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Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury

Neural Regeneration Research 2020年第3期15卷 548-556页

作者： Si-Qun Jing Sai-Sai Wang Rui-Min Zhong Jun-Yan Zhang Jin-Zi Wu Yi-xian tu Yan Pu Liang-Jun Yan Yingdong College of Food Science and Engineering Shaoguan UniversityShaoguanGuangdong ProvinceChina School of Bioengineering Jiangnan UniversityWuxiJiangsu ProvinceChina Department of Pharmaceutical Sciences UNT System College of PharmacyUniversity of North Texas Health Science CenterFort WorthTXUSA College of Life Sciences and Technology Xinjiang UniversityUrumqiXinjiang Uygur Autonomous RegionChina

Orientin is a flavonoid *** recent years,its importance as a source of pharmacological active substance is growing rapidly due to its properties such as anti-myocardial ischemia,anti-apoptosis,anti-radiation,anti-tumor,and ***,the neuroprotective effects of Orientin on stroke injury have not been comprehensively *** aim of the present study was thus to investigate the neuroprotective capacity and the potential mechanisms of Cyperus esculentus ***(CLO)from Cyperus esculentus *** against ischemia/reperfusion(I/R)injury using standard orientin as *** in vitro studies,we treated HT22 cells with CoCl2 as an in vitro ischemic injury ***22 cells in the control group were treated with *** in vivo studies,we used rat models of middle cerebral artery occlusion,and animals that received sham surgery were used as *** found that CLO protected CoCl2-induced HT22 cells against ischemia/reperfusion injury by lowering lipid peroxidation and reactive oxygen species formation as well as decreasing protein ***,CLO did not reduce the release of lactate dehydrogenase nor increase the activity of superoxide *** showed that CLO could decrease neurological deficit score,attenuate brain water content,and reduce cerebral infarct volume,leading to neuroprotection during cerebral ischemia-reperfusion *** studies indicate that CLO flavonoids can be taken as a natural antioxidant and bacteriostastic substance in food and pharmaceutical *** molecular mechanisms of CLO could be at least partially attributed to the antioxidant properties and subsequently inhibiting activation of *** experimental procedures and protocols were approved on May 16,2016 by the Experimental Animal Ethics Committee of Xinjiang Medical University of China(approval ***20160516-57).

关键词： antioxidants caspase-3 cerebral ischemia/reperfusion injury cobalt chloride Cyperus esculentus L.orientin(CLO) lipid peroxidation nerve regeneration neurological deficits oxidative stress reactive oxygen species

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Neolignans and Norlignans from Insect Medicine Polyphaga plancyi and Their Biological Activities

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Natural Products and Bioprospecting 2021年第1期11卷 51-62页

作者： Hong-Jie Zhu Te Xu Yong-Ming Yan Zheng-Chao tu Yong-xian Cheng School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhen 518060People’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) College of PharmacyJinan UniversityGuangzhou 510632People’s Republic of China Drug Discovery Pipeline&Guangdong Provincial Key Laboratory of Biocomputing Guangzhou Institutes of Biomedicine and HealthGuangzhou 510530People’s Republic of China

Ten neolignans or norlignans(1-10)including eight new compounds were isolated from the whole bodies of Polyphaga plancyi *** structures were identified by spectroscopic *** 3,4,8,and 9 are racemates indicated by chiral HPLC *** separation followed by ECD calculations allowed to clarify the absolute configurations of all the *** the new compounds were evaluated for their biological properties toward extracellular matrix in rat renal proximal tubular cells,human cancer cells(K562,A549,and Huh7),EV71,ROCK2,JAK3,DDR1,and coagulation.

