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<i>NOS</i>3 894G >T Gene Polymorphism: A Potential Risk Factor of Stroke in Bahraini Patients

World Journal of Neuroscience 2018年第1期8卷 98-107页

作者： Manal A. Fadl Adel A. AlJishi safa Taha Moiz Bakhiet Faculty of Science and Technology Al Neelain University Khartoum Sudan Salmanyia Medical Complex Manama Bahrain Department of Molecular Medicine CMMS Princess Al-Jawhara Center Arabian Gulf University Manama Bahrain

The endothelial nitric oxide synthase (eNOS) encoded by the NOS3 gene is responsible for the synthesis of a vasoactive endothelium-derived nitric oxide (NO). The genetic polymorphism of this gene explains, in part, why some people are prone to develop stroke than others. In this study we conducted a case control study in Bahrainis to investigate “for the first time” the relationship between NOS3 894G > T (rs1799983) and 786T > C (rs2070744) polymorphisms with the stroke predisposition in Bahraini population. Detection of NOS3 polymorphism was performed by PCR RFLP genotyping method. The level of NO among cases and controls was measured using ELISA. A total of 93 unrelated stroke patients and 86 controls were included in the study. The three types of stroke;Ischemic, hemorrhagic and transient ischemic attack were reported (91.4%, 7.5% and 1.1% respectively). No significant gender difference was observed (P = 0.74). Having previous stroke was a highly significant risk factor of the disease (P = 0.001, OR = 1.4), where as a family history of stroke was not (OR = 0.11). The analysis provides evidence that the mutant 894GT + TT genotypes of NOS3 894G > T polymorphism were positively associated with stroke predisposition and it increased the risk of stroke nearly two folds (P = 0.037, OR = 1.936). Although we found an association between the mutant genotype786 TC + CC of the NOS3 786T > C polymorphism with the susceptibility to stroke (P = 0.023) suggesting that the mutant C allele might have a protective effect against stroke in this population, the strength of this association was rather low (OR = 0.484). The level of NO in stroke patients was significantly low compared to healthy controls (P 0.005). Diabetes, hypertension, heart diseases were reported in stroke patients (67%, 71.4% and 52.1% respectively). More over 50% of the cases with previous stroke are both diabetic and hypertensive. This indicates that these diseases could be considered as a significant factor in

关键词： Gene Polymorphisms Nitric Oxide Synthase Stroke Risk Factors

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Optimization of the Cooling System of Electric Vehicle Batteries

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Fluid Dynamics & Materials Processing 2022年第3期18卷 835-850页

作者： A.Heri Iswanto Iwan Harsono Alim Al Ayub Ahmed Sergushina Elena Sergeevna Stepan Krasnikov Rustem Zalilov John William Grimaldo Guerrero Liliya N.Latipova safa Kareem Hachim Public Health Department Faculty of Health ScienceUniversity of Pembangunan Nasional Veteran JakartaJakarta16426Indonesia Universitas Mataram West Nusa Tenggara83116Indonesia School of Accounting Jiujiang UniversityJiujiang330300China National Research Ogarev Mordovia State University Saransk430005Russia Russian Technological University Moscow119454Russian Nosov Magnitogorsk State Technical University Magnitogorsk455000Russian Departamento de Energía Universidad de la CostaBarranquilla080002Colombia Kazan Federal University Kazan628400Russia College of Technical Engineering The Islamic UniversityNajaf54001Iraq

The most important components of electrical vehicles are the battery and the related cooling *** subsystems play a major role in determining the overall electric vehicle *** this study,a novel cooling system with fluid in the battery cell is proposed,by which the energy storage system can be optimized through control of the temperature of the batteries.A sensitivity analysis is conducted considering the maximum temperature,the heat rate,the coolant temperature,and the geometry of the *** numerical simulations show that the parameters for the trapezoidal compartment have an impact on the thermal performance of *** optimal geometry is proposed *** is concluded that for high values of Reynolds number for which the flow becomes turbulent,a decrease in the battery temperature can be obtained thereby avoiding thermal stresses.

