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Sexuality of Repartnered Men and Women in France: Sexual Behaviors, Perceptions, Expectations and Sexual Dysfunctions

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Advances in Sexual Medicine 2012年第1期2卷 10-19页

作者： Marie-helene Colson Antoine Lemaire Patrick Klein 不详

Introduction. Although many epidemiological studies on sexuality have been published, none have specifically addressed male and female sexuality in repartnered couples. Aim. To investigate men and women’s sexual behaviors, perceptions and expectations, and the frequency of their sexual dysfunctions, with a focus on repartnered couples, i.e, subjects living with a partner in a stable relationship after divorce or widowhood (including both remarried couples and cohabitating unmarried couples). Methods. Analysis of telephone survey data collected from 1,002 French subjects (483 men, 519 women) ≥35years. Of these, 748 were living with their partner as part of a heterosexual couple. For these subjects, the sexuality of 149 repartnered subjects was compared to that of the other 599 subjects. Main Outcome Measures. A 39-item questionnaire assessing subjects' perceptions, expectations, sexual behaviors and dysfunctions. Results. Compared with other subjects, men and women in repartnered couples had more active sexuality and more interest in sexuality (men 93% vs 80%, P < 0.01, women 73% vs 65%, P < 0.05). They were generally more sensitive to feelings and emotions linked to their sexuality, and these feelings seemed to increase steadily with age. Their sexuality was more attuned to their partner’s pleasure (men 79% vs. 59% P < 0.001, women 50% vs. 34% P < 0.01). Concern for the future of the relationship and for sexuality was equally present for both groups, although repartnered couples were more often concerned about potential inadequacy and conflicts between the two partners. Although repartnered men seemed to be less affected by diminished desire, they had slightly higher rates of premature ejaculation and erectile dysfunction, and considered their quality of life to be more affected by these problems. Conclusion. The sexuality of repartnered couples remains poorly studied, but seems to differ from that of non-repartnered couples. Our findings open interesting avenues of

关键词： Repartnered Couples Remarried Couples Sexual Behavior Sexual Inadequency Marital Relationship

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Effect of Initial Size and Shape Importance on Masse Transfer during Convective Drying

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Food and Nutrition Sciences 2018年第12期9卷 1514-1524页

作者： Kondia Honore Ouoba Francois Zougmore helene Desmorieux Laboratoire des Materiaux et Environnement(LA.M.E.) Ecole Doctorale Sciences et Technologies(EDST)Universite Ouaga I Pr Joseph KI-ZERBOBurkina Faso Laboratoire d’Automatique et de Genie des Procedes LAGEPUMR CNRS 5007Universite Claude Bernard Lyon1-CPE-bat.Villeurbanne CedexFrance

In this paper the influence of sample initial size on their convective drying at 80°C using convective dryer is determined. Results prove that initial size must be taken into account when drying process was estimated. This influence is limited by its form of cut. Comparing cubic form and parallelepiped (slice) one;results seem to show that thickness is the most important parameter governing the transfer phenomena during foodstuff convective drying. Three slices with thickness of 0.5 cm and surface area of 17, 82 and 112 cm2 respectively, dry better than cubic sample with a = 1 cm or a = 2 cm of arrest and having respectively 6 and 24 cm2 of surface area. All things seem to show that initial surface is not only the essential parameter;but also the thickness of the sample must be taken into account. Indeed, all of the samples with equal thickness (0.5 cm) and different exchange surfaces dry at the same time, about 210 min, comparing with cubic form 1 cm of arrest and 6 cm2 of surface and drying time of 230 min. A new parameter noted Dc called characteristic diameter is so considered to bridge the gaps. It is defined to be the diameter of the biggest sphere we can cut into a sample. This parameter is independent of form of the sample, and time increase with characteristic diameter increasing.

