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Assessment of Patulin Content in Apple Puree and Apple and Fruit Puree by.High Performance Liquid Chromatography

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Journal of Environmental Science and Engineering(A) 2016年第7期5卷 371-381页

作者： Monica Catana Luminita Catana Enuta Iorga Mioara Negoita Valentin Ionescu Nastasia Belc Dragos Efstatiade hassan y. aboul-enein National R & D Institute for Food Bioresources-IBA 6 Dinu Vanita Street Bucharest 2021102 Romania Pro Analy.is Sy.tems 29 Sfanta Vineri Street Bucharest 030203 Romania Department of Pharmaceutical and Medicinal Chemistry The Pharmaceutical and Drug Industries Research Division NationalResearch Centre Dokki Giza 12622 Egypt

An analy.ical method was developed and validated for determination of patulin in apple puree by.HPLC. Extraction and clean-up ofpatulin from clear extract are achieved on AFFINIMIP SPEPATULIN cartridges. Patulin is then separated on a Hy.ersil GOLD column 150 mm × 4 mm, 5 μtmand detected at 276 nm. The recovery.in the range of 5 μg/kg-80 μg/kg was 81.47%. The limit of detection （LOD） was 1.36 μg/kg, and the limit of quantification （LOQ） was 4.55 μg/kg. The patulin content of the commercial samples of apple puree and samples of apple and fruit puree forinfants and y.ung children as well as the samples of apple puree prepared from two apple varieties intended for processing （Jonathan, Florina） and obtained from conventional and uncertified organic cultures has been evaluated in this paper. The 44.83% patulin concentration of the analy.ed samples were under the maximum level of the European Commission Regulation （EC） 1881/2006, in 46.55% of the analy.ed samples patulin was not detected and in 8.62% of samples patulin concentration was lower than LOQ （European Comission, 2006a） Patulin was not detected in samples of apple puree intended for infants and y.ung children consumption.

关键词： Patulin HPLC-DAD apple puree method performance parameters.

SBL-JP-0004:A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology.Research 2025年第1期33卷 235-243页

作者： hassan M.OTIFI Department of Pathology College of MedicineKing Khalid UniversityAbha62521Saudi Arabia

Background:Gastric cancer(GC)remains a global health burden and is often characterized by.heterogeneous molecular profiles and resistance to conventional *** phosphoinositide 3-kinase and PI3K and Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathway. play.pivotal roles in GC progression,making them attractive targets for therapeutic ***:This study.applied a computational and molecular dy.amics simulation approach to identify.and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD *** and SNU-5 GC cells were used for in vitro ***:SBL-JP-0004 exhibited a robust binding affinity.for JAK2 and PI3KCD kinases,as evidenced by.molecular docking scores and molecular dy.amics *** interactions and Gibbs binding free energy.estimates confirmed stable and favorable interactions with target ***-JP-0004 display.d an half-maximal inhibitory.concentration(IC_(50))value of 118.9 nM against JAK2 kinase and 200.9 nM against PI3KCD ***-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells,with half-maximal growth inhibitory.concentration(GI50)values of 250.8 and 516.3 nM,respectively.A significant elevation in the early.phase apoptosis(28.53%in KATOIII cells and 26.85%in SNU-5 cells)and late phase apoptosis(17.37%in KATOIII cells and 10.05%in SNU-5 cells)were observed with SBL-JP-0004 treatment compared to 2.1%and 2.83%in their respective ***:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility.in clinical settings.

关键词： Gastric cancer(GC) Dual inhibition JAK2 PI3KCD SBL-JP-0004 Molecular docking Molecular dy.amics simulation

Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using MAX phase Cr_(2)TiAlC_(2) saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir AL-HITI Hiba hassan Department of Electrical Engineering Faculty of EngineeringUniversity of AnbarAnbar 31001Iraq Department of Laser and Optoelectronics Engineering University of Technology-IraqBaghdadIraq

We demonstrated a new ty.e of MAX phase material,chromium titanium aluminum carbide(Cr_(2)TiAlC_(2)) poly.er film,to generate a passively.Q-switched erbium-doped fiber laser(EDFL).The film thickness was measured to be around 45 μm,which was fabricated using the embedding method with poly.iny. alcohol(PVA) poly.er as *** saturable absorber(SA) film demonstrates a dual-wavelength passively.Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm,*** Q-switching pulse duration could be varied from 2.46 μs to 770 ns,while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 *** maximum output power and pulse energy.of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW,respectively.

