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The response of structure and nitrogen removal function of the biofilm on submerged macrophytes to high ammonium in constructed wetlands

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Journal of Environmental Sciences 2024年第8期142卷 129-141页

作者： Xue Jiang Mengmeng Wang Shunqing Yang di he Fei Fang Liuyan Yang State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing UniversityNanjing 210023China School of Resources and Environment Anqing Normal UniversityAnqing 246133China

The ammonium exceedance discharge from sewage treatment plants has a great risk to the stable operation of subsequent constructed wetlands(CWs).The effects of high ammonium shocks on submerged macrophytes and epiphytic biofilms on the leaves of submerged macrophytes in CWs were rarely mentioned in previous *** this paper,the 16S rRNA sequencing method was used to investigate the variation of the microbial communities in biofilms on the leaves of Vallisneria natans plants while the growth characteristics of *** plants were measured at different initial ammonium *** results demonstrated that the total chlorophyll and soluble sugar synthesis of *** plants decreased by 51.45%and 57.16%,respectively,and malondialdehyde content increased threefold after8 days if the initial NH_(4)^(+)-N concentration was more than 5 mg/*** density,bacterial quantity,dissolved oxygen,and pH increased with high ammonium *** average removal efficiencies of total nitrogen and NH_(4)^(+)-N reached 73.26%and 83.94%,*** heat map and relative abundance analysis represented that the relative abundances of phyla Proteobacteria,Cyanobacteria,and Bacteroidetes *** numbers of autotrophic nitrifiers and heterotrophic nitrification aerobic denitrification(HNAD)bacteria expanded in *** particular,HNAD bacteria of Flavobacterium,Hydrogenophaga,Acidovorax,Acinetobacter,Pseudomonas,Aeromonas,and Azospira had higher abundances than autotrophic nitrifiers because there were organic matters secreted from declining leaves of *** *** analysis of the nitrogen metabolic pathway showed aerobic denitrification was the main nitrogen removal ***,the nitrification and denitrification bacterial communities increased in epiphytic biofilms on submerged macrophytes in constructed wetlands while submerged macrophytes declined under ammonium shock loading.

关键词： Ammonium shock loading Biofilm Autotrophic nitrifiers heterotrophic nitrification aerobic denitrification bacteria Submerged macrophyte

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Combining field data and modeling to better understand maize growth response to phosphorus(P) fertilizer application and soil P dynamics in calcareous soils

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Journal of Integrative Agriculture 2024年第3期23卷 1006-1021页

作者： Weina Zhang Zhigan Zhao di he Junhe Liu Haigang Li Enli Wang School of Biological and Food Processing Engineering Huanghuai UniversityZhumadian 463000China Key Laboratory of Plant-Soil Interactions Ministry of Education/College of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China Inner Mongolia Key Laboratory of Soil Quality and Nutrient Resources/Key Laboratory of Grassland Resource(IMAU) Ministry of Education/College of GrasslandResources and EnvironmentInner Mongolia Agricultural UniversityHohhot 010018China CSIRO Agriculture and Food CanberraACT 2601Australia

We used field experimental data to evaluate the ability of the agricultural production system model (APSIM) to simulate soil P availability,maize biomass and grain yield in response to P fertilizer applications on a fluvo-aquic soil in the North China *** and soil data from a 2-year experiment with three P fertilizer application rates(0,75 and 300 kg P_(2)O_(5) ha^(–1)) were used to calibrate the *** analysis was carried out to investigate the influence of APSIM SoilP parameters on the simulated P availability in soil and maize *** and soil P parameters were then derived by matching or relating the simulation results to observed crop biomass,yield,P uptake and Olsen-P in *** re-parameterized model was further validated against 2 years of independent data at the same *** re-parameterized model enabled good simulation of the maize leaf area index (LAI),biomass,grain yield,P uptake,and grain P content in response to different levels of P additions against both the calibration and validation *** results showed that APSIM needs to be re-parameterized for simulation of maize LAI dynamics through modification of leaf size curve and a reduction in the rate of leaf senescence for modern staygreen maize cultivars in *** P concentration limits (maximum and minimum P concentrations in organs)at different stages also need to be *** results further showed a curvilinear relationship between the measured Olsen-P concentration and simulated labile P content,which could facilitate the initialization of APSIM P pools in the NCP with Olsen-P measurements in future *** remains difficult to parameterize the APSIM SoilP module due to the conceptual nature of the pools and simplified conceptualization of key P transformation processes.A fundamental understanding still needs to be developed for modelling and predicting the fate of applied P fertilizers in soils with contrasting physical and chemical characteristics.

