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CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia Ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel Colm Morrsey Sanjoy Mehta Jesse Barnes Michael C.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi helena a.yu Joseph M.Chan Charles M.Rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility Memorial Sloan Kettering Cancer Center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell Medical College New York NYUSA Present address:Swiss Institute for Experimental Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional Corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the MYC Proto-Oncogen(MYC),implicated in stemness and histological *** overexpression of a degradation-resistant MYC isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

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Littoral landforms of Lake Hulun and Lake Buir(China and Mongolia):Wind-driven hydro-sedimentary dynamics and resulting clastics distribution

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Journal of Palaeogeography 2024年第2期13卷 309-326页

作者： Li Wang Mathieu Schuster Shi-Wei Xin Florin Zainescu Xin-yu Xue Joep Storms Jan-Hendrik May Alexis Nutz helena van der Vegt Guilherme Bozetti Zai-Xing Jiang School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Universite de Strasbourg CNRSENGEESInstitut Terre et Environnement de StrasbourgUMR 70635 Rue DescartesStrasbourgFrance Tamsag Mongolia(XIX)Ltd. PetroChinaDaqing 163000China CEREGE Aix-Marseille UniversitéCNESIRDCollege de FranceINRAAix en ProvenceFrance School of Marine Science Sun Yat-sen UniversityZhuhai 519083China Delft University of Technology Department of Geoscience and EngineeringDelfthe Netherlands School of Geography Earth and Atmospheric SciencesUniversity of Melbourne253 Elgin St.CarltonVIC 3053Australia Deltares Delfthe Netherlands SCMF Faculty of GeographyUniversity of Bucharest1 N.Balcescu Blv.BucharestRomania

Two rectangular-shaped lakes,Lake Hulun and Lake Buir,located at the boundary between China and Mongolia,only c.75 km apart and therefore experiencing similar wind fields,have been studied based on satellite images and field surveys in order to compare their geomorphological and sedimentological *** wind-driven hydrodynamics,which have a significant effect on the development of littoral landforms and on sediment distribution,have been discussed for the two similar lakes that experienced a prevailing wind perpendicular to their long axis.A conceptual model related to wind-driven water bodies and sediment distribution is ***-influenced to wave-dominated deltas,beaches,spits,and eolian dune deposits develop around these two lakes,with a strikingly similar distribution *** features locally inform the longshore drift and help reconstruct the water circulation induced by wind *** the NW prevailing wind regime,the spits developed on the SW coast with a NW—SE extension,which was influenced by the NW—SE longshore *** same influence was observed in the delta extension in the NE *** differences lie in the presence of fan deltas in the NW region of Lake Hulun,but not in Lake ***,the width of the beach and eolian deposits on the downwind coast of Lake Hulun is three times greater than that of Lake Buir which were caused by the differences in sediment supply and wind fetch between the two *** Hulun and Lake Buir provide two reliable examples to understand the relationship among the wind field,provenance,hydrodynamics,landforms,and asymmetrical distribution of clastics in elongated *** also represent relevant modern analogs,which may also be of guiding significance to wind-driven sand body prediction in lacustrine basins.

关键词： Wind-driven lakes Fetch Sedimentary facies Hydrodynamics Geomorphology Spits Shoreline Lake Hulun Lake Buir

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Species-specific responses to drought,salinity and their interactions in Populus euphratica and *** seedlings

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Journal of Plant Ecology 2020年第5期13卷 563-573页

作者： Lei yu Haojie Dong Zhijun Li Zhanjiang Han helena Korpelainen Chunyang Li Department of Ecology College of Life and Environmental SciencesHangzhou Normal UniversityHangzhou 311121China Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang College of Life SciencesTarim UniversityAlar 843300China Department of Agricultural Sciences Viikki Plant Science CentrePO Box 27FI-00014 University of HelsinkiFinland

