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Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model

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Chinese Journal of Natural Medicines 2017年第3期15卷 192-201页

作者： JANG sun-hee par. Jisang KIM Sae-Hae CHOI Kyung-Min KO Eun-Sil CHA Jeong-Dan LEE Young-Ran JANG Hyonseok JANG Yong-Suk Depar.ment of Molecular Biology and Institute for Molecular Biology and Genetics Chonbuk National UniversityJeonju 54896Korea Depar.ment of Bioactive Material Sciences and Research Center of Bioactive Materials Chonbuk National UniversityJeonju 54896Korea Depar.ment of Efficacy Research Institute of Jinan Red GinsengJinan 55442Korea Depar.ment of Mathematics Sogang UniversitySeoul 04107Korea Depar.ment of Oral Maxillofacial Surgery Korea University Ansan HospitalAnsan 15355Korea

Red ginseng is a well-known alternative medicine with anti-inflammatory *** exerts pharmacological effects through the transformation of saponin into metabolites by intestinal *** that intestinal microflora vary among individuals,the pharmacological effects of red ginseng likely vary among *** order to produce homogeneously effective red ginseng,we prepar.d probiotic-fermented red ginseng and evaluated its activity using a dextran sulfate sodium(DSS)-induced colitis model in *** analysis of intestinal damage indicated that the administration of probiotic-fermented red ginseng significantly decreased the severity of colitis,compar.d with the control and the activity was higher than that induced by oral administration of ginseng powder or probiotics *** analysis of the levels of serum IL-6 and TNF-α,inflammatory biomarkers that are increased at the initiation stage of colitis,were significantly decreased in probiotic-fermented red ginseng-treated groups in compar.son to the control *** levels of inflammatory cytokines and mR NAs for inflammatory factors in colorectal tissues were also significantly decreased in probiotic-fermented red ginseng-treated ***,oral administration of probiotic-fermented red ginseng reduced the severity of colitis in a mouse model,suggesting that it can be used as a uniformly effective red ginseng product.

关键词： Colitis Fermentation Inflammation Probiotics Red ginseng

Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第48期24卷 5477-5490页

作者： Waqar Khalid Saeed Dae Won Jun Kiseok Jang Sang Bong Ahn Ju hee Oh Yeon Ji Chae Jai sun Lee Hyeon Tae Kang Depar.ment of Gastroenterology Hanyang University College of Medicine Seoul 04763 South Korea Depar.ment of Pathology Hanyang University College of Medicine Seoul 04763 South Korea Depar.ment of Internal Medicine Eulji University Daejeon 34824 South Korea Depar.ment of Translational Medicine Hanyang University College of Medicine Seoul 04763 South Korea

AIM To validate the effects of receptor interacting protein kinase-3(RIP3) deletion in non-alcoholic fatty liver disease(NAFLD) and to clarify the mechanism of *** Wild-type(WT) and RIP3 knockout(KO) mice werefed normal chow and high fat(HF) diets for 12 wk. The body weight was assessed once weekly. After 12 wk, the liver and serum samples were extracted. The liver tissue expression levels of RIP3, microsomal triglyceride transfer protein, protein disulfide isomerase, apolipoprotein-B, X-box binding protein-1, sterol regulatory element-binding protein-1c, fatty acid synthase, cluster of differentiation-36, diglyceride acyltransferase, peroxisome proliferator-activated receptor alpha, tumor necrosis factor-alpha(TNF-α), and interleukin-6 were assessed. Oleic acid treated primary hepatocytes from WT and RIP3 KO mice were stained with Nile red. The expression of inflammatory cytokines, including chemokine(C-X-C motif) ligand(CXCL) 1, CXCL2, and TNF-α, in monocytes was *** RIP3 KO HF diet fed mice showed a significant gain in body weight, and liver weight, liver to body weight ratio, and liver triglycerides were increased in HF diet fed RIP3 KO mice compar.d to HF diet fed WT mice. RIP3 KO primary hepatocytes also had increased intracellular fat droplets compar.d to WT primary hepatocytes after oleic acid treatment. RIP3 overexpression decreased hepatic fat content. Quantitative real-time polymerase chain reaction analysis showed that the expression of very-low-density lipoproteins secretion markers(microsomal triglyceride transfer protein, protein disulfide isomerase, and apolipoprotein-B) was significantly suppressed in RIP3 KO mice. The overall NAFLD Activity Score was the same between WT and RIP3 KO mice; however, RIP3 KO mice had increased fatty change and decreased lobular inflammation compar.d to WT mice. Inflammatory signals(CXCL1/2, TNF-α, and interleukin-6) increased after lipopolysaccharide and pancaspase inhibitor(necroptotic conditi