关键词： Polyphaga plancyi Insect medicine Lignans Renal protection Anticoagulant activity

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Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid-βand Prevents Alzheimer’s Disease-Type Pathology and Cognitive Deficits

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Neuroscience Bulletin 2023年第12期39卷 1775-1788页

作者： Zhi-Hao Liu Yu-Di Bai Zhong-Yuan Yu Hui-Yun Li Jie Liu Cheng-Rong Tan Gui-Hua Zeng Yun-Feng tu Pu-Yang Sun Yu-Juan Jia Jin-Cai he Yan-Jiang Wang xian-Le Bu Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China Institute of Brain and Intelligence Third Military Medical UniversityChongqing400042China State Key Laboratory of Trauma Burns and Combined InjuryThird Military Medical UniversityChongqing400042China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai201200China

Deficiencies in the clearance of peripheral amyloidβ(Aβ)play a crucial role in the progression of Alzheimer’s disease(AD).Previous studies have shown that the ability of blood monocytes to phagocytose Aβis decreased in ***,the exact mechanism of Aβclearance dysfunction in AD monocytes remains *** the present study,we found that blood monocytes in AD mice exhibited decreases in energy metabolism,which was accompanied by cellular senescence,a senescence-associated secretory phenotype,and dysfunctional phagocytosis of Aβ.Improving energy metabolism rejuvenated monocytes and enhanced their ability to phagocytose Aβin vivo and in ***,enhancing blood monocyte Aβphagocytosis by improving energy metabolism alleviated brain Aβdeposition and neuroinflammation and eventually improved cognitive function in AD *** study reveals a new mechanism of impaired Aβphagocytosis in monocytes and provides evidence that restoring their energy metabolism may be a novel therapeutic strategy for AD.

关键词： Alzheimer's disease Aβclearance Monocyte Phagocytosis Energy metabolism

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Role of bone marrow-derived mesenchymal stem cells in a rat model of severe acute pancreatitis

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World Journal of Gastroenterology 2012年第18期18卷 2270-2279页

作者： Xiao-Huang tu Jing-xiang Song Xiao-Jun Xue xian-Wei Guo Yun-Xia Ma Zhi-Yao Chen Zhong-Dong Zou Lie Wang Department of General Surgery Fuzhou General Hospital of Nanjing Military RegionFuzhou 350025Fujian ProvinceChina

AIM:To investigate the role and potential mechanisms of bone marrow mesenchymal stem cells(MSCs) in severe acute peritonitis(SAP).METHODS:Pancreatic acinar cells from Sprague Dawley rats were randomly divided into three groups:nonsodium deoxycholate(SDOC) group(non-SODC group),SDOC group,and a MSCs intervention group(i.e.,a co-culture system of MSCs and pancreatic acinar cells + SDOC).The cell survival rate,the concentration of malonaldehyde(MDA),the density of superoxide dismutase(SOD),serum amylase(AMS) secretion rate and lactate dehydrogenase(LDH) leakage rate were detected at various time *** a separate study,Sprague Dawley rats were randomly divided into either an SAP group or an SAP + MSCs *** AMS,MDA and SOD,interleukin(IL)-6,IL-10,and tumor necrosis factor(TNF)-α levels,intestinal mucosa injury scores and proliferating cells of small intestinal mucosa were measured at various time points after injecting either MSCs or saline into *** both studies,the protective effect of MSCs was ***:In vitro,The cell survival rate of pancreatic acinar cells and the density of SOD were significantly reduced,and the concentration of MDA,AMS secretion rate and LDH leakage rate were significantly increased in the SDOC group compared with the MSCs intervention group and the Non-SDOC group at each time *** vivo,Serum AMS,IL-6,TNF-α and MAD level in the SAP + MSCs group were lower than the SAP group;however serum IL-10 level was higher than the SAP *** SOD level was higher than the SAP group at each time point,whereas a significant betweengroup difference in SOD level was only noted after 24 *** mucosa injury scores was significantly reduced and the proliferating cells of small intestinal mucosa became obvious after injecting ***:MSCs can effectively relieve injury to pancreatic acinar cells and small intestinal epithelium,promote the proliferation of enteric epithelium and repair of the mucosa,attenuate systemic in

关键词： Bone marrow mesenchymal stem cells Severe acute pancreatitis Intestinal barricade function Pancreatic acinar cells

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Optimization method of urban rail train operational plan based on O-D time-varying demand

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Railway Sciences 2022年第1期1卷 148-166页

作者： Feng Shi xian tu Shuo Zhao School of Traffic and Transportation Engineering Central South UniversityChangshaChina Security Department Central South UniversityChangshaChina Institute of Computing Technologies China Academy of Railway Sciences Corporation LimitedBeijingChina

