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Diagnostic procedures and classification of antisocial behavior in Norwegian inmates in preventive detention

Open Journal of Psychiatry 2012年第3期2卷 207-210页

作者： henning vaeroy Department of Psychiatric R & D Akershus University Hospital Lorenskog Norway

In official Norwegian government reports’ prison statistics, it is claimed that the prevalence of Dissocial Personality Disorder (DPD) or Antisocial Personality Disorder (APD) among inmates in preventive detention is approximately 50%. Furthermore, previous findings have described a practice in which forensic examiners use the DSM SCID axis II for APD to confirm an ICD 10 diagnosis of DPD. Clinical investigation supported by the use of SCID Axis II for quality assurance was performed on almost half the population of inmates (46.4%) in preventive detention at a high security prison. The inmates had all committed severe violent acts including murder. All the information obtained by applying the DSM IV-TR criteria was tested against the ICD-10 Research Criteria (ICD-10-RC) for Dissocial Personality Disorder (ICD-10, DPD). It was found that all inmates met the ICD-10-RC for (DPD) and the DSM-IV-TR definition for Adult Antisocial Behavior (AAB). On the other hand, none met the DSM-IV-TR criteria for (APD). The SCID Axis II failed to identify inmates with APD because the DSM-IV-TR C-criteria, referring to symptoms of childhood Conduct Disorder (CD), were not met. These findings raise important questions since the choice of diagnostic system may influence whether a person’s clinically described antisocial behaviour should be classified as a personality disorder or not. For the inmates, a diagnosis of APD or DPD may compromise their legal rights and affect decisions on prolongation of the preventive detention. Studies have shown that combining the DSM and the ICD diagnostic systems may have consequences for the reliability of the diagnosis.

关键词： Antisocial Personality Disorder Adult Antisocial Behavior Forensic Psychiatry Prisoners Preventive Detention

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ITPK1 is an InsP/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi Dorothea Fiedler henning J.Jessen Gabriel Schaaf Ricardo F.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2D,3C,4C,and 7D and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

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Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants

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神经科学通报:英文版 2023年第8期39卷 1327-1329页

作者： Qing Ye Si‑Si Lin henning Ulrich Yong Tang International Joint Research Centre on Purinergic Signalling/School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Biochemistry Institute of ChemistryUniversity of São PauloSão Paulo 05508Brazil Acupuncture and Chronobiology Key Laboratory of Sichuan Province/School of Health and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610075China

Major depressive disorder(MDD)is one of the most common psychiatric disorders,and~4.7%of the world's population has an onset of depression in any one-year *** causes constant distress,impairs social function and physiological health,and even leads to suicide[1].Numerous studies support the classic monoamine hypothesis of depressive *** majority of clinical antidepressants have been developed on the basis of this hypothesis to increase 5-hydroxytryptamine(5-HT).

关键词： distress hypothesis clinical

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PIEZO1 channels in cutaneous free nerve endings:novel insights into itch-scratch-mechanisms

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Signal Transduction and Targeted Therapy 2023年第2期8卷 319-320页

作者： Manuel Pedro Pereira henning Wiegmann Sonja Ständer Department of Dermatology and Center for Chronic Pruritus University Hospital Münster48149MünsterGermany

A recent study published in Nature by Hill et al.1 identified mechano-sensitive PIEZO1 ion channels in pruriceptive ***,PIEZO1 is involved in acute itch transmission and in mechanical alloknesis in chronic pruritus(CP... 详细信息

关键词： ZO1 insight scratch

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Understanding health literacy from a traditional Chinese medicine perspective

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Journal of Integrative Medicine 2023年第3期21卷 215-220页

作者： Zhiyi Qian Grace Y.Wang Marcus henning Yan Chen Centre for Medical and Health Science Education University of AucklandAuckland 1010New Zealand School of Psychology and Wellbeing University of Southern QueenslandToowoombaQueensland 4350Australia

Health literacy is critical to improving individual and public ***,indigenous perceptions of health are largely absent from Western-derived measurements,contributing to disparities in health outcomes between indigenous and non-indigenous *** is the country with the world's largest population and only officially introduced the term"health literacy"in *** measures of health literacy in China are primarily based on Western-derived constructs,which have been shown to have poor comparability to the unique dual medical system in *** its significant importance to health management globally,understanding health perceptions from a traditional Chinese medicine perspective is *** review explores the concept and core elements of indigenous health literacy,evaluates the existing definitions and measurement tools as applied to the concept,and proposes a new model of traditional Chinese medicine health literacy.

关键词： Traditional Chinesemedicine Health literacy Conceptual model Measurement

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AI如何助力提高人类表现

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商学院 2024年第1期 14-14页

作者： Fabian Gaessler henning Piezunka 庞培法布拉大学经济与商业系宾夕法尼亚大学沃顿商学院

宾夕法尼亚大学沃顿商学院最近的研究揭示了AI(人工智能)训练和增强人类表现的能力,特别是在复杂的战略互动中要了解AI如何培训企业员工并提高绩效,不妨先回顾一下过去。国际象棋计算机一直处于AI的前沿,体现在复杂性和模仿人类思维过... 详细信息

宾夕法尼亚大学沃顿商学院最近的研究揭示了AI(人工智能)训练和增强人类表现的能力,特别是在复杂的战略互动中要了解AI如何培训企业员工并提高绩效,不妨先回顾一下过去。国际象棋计算机一直处于AI的前沿,体现在复杂性和模仿人类思维过程的能力两个基本方面。我们的分析表明,使用国际象棋计算机可以加快棋手的学习速度,并为棋手带来竞争优势,不过AI系统必须超越棋手的技术水平,才能提供有效的训练,否则,棋手就能预测AI的棋步,会限制训练价值。