Aims Drought and salinity are severe abiotic stress factors,which limit plant growth and productivity,particularly in desert *** this study,we employed two desert poplars,Populus euphratica Oliver and Populus pruinosa Schrenk seedlings,to compare their tolerance to drought,salinity and combined *** We investigated species-specific responses of *** and *** in growth,photosynthetic capacity and pigment contents,nonstructural carbohydrate concentrations,Cl−allocation,osmotic regulation and the accumulation of reactive oxygen species(ROS)under drought,salinity and the combined *** Findings Populus pruinosa exhibited greater growth inhibitory effects,photosynthesis decline,stomatal closure and ROS accumulation,and lower antioxidant enzyme activities and osmotic regulation compared with *** under drought,salinity and especially under their combined *** the other hand,salt-stressed *** plants restricted salt transportation from roots to leaves,and allocated more Cl−to coarse roots and less to leaves,whereas salt-stressed *** allocated more Cl−to *** was shown that there is species-specific variation in these two desert poplars,and *** suffers greater negative effects compared with *** under drought,salinity and especially under the combined ***,in ecological restoration and afforestation efforts,species-specific responses and tolerances of these two poplar species to drought and salinity should be considered under climate change with increasing drought and soil salinity developing.

关键词： desert poplars drought and salinity Cl−allocation and transportation coarse and fine roots tolerance

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Lztfl1/BBS17 controls energy homeostasis by regulating the leptin signaling in the hypothalamic neurons

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Journal of Molecular Cell Biology 2018年第5期10卷 402-410页

作者： Qun Wei Yi-Feng Gu Qing-Jun Zhang helena yu Yan Peng Kevin W. Williams Ruitao Wang Kajiang yu Tiemin Liu Zhi-Ping Liu Department of Surgical Oncology and Institute of Clinical Medicine Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou 310016 China Department of Internal Medicine UT Southwestern Medical Center Dallas TX 75235 USA Department of Pathology UT Southwestern Medical Center Dallas TX 75235 USA Department of Intensive Care Unit The Third Affiliated Hospital Harbin Medical University Harbin 150081 China Sate Key Laboratory of Genetic Engineering School of Life Sciences Department of Endocrinology and Metabolism Zhongshan Hospital Collaborative Innovation Center for Genetics and Development Fudan University Shanghai 200438 China Department of Molecular Biology UT Southwestern Medical Center Dallas TX 75235 USA

Leptin receptor （LepRb） signaling pathway in the hypothalamus of the forebrain controls food intake and energy expenditure in response to an altered energy state. Defects in the LepRb signaling pathway can result in leptin-resistance and obesity. Leucine zipper transcription factor like 1 （Lztfl1）/BBS17 is a member of the Bardet-Biedl syndrome （BBS） gene family. Human BBS patients have a wide range of pathologies including obesity. The cellular and molecular mechanisms underlying Lztfl1-regulated obesity are unknown. Here, we generated Lztfl1lf/f mouse model in which Lztfl1 can be deleted globally and in tissue-specific manner. Global Lztfl1 deficiency resulted in pleiotropic phenotypes including obesity. Lztfl1^-/- mice are hyperphagic and showed similar energy expenditure as WT littermates. The obese phenotype of Lztfl1-/- mice is caused by the loss of Lztfl1 in the brain but not in the ***1-/- mice are leptin-resistant. Inactivation of Lztfl1 abolished phosphorylation of Stat3 in the LepRb signaling pathway in the hypothalamus upon leptin stimulation. Deletion of Lztfl1 had no effect on LepRb membrane localization. Furthermore, we observed that Lztfl1-/- mouse embryonic fibroblasts （MEFs） have significantly longer cilia than WT MEFs. We identified several proteins that potentially interact with Lztfl1. As these proteins are known to be involved in regulation of actin/cytoskeleton dynamics, we suggest that Lztfl1 may regulate leptin signaling and ciliary structure via these proteins. Our study identified Lztfl1 as a novel player in the LepRb signaling pathway in the hypothalamus that controls energy homeostasis.

