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Two distinct stem cell-like subtypes of hepatocellular carcinoma with clinical significance and their therapeutic potentials

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Cancer Communications 2022年第2期42卷 179-183页

作者： Sung hwan Lee Yun Seong Jeong Sunyoung Lee Bo hwa Sohn ho Kyoung hwang Gi hong Choi Chang Moo Kang Jin Sub Choi Woo Jung Lee Jae-ho Cheong hee Jin Jang Ahmed Kaseb Lewis Roberts Sun Young Yim Yun Shin Chun Ju-Seog Lee Department of Systems Biology the University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722Republic of Korea Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryCHA Bundang Medical CenterCHA UniversitySeongnam 13496Republic of Korea Department of GI Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Surgery Yonsei University Health SystemYonsei University College of MedicineSeoul 03722Republic of Korea Division of Thoracic Surgery Michael E.DeBakey Department of SurgeryBaylor College of MedicineHoustonTX 77030USA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMN 55902USA Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 02841Republic of Korea Department of Surgery The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Dear Editor Hepatocellular carcinoma(HCC)is among the most com-mon cancers worldwide,causing about 600,000 deaths annully[1].In HCC,stem cell-like characteristics,which drive early recurrence and therapy resistance,are major contributors to poor prognosis[2].In this current study,we integrated and analyzed gene expression data from human fetal liver cells and primary HCC tumors(n=1231)*** two clinically and biologically distinct hepatic stem cell(HS)subtypes,potential biomarkers associated with these subtypes,and a potential new therapeutic inter-vention for these subtypes.

关键词： therapeutic subtypes prognosis

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Enhanced efficiency in lead-free bismuth iodide with post treatment based on a hole-conductor-free perovskite solar cell

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Nano Research 2018年第12期11卷 6283-6293页

作者： Jongmoon Shin Maengsuk Kim Sujeong Jung Chang Su Kim Jucheol Park Aeran Song Kwun-Bum Chung Sung-ho Jin Jun hee Lee Myungkwan Song Surface Technology Division Korea Institute of Materials Science (K/MS)797ChangwondaeroSungsan-GuChangwonGyeongnam642-83IRepublic of Korea School of Energy and Chemical Engineering Ulsan Nationallnstitute ofSdence &Technology(UNIST)Ulsan44919Republic of Korea Structure Analysis Group Gyeongbuk Science &Technology Promotion CenterFuture Strategy Research Institute17Cheomdangieop 1-roSangdong-myeonGumiGyeongbuk39171Republic of Korea Division of Physics andSemiconductorScience Dongguk UniversitySeou1100-715Repubfic of Korea Department of Chemistry Education Graduate Department of Chemical Materialsand Institute for Plastic Information and Energy MaterialsPusan National UniversityBusan 46241Republicof Korea

Despite the excellent merits of lead perovskite solar cells, their instability and toxicity still present a bottleneck for practical applications. Bismuth perovskite has emerged as a candidate for photovoltaic (PV) applications, because it not only has a low toxicity but is also stable in air. however, the power conversion efficiency (PCE) remains an unsolved problem. We performed band gap tuning experiments to improve the efficiency. The absorption of ABi3I10 structure films was extended within the visible region, and the optical band gap was decreased considerably compared to that for Cs3Bi2I9. Furthermore, we explained the correlation between the structure and the optical properties via a first-principles study. A device employing CsBi3I10 as a photoactive layer exhibits a PCE of 1.51% and an excellent ambient stability over 30 days.

关键词： solar cells perovskite band-gap engineering bismuth halide lead free

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Conventional endoscopic features are not sufficient to differentiate small, early colorectal cancer

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World Journal of Gastroenterology 2014年第21期20卷 6586-6593页

作者： Wan Park Bun Kim Soo Jung Park Jae hee Cheon Tae Il Kim Won ho Kim Sung Pil hong Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea

AIM: To evaluate the depth of invasion of small, early colorectal cancers (ECCs) using conventional endoscopic features.