关键词：宾夕法尼亚大学沃顿商学院人工智能技术水平国际象棋思维过程 AI 战略互动

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The vascular endothelial growth factor system-a new player in the pathogenesis and development of metabolic dysfunction-associated steatotic liver disease

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 963-965页

作者： henning Grønbæk Anders Mellemkjær Søren Nielsen Faidon Magkos Department of Hepatology&Gastroenterology Aarhus University HospitalAarhusDenmark Clinical Institute Aarhus UniversityAarhusDenmark Steno Diabetes Center Aarhus Aarhus University HospitalAarhusDenmark Department of Nutrition Exercise and SportsUniversity of CopenhagenFrederiksbergDenmark

The pathogenesis of liver disease from simple steatosis-metabolic dysfunction-associated steatotic liver disease(MASLD)-and the transition to inflammation and fibrosis-metabolic dysfunction-associated steatohepatitis(... 详细信息

关键词： Vascular endothelial growth factor B(VEGF-B) metabolic dysfunction-associated steatotic liver disease(MASLD) non-alcoholic fatty liver disease(NAFLD)

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Supportive angiogenic and osteogenic differentiation of mesenchymal stromal cells and endothelial cells in monolayer and co-cultures

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International Journal of Oral Science 2016年第4期8卷 223-230页

作者： Florian Bohrnsen henning Schliephake Clinic of Oral and Maxillofacial Surgery Georg August University Gottingen Germany

Sites of implantation with compromised biology may be unable to achieve the required level of angiogenic and osteogenic regeneration. The specific function and contribution of different cell types to the formation of prevascularized, osteogenic networks in co-culture remains unclear. To determine how bone marrow-derived mesenchymal stromal cells （BMSCs） and endothelial cells （ECs） contribute to cellular proangiogenic differentiation, we analysed the differentiation of BMSCs and ECs in standardized monolayer, Transwell and co-cultures. BMSCs were derived from the iliac bone marrow of five patients, characterized and differentiated in standardized monolayers, permeable Transwells and co-cultures with human umbilical vein ECs （HUVECs）. The expression levels of CD31, von Willebrand factor, osteonectin （ON） and Runx2 were assessed by quantitative reverse transcriptase polymerase chain reaction. The protein expression of alkaline phosphatase, ON and CD31 was demonstrated via histochemical and immunofluorescence analysis. The results showed that BMSCs and HUVECs were able to retain their lineage-specific osteogenic and angiogenic differentiation in direct and indirect co-cultures. In addition, BMSCs demonstrated a supportive expression of angiogenic function in co-culture, while HUVEC was able to improve the expression of osteogenic marker molecules in BMSCs.

关键词： angiogenic co-culture differentiation endothelial cell mesenchymal stromal cell osteogenic

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MYB34, MYB51, and MYB 122 Distinctly Regulate Indolic Glucosinolate Biosynthesis in Arabidopsis thaliana

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Molecular Plant 2014年第5期7卷 814-828页

作者： henning Frerigmann Tamara Gigolashvili Botanical Institute and Cluster of Excellence on Plant Sciences (CEPLAS) University of Cologne Cologne Biocenter D-50674 Cologne Germany

The MYB34, MYB51, and MYB122 transcription factors are known to regulate indolic glucosinolate （IG） biosynthesis in Arabidopsis thaliana. To determine the distinct regulatory potential of MYB34, MYB51, and MYB122, the accumulation of IGs in different parts of plants and upon treatment with plant hormones were analyzed in A. thaliana seedlings. It was shown that MYB34, MYB51, and MYB122 act together to control the biosynthesis of 13M in shoots and roots, with MYB34 controlling biosynthesis of IGs mainly in the roots, MYB51 regulating biosynthesis in shoots, and MYB122 having an accessory role in the biosynthesis of IGs. Analysis of glucosinolate levels in seedlings of myb34, myb51, myb122, myb34 myb51 double, and myb34 myb51 myb122 triple knockout mutants grown in the presence of abscisic acid （ABA）, salicylic acid （SA）, jasmonate （JA）, or ethylene （ET） revealed that：（1） MYB51 is the central regulator of IG synthesis upon SA and ET signaling, （2） MYB34 is the key regulator upon ABA and JA signaling, and （3） MYB122 plays only a minor role in JA/ET-induced glucosinolate biosynthesis. The myb34 myb51 myb122 triple mutant is devoid of IGs, indicating that these three MYB factors are indispensable for IG production under standard growth conditions.

关键词： indolic glucosinolates regulation R2R3 MYB the triple myb34 myb51 myb122 mutant.

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P2X receptors in maintenance and differentiation of neural progenitor cells

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Neural Regeneration Research 2014年第23期9卷 2040-2041页

作者： henning Ulrich Peter Illes Departamento de Bioquímica Instituto de Química Universidade de Sao Paulo Rudolf-Boehm-Institut für Pharmakologie und Toxikologie der Universitat Leipzig

Purinergic receptors are among the first cell surface receptors expressed during embryonic development （Burnstock and Ulrich, 2011）. These are characterized based on their pharmacological properties of being activated by adenosine or purine/pyrimidine nucleotides as P1 and P2 receptors. P2 receptors are further classified by their structure as P2Y metabotropic and P2X ionotropic receptors.

关键词： P2X receptors in maintenance and differentiation of neural progenitor cells

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