Purpose–Under the constraints of given passenger service level and coupling travel demand with train departure time,this study optimizes the train operational plan in an urban rail corridor to minimize the numbers of train trips and rolling stocks considering the time-varying demand of urban rail passenger ***/methodology/approach–The authors optimize the train operational plan in a special network layout,*** urban rail corridor with dead-end terminal yard,by decomposing it into two sub-problems:train timetable optimization and rolling stock circulation *** for train timetable optimization,the authors propose a schedule-based passenger flow assignment method,construct the corresponding timetabling optimization model and design the bi-directional coordinated sequential optimization *** the optimization of rolling stock circulation,the authors construct the corresponding optimization assignment model and adopt the Hungary algorithm for solving the ***–The case study shows that the train operational plan developed by the study’s approach meets requirements on the passenger service quality and reduces the operational cost to the maximum by minimizing the numbers of train trips and rolling ***/value–The example verifies the efficiency of the model and algorithm.

关键词： Urban rail transit Train operational plan Time-varying passenger demand Passenger assignment Passenger service quality

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Spatial and Temporal Variations of Pneumoconiosis in the Pearl River Delta Region in 2006–2015

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Biomedical and Environmental Sciences 2020年第3期33卷 191-195页

作者： LI Xu Dong tu Hong Wei LIU Yi Ming WEN xian Zhong YU Hong Wei QU Hong Ying CheN Qing Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou 510300GuangdongChina Guangodng Provincial Center for Diseases Control and Prevention Guangzhou 511430GuangdongChina Guangzhou No.12 Hospital Guangzhou 510620GuangdongChina Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment Guangzhou 510300GuangdongChina

Pneumoconiosis is a restrictive lung disease mostly caused by occupational exposure to dust,including silica dust,asbestos,and other *** particles smaller than 10μm can enter the bronchioles,injure lung cells,and ind... 详细信息

关键词： Spatial and Temporal Variations of Pneumoconiosis in the Pearl River Delta Region in 2006 Delta

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Litterfall,Litter Decomposition,and Nutrient Dynamics in Two Subtropical Bamboo Plantations of China

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Pedosphere 2014年第1期24卷 84-97页

作者： tu Li-Hua HU Hong-Ling HU Ting-Xing ZHANG Jian LI xian-Wei LIU Li XIAO Yin-Long CheN Gang LI Ren-Hong College of Forestry Sichuan Agricultural University Institute of Ecological Forestry College of ForestrySichuan Agricultural UniversityChengdu CampusWenjiang District Personnel Department Sichuan Agricultural University Sichuan Forestry Inventory and Plan Institute

Bamboos are one of the fast-growing and multiple use species in the world, and thus bamboo forests/plantations play an important role in C sequestration at regional and global levels. We studied aboveground litterfall, litter decomposition and nutrient dynamics for two years in two subtropical bamboo ecosystems in Southwest China so as to test the hypothesis that litter quality determine the rate and nutrient dynamics during decomposition of different litter fractions. Mean annual total aboveground litter production ranged from 494 to 434 g m-2 in two bamboo stands （P stand, dominated by Pleioblastus amarus and H stand, hybrid bamboo dominated by Bambusa pervariabilis x Dendrocalamopsis daii）. Bulk （-80%） of litter production was contributed by leaf litter in two stands followed by twigs and sheathes. Different litter fractions represented considerable variations in the rates of mass loss and nutrient release. Variation of the mass remaining after 2 years of decomposition was significantly explained by initial C/N ratio and initial P concentration. Initial concentrations of N, P, Ca, and Mg explained 57.9%, 95.0%, 99.8% and 98.1%, respectively, of the variations of these elements mass remaining after 2 years of decomposition. The patterns of nutrient dynamics and the final amount remaining were mainly determined by their initial litter substrate quality in tl^ese two subtropical bamboo plantations.