关键词： switched pulse fiber

Mossbauer,optical and structural properties of Fe^(3+) ion in borate glass

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Journal of Rare Earths 2025年第1期43卷 162-170,I0006页

作者： Essam A.Elkelany.Hesham y.Amin A.Samir M.M.EL-Hady.H.H.El-Bahnasawy.Moukhtar A.hassan Basic Science Department Faculty of EngineeringSinai UniversityAl-Arish45511Egypt School of Information and Electrical Engineering Hangzhou City UniversityHangzhou30015China State Key.Laboratory.of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou310027China Basic Science Department Faculty of Engineering at ShoubraBenha University11629Egypt Phy.ics Department Faculty of ScienceAl-Azhar University11884CairoEgypt

Lanthanum-bearing iron lithium borate glass is a quaternary.sy.tem for oxide glasses and was prepared via the melt-quenching *** present article correlates the structure,optical,ligand field and M?ssbauer data on iron lithium borate glass co ntaining La^(3+).The density.was measured,while the molar volume was *** phy.ical parameters are *** increasing the La_(2)O_(3) content within the glass network,infrared spectra analy.is reveals structural modifications such as the increase in BO_(4) units and the decline in both BO_(3) units and NBO bonds ***,optical absorption spectra were *** absorption spectra disclose a plethora of electronic transitions that are related to Fe^(3+)in tetrahedral and octahedral sites,however,Fe^(2+)phase is not observed in optical spectra,but it has a clear signature in M?ssbauer ***,the glass absorption edges undergo a clear blue shift,reflecting an increased band gap energy.1.96-2.28 eV).The decline in NBO bonds justifies this ***,the values of cry.tal field splitting are increased,while the values of Racah parameters are *** trend is justified by.the decline in NBO bonds and increases electron localization around Fe cations.M?ssbauer spectra confirm the existence of Fe^(3+)in tetrahedral and octahedral sites,while Fe^(2+)exists in only.a tetrahedral *** increasing La_(2)O_(3) content,the isomer shift of Fe^(3+)in tetrahedral sites changes to be 0.312-0.329 mm/s,while the isomer shift of octahedral Fe^(3+)is 0.424-0.456 mm/*** findings coincide with optical *** the isomer shift of tetrahedral Fe^(2+)is 0.902-0.911 mm/*** results of structural,optical and ligand field associated with M?ssbauer spectra open more vistas toward the utility.of these samples in the optics realm.

关键词： Fe3+ions Rare-earth oxide Mossbauer spectra Ligand field parameters Optical properties

Innovative dispersion techniques of graphene nanoplatelets(GNPs)through mechanical stirring and ultrasonication:Impact on morphological,mechanical,and thermal properties of epoxy.nanocomposites

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Defence Technology.防务技术) 2025年第1期43卷 13-25页

作者： Vasi Uddin Siddiqui S.M.Sapuan Mohd Roshdi hassan Advanced Engineering Materials and Composites Research Centre(AEMC) Department of Mechanical and Manufacturing EngineeringUniversiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia Department of Mechanical and Manufacturing Engineering Universiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia

Graphene nanoplatelets(GNPs)have attracted tremendous interest due to their unique properties and bonding *** study.focuses on the effect of GNP dispersion on the mechanical,thermal,and morphological behavior of GNP/epoxy.*** study.aims to understand how the dispersion of GNPs affects the properties of epoxy.nanocomposite and to identify.the best dispersion approach for improving mechanical performance.A solvent mixing technique that includes mechanical stirring and ultrasonication was used for producing the *** transform infrared spectroscopy.was used to investigate the interaction between GNPs and the epoxy.*** measurements of density.and moisture content were used to confirm that GNPs were successfully.incorporated into the *** findings showed that GNPs are successfully.dispersed in the epoxy.matrix by.combining mechanical stirring and ultrasonication in a single step,producing well-dispersed nanocomposites with improved mechanical ***,the nanocomposites at a low GNP loading of 0.1 wt%,demonstrate superior mechanical strength,as shown by.increased tensile properties,including improved y.ung's modulus(1.86 GPa),strength(57.31 MPa),and elongation at break(4.98).The nanocomposite with 0.25 wt%GNP loading performs better,according to the viscoelastic analy.is and flexural properties(113.18 MPa).Except for the nanocomposite with a 0.5 wt%GNP loading,which has a higher thermal breakdown temperature,the thermal characteristics do not significantly.*** effective dispersion of GNPs in the epoxy.matrix and low agglomeration is confirmed by.the morphological *** findings help with filler selection and identify.ng the best dispersion approach,which improves mechanical *** effective integration of GNPs and their interaction with the epoxy.matrix provides the doorway.for additional investigation and the development of sophisticated *** fiel