关键词： maize phosphorus availability modeling APSIM maize APSIM SoilP

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Dysregulated N6-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis

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Frontiers of Medicine 2024年第2期18卷 285-302页

作者： di he Xunzhe Yang Liyang Liu Dongchao Shen Qing Liu Mingsheng Liu Xue Zhang Liying Cui Department of Neurology Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China Medical Doctor Program Chinese Academy of Medical Science and Peking Union Medical CollegeBeijing100730China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing100730China Neuroscience Center Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China

Amyotrophic lateral sclerosis(ALS)is a progressive neurogenerative disorder with uncertain *** evidence implicates N6-methyladenosine(m6A)modification in ALS *** RNA immunoprecipitation sequencing(MeRIP-seq)and liquid chromatography–mass spectrometry were utilized for m6A profiling in peripheral immune cells and serum proteome analysis,respectively,in patients with ALS(n=16)and controls(n=6).The single-cell transcriptomic dataset(GSE174332)of primary motor cortex was further analyzed to illuminate the biological implications of differentially methylated genes and cell communication *** of peripheral immune cells revealed extensive RNA hypermethylation,highlighting candidate genes with differential m6A modification and expression,including C-X3-C motif chemokine receptor 1(CX3CR1).In RAW264.7 macrophages,disrupted CX3CR1 signaling affected chemotaxis,potentially influencing immune cell migration in *** proteome analysis demonstrated the role of dysregulated immune cell migration in *** type-specific expression variations of these genes in the central nervous system(CNS),particularly microglia,were *** communication between neurons and glial cells was selectively altered in ALS *** integrated approach underscores m6A dysregulation in immune cells as a potential ALS contributor.

关键词： amyotrophic lateral sclerosis N^(6)-methyladenosine epi-transcriptome proteome single cell RNA sequencing analysis CX3CR1

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Efficient heterologous biosynthesis of verazine,a metabolic precursor of the anti-cancer drug cyclopamine,in Nicotiana benthamiana

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Plant Communications 2024年第6期5卷 1-4页

作者： Chengxi Kou Jingling Liu Xue Yin di he Jia Liu Xin Hua Rui Ma Wei Sun Zheyong Xue Pengda Ma College of Life Sciences Northwest A&F UniversityYangling 712100China Key Laboratory of Saline-alkali Vegetation Ecology Restoration(Northeast Forestry University) Ministry of EducationHarbin 150040China heilongjiang Key Laboratory of Plant Bioactive Substance Biosynthesis and Utilization Northeast Forestry UniversityHarbin 150040China Jilin Provincial Key Laboratory of Agricultural Biotechnology Jilin Academy of Agricultural SciencesChangchun 130033China Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China

Dear Editor,Among the large number of Veratrum steroid alkaloids(Zhang et al.,2020),cyclopamine has been shown to have various inhibitory mechanisms against cancer,including inhibition of the hedgehog signaling pathway,improvement of tumor tissue microenvironment,inhibition of cell respiration,promotion of cell apoptosis,and reversal of tumor drug resistance(Liu et al.,2023).The biosynthetic pathway of verazine,a possible metabolic precursor of cyclopamine,has been discovered in Veratrum californicum(Augustin et al.,2015).However,the content of Veratrum steroid alkaloids in plants is very low(Supplemental Figure 2),so reliance on direct extraction from plants for commercial production is not feasible.A more effective strategy is to synthesize rare plant secondary metabolites using synthetic biology technology(Liu et al.,2022).

关键词： al. cyclopamine cancer

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The"4+4"Medical Doctor(MD)Pilot Program at PUMC:Implementation,Performance,and Prospects

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Chinese Medical Sciences Journal 2024年第2期39卷 144-148页

作者： Jing-Jing Yi Wei-Wei Xu Chao Ma he di Jing Jin Le Zeng Wen-Ji Tu Wen-Wen Sun Qin Zhang Office of Educational Affairs Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100730China

Peking Union Medical College(PUMC)launched the"4+4"Medical Doctor(MD)pilot program in 2018,admitting students with non-medical backgrounds from top universities,aligning with national medical talent training policies to foster diverse and eager learners in *** the occasion of the graduation of the first class of the"4+4"MD pilot class at PUMC in 2023,we reviewed the teaching reform in the pilot program and carried out a systematic survey and interviews with students,faculties,and management staff of the pilot *** article reports on the measures taken by the pilot class at PUMC in enrollment and curriculum setting,and demonstrates the achievements of the pilot class in terms of student academic background structure,knowledge acquisition and skill learning,scientific research ability,and course *** results indicated that the pilot class had met the national demand for the"Medicine+X"talent training *** specifically,with a diverse academic backgrounds,the pilot class graduates had academic levels comparable to the eight-year medical education graduates,and their scientific research abilities were *** pilot program at PUMC will optimize the curriculum setting,strengthen the construction of faculty,learning resources,and teaching facilities,and reform the academic evaluation methods,thus deepening the reform of medical education and improving the"4+4"MD program as a novel medical education model.

