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Gene expression changes in blood RNA after swimming in a chlorinated pool

Journal of Environmental Sciences 2017年第8期29卷 250-261页

作者： Lucas A.Salas Laia Font-Ribera Mariona Bustamante Lauro Sumoy Joan O.Grimalt Sarah Bonnin Maria Aguilar heidi mattlin Manuela Hummel Anna Ferrer Manolis Kogevinas Cristina M.Villanueva ISGlobal Centre for Research in Environmental Epidemiology(CREAL)Barcelona Spain Department of Epiderniology The Geisel School of Medicine at Dartmouth Lebanon NH USA Universitat Pompeu Fabra (UPF) Barcelona Spain CIBER Epiclemiologia y Salud Publica (CIBERESP) Barcelona Spain IMIM (Hospital del Mar Medical Research Institute) Barcelona Spain Genomics and Disease Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology Barcelona Spain Genomics Core Facility Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology Barcelona Spain Institute of Predictive and Personalized Medicine of Cancer (IMPPC) Institut Germans Trias i Pujol (IGTP) Can Ruti Campus Badalona Spain Department of Environmental Chemistry Institute of Environmental Assessment and Water Research (CSIC) Barcelona Spain

Exposure to disinfection by-products（DBP） such as trihalomethanes（THM） in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes in blood gene expression of adult recreational swimmers after swimming in a chlorinated pool. Volunteers swam 40 min in an indoor chlorinated pool. Blood samples were drawn and four THM（chloroform,bromodichloromethane, dibromochloromethane and bromoform） were measured in exhaled breath before and after swimming. Intensity of physical activity was measured as metabolic equivalents（METs）. Gene expression in whole blood m RNA was evaluated using Illumina Human HT-12v3 Expression-Bead Chip. Linear mixed models were used to evaluate the relationship between gene expression changes and THM exposure. Thirty-seven before-after pairs were analyzed. The median increase from baseline to after swimming were： 0.7 to 2.3 for MET, and 1.4 to 7.1 μg/m^3 for exhaled total THM（sum of the four THM）.Exhaled THM increased on average 0.94 μg/m^3 per 1 MET. While 1643 probes were differentially expressed post-exposure. Of them, 189 were also associated with exhaled levels of individual/total THM or MET after False Discovery Rate. The observed associations with the exhaled THM were low to moderate（Log-fold change range：-0.17 to 0.15）. In conclusion, we identified short-term gene expression changes associated with swimming in a pool that were minor in magnitude and their biological meaning was unspecific. The high collinearity between exhaled THM levels and intensity of physical activity precluded mutually adjusted models with both covariates. These exploratory results should be validated in future studies.

关键词： Trihalomethanes Disinfection by-products Gene expression Swimming pools Metabolic rate

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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-Muñoz heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

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Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1077-1097页

作者： Lindokuhle Cindy Nene heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfontein 2028South Africa

Cancer remains one of the diseases with the highest incidence and mortality *** treatment modalities have demonstrated threatening drawbacks including invasiveness,noncontrollability,and development of resistance for some,including chemotherapy,radiation,and ***-photodynamic combinatorial therapy(SPDT)has been developed as an alternative treatment modality which offers a non-invasive and controllable therapeutic *** combines the mechanism of action of sonodynamic therapy(SDT),which uses ultrasound,and photodynamic therapy(PDT),which uses light,to activate a sensitizer and initiate cancer *** use of phthalocyanines(Pcs)as sensitizers for SPDT is gaining interest owing to their ability to induce intracellular oxidative stress and initiate toxicity under SDT and *** review discusses some of the structural prerequisites of Pcs which may influence their overall SPDT activities in cancer therapy.