关键词： Graphene nanoplatelets Epoxy Nanocomposites Mechanical properties Thermal properties Mechanical stirrer Sonication

Comparison of biomechanical indices measured by.ocular response analy.er between children and elderly.a sy.tematic review

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International Journal of Ophthalmology.English edition) 2025年第1期18卷 154-159页

作者： hassan Hashemi Fereshteh Shokrollahzadeh Hadi Ostadimoghaddam Abbasali y.kta Mehdi Khabazkhoob Noor Ophthalmology.Research Center Noor Eye HospitalTehran ***Iran Rehabilitation Research Center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Refractive Errors Research Center Mashhad University of Medical SciencesMashhad ***Iran Department of Optometry School of Paramedical SciencesMashhad University of Medical SciencesMashhad ***Iran Department of Medical Surgical Nursing School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

Biomechanical study.of the visual sy.tem by.ocular response analy.er investigates the inter-structural biological relationships,mechanics,and function of the visual *** review aimed to investigate the changes in corneal biomechanical parameters with age and *** articles published in PubMed between 2000 and 2021 were investigated and critiqued,and valid scientific evidence was collected,reviewed and concluded according to the inclusion and exclusion *** studies showed that corneal biomechanical changes occur infrequently.in children up to the age of 20y.and with increasing age and wider age range,there was a significant decrease in corneal biomechanical indices,especially.corneal *** children and adults,most studies have shown that these biomechanical indicators,especially.corneal resistance factor,were higher in *** hormonal changes may.contribute to this finding,the role of axial length and other biometric indicators should not be *** axial length,the intraocular pressure,and the corneal thickness are other factors associated with biomechanical parameters that should be taken into account in clinical diagnosis and management especially.for patients undergoing refractive surgery.as well as keratoconus patients.

关键词： ocular response analy.er corneal biomechanics visual function children elderly

Bacteria and host: what does this mean for sepsis bottleneck?

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World Journal of Emergency.Medicine 2025年第1期16卷 10-17页

作者： Azzah S Alharbi Raghad hassan Sany. Esam I Azhar Department of Clinical Microbiology.and Immunology Faculty of MedicineKing Abdulaziz UniversityJeddah 21362Saudi Arabia Special Infectious Agent Unit King Fahad Medical Research CenterKing Abdulaziz UniversityJeddah 21362Saudi Arabia College of Health and Medical Technology Middle Technical UniversityBaghdad 10047Iraq Department of Medical Laboratory.Sciences Faculty of Applied Medical SciencesKing Abdulaziz UniversityJeddah 21362Saudi Arabia

BACKGROUND: Sepsis is a life-threatening inflammatory.condition in which the invading pathogen avoids the host's defense mechanisms and continuously.stimulates and damages host cells. Consequently. many.immune responses initially.triggered for protection become harmful because of the failure to restore homeostasis, resulting in ongoing hy.erinflammation and immunosuppression. METHODS: A literature review was conducted to address bacterial sepsis, describe advances in understanding complex immunological reactions, critically.assess diagnostic approaches, and emphasize the importance of study.ng bacterial bottlenecks in the detection and treatment of ***: Diagnosing sepsis via a single laboratory.test is not feasible;therefore, multiple key.biomarkers are ty.ically.monitored, with a focus on trends rather than absolute values. The immediate interpretation of sepsis-associated clinical signs and sy.ptoms, along with the use of specific and sensitive laboratory.tests, is crucial for the survival of patients in the early.stages. However, long-term mortality.associated with sepsis is now recognized, and alongside the progression of this condition, there is an in vivo selection of adapted ***: Bacterial sepsis remains a significant cause of mortality.across all ages and societies. While substantial progress has been made in understanding the immunological mechanisms underly.ng the inflammatory.response, there is growing recognition that the ongoing host-pathogen interactions, including the emergence of adapted virulent strains, shape both the acute and long-term outcomes in sepsis. This underscores the urgent need for novel high-throughput diagnostic methods and a shift toward more pre-emptive, rather than reactive, treatment strategies in sepsis care.