关键词： Thermal flow batteries geometry cavity cooling system

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A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

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Animal Models and Experimental Medicine 2024年第5期7卷 591-605页

作者： Mohammad Yasin Zamanian Niloofar Taheri Montather FRamadan Yasser Fakri Mustafa safa Alkhayyat Klunko Nataliya Sergeevna Hashem OAlsaab Ahmed Hjazi Farnoosh Molavi Vasei Siamak Daneshvar Department of Physiology School of MedicineHamadan University of Medical SciencesHamadanIran Department of Pharmacology and Toxicology School of PharmacyHamadan University of Medical SciencesHamadanIran School of Medicine Shahroud University of Medical SciencesShahroudIran College of Dentistry Al-Ayen UniversityNasiriyahIraq Department of Pharmaceutical Chemistry College of PharmacyUniversity of MosulMosulIraq College of Pharmacy The Islamic UniversityNajafIraq Department of Training of Scientific and Scientific-Pedagogical Personnel Russian New UniversityMoscowRussian Federation Department of Pharmaceutics and Pharmaceutical Technology Taif UniversityTaifSaudi Arabia Department of Medical Laboratory College of Applied Medical SciencesPrince Sattam bin Abdulaziz UniversityAl-KharjSaudi Arabia Department of Clinical Biochemistry School of MedicineRafsanjan University of Medical SciencesRafsanjanIran Department of Surgery School of MedicineHamadan University of Medical SciencesHamadanIran

Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer(CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing CRC due to its diverse biological activities. It has been found to influence key cell signaling pathways related to inflammation, angiogenesis, apoptosis, and transcription *** results of this study demonstrate that fisetin induces colon cancer cell apoptosis through multiple mechanisms. It impacts the p53 pathway, leading to increased levels of p53 and decreased levels of murine double minute 2, contributing to apoptosis induction. Fisetin also triggers the release of important components in the apoptotic process, such as second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI and cytochrome c. Furthermore, fisetin inhibits the cyclooxygenase-2 and wingless-related integration site(Wnt)/epidermal growth factor receptor/nuclear factor kappa B signaling pathways, reducing Wnt target gene expression and hindering colony formation. It achieves this by regulating the activities of cyclin-dependent kinase 2 and cyclin-dependent kinase 4, reducing retinoblastoma protein phosphorylation, decreasing cyclin E levels, and increasing p21 levels, ultimately influencing E2 promoter binding factor 1 and cell division cycle 2(CDC2) protein levels. Additionally, fisetin exhibits various effects on CRC cells, including inhibiting the phosphorylation of Y-box binding protein 1 and ribosomal S6 kinase, promoting the phosphorylation of extracellular signal-regulated kinase 1/2, and disrupting the repair process of DNA double-strand breaks. Moreover, fisetin serves as an adjunct therapy for the prevention and treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α(PIK3CA)-mutant CRC, resulting in a reduction in phosphatidylinositol-3 kinase(PI3K) expressio

关键词： apoptosis colorectal cancer fisetin i nflammation p53 pathway

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活动性葡萄膜炎引起暂时性屈光度变化（英文）

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国际眼科杂志 2019年第10期19卷 1637-1642页

作者： Mahsa Zameni Homayoun Nikkhah safa Rahmani Alireza Ramezani Mehdi Yaseri Masoud Soheilian Shahid Beheshti医科大学 Labbafinejad医疗中心眼科研究中心伊朗德黑兰*** Shahid Beheshti医科大学Torfeh医院眼科伊朗德黑兰*** 哈佛医学院 Massachusetts眼耳医院眼科美国波士顿60611 Shahid Beheshti医科大学眼科流行病研究中心伊朗德黑兰*** 德黑兰医科大学公共卫生学院流行病学与生物统计学系伊朗德黑兰*** Negah眼科医院伊朗德黑兰***

目的:评估活动性葡萄膜炎对屈光不正变化的影响。方法:这是一项前瞻性队列研究,纳入66例88眼活动性葡萄膜炎患者。受试者根据其疾病活动的解剖位置分为前、中、后和全葡萄膜炎。在活动期和静止期均行睫状肌麻痹验光,并对结果进行比较。... 详细信息