关键词： Initial Size Characteristic Dimension Shrinkage Cut Form Exchange Surface Area

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Methods to Evaluate Rumen Protected Lysine for Dairy Cows

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Open Journal of Animal Sciences 2015年第4期5卷 495-499页

作者： Essi Evans Josh Lamont helene Leclerc Technical Advisory Services Inc. Bowmanville Canada Atlantic Dairy and Forage Institute Fredericton Junction Canada Jefo Nutrition Inc St. Hyacinthe Canada

There are many rumen protected amino acid products available for dairy cattle feeding. However, feed formulation programs require values related to rumen solubility, rate of disappearance in the rumen and total tract digestibility and often such values are not available. In vivo testing procedures are complex, time consuming and expensive. This study was conducted to determine if a newrapid, lower cost in vitro method developed for feed ingredients could be applied to a rumen protected lysine product (DairynatLys-30, Jefo Nutrition Inc). In vivo determination of the rapidly solubilized protein fraction, rate of degradation of the slowly solubilized fraction and total tract digestibility studies were compared to the in vitro method in use in many ingredient analysis laboratories for feed ingredients such as forages, protein supplements and grains. Results showed that the rapidly soluble fraction (8.33% and 8.66% of total N for in vivo and in vitro methods) and rates of disappearance in the rumen (2.64%/h and 2.43%/h for in vivo and in vitro procedures) compared favorably between the two methods for the rumen protected product. Total tract digestibility values were slightly higher (84.4%) with the in vivo method used than with the in vitro method (75.9%), and both are in the expected calculated range of digestibility of 80%. In conclusion the in vitro method appears to be an acceptable alternative for evaluating rumen protected amino acids.

关键词： Rumen Protected Amino Acids Lysine In Vitro Testing

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Development of a health education intervention strategy using an implementation research method to control taeniasis and cysticercosis in Burkina Faso

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Infectious Diseases of Poverty 2017年第1期6卷 833-847页

作者： Helena Ngowi Ivan Ozbolt Athanase Millogo Veronique Dermauw Telesphore Some Paul Spicer Lori L.Jervis Rasmane Ganaba Sarah Gabriel Pierre Dorny helene Carabin Department of Veterinary Medicine and Public Health Sokoine University of AgricultureP.O.Box 3021MorogoroTanzania Department of Anthropology University of OklahomaNormanOKUSA Language Department Citizen Potawatomi NationShawneeOKUSA Sourou Sanou University Teaching Hospital Bobo-DioulassoBurkina Faso Department of Biomedical Sciences Institute of Tropical MedicineAntwerpBelgium Agriculutral and Research Training Agency for Africa(AFRICSante) Bobo-DioulassoBurkina Faso Department of Anthropology and Center for Applied Social Research University of OklahomaOklahoma CityOKUSA Department of Biostatistics and Epidemiology College of Public HealthOklahoma University Health Sciences CenterOklahoma CityOKUSA

Background:Taeniasis and cysticercosis are two diseases caused by Taenia solium,a parasite transmitted between humans and pigs,leading to considerable economic loss and *** of the parasite is linked to environmental and behavioural factors such as inadequate sanitation and hygiene,poor pig management,and consumption of infected *** study used implementation research method to design a health education intervention strategy for reducing *** infections in Burkina Faso,a country endemic for the ***:Eighteen group discussions were conducted with 8-18 participants each in three *** addition,structured interviews were conducted among 4777 participants and 2244 pig owners,who were selected through cluster random sampling in 60 villages of three provinces of Burkina *** approaches assessed knowledge and practices related to *** information obtained was used to develop a community-adapted health education intervention strategy to control taeniasis and cysticercosis in Burkina ***:The group discussions revealed that participants had a poor quality of life due to the diseases as well as inadequate access to latrines,safe water,and healthcare *** addition,it was found that pig production was an important economic activity,especially for ***,financial and knowledge constraints were important limitations to improved pig management and latrine *** survey data also showed that open defecation and drinking unboiled water were common behaviours,enhanced by a lack of knowledge regarding the transmission of the parasite,perceived financial barriers to the implementation of control measures,lack of public sensitization,as well as a lack of self-efficacy towards control of the ***,the perceived financial benefits of controlling porcine cysticercosis could be emphasized by an education program that discourages open defecation and encourages drinking safe water