关键词： Necroptosis Receptor interacting protein kinase-3 Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Steatosis

Interleukin-2 gene-encoded stromal cells inhibit the growth of metastatic cholangiocarcinomas

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World Journal of Gastroenterology 2006年第12期12卷 1889-1894页

作者： Myung-HwanKim Sang Soo Lee sung Koo Lee Seung-Gyu Lee Chul-Won Suh Gyung-Yub Gong Jung-sun par. Young-Hoon Kim Sang-hee Kim Depar.ment of Gastroenterology University of Ulsan College of MedicineAsan Medical CenterSeoulKorea Depar.ment of Surgery University of Ulsan College of MedicineAsan Medical CenterSeoulKorea Depar.ment of Oncology University of Ulsan College of MedicineAsan Medical CenterSeoul Korea Depar.ment of Pathology University of Ulsan College of MedicineAsan Medical CenterSeoulKorea Asan Institute for Life Sciences.Seoul Korea

AIM： To demonstrate bone marrow stromal cells （BMSCs） can be used as an attractive target for genetic modification in the treatment of malignant diseases. METHODS： Using a hamster model of biliary cancer, we investigated the therapeutic effects of interleukin-2 （IL-2） gene-modified BHSCs. Syrian golden hamsters were injected via the femoral vein with 5×10^5 cells of the KIGB-5 biliary cancer cell line （n=20）. One week later, the hamsters were injected intraperitoneally with BMSCs containing Ad/hIL-2 and Ad/△E1, unmodified BHSCs, or RPHI only （control） and observed for 12 wk （n=5/each group）. RESULTS： All hamsters treated with BMSCs containing Ad/hIL-2 survived with no evidence of the disease during this period. In contrast, hamsters in the other three groups showed disseminated metastases involving the lungs as eady as 4 wk.CONCLUSION： Ad/IL-2 therapy is effective in the treatment of biliary cancer.

关键词： Bone marrow stromal cell Adenovirus/hIL-2 Biliary cancer

韩国豹猫与其它豹猫及西表猫之间的遗传分化：基于IRBP、12S rRNA和Cyt b序列的分析(英文)

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兽类学报 2014年第4期34卷 374-380页

作者： KOH Hung sun KWEON Gu hee HAM Eui Jeong JANG Kyung hee YANG Beong Guk AN Na Hyeon Depar.ment of Biology Chungbuk University Cheongju 361-763 Korea National Institute of Environmental Research Incheon 404 - 708 Korea

利用韩国豹猫的IRBP、12S rRNA和细胞色素b(Cyt b)序列,并将其与Gen Bank中的豹猫及西表猫的上述基因进行比较,以此来重新分析韩国豹猫和其它豹猫及西表猫之间的遗传分化情况。首先,我们从18只韩国豹猫的IRBP、12S rRNA和Cyt b序列分析... 详细信息

利用韩国豹猫的IRBP、12S rRNA和细胞色素b(Cyt b)序列,并将其与Gen Bank中的豹猫及西表猫的上述基因进行比较,以此来重新分析韩国豹猫和其它豹猫及西表猫之间的遗传分化情况。首先,我们从18只韩国豹猫的IRBP、12S rRNA和Cyt b序列分析中分别检测到6个等位基因、1个单倍型和3个单倍型,推测曾经发生在豹猫种群的瓶颈事件可能是本文发现的不同分子标记之间存在基因型丢失差异的原因。基于Cyt b序列分析,证实东亚的豹猫形成一个单独的进化枝,本文得到的Cyt b序列和之前发布结果支持一个分类理论,即认为东亚的豹猫就是东北森林猫。我们发现在IRBP、12S rRNA基因上,韩国豹猫和西表猫存在相同的序列,支持将西表猫和豹猫视为同一物种。