目的:评估活动性葡萄膜炎对屈光不正变化的影响。方法:这是一项前瞻性队列研究,纳入66例88眼活动性葡萄膜炎患者。受试者根据其疾病活动的解剖位置分为前、中、后和全葡萄膜炎。在活动期和静止期均行睫状肌麻痹验光,并对结果进行比较。结果:活动性前非肉芽肿性葡萄膜炎的球镜变化导致平均-0.25(0.77)D(95%CI:-0.5~0)的近视转变(P=0.039),在活动性中层葡萄膜炎中,平均+0.39(0.8)D(95%CI:0.09~0.69)的远视转变(P=0.003)。活动性中层葡萄膜炎的等效球镜的变化导致远视转变[+0.43(0.94)D,95%CI:0.08~0.79,P=0.005]。柱镜仅在全色素膜炎时有明显改变[-0.3(0.39)D,95%CI:-0.58^-0.02,P=0.043]。在多元分析中,我们发现疾病活动过程(急性与复发)和疾病活动的解剖位置对等效球镜变化具有统计学意义(分别为P=0.003和P=0.004)结论:活动性葡萄膜炎对屈光度有重要影响,该变化取决于具体的炎症发生部位。

关键词：前葡萄膜炎中间葡萄膜炎后葡萄膜炎全葡萄膜炎屈光不正

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Depression of the elderly revealing a primary hypothyroidism

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Advances in Generial Practice of Medicine 2019年第1期2卷 1-4页

作者： Salem Bouomrani Mouna Guermazi Souad Yahyaoui safa Trabelsi Latifa Ghanmi Department of Internal medicine Military Hospital of Gabes Gabes 6000 Tunisia Sfax Faculty of Medicine University of Sfax Sfax 3029 Tunisia Department of Psychiatry Gabes Regional Hospital Gabes 6000 Tunisia

Introduction Psychiatric manifestations are exceptional during hypothyroidism and are not always easy to diagnose, especially since the clinical signs of hypothyroidism can be confused with those of the depressive syndrome. We report an original observation of depression of the elderly revealing an isolated primary hypothyroidism. Observation A 78-year-old patient, followed for essential hypertension, well-balanced under monotherapy with calcium channel blockers, and without degenerative complications, was referred by her family doctor for depressive syndrome not improved by the specific treatment prescribed and correctly taken for six months. The clinical examination noted in particular macroglossia with dental impressions and dry and cracked skin. The biological assessment showed hypothyroidism with TSH at 28μmol/l. Thyroid ultrasound showed atrophy of the thyroid gland. The thyroid autoimmunity (anti-thyroglobulin and anti-thyroperoxidase antibodies) was negative. The rest of the biological tests were in the normal range. The diagnosis of Riedel’s thyroiditis was retained and the patient was treated with levothyroxine in progressive doses until TSH normalization was achieved. The evolution on the psychiatric level was also favorable with disappearance of the signs of the depression and the anti-depressive treatment was discontinued. Conclusion Depression is rare, complicating only 4% of overt hypothyroidism and its diagnosis is not always easy, especially in the elderly. Hormone replacement therapy significantly improves the depressive syndrome and protects against cognitive decline. Thus, hypothyroidism screening seems appropriate for any depressive syndrome in the elderly.

关键词： depression hypothyroidism elderly

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Gap Filling of Net Ecosystem CO<sub>2</sub>Exchange (NEE) above Rain-Fed Maize Using Artificial Neural Networks (ANNs)

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Journal of Software Engineering and Applications 2021年第5期14卷 150-171页

作者： Babak safa Timothy J. Arkebauer Qiuming Zhu Andy Suyker Suat Irmak Daugherty Water for Food Global Institute at the University of Nebraska Lincoln USA Department of Agronomy & Horticulture University of Nebraska-Lincoln Lincoln USA Department of Computer Science University of Nebraska-Omaha Omaha USA School of Natural Resources University of Nebraska-Lincoln Lincoln USA Biological Systems Engineering Department University of Nebraska-Lincoln Lincoln USA