关键词： Taenia solium control plan Taeniasis Cysticercosis PHAST Burkina Faso

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Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models

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World Journal of Gastroenterology 2018年第17期24卷 1888-1900页

作者： Illona-Marie Boulete Anusha Thadi Catherine Beaufrand Viren Patwa Apoorva Joshi John A Foss E Priya Eddy helene Eutamene Vaseem A Palejwala Vassilia Theodorou Kunwar Shailubhai UMR 1331 Toxalim INRA/INPT Toulouse 31555France Baruch S.Blumberg Institute DoylestownPA 18902United States Synergy Pharmaceuticals Inc. 420 Lexington AvenueNew YorkNY 10170United States

AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS Transport of fluorescein isothiocyanate(FITC)-dextran was measured to assess permeability across cell monolayers and rat colon tissues. Effects of plecanatide and dolcanatide on the integrity of tight junctions in Caco-2 and T84 monolayers and on the expression and localization of occludin and zonula occludens-1(ZO-1) were examined by immunofluorescence microscopy. Anti-nociceptive activity of these agonists was evaluated in trinitrobenzene sulfonic acid(TNBS)-induced inflammatory as well as in non-inflammatory partial restraint stress(PRS) rat models. Statistical significance between the treatment groups in the permeability studies were evaluated using unpaired *** Treatment of T84 and Caco-2 monolayers with lipopolysaccharide(LPS) rapidly increased permeability, which was effectively suppressed when monolayers were also treated with plecanatide or dolcanatide. Similarly, when T84 and Caco-2 monolayers were treated with LPS, cell surface localization of tight junction proteins occludin and ZO-1 was severely disrupted. When cell monolayers were treated with LPS in the presence of plecanatide or dolcanatide, occludin and ZO-1 were localized at the cell surface of adjoining cells, similar to that observed for vehicle treated cells. Treatment of cell monolayers with plecanatide or dolcanatide without LPS did not alter permeability, integrity of tight junctions and cell surface localization of either of the tight junction proteins. In rat visceral hypersensitivity models, both agonists suppressed the TNBS-induced increase in abdominal contractions in response to colorectal distension without affecting the colonic wall elasticity, and both agonists also reduced colonic hypersensitivity in the PRS model. CONCLUSION Our results suggest that activation of GC-C signaling mi

关键词： Plecanatide Guanylyl cyclase-C agonists Dolcanatide Uroguanylin Preclinical cyclic guanosine monophosphate Constipation Inflammatory bowel diseases

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虚拟现实技术应用于神经心理评估的研究概述

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心理科学进展 2010年第3期18卷 511-521页

作者：郑霞 SAUZEON helene 周明全 N'KAOUA Bernard 北京师范大学认知神经科学与学习国家重点实验室北京100875 北京师范大学信息科学与技术学院北京100875 Laboratory of Cognition and Human Factors(EA-487) Institute of cognitive scienceUniversity of Bordeaux II-Victor SegalenBordeaux33076France

传统神经心理评估的实验控制和生态效度的平衡问题日益受到研究人员的关注,而新兴的虚拟现实(Virtual Reality,VR)技术为问题的改善带来了希望,它不仅可以模拟现实环境并支持被试的直接交互,而且能对传统测试进行再现和扩展。它所形成... 详细信息

