检索结果-南通市图书馆

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

政府内部和外部的管理:不同的理论关注

江苏行政学院学报 2011年第4期 120-125页

作者：薛恒南京信息工程大学公共行政管理学院南京210044

行政学创立以来就包含着政府对内部和外部事务管理两个领域。行政学研究对两个领域区别的忽略造成了影响行政学发展的基础性缺陷。政府内部和外部行政管理有着不同的管理内容、特点和理论关注。从学理上明确两者之间的分野和定位,将为... 详细信息

行政学创立以来就包含着政府对内部和外部事务管理两个领域。行政学研究对两个领域区别的忽略造成了影响行政学发展的基础性缺陷。政府内部和外部行政管理有着不同的管理内容、特点和理论关注。从学理上明确两者之间的分野和定位,将为行政学研究趋近行政真实、指导行政实践开辟新进路。

关键词：政府内部管理外部管理理论关注

在线全文

学校读者我要写书评

暂无评论

甲午之前士人对西方议会制的认识

南京社会科学 2007年第2期 55-61页

作者：薛恒南京信息工程大学公共管理系教授博士南京210044

鸦片战争知彼知已的需要,使中国人通过《四洲志》一书初识了英美国家的议会制度及其价值。议会制度的基本内容介绍到中国后,到同光时代,得到了官僚士大夫阶层中有识之士的高度认同。他们从“三代”遗风中发掘出议会制的历史和理论基础... 详细信息

鸦片战争知彼知已的需要,使中国人通过《四洲志》一书初识了英美国家的议会制度及其价值。议会制度的基本内容介绍到中国后,到同光时代,得到了官僚士大夫阶层中有识之士的高度认同。他们从“三代”遗风中发掘出议会制的历史和理论基础。梳理甲午之前士人对西方议会制度的认识的过程可知:体认西方议会制既是近代中国了解把握西方民主的门径,也是后来变法和立宪———中国二千多年道统之变的先声。

关键词：士人西方议会制认识

在线全文

学校读者我要写书评

暂无评论

辛亥革命中的三大妥协及其历史遗产

南京师大学报（社会科学版） 2012年第3期 69-75页

作者：薛恒南京信息工程大学公共管理学院教授 210044

辛亥革命中形成了汉满民族妥协、南北政治妥协和孙袁权力妥协三大妥协,这既是参与政治各方发挥政治智慧的结果,更是革命的大势所趋所逼的结果。三大妥协使得辛亥革命以较小的代价和低烈度的震荡实现了共和政制的跃迁,结束了秦汉以来垂... 详细信息

辛亥革命中形成了汉满民族妥协、南北政治妥协和孙袁权力妥协三大妥协,这既是参与政治各方发挥政治智慧的结果,更是革命的大势所趋所逼的结果。三大妥协使得辛亥革命以较小的代价和低烈度的震荡实现了共和政制的跃迁,结束了秦汉以来垂两千多年的君主专制。百年以来,这一妥协成果依然是后人享受且在升值的宝贵遗产。

关键词：辛亥革命妥协遗产

维普期刊数据库博看期刊

Schaftoside inhibits 3CL^(pro)and PL^(pro)of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第11期12卷 4154-4164页

作者： Yang Yi Meng Zhang heng xue Rong Yu Yang-Oujie Bao Yi Kuang Yue Chai Wen Ma Jing Wang Xiaomeng Shi Wenzhe Li Wei Hong Junhua Li Elishiba Muturi Hongping Wei Joachim Wlodarz Szczepan Roszak xue Qiao Hang Yang Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Bejing 100049China Faculty of Science and Technology University of SilesiaKatowice 40-007Poland Department of Phrysical and Quantum Chenmistry Faculty of ChemistryWroclaw University of Science and Technology Wroclaw 50-370Poland

It is an urgent demand worldwide to control the coronavirus disease 2019(COVID-19)pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** 3-chymotrypsin-like protease(3CL^(pro))and papain-like protease(PL^(pro))are key targets to discover SARS-CoV-2 *** screening 12 Chinese herbal medicines and 125 compounds from licorice,we found that a popular natural product schaftoside inhibited 3CL^(pro)and PL^(pro)with IC_(50)values of 1.73±0.22 and 3.91±0.19μmol/L,respectively,and inhibited SARS CoV-2 virus in Vero E6 cells with EC_(50)of 11.83±3. 23μmol/L. Hydrogen-deuterium exchange mass spectrometry analysis, quantum mechanics/molecular mechanics calculations, together with site-directed mutagenesis indicated the antiviral activities of schaftoside were related with non-covalent interactions with H41, G143 and R188 of3CLpro, and K157, E167 and A246 of PLpro. Moreover, proteomics analysis and cytokine assay revealed that schaftoside also regulated immune response and inflammation of the host cells. The antiinflammatory activities of schaftoside were confirmed on lipopolysaccharide-induced acute lung injury mice. Schaftoside showed good safety and pharmacokinetic property, and could be a promising drug candidate for the prevention and treatment of COVID-19.

