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Korean red ginseng promotes hippocampal neurogenesis in mice

Neural Regeneration Research 2020年第5期15卷 887-893页

作者： Sun Ryu Hyongjun Jeon hee-young kim Sungtae Koo Seungtae kim Korean Medicine Research Center for Healthy Aging Pusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National University49 Busandaehak-roMulgeum-eupYangsan-siGyeongsangnam-do 50612Republic of Korea

Neurogenesis in the adult hippocampus plays a major role in cognitive ability of animals including learning and *** red ginseng (KRG) has long been known as a medicinal herb with the potential to improve learning and memory;however,the mechanisms are still ***,we evaluated whether KRG can promote cognitive function and enhance neurogenesis in the ***-week-old male C57BL/6 mice received 50 mg/kg of 5-bromo-2′-deoxyuridine (BrdU) intraperitoneally and 100 mg/kg of KRG or vehicle orally once a day for 14 ***,Rotarod and Morris water maze tests were performed and the brains were collected after the last behavioral *** in the numbers of BrdU- and BrdU/ doublecortin (DCX;a marker for neuronal precursor cells and immature neurons)-positive cells in the dentate gyrus and the gene expression of proliferating cell nuclear antigen (a marker for cell differentiation),cerebral dopamine neurotrophic factor and ciliary neurotrophic factor in the hippocampus were then ***-treated mice came down the pole significantly faster and stood on the rotarod longer than vehicle-treated *** Morris water maze test showed that KRG administration enhanced the learning and memory abilities *** also significantly increased BrdU- and BrdU/DCX-positive cells in the dentate gyrus as well as the proliferating cell nuclear antigen,cerebral dopamine neurotrophic factor and ciliary neurotrophic factor mRNA expression levels in the hippocampus compared to *** of KRG promotes learning and memory abilities,possibly by enhancing hippocampal *** study was approved by the Pusan National University Institutional Animal Care and Use Committee (approval ***-2016-1071) on January 19,2016.

关键词： bromodeoxyuridine cerebral dopamine neurotrophic factor ciliary neurotrophic factor doublecortin ginseng hippocampus Korean red ginseng learning memory neurogenesis proliferating cell nuclear antigen red ginseng

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Korean red ginseng decreases 1-methyl-4-phenylpyridinium-induced mitophagy in SH-SY5Y cells

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Journal of Integrative Medicine 2021年第6期19卷 537-544页

作者： Hyongjun Jeon hee-young kim Chang-Hwan Bae Yukyung Lee Sungtae Koo Seungtae kim Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Korean Medicine Research Center for Healthy Aging Pusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea

Objective:Mitophagy is known to contribute towards progression of Parkinson’s *** red ginseng(KRG)is a widely used medicinal herb in East Asia,and recent studies have reported that KRG prevents 1-methyl-4-phenylpyridinium ion(MPP^(+))-induced cell *** study was undertaken to investigate whether KRG suppresses MPP^(+)-induced apoptosis and ***:SH-SY5 Y cells were incubated with KRG for 24 h,and subsequently exposed to MPP^(+).The MPP^(+)-induced cell death was confirmed with the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay,and the terminal deoxynucleotidyl transferase-mediated d UTP nick end-labeling *** in the structure and function of mitochondria were confirmed using mitotracker,Mito SOX red mitochondrial superoxide indicator,parkin,and phosphatase and tensin homolog deleted on chromosome ten-induced putative kinase 1(PINK1)immunofluorescent *** blotting was performed to evaluate the expression of apoptosis-related factors in whole cells,including Bax,Bcl-2 and cleaved caspase-3,and mitophagy-related factors in the mitochondrial fraction,including cytochrome c,parkin,PINK1,translocase of the outer membrane 20(TOM20),p62 and Beclin ***:MPP^(+)induced cell death by cytochrome c release and caspase-3 activation;however,this effect was suppressed by KRG’s regulation of the expressions of Bcl-2 and ***,MPP^(+)exposure increased the mitochondrial expressions of parkin,PINK1,Beclin 1 and p62,and decreased TOM20,cytochrome c and Bcl-2 *** MPP^(+)-induced changes in the mitochondrial fraction were attenuated by treatment with ***:KRG effectively prevents MPP^(+)-induced SH-SY5 Y cell death by regulating cytochrome c release from mitochondria and PINK1/parkin-mediated mitophagy,through regulation of the Bcl-2 family.