传统神经心理评估的实验控制和生态效度的平衡问题日益受到研究人员的关注,而新兴的虚拟现实(Virtual Reality,VR)技术为问题的改善带来了希望,它不仅可以模拟现实环境并支持被试的直接交互,而且能对传统测试进行再现和扩展。它所形成的评估系统能对刺激的内容和表象、任务的复杂度和被试的响应进行灵活控制,所获取的信息更丰富、准确。在初步评估注意过程(注意、单侧空间忽略)、记忆(前瞻记忆、情景记忆、空间记忆、地形定向)和执行功能方面已获得了令人满意的效果。然而目前VR评估的应用仍存在技术和设备方面的不足,以及对评估者和被试不同操作要求的局限,因此今后除了要规范化现有VR评估系统,还应该进一步发展基础条件来推动系统的广泛应用。

关键词：虚拟现实神经心理评估注意过程记忆执行功能

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TREM-1 multimerization is essential for its activation on monocytes and neutrophils

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Cellular & Molecular Immunology 2019年第5期16卷 460-472页

作者： Kevin Carrasco Amir Boufenzer Lucie Jolly helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive INOTREM Vandœuvre-les-NancyFrance UMR-S 1116 Defaillance cardiovasculaire aigue et chroniqueVandœuvre-les-NancyFrance UMR7365 Ingénierie Moléculaire et Physiopathologie Articulaire(IMoPA)CNRS-Universitéde LorraineVandœuvre-les-NancyFrance Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences and Netherlands Proteomics CenterUtrecht UniversityUtrechtThe Netherlands Innate Immunity German Cancer Research Center(DKFZ)HeidelbergGermany CovalX ZurichSwitzerland Service Commun de Biophysique Interactions Moléculaires(SCBIM) FR3209Biopole de l’Universitede LorraineVandœuvre-les-NancyFrance Inatherys Evry CedexFrance

The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune *** promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel ***,the molecular events leading to the activation of TREM-1 in innate immune cells remain ***,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 ***-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and *** addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its *** further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and ***-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 *** results provide evidence for ligand-induced,receptor-mediated dimerization of ***,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils.

关键词： TREM-1 multimerization activation monocytes neutrophils

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Clinical high-risk criteria of psychosis in 8–17-year-old community subjects and inpatients not suspected of developing psychosis

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World Journal of Psychiatry 2022年第3期12卷 425-449页

作者： Frauke Schultze-Lutter Petra Walger Maurizia Franscini Nina Traber-Walker Naweed Osman helene Walger Benno G Schimmelmann Rahel Flückiger Chantal Michel Department of Psychiatry and Psychotherapy Medical FacultyHeinrich-Heine UniversityDüsseldorf 40629North-Rhine WestphaliaGermany Department of Psychology Faculty of PsychologyAirlangga UniversitySurabaya 60286Indonesia University Hospital of Child and Adolescent Psychiatry and Psychotherapy University of BernBern 3000Switzerland Department of Child and Adolescent Psychiatry and Psychotherapy University of ZürichZürich 8032Germany Department of Psychiatry and Psychotherapy Ludwig-Maximilian-UniversityMunich 80336BavariaGermany University Hospital of Child and Adolescent Psychiatry University Hospital Hamburg-EppendorfHamburg 20246Germany

BACKGROUND In children and adolescents compared to adults,clinical high-risk of psychosis(CHR)criteria and symptoms are more prevalent but less psychosis-predictive and less clinically *** on high rates of non-converters to psychosis,especially in children and adolescents,it was suggested that CHR criteria were:(1)Pluripotential;(2)A transdiagnostic risk factor;and(3)Simply a severity marker of mental disorders rather than specifically *** any of these three alternative explanatory models were true,their prevalence should differ between persons with and without mental disorders,and their severity should be associated with functional impairment as a measure of *** To compare the prevalence and severity of CHR criteria/symptoms in children and adolescents of the community and *** In the mainly cross-sectional examinations,8–17-year-old community subjects(n=233)randomly chosen from the population register of the Swiss Canton Bern,and inpatients(n=306)with primary diagnosis of attention-deficit/hyperactivity disorder(n=86),eating disorder(n=97),anxiety including obsessive–compulsive disorder(n=94),or autism spectrum disorder(n=29),not clinically suspected to develop psychosis,were examined for CHR symptoms/*** items of the Structured Interview for Psychosis-Risk Syndromes(SIPS)were used to assess the symptomatic ultra-high-risk criteria,and the Schizophrenia Proneness Instrument,Child and Youth version(SPI-CY)was used to assess the 14 basic symptoms relevant to basic symptom *** examined group differences in frequency and severity of CHR symptoms/criteria usingχ^(2) tests and nonparametric tests with Cramer’s V and Rosenthal’s r as effect sizes,and their association with functioning using correlation *** The 7.3%prevalence rate of CHR criteria in community subjects did not differ significantly from the 9.5%rate in *** and severity of CHR criteria never differed bet