关键词： "4+4"MD pilot program teaching reform medical education

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Experimental and numerical investigations on acoustic damping of monoclinic crystalline wideband sound absorbing structures

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Journal of Central South University 2024年第6期31卷 1931-1944页

作者： XIE Su-chao he Lei YAN Hong-yu ZHANG Feng-yi he Guan-di WANG Jia-cheng Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha 410075China Joint International Research Laboratory of Key Technology for Rail Traffic Safety Changsha 410075China National&Local Joint Engineering Research Center of Safety Technology for Rail Vehicle Changsha 410075China

In order to overcome the limitations of traditional microperforated plate with narrow sound absorption bandwidth and a single structure,two multi-cavity composite sound-absorbing materials were designed based on the shape of monoclinic crystals:uniaxial oblique structure(UOS)and biaxial oblique structure(BOS).Through finite element simulation and experimental research,the theoretical models of UOS and BOS were verified,and their sound absorption mechanisms were *** the same time,the influence of multi-cavity composites on sound absorption performance was analyzed based on the theoretical model,and the influence of structural parameters on sound absorption performance was *** research results show that,in the range of 100-2000 Hz,UOS has three sound absorption peaks and BOS has five sound absorption *** frequency range of the half-absorption bandwidth(α>0.5)of UOS and BOS increases by 242% and 229%,*** with traditional microperforated sound-absorbing structures,the series and parallel hybrid methods significantly increase the sound-absorbing bandwidth of the sound-absorbing *** research has guiding significance for noise control and has broad application prospects in the fields of transportation,construction,and mechanical design.

关键词： monoclinic crystal microperforated plate acoustic metamaterials inclined cavity sound absorption

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A comparison of the effect of alendronate and You-Gui-Wan on osteoporosis in female rats with kidney-yang deficiency

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Traditional Medicine Research 2024年第6期9卷 31-41页

作者： Mei-Mei Wu Xing-Peng he Wan-Ting Wu Wen-Jie Lu Yan-Yang Mai Kun-Cai Xu Yao-Feng Zhi Hai-Xin Mo Jia-di he Xin Zhang Peng-Fei Li Clinical Experimental Center Jiangmen Engineering Technology Research Center of Clinical Biobank and Translational ResearchJiangmen Central HospitalJiangmen 529030China Traumatic Orthopedics Baiyun Hospital of The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510470China Department of Intelligent Engineering Guiyang Institute of Information Science and TechnologyGuiyang 550025China

Background:In traditional Chinese medicine,You-Gui-Wan(YGW)is typically used to treat osteoporosis associated with kidney-yang ***,there have been few mechanistic studies on the effectiveness of kidney-yang deficiency-type osteoporosis with *** further clarify the role of YGW in the effect of osteoporosis with kidney-yang deficiency,the study analyzed the therapeutic advantages of YGW by comparing the therapeutic effects of YGW and alendronate(ALN)on osteoporosis with kidney-yang ***:SPF female SD rats were randomly divided into control,osteoporosis,osteoporosis with kidney-yang deficiency,osteoporosis with kidney-yang deficiency+YGW and osteoporosis with kidney-yang deficiency+ALN *** for the control group,osteoporosis was induced by the removal of bilateral *** 12 weeks,rats with osteoporosis in the kidney-yang deficiency group had kidney-yang deficiency syndrome triggered by hydrocortisone for 14 *** were treated with YGW or ALN for 12 *** weights of rats were ***-eosin staining staining was used to observe pathological changes in bone trabeculae,liver,spleen,and kidneys of *** of the growth plate cartilage of rats in different groups was observed by safranine-O *** expression of osteoclast key indices(ACP)and osteoblast key indices(ALP)in the bone tissue of rats in the different groups was observed by immunohistochemical *** expression of bone resorption-related indicators(TRAP and NXT-1),bone formation-related indicators(BALP,BGP,and P1NP),and major indicators of kidney-yang deficiency(ACTH,T3,T4,cAMP,and cGMP)were observed using an ELISA detection *** expression levels of the main indices of liver function(ALT and AST)were detected in different ***:The differences between the osteoporosis with kidney-yang deficiency group and osteoporosis group were that the weight of rats and the expression of ACTH,T3,T4,and cAMP decreased significantl