关键词： Parkinson’s disease Apoptosis Mitophagy 1-Methyl-4-phenylpyridinium Korean red ginseng

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Effect of Pd content on crystallization and shape memory properties of Ti-Ni-Pd thin films

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International Journal of Smart and Nano Materials 2011年第1期2卷 9-21页

作者： hee young kim Yimin Yuan Tae-hyun Nam Shuichi Miyazaki Institute of Materials Science University of TsukubaTsukubaIbaraki 305-8573Japan School of Materials Science and Engineering&ERI Gyeongsang National University900 GazwadongJinjuGyeongnam 660-701Korea

The Pd content dependence of the crystallization process of Ti–Ni–(19.1–35.3)Pd(at.%)thin films fabricated by a sputter-deposition method was ***–Ni–(19.1–26.1)Pd(at.%)as-deposited thin films were found to be amorphous,whereas Ti–Ni–(29.1–35.3)Pd(at.%)thin films were crystalline in the as-deposited *** the crystallization temperature and activation energy for the crystallization of the amorphous thin films decrease with increasing Pd *** shape memory effect was confirmed in the in situ crystallized thin *** finer grain size in the in situ crystallized thin film results in a higher critical stress for slip and a smaller recovery strain when compared with the thin film crystallized by post annealing.

关键词： shape memory alloy thin film martensitic phase transformation crystallization sputtering

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Visible light induced catalytic properties of CdSe-graphene nanocomposites and study of its bactericidal effect

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Chinese Chemical Letters 2014年第6期25卷 941-946页

作者： Kefayat Ullah young-hee kim Byung-Eui Lee Sun-Bok Jo Lei Zhu Shu Ye Won-Chun Oh Department of Advanced Materials Science﹠Engineering Hanseo University Department of Immunology College of MedicineSoonchunhyang UniversityCheonan 330-721Republic of Korea Department of Chemistry Soonchunhyang UniversityAsanChungnam 336-745Republic of Korea

A novel composite, CdSe-graphene, was synthesized using facile hydrothermal method. The structural characteristics studies of the synthesized composites were investigated by X-ray diffraction （XRD）, scanning electron microscope （SEM）, transmission electron microscope （TEM）, Brunauer, Emmett, Teller specific surface area （BET） and X-ray photoelectron spectroscopy （XPS）. The photocatalytic activity was investigated by the degradation of methylene blue as standard dye. The degradation of M8 was calculated based on the decrease in concentration of the dye with respect to regular time intervals. The reusability tests were done to investigate the stability of the used catalysts. Additionally the antibacterial activity of CdSe-graphene was also investigated using bacterium Streptococcus aureus （S. aureus）.

关键词： Semiconductors Hydrothermal method Antimicrobial Photocatalysis

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Postmortem ^(7)Li NMR analysis for assessing the reversibility of lithium metal electrodes in lithium metal batteries

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Journal of Energy Chemistry 2024年第7期94卷 430-440页

作者： Jaewon Baek Sunha kim hee-Tak kim Oc hee Han Department of Chemical&Biomolecular Engineering KAISTDaejeon 34141Republic of Korea Metropolitan Seoul Center Korea Basic Science InstituteSeoul 03759Republic of Korea Graduate School of Analytical Science&Technology Chungnam National UniversityDaejeon 34134Republic of Korea

Despite the proficiency of lithium(Li)-7 NMR spectroscopy in delineating the physical and chemical states of Li metal electrodes,challenges in specimen preparation and interpretation impede its *** this study,we conducted a comprehensive postmortem analysis utilizing ^(7)Li NMR,employing a stan-dard magic angle spinning probe to examine protective-layer coated Li metal electrodes and LiAg alloy electrodes against bare Li metal electrodes within Li metal batteries(LMBs).Our investigation explores the effects of sample burrs,alignment with the magnetic field,the existence of liquid electrolytes,and precycling on the ^(7)Li NMR *** contrasting NMR spectra before and after cycling,we identi-fied alterations in Li^(0) and Li^(+) signals attributable to the degradation of the Li metal *** NMR analyses decisively demonstrate the efficacy of the protective layer in mitigating dendrite and solid elec-trolyte interphase ***,we noted that Li*ions near the Li metal surface exhibit magnetic susceptibility anisotropy,revealing a novel approach to studying diamagnetic species on Li metal elec-trodes in *** study provides valuable insights and practical guidelines for characterizing distinct lithium states within LMBs.