The eddy covariance technique is an accurate and direct tool to measure the Net Ecosystem Exchange (NEE) of carbon dioxide. However, sometimes conditions are not amenable to measurements using this technique. Thus, different methods have been developed to allow gap-filling and quality assessment of eddy covariance data sets. In this study first, two different Artificial Neural Networks (ANNs) approaches, the Multi-layer Perceptron (MLP) trained by the Back-Propagation (BP) algorithm, and the Radial Basis Function (RBF), were used to fill missing NEE data measured above rain-fed maize at the University of Nebraska-Lincoln Agricultural Research and Development Center near Mead, Nebraska. The gap-filled data were then compared by different statistical indices to gap-filled data obtained with the technique suggested by Suyker and Verma in 2005 [S&V method], and the ANN approach presented by Papale in 2003. The results showed that the RBF network was able to find better fits for missing values compared to the MLP (BP) network and S&V method. In addition, unlike the S&V method, which depends on different gap-filling procedures over the year;the structure of RBF and MLP (BP) networks was constant. However, data analysis indicated Papale’s approach gave better fits than the RBF and MLP (BP) methods. Thus, based on this work, Papale’s approach is the best method to estimate the missing data;though the applied statistical indices, which were used for model evaluation, show little difference between Papale’s approach and the RBF and MLP (BP).

关键词： Gap Filling Net Ecosystem Exchange of Carbon Dioxide Artificial Neural Networks Eddy Covariance System

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A simplified two-dimensional boundary element method with arbitrary uniform mean flow

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Theoretical & Applied Mechanics Letters 2017年第4期7卷 207-221页

作者： Bassem Barhoumi safa Ben Hamouda Jamel Bessrour University of Tunis El Manar National Engineering School of Tunis MAI Laboratory BP 37 El Belvedere 1002 Tunis Tunisia

To reduce computational costs, an improved form of the frequency domain boundary element method（BEM） is proposed for two-dimensional radiation and propagation acoustic problems in a subsonic uniform flow with arbitrary orientation. The boundary integral equation（BIE） representation solves the two-dimensional convected Helmholtz equation（CHE） and its fundamental solution, which must satisfy a new Sommerfeld radiation condition（SRC） in the physical space. In order to facilitate conventional formulations, the variables of the advanced form are expressed only in terms of the acoustic pressure as well as its normal and tangential derivatives, and their multiplication operators are based on the convected Green＇s kernel and its modified derivative. The proposed approach significantly reduces the CPU times of classical computational codes for modeling acoustic domains with arbitrary mean flow. It is validated by a comparison with the analytical solutions for the sound radiation problems of monopole,dipole and quadrupole sources in the presence of a subsonic uniform flow with arbitrary orientation.

关键词： Two-dimensional convected Helmholtz equation Two-dimensional convected Green’s function Two-dimensional convected boundary element method Arbitrary uniform mean flow Two-dimensional acoustic sources

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Protective effects of Aristolochia longa and Aquilaria malaccensis against lead induced acute liver injury in rats

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Journal of Acute Disease 2017年第5期6卷 193-197页

作者： Derouiche Samir Zeghib Khaoula Gharbi safa Khelef Yahia Feriani Anouar Department of Cellular and Molecular Biology Faculty of natural science and lifeUniversity of Echahid Hamma Lakhdar-ElouedEl-oued39000El-ouedAlgeria Laboratory of Animal Ecophysiology Faculty of Science of Sfax3018SfaxTunisia

Objective: To investigate the protective effects of Aristolochia longa (A. longa) and Aquilaria malaccensis (A. malaccensis) on acute hepatotoxicity induced by lead in female albino rats. Methods: Twenty five (25) apparently healthy female Wistar rats were randomly divided into five groups of five rats in each: control, Pb, Pb + A. longa (Ar), Pb+ A. malaccensis (Aq), and Pb+ A. longa (Ar) + A. malaccensis (Aq) lead (100 mg/kg b.w.) as Pb (C2H3O2)2 added in their drinking water for 75 days. A. longa (rhizome powder at a dose of 10 g/kg of diet ) and A. malaccensis (heartwood powder at a dose 10 g/kg of diet) were added to the feed during the last 15 days of lead exposed in the animals. Results: Obtained results revealed that lead treatment caused a significant increase in serum GOT, GPT and ALP activities and in liver of MDA level and CAT activity. In contrast, it led to an decrease in the liver GOT, GPT and GST activities and in GSH level in rats. Also, the results clearly showed that lead causes alterations of hepatic tissue in comparison with controls. Our results showed that treatment with A. malaccensis and A. longa a partial correction of the previous parameters. The histological observations confirmed the hepatoprotection results by the biochemical parameters. Conclusions: Results demonstrated beneficial effects of A. longa and A. malaccensis treatment in Pb-induced oxidative stress and tissue damage in liver.

