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Systematic Security Guideline Framework through Intelligently Automated Vulnerability Analysis

Computers, Materials & Continua 2024年第3期78卷 3867-3889页

作者： Dahyeon kim Namgi kim Junho Ahn Computer Information Technology Korea National University of TransportationChungju27469Korea Department of AI Computer Science and Engineering Kyonggi UniversitySuwon16227Korea

This research aims to propose a practical framework designed for the automatic analysis of a product’s comprehensive functionality and security vulnerabilities,generating applicable guidelines based on real-world *** existing analysis of software security vulnerabilities often focuses on specific features or *** partial and arbitrary analysis of the security vulnerabilities makes it challenging to comprehend the overall security vulnerabilities of the *** key novelty lies in overcoming the constraints of partial *** proposed framework utilizes data from various sources to create a comprehensive functionality profile,facilitating the derivation of real-world security *** guidelines are dynamically generated by associating functional security vulnerabilities with the latest Common Vulnerabilities and Exposure(CVE)and Common Vulnerability Scoring System(CVSS)scores,resulting in automated guidelines tailored to each *** guidelines are not only practical but also applicable in real-world software,allowing for prioritized security *** proposed framework is applied to virtual private network(VPN)software,wherein a validated Level 2 data flow diagram is generated using the Spoofing,Tampering,Repudiation,Information Disclosure,Denial of Service,and Elevation of privilege(STRIDE)technique with references to various papers and examples from related *** analysis resulted in the identification of a total of 121 *** successful implementation and validation demonstrate the framework’s efficacy in generating customized guidelines for entire systems,subsystems,and selected modules.

关键词： Framework automation vulnerability analysis security guidelines

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CFD-based hull optimization in calm water using adaptive grid deformation method

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Journal of Hydrodynamics 2024年第2期36卷 241-262页

作者： Shuguang Wang Yonghwan kim Department of Naval Architecture and Ocean Engineering Seoul National UniversitySeoulKorea

This paper presents an adaptive grid deformation technique for optimizing ship hull forms using computational fluid dynamics(CFD).The proposed method enables accurate and smooth updates of the hull surface and 3-D CFD grids in response to design *** technique incorporates a two-level point-transformation approach to move the grid points by a few design ***,generic B-splines are utilized to transform grid points according to the displacements of the control points within a defined control *** ensures surface modification accuracy and smoothness,similar to those provided by non-uniform rational ***,radial basis functions are used to interpolate the movements of the control points with a limited set of design *** developed method effectively maintains the mesh quality and simulation *** applying this method to surface and grid adaptation,a regression model is proposed in the form of a second-order polynomial to represent the relationship between the geometric parameters and design *** polynomial is then used to introduce geometric ***,a radial basis function surrogate model for the calm-water resistance is constructed to approximate the objective *** enhanced optimization framework is proposed for CFD–based hull optimization and applied to KVLCC2 to validate its feasibility and efficiency.

关键词： Hull-form optimization adaptive grid deformation ship resistance OpenFOAM radial basis function(RBF)surrogate model

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Fabrication of heteroatom-doped cobalt oxide yolk–shell microsphere using recycled solution from waste materials and their excellent electrochemical properties as an anode material for lithium-ion batteries

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Rare Metals 2024年第10期43卷 4934-4947页

作者： yeong Beom kim Chanho kim Seung-Hyun kim Yun Chan Kang Dongju Lee Gi Dae Park Department of Advanced Materials Engineering Chungbuk National University Department of Materials Science and Engineering Korea University Research Institute YKSintering Co.Ltd.