关键词： NMR spectroscopy Lithium-7 Lithium metal battery Electrolyte Electrode-protective layer Solid electrolyte interface Magnetic susceptibility anisotropy Lithium-metal NMR signal Diamagnetic^(7)Li NMR signal

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Primary Ewing sarcoma of the kidney mimicking cystic papillary renal cell carcinoma in an older patient:A case repor

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World Journal of Clinical Cases 2024年第15期12卷 2606-2613页

作者： Suhong kim Jongsoo Park young Hwii Ko hee Jung Kwon Department of Radiology Yeungnam UniversityDaegu 42415South Korea Department of Urology Yeungnam UniversityDaegu 42415South Korea Department of Pathology Yeungnam UniversityDaegu 42415South Korea

BACKGROUND Ewing’s sarcoma(ES)is a neuroectodermal tumor that typically occurs in the bones and soft tissues of children and young *** renal ES is rare;only a few cases and a small case series have been documented,and only four cases involved primary renal ES in older people(>65 years old).CASE SUMMARY Herein,we describe the radiological and pathological features of primary renal ES in an older person.A 76-year-old man complained of poor oral intake and was found to have a large cystic renal mass with indistinct margins on computed ***-guided biopsy revealed that the tumor contained small round blue *** patient underwent a right radical *** tumor cells showed diffuse membranous CD99,and nuclear friend leukemia integration 1 transcription factor and NK2 Homeobox *** in situ hybridization revealed EWSR1 ***,18F-fluorodeoxyglucose positron emission tomography revealed no evidence of *** patient was diagnosed with primary renal *** months following the surgery,local recurrence and distant metastasis were *** renal ES is rare and often lethal in older *** specific imaging findings are unknown,and treatment protocols have not been *** This case report describes the radiological and pathological features of primary renal ES in an older person.

关键词： Ewing sarcoma Elder Renal Kidney Neuroectodermal Case report

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Comparison of clinical outcomes after femtosecond laser in situ keratomileusis in eyes with low or high myopia

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International Journal of Ophthalmology(English edition) 2020年第11期13卷 1780-1787页

作者： Su Hwan Park Cheng-Ye Che Sung Il kim Choul Yong Park Jong Heon Lee young hee kim Ji Won Jung Jong Soo Lee Ji Eun Lee Department of Ophthalmology School of MedicinePusan National UniversityYangsan 50612Gyeongnam ProvinceRepublic of Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsan 50612Gyeongnam ProvinceRepublic of Korea Department of Ophthalmology the Affiliated Hospital of Medical CollegeQingdao UniversityQingdao 266003Shandong ProvinceChina Department of Ophthalmology Dongguk University Ilsan HospitalDongguk University College of MedicineGoyang 10326Gyeonggi ProvinceRepublic of Korea Busan Medical Center Busan 47527Republic of Korea BalGunNun Eye Hospital Busan 47195Republic of Korea

AIM:To compare the clinical results of femtosecond(FS)laser in situ keratomileusis(LASIK)in high myopic patients and low myopic ***:This study included 212 myopic eyes undergoing LASIK using a VisuMax 500kHz FS *** treated eyes were assigned to one of two groups according to preoperative manifest spherical refraction:low myopia group(A,>-4.0 D)and high myopia group(B,0.50 D in spherical equivalent from Iwk to 6mo postoperatively(P=0.005).In terms of postoperative astigmatism,each group had 89.1%and 76.6%within±0.50 D,respectively and there was significant difference(P=0.006).Group A tends to induce smaller HOAs than group ***:FS LASIK is effective and safe for correcting high myopia as well as low ***,high myopic eyes showed more postoperative astigmatism and HOAs which affect visual acuity.

关键词： femtosecond laser LASIK myopia

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Insights into the changes in the surface properties of goethite with Ni in the lattice in the presence of salicylhydroxamic acid:Experimental and density functional theory studies

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 665-677页

作者： Levie Mweene Gilsang Hong hee-Eun Jeong hee-won Kang Hyunjung kim Department of Earth Resources and Environmental Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea

Comparative experiments and theoretical analysis of the surface chemistry changes of goethite(GT)and goethite containing Ni(GTN)in the lattice in the presence of salicylhydroxamic acid(SA)were *** was revealed that in the presence of 100 g·t^(-1)of SA,the flotation recovery of GTN and GT increased with increasing pH,achieving a maximum recovery of 98.9%for both minerals at p H 8.3 and decreasing beyond that pH,with GTN having a slightly higher recovery than GT,except at pH *** was further confirmed by the higher complexation energies of GTN···SA(-883.87 kJ·mol^(-1))compared with GT···SA(-604.23 kJ·mol^(-1))resulting from covalent,closed-shell,and conventional hydrogen *** higher adsorption of SA onto GTN relative to GT was due to the formation of aπ-hole in GTN,thereby promoting a higher interaction of the collector with the ***,the presence of Ni in the GT lattice improves and decreases the adsorption and desorption of SA onto and from the mineral,respectively,compared with those onto and from GT.