关键词： C/N ratio litter fraction litter substrate mass loss Pleioblastus amarus

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Separated root tip formation associated with a fractured tubercle of dens evaginatus: A case report

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World Journal of Clinical Cases 2021年第12期9卷 2944-2950页

作者： Zhi-Fang Wu Ling-Jiao Lu Hai-Yan Zheng Yan tu Ying Shi Zi-Huai Zhou Lin-xian Fang Bai-Ping Fu Department of Pediatric Dentistry The Affiliated Hospital of StomatologySchool of StomatologyZhejiang University School of MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006Zhejiang ProvinceChina Department of Prosthodontics The Affiliated Hospital of StomatologySchool of StomatologyZhejiang University School of MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006Zhejiang ProvinceChina Department of Endodontics The Affiliated Hospital of StomatologySchool of StomatologyZhejiang University School of MedicineKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Several previous studies have reported an unusual root formation in which a fractured apical fragment of an immature root continued to develop independent of the main root after trauma to an immature *** date,there have been only rare reports of the continuing apical formation of the fractured root associated with dens evaginatus(DE).This paper presents a case of a separated root tip formation associated with a fractured tubercle of *** SUMMARY An 11-year-old boy was referred for gingival sinus on the buccal side of the right mandibular second premolar(tooth#45).Clinically,tooth#45 was free of caries,but there was a sign of a fractured tubercle of DE on the occlusal *** showed that the root canal of tooth#45 was widely radiolucent.A separated root apex was found apically under the main root and was nearly completely formed with an apical orifice at the apical ***#45 was diagnosed as tubular fracture of DE with chronic apical periodontitis.A revascularization technique was recommended to treat the *** 3-mo and 1-yr follow-up,the patient remained *** radiography revealed that the separated root tip distally drifted with closure of the ***,the root length and thickness of the main root did not *** Clinicians should be aware that even if tubercle of DE is fractured in an immature tooth,the root tip may be separated from the main root and completely formed.

关键词： Separated root tip Dens evaginatus tubercle fracture Young permanent tooth Revascularization Case report

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Climatic and geographic factors affect ecosystem multifunctionality through biodiversity in the Tibetan alpine grasslands

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Journal of Mountain Science 2017年第8期14卷 1604-1614页

作者： PAN Ying WU Jun-xi LUO Li-ming tu Yan-li YU Cheng-qun ZHANG xian-zhou MIAO Yan-jun ZHAO Yan YANG Jun-ling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Key Laboratory of Ecosystem Network Observation and Modelling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences Agricultural Research Institute Tibet Academy of Agricultural and Animal Sciences Tibet Plateau Institute of Biology Agricultural and Animal Husbandry College of Tibet University

Ecosystem multifunctionality(EMF), the simultaneous provision of multiple ecosystem functions, is often affected by biodiversity and environmental factors. We know little about how the interactions between biodiversity and environmental factors affect EMF. In this case study, a structural equation model was used to clarify climatic and geographic pathways that affect EMF by varying biodiversity in the Tibetan alpine grasslands. In addition to services related to carbon, nitrogen, and water cycling, forage supply, which is related to plantproductivity and palatability, was included in the EMF index. The results showed that 72% of the variation in EMF could be explained by biodiversity and other environmental factors. The ratio of palatable richness to all species richness explained 8.3% of the EMF variation. We found that air temperature, elevation, and latitude all affected EMF, but in different ways. Air temperature and elevation impacted the aboveground parts of the ecosystem, which included plant height, aboveground biomass, richness of palatable species, and ratio of palatable richness to all species richness. Latitude affected EMF by varying both aboveground and belowground parts of the ecosystem, which included palatable speciesrichness and belowground biomass. Our results indicated that there are still uncertainties in the biodiversity–EMF relationships related to the variable components of EMF, and climatic and geographic factors. Clarification of pathways that affect EMF using structural equation modeling techniques could elucidate the mechanisms by which environmental changes affect EMF.

关键词： Alpine grassland Biodiversity Structural equation model Tibetan Plateau

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离子注入对纳米氮化硅量子点蓝光增强效应

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物理学报 2000年第7期49卷 1383-1385页

作者：涂鲜花李道火中国科学院安徽光学精密机械研究所合肥230031

观察到纳米氮化硅量子点在室温下的蓝光发射现象 (44 9nm) .发现离子注入对蓝光发射有成倍增强效应 (高达 6 .3倍 ) ,并用量子限制发光中心模型给出解释 .提供了一种新的蓝光发射材料 .

关键词：蓝光增强离子注入纳米氮化硅量子点

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