关键词： obesity BBS leptin-resistance cilia actin/cytoskeleton

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Development and challenges of cells-and materials-based tooth regeneration

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Engineered Regeneration 2022年第2期3卷 163-181页

作者： Zeyu Fu yu Zhuang Jinjie Cui Ruilong Sheng helena Tomás João Rodrigues Bin Zhao Xudong Wang Kaili Lin Department of Oral and Cranio-Maxillofacial Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyResearch Unit of Oral and Maxillofacial Regenerative MedicineChinese Academy of Medical SciencesShanghai 200011China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9000-390 FunchalMadeiraPortugal School of Materials Science and Engineering Center for Nano Energy MaterialsNorthwestern Polytechnical UniversityXi’an710072China

Tooth defect and loss are common clinical diseases in *** the extension of life expectancy,there is an increasing demand for tooth tissue and whole tooth *** with traditional oral prosthetic treatment,tooth regeneration has unique advantages and has become one of the hotspots towards oral biomedical *** this review,we discussed the development and challenges of tooth regeneration based on cells and materials,including tooth enamel,dentin,dental pulp,cementum,dentin-pulp complex,and the whole tooth regeneration,in order to provide a comprehensive,up-to-date,illustrative overview of tooth regeneration *** mechanisms of the regeneration were also summarized and ***,this review hints the future perspective and research direction of tooth regeneration in the challenging field of regenerative dentistry.

关键词： Tooth regeneration Cells Materials Regenerative dentistry

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植物雌激素对血压的影响

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中华心血管病杂志 2006年第8期34卷 726-729页

作者：梁雨露 helenaTeede FabienDalais BarryPMcGrath 上海同济大学附属肺科医院心肺血管中心 200433 DepartmentofVascularSciences&MedicineDandenongHospital MonashUniversityAustralia

目的研究大豆饮食中所含的植物雌激素对健康人血压、血脂谱的影响。方法213名健康受试者(男性108人,绝经后女性105人),年龄50-75岁,随机、双盲接受特定大豆蛋白饮食(试验组)或酪蛋白安慰剂(安慰剂组)干预,为期3个月。建立多变量模型以... 详细信息

目的研究大豆饮食中所含的植物雌激素对健康人血压、血脂谱的影响。方法213名健康受试者(男性108人,绝经后女性105人),年龄50-75岁,随机、双盲接受特定大豆蛋白饮食(试验组)或酪蛋白安慰剂(安慰剂组)干预,为期3个月。建立多变量模型以评价治疗效果。结果饮食干预后,仅在试验组受试者尿液中植物雌激素含量增高。试验组血压较安慰剂组下降明显[收缩压(-7.5±1.2)mm Hg比(-3.6±1.1)mm Hg,P<0.01;舒张压(-4.3±0.8)mm Hg比(-1.9±0.7)mm Hg,P<0.05;平均压(-5.5±1.0)mm Hg比(-0.9±1.0)mm Hg,P<0.008]。试验组血脂水平较安慰剂组有显著改变(P<0.001),其中试验组低密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值显著下降[(-0.33±0.10) mmol/L比(0.04±0.10) mmol/L,P<0.05],甘油三酯水平也有显著下降[(-0.20±0.05)mmol/L比(-0.01±0.05)mmol/L,P<0.05],而脂蛋白(a)水平升高(±95%可信区间)[42(17-67)mg/L比4(-22-31)mg/L,P<0.05]。两组中总胆固醇和低密度脂蛋白胆固醇水平均下降,高密度脂蛋白胆固醇水平升高。副作用的发生率两组相似,并且都没有观察到男性激素水平发生改变。结论在正常血压男性和绝经后女性人群中,大豆饮食对血压和血脂水平有改善作用。

关键词：黄豆植物雌激素血压脂类

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空灵的表达:芭蕾作为全球身体文化的悖论

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当代舞蹈艺术研究 2022年第4期7卷 103-112页