关键词： nickel goethite adsorption salicylhydroxamic acid recovery

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Development and application of a multi-step porcine in vitro system to evaluate feedstuffs and feed additives for their efficacy in nutrient digestion, digesta characteristics, and intestinal immune responses

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Animal Nutrition 2024年第2期17卷 265-282页

作者： hee Yeon kim Jun-Ok Moon Sung Woo kim Application Center CJ Blossom Park Department of Animal Science North Carolina State University

In vitro model provides alternatives to the use of live animals in research. In pig nutrition, there has been a tremendous increase in in vivo research over the decades. Proper utilization of in vitro models could provide a screening tool to reduce the needs of in vivo studies, research duration, cost, and the use of animals and feeds. This study aimed to develop a multi-step porcine in vitro system to simulate nutrient digestion and intestinal epithelial immune responses affected by feedstuffs and feed additives. Seven feedstuffs(corn, corn distillers dried grains with solubles [corn DDGS], barley, wheat, soybean meal, soy protein concentrates, and Corynebacterium glutamicum cell mass [CGCM]), feed enzymes(xylanase and phytase), and supplemental amino acids(arginine, methionine, and tryptophan), were used in this in vitro evaluation for their efficacy on digestibility, digesta characteristics, and intestinal health compared with the results from previously published in vivo studies. All in vitro evaluations were triplicated. Data were analyzed using Mixed procedure of SAS9.4. Evaluations included(1) nutrient digestibility of feedstuffs,(2) the effects of feed enzymes, xylanase and phytase, on digestibility of feedstuffs and specific substrates, and(3) the effects of amino acids, arginine, tryptophan, and methionine, on anti-inflammatory, anti-oxidative, and anti-heat stress statuses showing their effects(P < 0.05) on the measured items. Differences in dry matter and crude protein digestibility among the feedstuffs as well as effects of xylanase and phytase were detected(P < 0.05), including xylo-oligosaccharide profiles and phosphorus release from phytate. Supplementation of arginine, tryptophan, and methionine modulated(P < 0.05) cellular inflammatory and oxidative stress responses. The use of this in vitro model allowed the use of 3 experimental replications providing sufficient statistical power at P < 0.05. This indicates in vitro models can have increased prec

关键词： Digestion Feed additive Feedstuff In vitro Intestine Pig

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Methane Emission from Rice Fields:Necessity for Molecular Approach for Mitigation

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Rice science 2024年第2期31卷 159-178页

作者： Sujeevan RAJENDRAN Hyeonseo PARK Jiyoung kim Soon Ju PARK Dongjin SHIN Jong-hee LEE young Hun SONG Nam-Chon PAEK Chul Min kim Department of Horticulture Industry Wonkwang UniversityIksan 54538Korea Plant Molecular Biology and Biotechnology Research Center Gyeongsang National UniversityJinju 52828Korea Department of Southern Area Crop Science National Institute of Crop ScienceMiryang 50424Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Plant Science Plant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Korea

Anthropogenic methane emissions are a leading cause of the increase in global averagetemperatures,often referred to as global *** soils play a significant role in methaneproduction,where the anaerobic conditions promote the production of methane by *** fields contribute a considerable portion of agricultural methane emissions,as riceplants provide both factors that enhance and limit methane *** plants harbor both methaneproducingand methane-oxidizing *** from rice roots provide source for methaneproduction,while oxygen delivered from the root aerenchyma enhances methane *** haveshown that the diversity of these microorganisms depends on rice cultivars with some genes characterizedas harboring specific groups of microorganisms related to methane ***,there is still aneed for research to determine the balance between methane production and oxidation,as rice plantspossess the ability to regulate net methane *** agronomical practices,such as fertilizerand water management,have been employed to mitigate methane ***,studiescorrelating agronomic and chemical management of methane with productivity are ***,evidences for breeding low-methane-emitting rice varieties are scattered largely due to the absence ofcoordinated breeding *** has indicated that phenotypic characteristics,such as rootbiomass,shoot architecture,and aerenchyma,are highly correlated with methane *** reviewdiscusses available studies that involve the correlation between plant characteristics and *** emphasizes the necessity and importance of breeding low-methane-emitting rice varieties inaddition to existing agronomic,biological,and chemical *** review also delves into the idealphenotypic and physiological characteristics of low-methane-emitting rice and potential breeding techniques,drawing from studies conducted

关键词： methane emission rice breeding aerenchyma greenhouse gas radial oxygen loss

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