关键词： Sonodynamic therapy Photodynamic therapy Combinatorial therapy Phthalocyanines Sensitizer Cancer

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Ecohydrological processes and ecosystem services in the Anthropocene: a review

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Ecological Processes 2017年第1期6卷 364-372页

作者： Ge Sun Dennis Hallema heidi Asbjornsen Eastern Forest Environmental Threat Assessment Center Southern Research StationU.S.Department of Agriculture Forest Service920 Main Campus Dr.Suite 300RaleighNC 27606USA Oak Ridge Institute for Science and Education U.S.Department of EnergyOak RidgeTN 37830USA Institute for the Study of Earth Oceansand SpaceUniversity of New HampshireDurhamNHUSA

The framework for ecosystem services has been increasingly used in integrated watershed ecosystem management practices that involve scientists,engineers,managers,and policy *** objective of this review is to explore the intimate connections between ecohydrological processes and water-related ecosystem services in human-dominated ecosystems in the *** synthesize current literature to illustrate the importance of understanding the ecohydrological processes for accurately quantifying ecosystem services under different environmental and socioeconomic settings and *** synthesis focuses on managed ecosystems that are dominated by humans and explores how ecological processes affect the tradeoffs and synergies of multiple ecosystem *** identify research gaps in studying ecological processes mainly including energy,carbon,water,and nutrient balances to better assess and quantify ecosystem services that are critical for sustaining natural resources for future *** better assess ecosystem services,future ecohydrological studies need to better account for the scaling effects of natural and anthropogenic stressors exerted on evapotranspiration and other water supply and demand *** studies should focus on the bidirectional interactions between hydrological functions and services and human actions to solve real world problems such as water shortages,ecological degradation,and climate change adaptation.

关键词： watershed services ecosystem

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Spatial context in the calculation of gas emissions for underground coal mines

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International Journal of Mining Science and Technology 2017年第5期27卷 787-794页

作者： Patrick Booth heidi Brown Jan Nemcik Ren Ting School of Civil Mining and Environmental EngineeringSchool of Earth and Environmental SciencesUniversity of WollongongWollongong 2500Australia

The prediction of gas emissions arising from underground coal mining has been the subject of extensive research for several decades, however calculation techniques remain empirically based and are hence limited to the origin of calculation in both application and resolution. Quantification and management of risk associated with sudden gas release during mining(outbursts) and accumulation of noxious or combustible gases within the mining environment is reliant on such predictions, and unexplained variation correctly requires conservative management practices in response to risk. Over 2500 gas core samples from two southern Sydney basin mines producing metallurgical coal from the Bulli seam have been analysed in various geospatial context including relationships to hydrological features and geological structures. The results suggest variability and limitations associated with the present traditional approaches to gas emission prediction and design of gas management practices may be addressed using predictions derived from improved spatial datasets, and analysis techniques incorporating fundamental physical and energy related principles.

关键词： Gas emission prediction Spatial analysis Underground coal mining Risk management Greenhouse gas Climate

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The Shifting Landscape of Latent Print Testimony:An American Perspective

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Journal of Forensic Science and Medicine 2017年第2期3卷 72-81页

作者： heidi Eldridge RTI International Research Triangle ParkNCUSA School of Criminal Justice University of LausanneLausanneSwitzeriand

Friction ridge comparison testimony in the United States has long been characterized by speaking in absolutes:fingerprints are unique,the Analysis,Comparison,Evaluation,and Verification methodology has a zero-error rate,and the testimony presented by the expert should be regarded as an incontrovertible *** the National Research Council released their watershed report in 2009,questioning and criticizing these clear overstatements of the strength of the evidence,many commentators and professional organizations recommended that the friction ridge community rethink the way their evidence was presented in reports and in ***,change has been slow to *** some agencies have begun a shift in the way they present their findings,many others still testify the same way they always *** paper presents the historical context of where American friction ridge testimony has been,lays out the arguments for why it needs to change,describes some recent efforts to improve,and highlights some likely directions for the future of friction ridge reporting and testimony in the United States.