作者： [瑞典]海伦娜·伍尔夫周渝(译) 瑞典斯德哥尔摩大学社会人类学系东南大学艺术学院

发端于19世纪浪漫主义的古典芭蕾,至今仍风靡于全球各地歌剧院。本文探讨了芭蕾作为一种全球身体文化,在台前幕后的那些时间、文化资本以及性别的悖论。本文依据源自斯德哥尔摩、伦敦和纽约三家国家芭蕾舞团,以及美因河畔法兰克福的法... 详细信息

发端于19世纪浪漫主义的古典芭蕾,至今仍风靡于全球各地歌剧院。本文探讨了芭蕾作为一种全球身体文化,在台前幕后的那些时间、文化资本以及性别的悖论。本文依据源自斯德哥尔摩、伦敦和纽约三家国家芭蕾舞团,以及美因河畔法兰克福的法兰克福当代芭蕾舞团的民族志研究,笔者建议保留古典芭蕾舞种。因为它不仅是一种“高雅”文化,而且是一种身体文化,数百年来一直通过身体传授与培养得以延续发展。在古典浪漫主义芭蕾形成的那段欧洲岁月中,超自然是一种时尚,阶级和文化背景对婚姻选择的影响远胜于今。我们可见芭蕾依旧能通过一些经典母题故事来感动观众,这些母题往往呈现爱与社会结构、准则、欲望和道德的缠结关系。最受欢迎的古典芭蕾舞剧如《天鹅湖》(Swan Lake)、《仙女》(La Sylphide)和《吉赛尔》(Giselle),这类舞剧均在激进的当代版本中遭遇挑战,这确立了古典芭蕾在芭蕾舞界及全社会各领域中的突出地位。文章基于不同地区芭蕾学校的比较民族志研究,旨在揭示芭蕾的一种全球性关联,进而指明芭蕾作为一种样式身体文化的稳固存在。

关键词：芭蕾时间文化资本性别礼仪规训全球化

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An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 386-403,I0014-I0016页

作者： Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan yusuf Yilmaz yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng Department of Nephrology Jiangnan University Medical CenterWuxiChina Affiliated Wuxi Clinical College of Nantong University WuxiChina Section of Endocrinology Diabetes and MetabolismDepartment of MedicineAzienda Ospedaliera Universitaria Integrata VeronaVeronaItaly Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southamptonand Southampton General HospitalUniversity of SouthamptonSouthamptonUK Department of Renal Medicine University College LondonLondonUK Department of Medicine and Therapeutics Chinese University of Hong KongHong KongChina Center for Fatty Liver Department of GastroenterologyXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Internal Medicine I GastroenterologyEndocrinology&MetabolismMedical University InnsbruckInnsbruckAustria Department of Nephrology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Division of Nephrology Department of MedicineWürzburg University ClinicWürzburgGermany Department of Endocrinology and Metabolism Zhongshan HospitalFudan UniversityShanghaiChina Section of Gastroenterology Boston Medical CenterBoston University School of MedicineBostonMAUSA Division of Nephrology Department of Medicine(M.K.)Koc University School of MedicineIstanbulTurkey Division of Gastroenterology and Hepatology Department of MedicineStanford University Medical CenterPalo AltoCAUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCAUSA Section of Nephrology and Institute of Clinical and Translational Research Baylor College of Medicineand Michael E.DeBakey VA Medical CenterHoustonTXUSA Department of Gastroenterology School of MedicineMarmara UniversityIstanbulTurkey Department of Gastroenterology School of MedicineRecep Tayyip Erdoğan UniversityRizeTurkey Department of Cardiology Shunde HospitalSouthern Medical UniversityFoshanChina Division of Hepat

Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly *** 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without ***,to date,there is no appropriate guidance on CKD in individuals with ***,there has been little attention paid to the link between MAFLD and CKD in the Nephrology *** and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and ***:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases.