关键词： Aristolochia longa Aquilaria malaccensis Acute hepatotoxicity Acetate lead Stress oxidative

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Esthetic and Functional Rehabilitation of Amelogenesis Imperfecta: Report of Four Cases with a One-Year Follow-Up

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Open Journal of Stomatology 2016年第4期6卷 103-113页

作者： Neslihan Tekce Gizem Guder Mustafa Demirci safa Tuncer Alper Sinanoglu Emre Ozel Department of Restorative Dentistry Faculty of Dentistry University of Kocaeli Kocaeli Turkey Department of Conservative Dentistry Faculty of Dentistry Istanbul University Istanbul Turkey Department of Oral and Maxillofacial Radiology Faculty of Dentistry University of Kocaeli Kocaeli Turkey

In this report, we describe the performance of a conservative and minimally invasive dental approach in four patients exhibiting Amelogenesis Imperfecta (AI), a structural anomaly of the enamel. In each patient, approximately 0.5 mm of the most external, porous, and colored enamel layer was removed, and the teeth were restored using two different nanocomposites. Posterior restorations were completed with the same approach. As a result, this contemporary restorative system is a conservative and successful treatment option to restore the loss of oral esthetics and function due to AI. Rehabilitation with direct resin restorations is not only an inexpensive treatment choice, but also a more conservative technique that reduces the amount of preparation required for teeth that are already compromised.

关键词： Amelogenesis Imperfecta Nanohybrid Composite Nanofill Composite Universal Dentin Bonding Agents

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Allopurinol-induced DRESS syndrome in the elderly: an exceptional form of iatrogenesis

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Advances in Generial Practice of Medicine 2019年第1期2卷 5-8页

作者： Salem Bouomrani Fatma Rekik safa Trabelsi Souad Yahyaoui Nesrine Belgacem Department of Internal medicine Military Hospital of Gabes Gabes 6000 Tunisia Sfax Faculty of Medicine University of Sfax Sfax 3029 Tunisia

Introduction: The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a very rare iatrogenic accident that is characterized by its difficult diagnosis due to its clinical latency and heterogeneous clinic. The form induced by allopurinol remains exceptional and often ignored by clinicians, although potentially fatal. We are reporting an original observation of allopurinol-induced DRESS syndrome in elderly. Case report: A 64-year-old woman who had been treated with allopurinol for gout for three weeks, was hospitalized for a diffuse, erythematous and maculopapular cutaneous rash, associated with fever at 39℃ , dyspnea, generalized lymphadenopathy, and a hyperkeratotic and desquamative plantar eruption. The biology showed eosinophilia at 860/mm3 and cytolitic hepatitis without cholestasis or hepatocellular insufficiency with ASAT at 230 IU/l and alanine aminotransferase ( ALAT) at 280 IU/l. The infectious, immunological investigation, as well as the search for underlying malignant neoplasia or hematological malignancy were negative. The skin biopsy was inconclusive. The diagnosis of a DRESS syndrome induced by allopurinol was retained. The evolution was rapidly favorable after stopping allopurinol and treatment with systemic glucocorticoids. Conclusion: The incidence of cutaneous reactions to allopurinol is estimated at 1.5/100,000 H/year. The DRESS syndrome, the most serious form of these reactions, remains exceptional. This particular form of toxicity deserves to be known by clinicians, especially since allopurinol is widely prescribed in the elderly.

关键词： DRESS syndrome iatrogenesis allopurinol cutaneous drug reaction elderly

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