Heteroatom-doped transition metal oxides have attracted great attention as advanced anode materials for lithium-ion batteries due to their high theoretical capacity and superior ***,the limited resource availability has led to a substantial rise in prices for valuable metals such as Ni and Co,posing a significant challenge for their *** address this issue,recycling of these metals from waste materials have gained prominence,and particularly the recovery of Co has been mostly focused on its economic ***,we introduced a novel recycling strategy for fabrication of heteroatomdoped CoOx（comprising mainly Co3O4with a minor CoO phase） anode with a yolk–shell structure for lithium-ion batteries,by separating Co from cemented tungsten carbide *** employing a simple leaching process and subsequent spray pyrolysis,the yolk–shell structured microsphere comprising CoOxwas successfully ***,the presence of other waste metals in the leachate facilitated multi-heteroatom doping during ***,the introduction of various dopants into CoOxinduced oxygen vacancy formation,thereby enhancing the electrochemical properties of the *** a result,compared with the phase-pure （undoped） CoOxyolk–shell,the heteroatom-doped CoOxyolk–shell exhibited robust cycling stability (602 mAh·g-1for 200 cycles at 1 A·g-1) and excellent rate capability(210 mAh·g-1at 10 A·g-1).

关键词： Anode Cobalt oxide Heteroatom doping Lithium-ion batteries Recycling

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Incorporation of Ionic Conductive Polymers into Sulfide Electrolyte-Based Solid-State Batteries to Enhance Electrochemical Stability and Cycle Life

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Energy & Environmental Materials 2024年第6期7卷 4-12页

作者： Juhyoung kim Woonghee Choi Seong-Ju Hwang Dong Wook kim Advanced Materials Division Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea Department of Material Science and Engineering Yonsei UniversitySeoul 03722Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Korea Advanced Materials and Chemical Engineering University of Science and Technology(UST)Daejeon 34113Korea

Sulfide-based inorganic solid electrolytes are promising materials for high-performance safe solid-state *** high ion conductivity,mechanical characteristics,and good processability of sulfide-based inorganic solid electrolytes are desirable properties for realizing high-performance safe solid-state batteries by replacing conventional liquid ***,the low chemical and electrochemical stability of sulfide-based inorganic solid electrolytes hinder the commercialization of sulfide-based safe solid-state ***,the instability of sulfide-based inorganic solid electrolytes is intensified in the cathode,comprising various *** this study,carbonate-based ionic conductive polymers are introduced to the cathode to protect cathode materials and suppress the reactivity of sulfide *** instruments,including electrochemical spectroscopy,X-ray photoelectron spectroscopy,and scanning electron microscopy,confirm the chemical and electrochemical stability of the polymer electrolytes in contact with sulfide-based inorganic solid ***-based solid-state cells show stable electrochemical performance over 100 cycles when the ionic conductive polymers were applied to the cathode.

关键词： composite cathode electrochemical stability ionic conductive polymer solid-state battery sulfide solid electrolyte

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A comprehensive review on the resynthesis of ternary cathode active materials from the leachate of Li-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 446-463,I0010页

作者： Dongwoo kim Hyeoncheol Joo Chanmin kim Seoa kim Wan-Yi kim Sangwoo Han Joongkil Park Soyeon Park heechul Jung Sanghyuk Park Kyungjung Kwon Department of Energy and Mineral Resources Engineering Sejong UniversitySeoul 05006Republic of Korea LIB Recycling Research Group LIB Materials R&D CenterPOSCO HoldingsPohang 37859Republic of Korea Department of Future Energy Convergence Seoul National University of Science&Technology232 Gongreung-roNowon-guSeoul 01811Republic of Korea Autonomous Intelligent Unmanned Flying Vehicles Institute Sejong UniversitySeoul 05006Republic of Korea

This review highlights the importance of recovering valuable metals from spent Li-ion battery(LIB)cathodes through the resynthesis of cathode active materials(CAMs).The resynthesis process of CAMs,a promising recycling method that directly produces CAM precursors from LIB leachate,is *** process encompasses six key steps,including pretreatment,leaching,purification,adjustment of metal concentrations,precursor synthesis,and *** review also investigates the potential introduction of impurity elements during CAM resynthesis and provides tolerance levels for these impurities based on thorough reference ***,it addresses challenges related to the commercialization of the resynthesis ***,this review represents the first comprehensive assessment of CAM resynthesis,including the systematic evaluation of 12 impurity elements(Fe,Li,Al,Cu,C,P,F,Na,Cl,S,Mg,and Zn).Overall,this comprehensive review is poised to support the commercial development of resynthesized CAMs by offering valuable guidelines for managing impurities and streamlining the purification process.