关键词： Sepsis Bacteria Bottleneck Inflammation

Topographic factors associated with anterior chamber angle narrowing in patients with keratoconus

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International Journal of Ophthalmology.English edition) 2025年第1期18卷 67-73页

作者： Hamed Soltan-Dehghan Abdollah Farzaneh hassan Hashemi Pay.m Nabovati Mehdi Khabazkhoob Rehabilitation Research Center Department of OptometrySchool of Rehabilitation SciencesIran University of Medical SciencesTehran ***Iran Noor Ophthalmology.Research Center Noor Eye HospitalTehran ***Iran Department of Medical Surgical Nursing School of Nursing and MidwiferyShahid Beheshti University of Medical SciencesTehran ***Iran

AIM:To identify.topographic determinants of the anterior chamber angle(ACA)in patients with keratoconus(KCN).METHODS:Four hundred and ten ey.s of 294 patients with KCN were recruited for this ***,complete ocular examinations were performed for all patients,including visual acuity.measurement,refraction,and slit-lamp ***,all participants underwent corneal imaging by.the Oculus Pentacam ***:The mean age of the participants was 32.40±8.52y.15-60y.and 69.5%of them were *** mean ACA was 38.47°±5.75°(range:14.40°to 56.50°)in the whole sample,38.24°±6.00°in males,and 38.98°±5.11°in females(P=0.447).The mean ACA was significantly.different among different groups of cone morphology.as patients with nipple cones showed the lowest mean ***,there were statistically.significant differences in the mean ACA among different groups of cone locations,with patients having central cones exhibiting the lowest mean ACA(Py.directly.correlated with ACA(anterior Q:r=0.122,P=0.014,posterior Q:r=0.192,Py.provides critical insights into the risk factors for ACA narrowing in KCN patients,which is essential for planning intraocular *** with nipple and central cones exhibited the most significant ACA ***,more negative Q-values are associated with increased ACA narrowing,highlighting the need for targeted diagnostic and therapeutic strategies.

关键词： keratoconus anterior chamber angle cone morphology cone location

MARIE:One-Stage Object Detection Mechanism for Real-Time Identify.ng of Firearms

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 279-298页

作者： Diana Abi-Nader hassan Harb Ali Jaber Ali Mansour Christophe Osswald Nour Mostafa Chamseddine Zaki Computer Science Department Faculty of SciencesLebanese UniversityBeirut146404Lebanon College of Engineering and Technology American University of the Middle EastEgaila54200Kuwait Lab-STICC CNRS UMR 6285ENSTA-BretagneBrest29200France

Security.and safety.remain paramount concerns for both governments and individuals *** today.s context,the frequency.of crimes and terrorist attacks is alarmingly.increasing,becoming increasingly.intolerable to ***,there is a pressing need for swift identification of potential threats to preemptively.alert law enforcement and security.forces,thereby.preventing potential attacks or violent *** advancements in big data analy.ics and deep learning have significantly.enhanced the capabilities of computer vision in object detection,particularly.in identify.ng *** paper introduces a novel automatic firearm detection surveillance sy.tem,utilizing a one-stage detection approach named MARIE(Mechanism for Realtime Identification of Firearms).MARIE incorporates the Single Shot Multibox Detector(SSD)model,which has been specifically.optimized to balance the speed-accuracy.trade-off critical in firearm detection *** SSD model was further refined by.integrating MobileNetV2 and InceptionV2 architectures for superior feature extraction *** experimental results demonstrate that this modified SSD configuration provides highly.satisfactory.performance,surpassing existing methods trained on the same dataset in terms of the critical speedaccuracy.*** these innovations,MARIE sets a new standard in surveillance technology.offering a robust solution to enhance public safety.effectively.

关键词： Firearm and gun detection single shot multi-box detector deep learning one-stage detector MobileNet inception convolutional neural network