关键词： COVID-19 SARS-CoV-2 3-Chymotrypsin-like protease Papain-like protease Licorice Schaftoside Immune response Infammation

In situ mitigation strategies for field emission-induced cavity faults using low-level radiofrequency system

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2022年第11期33卷 46-60页

作者： Feng Qiu Yuan He An-Dong Wu Zhen-Long Zhu Guo-Dong Jiang Tian-Cai Jiang Zheng Gao Qi Chen Zong-heng xue Jin-Ying Ma Cheng-Ye Xu Zi-Qin Yang Gui-Rong Huang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

In the Chinese ADS front-end demo superconducting radiofrequency linac(CAFe)at the Institute of Modern Physics,a burst-noise signal-triggered cavity fault frequently appears during beam *** events are characterized by a rapid burst noise in the cavity pick-up,which may lead to an unexpected low-level radiofrequency(LLRF)response that eventually causes a cavity *** eliminate the undesirable reaction of the LLRF control loop,we propose a method that uses a burstnoise detection and processing algorithm integrated into the LLRF feedback *** algorithm can prevent undesired regulations in LLRF *** analysis revealed that some burst-noise events did not exhibit measurable energy *** contrast,the other events were accompanied by a rapid loss of cavity stored energy and exhibited similarities to the‘‘E-quench’’phenomena reported in other laboratories.A particle-in-cell simulation indicated that the suspected E-quench phenomenon may be related to a plasma formation process inside the ***,the LLRF algorithm is robust to the two different types of burst-noise events and can significantly mitigate the corresponding cavity faults in CAFe beam commissioning.

关键词： Field emission Flashover E-quench Superconducting LLRF CAFe Plasma formation

Simulation of a soft-gamma-ray polarimeter on board a microsatellite

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第11期34卷 64-76页

作者： Xiang‑Man Liu Shu‑Wen Tang Wei Wang Yu‑Hong Yu Zhi‑Yu Sun Yong‑Jie Zhang Fang Fang Duo Yan Shi‑Tao Wang xue‑heng Zhang Shu‑Ya Jin Bi‑Tao Hu Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Department of Astronomy School of Physics and TechnologyWuhan UniversityWuhan 430072China Wuhan University‑National Astronomical Observatories Joint Center for Astronomy Wuhan UniversityWuhan 430072China

Gamma-ray polarimetry is a new and prospective tool for studying extremely high-energy celestial objects and is of great significance for the field of *** the rapid development of microsatellite technology,the advantages of space exploration have become increasingly ***,we simulated a soft-gamma-ray polarimeter for a microsatellite based on the Compton scattering *** performed detailed Monte Carlo simulations using monoenergetic gamma-ray linear-polarization sources and Crab-like sources in the energy range of 0.1-10 MeV considering the orbital *** polarimeter exhibited excellent polarization detection *** modulation factor was 0.80±0.01,and the polarization angles were accurate within an error of 0.2°at 200 keV for on-axis *** the Crab-like sources for on-axis incidence,the polarization degrees were consistent with the set values within the error tolerance,the modulation factor was 0.76±0.01,and the minimum detectable polarization reached 2.4%at 3σfor an observation time of10^(6) ***,the polarimeter exhibited recoil electron tracking,imaging,and powerful background suppression in a large field of view(FoV;∼2πsr).The proposed polarimeter meets the requirements of a space soft-gamma-ray polarization detector and has promising research prospects.