关键词： Li-ion battery Recycling Resynthesis Leachate Impurity

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Retinal artery/arteriole occlusion risks after endovascular treatment for unruptured intracranial aneurysm

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Stroke & Vascular Neurology 2024年第3期9卷 295-305,I0251-I0263页

作者： Hae Rang kim Min Jeoung kim Sunyeup kim Myung Soo Chang Dong Joon kim Byung Moon kim Keun Young Park Yong Bae kim Christopher Seungkyu Lee Suk Ho Byeon Sung Soo kim Seung Won Lee Yong Joon kim Department of Ophthalmology CHA Bundang Medical CenterCHA University College of MedicineSeongnamKorea(the Republic of) Department of Neurosurgery Severance Stroke CenterSeverance HospitalYonsei University College of MedicineSeoulKorea(the Republic of) Department of Neurosurgery Uijeongbu St.Mary’s HospitalThe Catholic University of Korea College of MedicineUijeongbuKorea(the Republic of) Department of Medical AI Sungkyunkwan University School of MedicineSuwonKorea(the Republic of) Department of Ophthalmology Institute of Vision ResearchYonsei University College of MedicineSeoulKorea(the Republic of) Department of Radiology Severance Stroke CenterSeverance HospitalYonsei University College of MedicineSeoulKorea(the Republic of) Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonKorea(the Republic of)

Background To evaluate the association between retinal artery/arteriole occlusion(RAO)and unruptured intracranial aneurysm(UIA).Methods Incident UIA patients from a nationwide cohort(n=253240)were categorised into three groups based on subsequent treatment:observation(n=208993),microsurgical clipping(n=14168)and endovascular treatment(EVT)groups(n=30079).The incidence and the incident time of RAO were *** of RAO and associated risk factors were ***,a hospital cohort comprising 2569 consecutive UIA patients treated at a tertiary hospital was analysed with detailed clinical information of *** In the nationwide cohort analysis,the incidence of RAO was significantly higher in EVT group than in observation and clipping groups,especially within 60 days(early RAO(within 60 days):HR=4.00,95%CI:2.44 to 6.56);delayed RAO(after 60 days:HR=1.74,95%CI:1.13 to 2.68).Multivariable analysis showed that the presence of chronic kidney disease(p=0.009)and use of a balloon microcatheter during the procedure(p=0.013)were associated with a higher risk of *** hospital cohort analysis,11(0.8%)cases of RAO occurred after EVT,whereas none occurred after microsurgical clipping(p<0.001).Patients with RAO were younger and received balloon microcatheters more frequently than their *** cases of RAO(90.9%)occurred in paraclinoid aneurysms,where EVT was preferred over microsurgical *** Performing EVT for UIA may increase the risk of subsequent *** should be taken when treating paraclinoid aneurysms with balloon microcatheters.

关键词： treatment nationwide balloon

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Anomaly Detection in Imbalanced Encrypted Traffic with Few Packet Metadata-Based Feature Extraction

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 585-607页

作者： Min-Gyu kim Hwankuk kim Department of Financial Information Security Kookmin UniversitySeoul02707Republic of Korea Department of Information Security Cryptography Mathematics Kookmin UniversitySeoul02707Republic of Korea

In the IoT(Internet of Things)domain,the increased use of encryption protocols such as SSL/TLS,VPN(Virtual Private Network),and Tor has led to a rise in attacks leveraging encrypted *** research on anomaly detection using AI(Artificial Intelligence)is actively progressing,the encrypted nature of the data poses challenges for labeling,resulting in data imbalance and biased feature extraction toward specific *** study proposes a reconstruction error-based anomaly detection method using an autoencoder(AE)that utilizes packet metadata excluding specific node *** proposed method omits biased packet metadata such as IP and Port and trains the detection model using only normal data,leveraging a small amount of packet *** makes it well-suited for direct application in IoT environments due to its low resource *** experiments comparing feature extraction methods for AE-based anomaly detection,we found that using flowbased features significantly improves accuracy,precision,F1 score,and AUC(Area Under the Receiver Operating Characteristic Curve)score compared to packet-based ***,for flow-based features,the proposed method showed a 30.17%increase in F1 score and improved false positive rates compared to Isolation Forest and ***,the proposedmethod demonstrated a 32.43%higherAUCwhen using packet features and a 111.39%higher AUC when using flow features,compared to previously proposed oversampling *** study highlights the impact of feature extraction methods on attack detection in imbalanced,encrypted traffic environments and emphasizes that the one-class method using AE is more effective for attack detection and reducing false positives compared to traditional oversampling methods.