关键词： Psychotic disorders Risk assessment Minors Community Inpatients Psychosocial functioning

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Predictive Study of Velocimetry in the Coronary Artery after Iodinated Contrast Agent Injection

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第1期6卷 93-104页

作者： Nora Hocine Julie Colnot helene Masset Didier Franck Institut de Radioprotection et de Surete Nucleaire(IRSN) Fontenay-aux-RosesFrance Centre Hospitalier Universitaire Henri Mondor CreteilFrance

This study aims to determine the retention time of iodinated contrast agents (ICA) in the coronary artery. The mechanical aspect of ICA displacement was studied in order to better understand the effect of these products on the inner wall of the artery of patients with coronary artery stenosis, undergoing repeated imaging examinations with iodinated contrast agents. ICA flow, ICA and blood flow in the artery were modelled. The fluid was regarded to be viscous, incompressible and Newtonian. Blood flow was presumed to be unidirectional, laminar and unstationary. Iodine flow velocity and retention time were calculated using the Runge-Kutta 4th order method programmed in C++ and MatLab R2013a language. The results showed that for coronary artery CT-scans, ICA retention time is 1 minute 40 seconds and for coronary arteriography it is between 2.41 and 3.61 seconds. The values calculated were compared to theoretical values and to clinical observations. The results enabled us to validate our model.

关键词： Coronary Artery Iodinated Contrast Agent Blood Flow

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Depressive symptoms and the associations with individual, psychosocial, and structural determinants in Swedish adolescents

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Health 2012年第10期4卷 881-889页

作者： helene Z.Dahlqvist Evelina Landstedt Katja Gillander Gadin Department of Health Sciences Mid Sweden UniversitySundsvallSweden

Depressive symptoms in adolescents are an increasing public health issue in Sweden and in most Western countries. Aim: To explore how individual, psychosocial, and structural determinants are associated with depressive symptoms in Swedish adolescents. Methods: A web-based questionnaire was answered by 1193 13- to 16-year-old boys (n = 566) and girls (n = 627). Stepwise logistic regressions were employed to analyse the association between depressive symptoms and various determinants at the individual level (self-efficacy), the psychosocial level (parental, peer, and teacher support, school demands, sexual harassment, and bullying) and the structural level (family affluence, having less money than friends, and parental foreign background). Results: Determinants at the individual, psychosocial, and structural levels were independently associated with high levels of depressive symptoms in both boys and girls. The full model explained a high proportion of the variance in depressive symptoms in both genders;34.1% in boys and 36.8% in girls. The psychosocial level contributed the most to explaining the variance in depressive symptoms in boys. In girls, when harassment variables were separated from psychosocial variables, the harassment variables contributed as much to the full model as the rest of the psychosocial variables combined. Conclusions: Addressing psychosocial determinants provides the greatest benefits for preventing depressive symptoms in adolescents. Acknowledging the association between sexual harassment and depressive symptoms for girls and having less money than their friends for boys and girls are particularly important.

关键词： Mental Health Individual Determinants Psychosocial Determinants Structural Determinants Socioeconomic Factors Gender Harassment Social Support School Adolescence

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