关键词： Soft gamma ray Polarization Compton scattering Microsatellite Monte Carlo simulation

在线全文

学校读者我要写书评

暂无评论

国家“三农”政策的制度化建设

徐州师范大学学报（哲学社会科学版） 2009年第3期35卷 110-115页

作者：薛恒南京信息工程大学公共管理学院江苏南京210044

政策的制度化是指政策规范的长期化、稳定化、明确化和法制化。近年来,国家"三农"政策对解决"三农"问题,建设社会主义新农村起到了非常重要的作用。"三农"政策的制度化建设因而也成为人们关注的焦点。"三农"政策的制度化旨在为政府对"三... 详细信息

政策的制度化是指政策规范的长期化、稳定化、明确化和法制化。近年来,国家"三农"政策对解决"三农"问题,建设社会主义新农村起到了非常重要的作用。"三农"政策的制度化建设因而也成为人们关注的焦点。"三农"政策的制度化旨在为政府对"三农"公共政策的供给行为提供一种必须遵循的长期稳定的制度安排模式。它对于构成农业和农村相对稳定的利益关系秩序,形成合理的政策预期,实现并巩固政策的目标和价值意义重大。"三农"政策制度化建设应该进行的主要工作是提升政策制度化的价值;稳定政策的目标取向和行为导向;规范并优化政策制度化的基本举措;强化政策落实中的监控制度。推进国家"三农"政策制度化建设的基本条件和出路在于大力促进国家"三农"政策的社会认同,提高"三农"政策的合理性程度,加快推进"三农"政策的法制化进程。

关键词： “三农”政策制度化制度体系

在线全文

学校读者我要写书评

暂无评论

新都形象:以1930年代南京建筑为中心

江苏师范大学学报（哲学社会科学版） 2014年第1期40卷 82-88页

作者：薛恒南京信息工程大学公共管理学院江苏南京210044

1927年4月国民政府定都南京后,为了树立新的国都形象,在首都规划和建筑中提出了弘扬民族文化的指导思想。为此,在南京的机关公务、文教科学等建筑中新建了大批具有"民族文化"形式的建筑,成为南京新都建筑的主导。但由于建筑功能的需要... 详细信息

1927年4月国民政府定都南京后,为了树立新的国都形象,在首都规划和建筑中提出了弘扬民族文化的指导思想。为此,在南京的机关公务、文教科学等建筑中新建了大批具有"民族文化"形式的建筑,成为南京新都建筑的主导。但由于建筑功能的需要等多种原因,西式风格的建筑在南京也不断出现,由此造就出参酌古今、兼容中外、主流与多样并存的南京建筑风格,展现出1930年代民国首都民族化、国际化的形象。

关键词：新都形象 1930年代南京民国建筑

Licorice-saponin A3 is a broad-spectrum inhibitor for COVID-19 by targeting viral spike and anti-inflammation

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第1期14卷 115-127页

作者： Yang Yi Wenzhe Li Kefang Liu heng xue Rong Yu Meng Zhang Yang-Oujie Bao Xinyuan Lai Jingjing Fan Yuxi Huang Jing Wang Xiaomeng Shi Junhua Li Hongping Wei Kuanhui Xiang Linjie Li Rong Zhang Xin Zhao xue Qiao Hang Yang Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing100191China Yunnan Baiyao International Medical Research Center Peking UniversityBeijing100191China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterPeking UniversityBeijing100191China Hubei Jiangxia Laboratory Wuhan430000China Shenzhen Children's Hospital ShenzhenGuangdong518036China

Currently,human health due to corona virus disease 2019(COVID-19)pandemic has been seriously *** coronavirus severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)spike(S)protein plays a crucial role in virus transmission and several S-based therapeutic approaches have been approved for the treatment of ***,the efficacy is compromised by the SARS-CoV-2 evolvement and *** we report the SARS-CoV-2 S protein receptor-binding domain(RBD)inhibitor licorice-saponin A3(A3)could widely inhibit RBD of SARS-CoV-2 variants,including Beta,Delta,and Omicron BA.1,XBB and ***,A3 could potently inhibit SARS-CoV-2 Omicron virus in Vero E6 cells,with EC50 of 1.016μ*** mechanism was related to binding with Y453 of RBD determined by hydrogen-deuterium exchange mass spectrometry(HDX-MS)analysis combined with quantum mechanics/molecular mechanics(QM/MM)***,phosphoproteomics analysis and multi fluorescent immunohistochemistry(mIHC)respectively indicated that A3 also inhibits host inflammation by directly modulating the JNK and p38 mitogen-activated protein kinase(MAPK)pathways and rebalancing the corresponding immune *** work supports A3 as a promising broad-spectrum small molecule drug candidate for COVID-19.

关键词： COVID-19 Inflammation Licorice-saponin A3 Receptor-binding domain(RBD) SARS-CoV-2