关键词： One-class anomaly detection feature extraction auto-encoder encrypted traffic CICIoT2023

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Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

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Signal Transduction and Targeted Therapy 2024年第1期9卷 173-210页

作者： Md Entaz Bahar Hyun Joon kim Deok Ryong kim Department of Biochemistry and Convergence Medical Sciences and Institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea Department of Anatomy and Convergence Medical Sciences and Institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea

Metastatic dissemination of solid tumors,a leading cause of cancer-related mortality,underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis,chemoresistance,and the mechanistic backgrounds of individuals whose cancers are prone to *** most prevalent signaling cascade governed by multi-kinase inhibitors is the mitogen-activated protein kinase(MAPK)pathway,encompassing the RAS–RAF–MAPK kinase(MEK)–extracellular signal-related kinase(ERK)*** kinase is a primary mediator of the MAPK pathway,responsible for the sequential activation of downstream targets,such as MEK and the transcription factor ERK,which control numerous cellular and physiological processes,including organism development,cell cycle control,cell proliferation and differentiation,cell survival,and *** in this signaling cascade are associated with diseases such as *** inhibitors(RAFi)combined with MEK blockers represent an FDAapproved therapeutic strategy for numerous RAF-mutant cancers,including melanoma,non-small cell lung carcinoma,and thyroid ***,the development of therapy resistance by cancer cells remains an important ***,an intracellular lysosome-dependent catabolic recycling process,plays a critical role in the development of RAFi resistance in ***,targeting RAF and autophagy could be novel treatment strategies for RAF-mutant *** this review,we delve deeper into the mechanistic insights surrounding RAF kinase signaling in tumorigenesis and ***,we explore and discuss the ongoing development of next-generation RAF inhibitors with enhanced therapeutic ***,this review sheds light on the functional interplay between RAF-targeted therapies and autophagy in cancer.

关键词： RAF insight mechanism

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik kim Soyeon kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Strengthening mechanisms analysis and tailoring of bimodal grain structures for enhanced strength in CoCrFeMnNi high-entropy alloys

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Rare Metals 2024年第8期43卷 3893-3903页

作者： Jaesoung Lee Seulgi kim Taehyun Kwon Young II kim Suyeon kim Sung Ho Song Bin Lee Dongju Lee Department of Urban Energyand Environmental EngineeringChungbuk National UniversityCheongju 28644Republic of Korea Division of Advanced Materials Engineering Kongju National UniversityChungnam 330-717Republic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated-Education Institute for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYongin17104Republic of Korea

The CoCrFeMnNi high-entropy alloys(HEAs)with a(face-centered cubic) FCC structure has garnered considerable attention for its exceptional ductility and strain hardening ***,its yield strength is insufficient for structural *** this study,strengthening mechanisms in these HEAs were investigated to gain insight into the mechanical properties according to alloy powder ***,we present a novel approach to achieve both high strength and high ductility through the creation of a bimodal structure consisting of both coarse and fine grains via gas atomization and spark plasma sintering processes.A bimodally structured HEA prepared with a mass ratio of 2:8 between coarse particles(75-106 μm) and fine particles(≤25 μm)yielded optimal results,with a strength of 491.95 MPa and elongation of 19.64%.This strength value represents an~41% increase compared with the sample that displayed a fine single microstructure(347.08 MPa for yield strength).The strength enhancement was attributed to the prevention of plastic deformation initiation from the fine particles during *** innovative approach to the creation of HEAs with bimodal structures shows promise for various applications,such as structural components that require a combination of high strength and high ductility.

关键词： High-entropy alloys CrCoFeMoNi Bimodal Gas atomization Mechanical properties

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