关键词： Colonoscopy Colorectal neoplasms Differential diagnosis

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High efficiency and stable solid-state fiber dye-sensitized solar cells obtained using TiO_(2) photoanodes enhanced with metal organic frameworks

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Journal of Energy Chemistry 2022年第4期31卷 458-466页

作者： Jae ho Kim Hyun Woo Park Sung-Jun Koo Daseul Lee Eunyeong Cho Yong-Ki Kim Myunghun Shin Jin Woo Choi hee Jung Lee Myungkwan Song Department of Energy and Electronic Material Korea Institute of Materials Science(KIMS)797 Changwon-daeroSungsan-guChangwonGyeongsangnam-do 51508Republic of Korea Composites Research Division Korea Institute of Materials Science(KIMS)797 Changwon-daeroSungsan-GuChangwonGyeongsangnam-do 51508Republic of Korea School of Electronics and Information Engineering Korea Aerospace UniversityGoyang-cityGyeonggi-do 10540Republic of Korea

Solid-state fiber dye-sensitized solar cells(SS-FDSSCs) have been the subject of intensive attention and development in recent years. Although this field is only in its infancy, metal–organic frameworks(MOFs) are one such material that has been utilized to further improve the power conversion efficiency of solar cells. In this study, MOF-integrated DSSCs were shown to have potential in the development of solar cell devices with efficiency comparable to or better than that of conventional solar cells. The power conversion efficiency(PCE) of SS-FDSSCs was improved by embedding MOF-801 into a mesoporous-TiO_(2)(mp-TiO_(2)) layer, which was used as a photoanode in SS-FDSSCs, which are inherently flexible. The PCE of the MOF-integrated SS-FDSSCs was 6.50%, which is comparable to that of the reference devices(4.19%).The MOF-801 enhanced SS-FDSSCs decreased the series resistance(R_(s)) value, resulting in effective electron extraction with improved short-circuit current density(J_(SC)), while also increasing the shunt resistance(R_(sh)) value to prevent the recombination of photo-induced electrons. The result is an improved fill factor and, consequently, a higher value for the PCE.

关键词： Photoanode Metal organic frameworks Solid-state electrolyte Dye-sensitized solar cells Fiber-shaped solar cells

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Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain

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Neural Regeneration Research 2015年第7期10卷 1101-1106页

作者： ho-Sung Lee Dai-In Kang Seung Zhoo Yoon Yeon hee Ryu Inhyung Lee hoon-Gi Kim Byung-Cheon Lee Ki Bog Lee Ki Primo Research Laboratory Division of Electrical Engineering KAIST Institute for Information Technology Convergence Korea Advanced Institute of Science and Technology (KAIST) Nadi Primo Research Institute Graduate School of Integrative Medicine Sun Moon University Pharmacopuncture Medical Research Center Korean Pharmacopuncture Institute Department of Anesthesiology and Pain Medicine College of Medicine Korea University Acupuncture Moxibustion & Meridian Research Group Medical Research Division Korea Institute of Oriental Medicine Department of Veterinary Surgery College of Veterinary Medicine Seoul National University Faculty of Liberal Education Seoul National University Korea Atomic Energy Research Institute

With chromium-hematoxylin staining, we found evidence for the existence of novel age-dependent network structures in the dura mater of rat brains. Under stereomicroscopy, we noticed that chromium-hematoxylin-stained threadlike structures, which were barely observable in 1-weekold rats, were networked in specific areas of the brain, for example, the lateral lobes and the cerebella, in 4-week-old rats. In 7-week-old rats, those structures were found to have become larger and better networked. With phase contrast microscopy, we found that in 1-week-old rats, chromium-hematoxylin-stained granules were scattered in the same areas of the brain in which the network structures would later be observed in the 4- and 7-week-old rats. Such age-dependent network structures were examined by using optical and transmission electron microscopy, and the following results were obtained. The scattered granules fused into networks with increasing age. Cross-sections of the age-dependent network structures demonstrated heavily-stained basophilic substructures. Transmission electron microscopy revealed the basophilic substructures to be clusters with high electron densities consisting of nanosized particles. We report these data as evidence for the existence of age-dependent network structures in the dura mater, we discuss their putative functions of age-dependent network structures beyond the general concept of the dura mater as a supporting matrix.