关键词： Friction ridge latent prints testimony

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Hepatitis C virus:Is it time to say goodbye yet? Perspectives and challenges for the next decade

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World Journal of Hepatology 2015年第5期7卷 725-737页

作者： heidi Barth Laboratoire de Virologie Hopitaux Universitaires de Strasbourg67000 StrasbourgFrance

The majority of individuals exposed to hepatitis C virus(HCV) establish a persistent infection,which is a leading cause of chronic liver disease,cirrhosis and hepatocellular *** progress has been made during the past twenty-five years in understanding the HCV life cycle and immune responses against HCV *** evidence indicates that host genetic factors can significantly influence the outcome of HCV infection and the response to interferon alpha-based antiviral *** arrival of highly effective and convenient treatment regimens for patients chronically infected with HCV has improved prospects for the eradication of HCV *** trials are evaluating the best anti-viral drug combination,treatment doses and *** new treatments are better-tolerated and have shown success rates of more than 95%.However,the recent breakthrough in HCV treatment raises new questions and challenges,including the identification of HCVinfected patients and to link them to appropriate health care,the high pricing of HCV drugs,the emergence of drug resistance or naturally occurring polymorphism in HCV sequences which can compromise HCV treatment ***,we still do not have a vaccine against *** this concise review,we will highlight the progress made in understanding HCV infection and *** will focus on the most significant unsolved problems and the key future challenges in the management of HCV infection.

关键词： Pathogenesis Host genetics Direct-actingantivirals Drug resistance Vaccine Hepatitis C virus

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Caveolin and caveolae in age associated cardiovascular disease

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Journal of Geriatric Cardiology 2013年第1期10卷 66-74页

作者： heidi N. Fridolfsson Hemal H. Patel Departments of Anesthesiology University of California San Diego La Jolla California 92093 USA VA San Diego Healthcare System 3350 La Jolla Village Drive San Diego CA 92161 USA

It is estimated that the elderly (> 65 years of age) will increase from 13%��14% to 25% by 2035. If this trend continues, > 50% of the United States population and more than two billion people worldwide will be “aged”in the next 50 years. Aged individuals face formidable challenges to their health, as aging is associated with a myriad of diseases. Cardiovascular disease is the leading cause of morbidity andmortality in the United States with > 50% of mortality attributed to coronary artery disease and > 80%of these deaths occurring in those age 65 and older. Therefore, age is an important predictor of cardiovascular disease. The efficiency of youth is built upon cellular signaling scaffolds that provide tight and coordinated signaling. Lipid rafts are one such scaffold of which caveolae are a subset. In this review, we consider the importance of caveolae in common cardiovascular diseases of the aged and as potential therapeutic targets. We specifically address the role of caveolin in heart failure,myocardial ischemia, and pulmonary hypertension.

关键词： Cardiovascular disease Caveolin Lipid rafts The aged

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Improved source assessment of Si,Al and related mineral components to PM_(10) based on a daily sampling procedure

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Journal of Environmental Sciences 2010年第4期22卷 582-588页

作者： Ge Peng Hans Puxbaum heidi Bauer Nicole Jankowski Yao Shi Chemical Engineering College Ningbo University of Technology Ningbo 315016 China. Institute for Chemical Technologies and Analytics Vienna University of Technology Vienna 1060 Austria College of Environmental and Resource Sciences Zhejiang University Hangzhou 310027 China

Samples obtained from an industrialized valley in the East Alpine region were collected daily for a half year and analyzed using X-ray fluorescence to examine the elements Si, Al, Fe, Ca, Mg, Na, K, Zn, P, S and Cl. Some factors affecting the changes of these elements were considered, including time, elemental correlations, weekday, weekend and seasonal changes. Diagnostic analysis provided an insight into a decoupling behavior that occursin siliceous and carbonates minerals. A decrease in Si and Al and an increase in carbonates, Na, K, Zn and P were observed during the cold season. However, a consistently high correlation of Si and Al was observed in all seasons. It was established that such high levels originated from street surface abrasion. The increase in variability and absolute levels of carbonates during the cold season was demonstrated by adding carbonates to the street surface as gritting material to increase the grip on snowy surfaces. A marked increase in Na and Cl was observed in winter which may have been caused by thaw salt that is widely used in winter in Austria. This was associated with a significant increase in K, Zn, and P in the cold season that was the result of domestic space heating with wood. PM10 levels in December were 12 μ/m^3 and were higher than levels detected in July. It was established that such high levels originated from mineral oxides, wood smoke, and inorganic ionic material（s）.

关键词： particulate matter PM10 mineral aerosol silicates carbonates street dust wood combustion thaw salt

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