关键词： osteoporosis kidney-yang deficiency You-Gui-Wan alendronate

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大党“破题之钥”:以全过程人民民主健全全面从严治党体系

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党政研究 2024年第4期 50-60,125,126页

作者：刘伟何頔武汉大学政治与公共管理学院湖北武汉430072 武汉大学地方政治研究中心湖北武汉430072 武汉科技大学马克思主义学院湖北武汉430081

如何跳出治乱兴衰历史周期率,破解大党独有难题,是中国共产党坚持探索的重要问题,也是关系民族复兴大业的关键所在。基于对大党独有难题理论意蕴的把握,可以发现,全过程人民民主和全面从严治党是在实践中形成的跳出历史周期率的“两个... 详细信息

如何跳出治乱兴衰历史周期率,破解大党独有难题,是中国共产党坚持探索的重要问题,也是关系民族复兴大业的关键所在。基于对大党独有难题理论意蕴的把握,可以发现,全过程人民民主和全面从严治党是在实践中形成的跳出历史周期率的“两个答案”:全面从严治党具有从严以尚贤、任贤而兴民、民主护安邦的思想基础,并蕴含在其全面性、严格性和治理性的内在特质之中;而全过程人民民主既为全面从严治党提供了实践标尺,同时其发展也需要以全面从严治党作为保障。未来应通过发展维护党的全面领导的有效体制机制,探索人民群众监督与党内监督有机结合的有效方式,拓宽全面从严治党“靠人民”的有效渠道,进一步以全过程人民民主健全全面从严治党体系,将中国共产党的执政优势转化为实现中华民族伟大复兴的强大动能。

关键词：全过程人民民主全面从严治党大党独有难题历史周期率自我革命

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比例阀控气缸系统确定性鲁棒反步运动跟踪控制器

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国防科技大学学报 2024年第4期46卷 133-141页

作者：浦晨玮刘磊何迪钱鹏飞江苏大学机械工程学院江苏镇江212013

为实现气缸运动轨迹的高精度鲁棒控制,建立了比例阀控缸系统的数学模型,并基于反步法设计了一种能够有效抑制系统模型参数不确定性、未建模动态和外界扰动等因素影响的非线性确定性鲁棒控制器。利用MATLAB中的Simulink模块构建气缸运动... 详细信息

为实现气缸运动轨迹的高精度鲁棒控制,建立了比例阀控缸系统的数学模型,并基于反步法设计了一种能够有效抑制系统模型参数不确定性、未建模动态和外界扰动等因素影响的非线性确定性鲁棒控制器。利用MATLAB中的Simulink模块构建气缸运动轨迹跟踪控制系统仿真模型。采用MATLAB/Simulink中的xPC-Target开发了基于非线性确定性鲁棒控制器的气缸运动轨迹实时控制系统。仿真结果表明所设计控制器是可行的。试验结果表明该控制器能够有效地跟踪参考轨迹,跟踪0.3 Hz正弦轨迹时的最大跟踪误差为0.89 mm,约为幅值的2.97%;跟踪0.4 Hz正弦轨迹时的最大跟踪误差为1.02 mm,为幅值的3.4%。

关键词：比例阀气缸运动轨迹跟踪反步法确定性鲁棒控制

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“链主”企业提升产业链现代化水平的功能作用与实现路径

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科学管理研究 2024年第2期42卷 103-109页

作者：霍春辉何地庞铭辽宁大学经济学部商学院辽宁沈阳110136 辽宁大学经济学部亚澳商学院辽宁沈阳110136

产业链现代化是全面建成社会主义现代化强国的重要组成部分。“链主”企业是引领产业链发展的“牛鼻子”,对提升产业链现代化水平具有独特价值。为此,研究基于全球产业链重构背景,分析我国产业链现代化发展面临的现实挑战。进一步提出... 详细信息

产业链现代化是全面建成社会主义现代化强国的重要组成部分。“链主”企业是引领产业链发展的“牛鼻子”,对提升产业链现代化水平具有独特价值。为此,研究基于全球产业链重构背景,分析我国产业链现代化发展面临的现实挑战。进一步提出履行国家使命是驱动“链主”企业提升产业链现代化的源动力,并基于“架构者”角色理论,深入阐述了“链主”企业的主要功能。在此基础上,从加大战略性新兴产业布局、构建产业生态系统、打造原创技术“策源地”、加快数智化绿色化转型、厚植企业发展沃土、加强高水平开放合作等方面入手,探讨“链主”企业推动产业链现代化发展的实现路径。

关键词： “链主”企业产业链现代化使命驱动 “架构者”角色

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