关键词：种群瓶颈核基因和线粒体DNA 豹猫 DNA系统分类学西表猫韩国

2.5 GHz Multi-Channels Tunable Wavelength Converter Based on Cross Gain Modulation in Semiconductor Optical Amplifier

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光学学报 2003年第S1期23卷 349-350页

作者： Moon-Soon Kim Dong-Hyun Song Suk-Hun Lee Jin-hee Kim Sang-sun Lee Jyung-Chan Lee Dept of Electric and Computer Engineering Hanyang University Korea.Dept of Electric and Computer Engineering Hanyang University Korea.Dept of Electric and Computer Engineering Hanyang University Korea.Dept of Electric and Computer Engineering Hanyang University Korea.Dept of Electric and Computer Engineering Hanyang University Korea.Electronics and Telecommunication Research Institute Korea

Characteristics of 2.5GHz tunable wavelength converter multi-channels in conventional band based on cross gain modulation in a semiconductor optical amplifier are demonstrated.

关键词： in as SOA for AWG have of that

Function of flavonoids on different types of programmed cell death and its mechanism:a review

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The Journal of Biomedical Research 2019年第6期33卷 363-370页

作者： Preethi Vetrivel Seong Min Kim Venu Venkatarame Gowda Saralamma Sang Eun Ha Eun hee Kim Tae sun Min Gon Sup Kim Research Institute of Life Science and College of Veterinary Medicine Gyeongsang National UniversityJinju 52828Korea Depar.ment of Nursing Science International University of KoreaJinju 52833Korea Faculty of Biotechnology SARIJeju National UniversityJeju 63243Korea

Cell death in the living system plays a vital role in maintaining the homeostasis and balancing the cell count in the *** cell death(PCD)is a crucial component of several development and defense *** is also important in terms of aging which avoids the accumulation of cellular damage by maintaining cell *** on the execution of cell death and its role in destruction,PCD is categorized into several *** major different forms of PCD in animals are apoptosis,autophagy and necrosis,which can be distinct in morphological *** intense investigations of cell death have given close insight showing other important types of cellular destruction and their pivotal roles in treating disease conditions like *** have been acquired a great interest for disease therapies and chemoprevention through activation of several PCD *** significant potential of natural flavonoids in the induction of distinct signaling cascades is being a massive approach for targeting uncontrolled cell *** these reasons,understanding PCD mechanisms is a promising approach for the interventions in treating ***,it is intriguing that understanding the different forms of PCD mechanism induced by flavonoids with more accurate descriptions on the biochemical and cellular processes are gaining more significance in cancer ***,we provide a brief overview on the different types of PCD and aim to discuss the functional role of flavonoids in promoting different types of cell death as well as an extensive brief review on their mechanism of action has been highlighted.

关键词： programmed cell death apoptosis necrosis autophagy anoikis

Investigations on Structural Safety of Office Room Based on Fire Simulation and Transient Heat Transfer Analysis

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World Journal of Engineering and Technology 2014年第3期2卷 20-26页

作者： Ah Young An Eun Mi Ryu hee sun Kim Depar.ment of Architectural Engineering Ewha Woman’s University Seoul Korea

This study aims at investigating heat propagations inside the structural members due to fire using fire simulation and transient heat transfer analysis. Toward that goal, fire simulation and transient heat transfer analysis for a 5-story building are carried out sequentially using Fire Dynamics Simulator (FDS) and ABAQUS 6.10-3, respectively. As results from fire simulation, temporal temperature information is obtained depending on various locations of the building, which is used as boundary condition for the structural elements generated in transient heat transfer analysis. Predictions from the transient heat transfer analysis show that the structural members are exposed spatially non-uniform temperatures which can cause significant eccentric deformation and aceleration of structural damages.

关键词： Fire Simulation Heat Transfer Structural Safety Fire

Risk factors for metachronous gastric carcinoma development after endoscopic resection of gastric dysplasia: Retrospective, single-center study

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World Journal of Gastroenterology 2017年第24期23卷 4407-4415页

作者： hee Seok Moon Gee Young Yun Ju Seok Kim Hyuk Soo Eun sun Hyung Kang Jae Kyu sung Hyun Yong Jeong Kyu-Sang Song Depar.ment of Internal Medicine Chungnam National University Hospital Chungnam National University School of Medicine Depar.ment of Pathology Chungnam National University Hospital Chungnam National University School of Medicine

