

作者： Takashi Ohya Masakatsu Yanagimachi Kentaro iwasawa Shuichiro Umetsu Tsuyoshi Sogo Ayano Inui Tomoo Fujisawa Shuichi Ito Department of Pediatrics Yokohama City University Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama-shi Tobu Hostopital Department of Pediatrics Tokyo Medical and Dental University

AIM To screen primary immunodeficiency,Wiskott-Aldrich syndrome(WAS),and chronic granulomatous disease(CGD) among children with inflammatory bowel disease(IBD).METHODS This was a single-center retrospective study. Eighteen children with IBD were investigated. We analyzed their expression of Wiskott-Aldrich syndrome protein(WASP) in lymphocytes and superoxide generation in phagocytes using flow cytometry. When the expression of WASP or superoxide generation was low or absent,we performed genetic analysis to determine the cause of this. RESULTS Eighteen patients were classified as having ulcerative colitis(n = 10),Crohn's disease(n = 5),or IBDunclassified(n = 3). In total,three patients revealed low expression of WASP associated with a WAS gene c.1378 C>T ***460 Ser mutation,which has previously been reported as a pathogenic mutation in WAS and X-linked thrombocytopenia. However,with respect to the major symptoms of WAS,none of these three patients showed either thrombocytopenia or increased susceptibility to infection,but one patient showed generalized eczema. No CGD patients were discovered in this *** Despite the lack of typical clinical manifestations of WAS,low expression of WASP could be associated with the pathogenesis of a subtype of IBD patients.

关键词： Inflammatory bowel disease WiskottAldrich syndrome Primary immunodeficiency Children Screening

Fracture of ossified Achilles tendons:A review of cases

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World Journal of Orthopedics 2021年第4期12卷 207-213页

作者： Hisatoshi Ishikura Naoshi Fukui Mitsuyasu iwasawa Satoru Ohashi Takeyuki Tanaka Sakae Tanaka Department of Orthopedic Surgery University of TokyoTokyo 113-8655Bunkyo-kuJapan Department of Orthopedic Surgery National Hospital OrganizationSagamihara HospitalSagamihara 252-0392Kanagawa PrefectureJapan

Fracture of an ossification of the Achilles tendon(OAT)is a rare entity,and its etiology,pathology,and treatment remain *** reviewed and scrutinized 18 cases(16 articles)of the fracture of an *** most common etiologies of the ossifications include previous surgery and *** fractures often occur without any trigger or with minimal *** long,>5 cm,ossification in the body of the Achilles tendon may have a higher risk of *** OAT itself is often asymptomatic;however,its fracture causes severe local pain,swelling,and weakness of plantar flexion,which forces patients to undergo aggressive *** the treatments of the fractures,nonoperative treatment by immobilizing ankle joint could be an option for elderly ***,because it often cannot produce satisfactory results in younger patients,surgical treatment is typically *** of the fractured mass and repairing the tendon is applicable if the remnant is *** there is a defect after the excision,reconstruction with autologous grafts or adjacent tendon transfer is *** fascia turndown flap,hamstring tendon and tensor fascia lata are used as autologous grafts,whereas peroneus brevis and flexor hallucis longus tendons are used for the tendon *** the fracture of an OAT is treated properly,the functional result will be satisfactory.

关键词： Achilles tendon Ossification Fracture Tissue grafting Tendon transfer Treatment

Real-time characterization of active structures relevant to selective catalysis on designed catalyst surfaces

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Real-time characterization of active structures relevant to ...

Intestinal ascariasis at pediatric emergency room in a developed country

中国化学会第27届学术年会

作者： Yasuhiro iwasawa Department of Engineering Science The University of Electro-Communications Emeritus Professor The University of Tokyo

＜正＞Tremendous catalysis can appear with 2D aspect and unique ensemble on surfaces and nanoparticles, which may be hard to produce in homogeneous and 3D bulk systems, while active species can be supplied

关键词： Catalyst design Real-time characterization Dual functional catalysis.

来源： cnki会议评论

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World Journal of Gastroenterology 2014年第38期20卷 14058-14062页

作者： Shuichiro Umetsu Tsuyoshi Sogo Kentaro iwasawa Takeo Kondo Tomoyuki Tsunoda Manari Oikawa-Kawamoto Haruki Komatsu Ayano Inui Tomoo Fujisawa Department of Pediatric Hepatology and Gastroenterology Saiseikai Yokohama City Tobu Hospital Department of Pediatrics Toho University Medical CenterSakura Hospital

Ascaris lumbricoides infection is rare among children in developed *** large numbers of adult Ascaris in the small intestine can cause various abdominal symptoms,this infection remains asymptomatic until the number of worms in the intestine considerably increases in most *** causing bilious vomiting suggesting ileus is rare,especially in developed countries.A 6-year-old boy who lived in Japan,presented with abdominal colic,bilious vomiting at the pediatric emergency *** appeared pale,and had no abdominal distention,tenderness,palpable abdominal mass,or findings of *** experienced bilious vomiting again during a physical *** tests showed mild elevation of white blood cells and C-reactive protein *** of adenovirus,rotavirus,and norovirus were not detected from his stool,and stool culture showed normal *** showed multiple,round-shaped structures within the small intestine,and a tubular structure in a longitudinal scan of the small *** endoscopy showed a moving worm of Ascaris in the *** ascariasis should be considered as a cause of bilious vomiting in children,even at the emergency room in industrial *** examination and capsule endoscopy are useful for diagnosis of pediatric intestinal ascariasis.

关键词： Ascaris lumbricoides Paralytic ileus Capsule endoscopy Ultrasound Bilious vomiting