关键词： nerve regeneration dura mater chromium-hematoxylin staining fascia primo vascular system brain hormone neural regeneration

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Different cutoff values of methacholine bronchial provocation test depending on age in children with asthma

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World Journal of Pediatrics 2017年第5期13卷 439-445页

作者： Eun Lee Young-ho Kim Seungbong Han Song-I Yang Young-ho Jung Ju-hee Seo Hyo-Bin Kim So Yeon Lee Ji-Won Kwon Soo-Jong hong Department of Pediatrics Chonnam National University HospitalGwangjuKorea Department of Pediatrics Gyeongsang National University Changwon HospitalChangwonKorea Department of Applied Statistics Gachon UniversitySeongnamKorea Department of Pediatrics Hallym University Sacred Heart HospitalAnyangKorea Department of Pediatrics Bundang CHA Medical CenterCHA University School of MedicineSeongnamKorea Department of Pediatrics Dankook University College of MedicineCheonanKorea Department of Pediatrics Inje University Sanggye Paik HospitalSeoulKorea Department of Pediatrics Childhood Asthma Atopy CenterResearch Center for Standardization of Allergic DiseasesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pediatrics Seoul National University Bundang HospitalSeongnamKorea

Background:Bronchial hyperresponsiveness (BHR) is a fundamental pathophysiological characteristic of *** several factors such as airway caliber can affect BHR,no study has established age-dependent cutoff values of BHR to methacholine for the diagnosis of asthma in *** investigated the cutoff values of the methacholine challenge test (MCT) in the diagnosis of asthma according to ***:A total of 2383 individuals aged from 6 to 15 years old were included in this *** using the five-breath technique were performed in 350 children with suspected asthma based on symptoms by pediatric allergists and in 2033 healthy children from a general population-based *** determined the provocative concentration of methacholine producing a 20% decrease in forced expiratory volume in 1 second from baseline (PC20).A modified Korean version of the International Study of Asthma and Allergies in Childhood questionnaire was used to distinguish asthmatics and healthy *** characteristic curve analysis was used to assess the cutoff value of PC20 for the diagnosis of ***:Cutoff values of methacholine PC20,which provided the best combination of diagnostic sensitivity and specificity,showed an increasing pattern with age:5.8,9.1,11.8,12.6,14.9,21.7,23.3,21.1,21.1,and 24.6 mg/mL at ages 6,7,8,9,10,11,12,13,14,and 15 years,***:The application of different cutoff values of methacholine PC20 depending on age might be a practical modification for the diagnosis of asthma in children and adolescents with asthmatic symptoms.

关键词： asthma bronchial hyperresponsiveness cutoff value receiver-operator characteristics

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Amylase level in extra hepatic bile duct in adult patients with choledochal cyst plus anomalous pancreatico-biliary ductal union

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World Journal of Gastroenterology 2005年第13期11卷 1965-1970页

作者： In-ho Jeong Yong-Sik Jung hong Kim Bong-Wan Kim Jung-Woon Kim Jeong hong hee-Jung Wang Myung-Wook Kim Byung-Moo Yoo Jin-hong Kim Jae-ho Han Wook-hwan Kim Department of Surgery Department of Gastroenterology Department of Pathology

AIM: To investigate the relationship between pancreatic amylase in bile duct and the clinico-pathological features in adult patients with choledochal cyst and anomalous pancreatico-biliary ductal union (APBDU).METhoDS: From 39 patients who underwent surgery for choledochal cyst between March 1995 and March 2003,we selected 15 adult patients who had some symptoms and were radiologically diagnosed as APBDU, and their clinico-pathological features were subsequently evaluated retrospectively. however, we could not obtain biliary amylase in all the patients because of the surgeon's ***, we measured the amylase level in gall bladder of 10 patients and in common bile duct of 11 ***: Levels of amylase in common bile duct and gall bladder ranged from 11 500 to 212 000 IU/L, and the younger the patients, the higher the biliary amylase level (r= -0.982, P＜0.01). Pathologically, significant correlation was found between the size of choledochal cyst and the grade of inflammation (r= 0.798,P＜0.01). And, significant correlation was found between the level of amylase in gall bladder and the grade of hyperplasia. On the other hand, there was no correlation to the age of symptomatic onset or inflammatory grade (r = 0.743, P＜0.05). Level of lipase was elevated from 6 000 to 159 000 IU/L in bile duct and from 14 400 to 117 000 IU/L in the gall bladder;however, there was no significant correlation with age or clinico-pathological ***: The results support the notion that amylase has a particular role in the onset of symptoms, and suggest that a large amount of biliary amylase induces early onset of symptom, thereby making early diagnosis possible.