关键词： Metabolic dysfunction-associated fatty liver disease(MAFLD) non-alcoholic fatty liver disease(NAFLD) chronic kidney disease(CKD) consensus

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血小板聚集率与富血小板血浆血小板浓度关系的研究

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中国实验血液学杂志 2017年第2期25卷 582-586页

作者：韩松梅廖文丽于帅中国人民解放军总医院海南分院内分泌科海南三亚572013 海南医学院热带医学与检验医学院海南海口571199 解放总医院海南分院检验中心海南三亚572013

目的:探讨富血小板血浆(PRP)中血小板浓度对血小板聚集率的影响,初步确定诱聚剂二磷酸腺苷(ADP:5.0和15μmol/L)和花生四烯酸(AA:500.0μg/ml)对血小板浓度的允许范围。方法:选取健康查体人群枸橼酸钠抗凝外周血标本72例,每12例标本混合... 详细信息

目的:探讨富血小板血浆(PRP)中血小板浓度对血小板聚集率的影响,初步确定诱聚剂二磷酸腺苷(ADP:5.0和15μmol/L)和花生四烯酸(AA:500.0μg/ml)对血小板浓度的允许范围。方法:选取健康查体人群枸橼酸钠抗凝外周血标本72例,每12例标本混合为1组,分6组。将各组标本混合后,分别制备不同水平的血小板浓度,利用海伦娜血小板聚集分析仪分别检测AA和ADP诱导下的6组不同血小板浓度水平的血小板聚集率。结果:当诱聚剂浓度升高,不同浓度的血小板聚集率会随之增高。随着血小板浓度升高,AA和ADP(15μmol/L)诱导的血小板聚集率均呈现先快速上升而后平缓的趋势,其中当Plt浓度低于200×10~9/L时,AA诱导的血小板聚集率随着血小板浓度的降低出现陡降,而ADP诱导的血小板聚集率随着血小板浓度的升高稍平缓些。当Plt>200×10~9/L,AA 500μg/ml和ADP 15μmol/L诱导时,不同浓度Plt的血小板聚集率变化平缓、波动较少,较稳定。结论:进行血小板聚集率检测时,AA和ADP诱聚剂对应的适宜Plt浓度应大于200×10~9/L。

关键词：血小板聚集率富含血小板血浆血小板浓度二磷酸腺苷花生四烯酸

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破译欧莱雅“玻色因”的“黑匣子”

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乐山师范学院学报 2021年第12期36卷 18-22页

作者：狄磊勤虞海陈建明田怡陈封政四川省轻工业研究设计院四川成都610002 乐山师范学院后勤保障服务部四川乐山614000 乐山师范学院化学与资源环境学院四川乐山614000 乐山师范学院乐山特色农产品药用成分研发工程中心四川乐山614000 乐山利源科技看限公司四川乐山614000

玻色因是法国欧莱雅集团的专利化妆品原料,具有改善皮肤弹性、减轻皱纹和增加皮肤紧致度的功效,其相关数据仍处于一种隐秘状态。为了深入阐明玻色因异构体的组成,以欧莱雅集团生产的郝连娜活颜修复舒缓晚霜为样品,对其玻色因活性成分进... 详细信息

玻色因是法国欧莱雅集团的专利化妆品原料,具有改善皮肤弹性、减轻皱纹和增加皮肤紧致度的功效,其相关数据仍处于一种隐秘状态。为了深入阐明玻色因异构体的组成,以欧莱雅集团生产的郝连娜活颜修复舒缓晚霜为样品,对其玻色因活性成分进行了高效液相色谱分析和制备液相色谱分离制备,首次建立了玻色因异构体的分析方法和制备纯化方法,并对纯化出的单体化合物进行了X-单晶衍射解析和核磁共振解析,破译了欧莱雅集团玻色因异构体的比例,明确了玻色因异构体的空间结构和核磁数据归属,指出了高效液相色谱图上异构体的具体归属。结果表明欧莱雅集团的玻色因可通过高效液相色谱将异构体分开,谱图上峰形为"前小后大",异构体比例约为47:53。该研究为国内化妆品行业更好了判断和鉴别玻色因的优劣奠定了基础。

关键词：玻色因欧莱雅集团羟丙基四氢吡喃三醇高效液相色谱

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