To determine the gastric adenocarcinoma (GAC) occurrence rate and related factors, we evaluated the follow-up results of patients confirmed to have gastric dysplasia after endoscopic resection (ER). METHODSWe retrospectively analyzed the medical records, endoscopic examination records, endoscopic procedure records, and histological records of 667 cases from 641 patients who were followed-up for at least 12 mo, from among 1273 patients who were conformed to have gastric dysplasia after Endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) of gastric mucosal lesions between January 2007 and August 2013 at the Chungnam National University Hospital. RESULTSThe mean follow-up period was 33.8 mo, and the median follow-up period was 29 mo (range: 12-87). During the follow-up period, the occurrence of metachronous GAC was 4.0% (27/667). The mean and median interval periods between the occurrence of metachronous GAC and endoscopic treatment of gastric dysplasia were 36.3 and 34 mo, respectively (range: 16-71). The factors related to metachronous GAC occurrence after ER for gastric dysplasia were male sex (5.3% vs 1.0%), open-type atrophic gastritis (9.5% vs 3.4%), intestinal metaplasia (6.8% vs 2.4%), and high-grade dysplasia (HGD; 8.4% vs 3.2%). Among them, male sex [OR: 5.05 (1.18-21.68), P = 0.029], intestinal metaplasia [OR: 2.78 (1.24-6.23), P = 0.013], and HGD [OR: 2.70 (1.16-6.26), P = 0.021] were independent related factors in multivariate analysis. Furthermore, 24 of 27 GAC cases (88.9%) occurred at sites other than the previous resection sites, and 3 (11.1%) occurred at the same site as the previous resection site. CONCLUSIONMale sex, intestinal metaplasia, and HGD were significantly related to the occurrence of metachronous GAC after ER of gastric dysplasia, and most GACs occurred at sites other than the previous resection sites.

关键词： Gastric dysplasia Neoplasms Second primary Endoscopic mucosal resection Stomach neoplasms

Assessing significant fibrosis using imaging-based elastography in chronic hepatitis B patients: Pilot study

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World Journal of Gastroenterology 2019年第25期25卷 3256-3267页

作者： hee sun par. Won Hyeok Choe Hye Seung Han Mi Hye Yu Young Jun Kim sung Il Jung Jeong Han Kim So Young Kwon Depar.ment of Radiology Konkuk University School of MedicineSeoul 05030South Korea Depar.ment of Internal Medicine Konkuk University School of MedicineSeoul 05030South Korea Depar.ment of Pathology Konkuk University School of MedicineSeoul 05030South Korea

BACKGROUND Accurate detection of significant fibrosis(fibrosis stage 2 or higher on the METAVIR scale)is important especially for chronic hepatitis B(CHB)patients with high viral loads but with normal or mildly elevated alanine aminotransferase(ALT)levels because the presence of significant fibrosis is accepted as the indication for antiviral *** biopsy is the reference standard for diagnosing significant fibrosis,but it is an invasive ***,noninvasive imaging-based measurements,such as magnetic resonance elastography(MRE)or two-dimensional shear-wave elastography(2DSWE),have been proposed for the quantitative assessment of liver *** To explore MRE and 2D-SWE to identify fibrosis stage,and to compar. their performance with that of serum-based *** The study enrolled 63 treatment-na?ve CHB patients with high viral loads but with normal or mildly elevated ALT levels who underwent liver biopsy before a decision was made to initiate antiviral *** and 2D-SWE were performed,and serum-based indices,such as FIB-4 and aspar.ate transaminase to platelet ratio index(APRI),were *** diagnostic performances of MRE,2D-SWE,FIB-4,and APRI for assessing significant fibrosis(≥F2)and cirrhosis(F4)were evaluated with liver histology as the reference standard,using receiver operating characteristic *** The liver fibrosis stage was F0/F1 in 19,F2 in 14,F3 in 14,and F4 in 16 patients,*** significantly discriminated F2 from F0/1(P=0.022),whereas 2D-SWE showed a broad overlap in distinguishing those *** showed a higher correlation coefficient value with fibrosis stage than 2D-SWE with fibrosis stage(0.869 vs 0.649,Spearman test;P<0.001).Multivariate linear regression analyses showed that fibrosis stage was the only factor affecting the values of MRE(P<0.001),whereas body mass index(P=0.042)and fibrosis stage(P<0.001)were independent factors affecting 2D-SWE *** performance for diagnos

关键词： Antiviral therapy Chronic hepatitis B Liver fibrosis Magnetic resonance elastography Ultrasound elastography