关键词： Choledochal cyst Anomalous pancreaticobiliary ductal union Amylase Hyperplasia

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Gallbladder Metastasis of Non-small Cell Lung Cancer Presenting as Acute Cholecystitis

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Chinese Journal of Cancer Research 2012年第3期24卷 249-252页

作者： Yu-Sook Jeong Hye-Suk Han Sung-Nam Lim Mi-Jin Kim Joung-ho Han Min-ho Kang Dong-hee Ryu Ok-Jun Lee Ki-Hyeong Lee Seung-Taik Kim Department of Internal Medicine College of MedicineChungbuk National University Department of Radiology College of MedicineChungbuk National University Department of Surgery College of MedicineChungbuk National University Department of Pathology College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University

Although non-small cell lung cancer （NSCLC） can metastasize to almost any organ, metastasis to the gallbladder with significant clinical manifestation is relatively rare. Here, we report a case of gallbladder metastasis of NSCLC presenting as acute cholecystitis. A 79-year-old man presented with pain in the right upper quadrant and fever. A computed tomography （CT） scan of the chest and abdomen showed a cavitary mass in the right lower lobe of the lung and irregular wall thickening of the gallbladder. Open cholecystectomy and needle biopsy of the lung mass were performed. Histological examination of the gallbladder revealed a moderately-differentiated squamous cell carcinoma displaying the same morphology as the lung mass assessed by needle biopsy. Subsequent immunohistochemical examination of the gallbladder and lung tissue showed that the tumor cells were positive for P63 but negative for cytokeratin 7, cytokeratin 20 and thyroid transcription factor-1. A second primary tumor of the gallbladder was excluded by immunohistochemical methods, and the final pathological diagnosis was gallbladder metastasis of NSCLC. Although the incidence is extremely rare, acute cholecystitis can occur in association with lung cancer metastasis to the gallbladder.

关键词： Cholecystitis Gallbladder Non-small cell lung cancer Metastasis

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Actinomycosis of the appendix mimicking appendiceal tumor:A case report

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World Journal of Gastroenterology 2010年第3期16卷 395-397页

作者： Sang-Yun Lee hee-Jin Kwon Jin-Han Cho Jong-Young Oh Kyung-Jin Nam Jin-hwa Lee Seong-Kuk Yoon Myong-Jin Kang Jin-Sook Jeong Department of Radiology Dong-A University Hospital Department of Pathology Dong-A University Hospital

Actinomycosis is an uncommon chronic infectious disease. Common sites of involvement include the cervicofacial, thoracic and abdominopelvic regions. In abdominopelvic actinomycosis, the ileocecal region, including the appendix, is the most commonly involved site. In some reports, limited appendiceal actinomycosis has revealed a thickened appendiceal wall with peri-appendiceal inflammation as acute appendicitis or perforated appendicitis. We experienced pathologically confirmed intraluminal limited appendiceal actinomycosis without peri-appendiceal infiltration. Here, we report the computed tomography and ultrasound findings.

关键词： Actinomyces Actinomycosis Appendiceal neoplasms Appendicitis

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Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease

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World Journal of Gastroenterology 2012年第40期18卷 5771-5778页

作者： Hyun Jung Lee Youn Nam Kim Hui Won Jang Han ho Jeon Eun Suk Jung Soo Jung Park Sung Pil hong Tae Il Kim Won ho Kim Chung Mo Nam Jae hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Department of Biostatistics Yonsei University College of MedicineSeoul 120-752South Korea Department of Preventive Medicine Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METhoDS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April *** also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with *** endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was *** determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were ***:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the *** endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ***,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD *** with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the ***:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD ***,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak.

关键词： Intestinal Behcet's disease Disease activityindex Colonoscopy Ulcer Endoscopic severity

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