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Nanoparticles-based nanochannels assembled on a plastic flexible substrate for label-free immunosensing

Nano Research 2015年第4期8卷 1180-1188页

作者： Alfredo de la Escosura-Muniz Marisol Espinoza-Castaneda Madoka hasegawa Laetitia Philippe Arben Merkoci ICN2-Nanobioelectronics & Biosensors Group Institut Catala de Nanociencia i Nanotecnologia Campus UAB 08193 Bellaterra (Barcelona) Spain EMPA Swiss Federal Laboratories for Materials Science and Technology Feuerwerkerstrasse 39 3602Thun Switzerland ICREA-Institucio Catalana de Recerca i Esrudis Avan@ats 08010 Barcelona Spain

A novel, cheap, disposable and single-use nanoparticles-based nanochannel platform assembled on a flexible substrate for label-free immunosensing is pre- sented. This sensing platform is formed by the dip-coating of a homogeneous and assembled monolayer of carboxylated polystyrene nanospheres （PS, 200 and 500 nm-sized） onto the working area of flexible screen-printed indium tin oxide/polyethylene terephthalate （ITO/PET） electrodes. The spaces between the self-assembled nanospheres generate well-ordered nanochannels, with inter-PS particles distances of around 65 and 24 nm respectively. The formed nanochannels are used for the effective immobilization of antibodies and subsequent protein detection based on the monitoring of [Fe（CN）6]^4- flow through diffusion and the decrease in the differential pulse voltammetric signal upon immunocomplex formation. The obtained sensing system is nanochannel-size dependent and allows human immunoglobulin G （IgG）（chosen as a model analyte） to be detected at levels of 580 ng/mL. The system also exhibits an excellent specificity against other proteins present in real samples and shows good performance with a human urine sample. The developed device represents an integrated and simple biodetection system which overcomes many of the limitations of previously reported nanochannels-based approaches and can be extended in the future to several other immuno and DNA detection systems.

关键词： nanochannel dip-coating.electrochemical biosensor label-free immunosensing

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Update on the Diagnosis and Treatment of Combined Hepatocellular Cholangiocarcinoma

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 210-217页

作者： Kai-Jian Chu Yoshikuni Kawaguchi Han Wang Xiao-Qing Jiang Kiyoshi hasegawa Biliary Surgical Department No.1 Eastern Hepatobiliary Surgical HospitalThe Naval Medical UniversityShanghaiChina Hepato-Biliary-Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineThe University of TokyoTokyoJapan Department of Pathology Eastern Hepatobiliary Surgical HospitalThe Naval Medical UniversityShanghaiChina

Combined hepatocellular-cholangiocarcinoma(cHCC-CCA)is a unique type of liver tumor that contains both hepatocellular carcinoma and cholangiocarcinoma components within a single *** fifth edition of the World Health Organization classification provides a definition and diagnostic criteria for ***,the heterogeneous histomorphology and presentation resulting from variation of the proportion of each component poses challenges for clinical diagnosis and treatment.A diagnosis of cHCC-CCA may be suggested by the synchronous elevation of serum tumor markers for hepatocellular carcinoma and cholangiocarcinoma,a mixed enhancement pattern on imaging,and a discrepancy between the elevation of tumor marker and the imaging enhancement *** examination using hematoxylin and eosin staining is considered the gold standard for diagnosing cHCC-CCA,and comprehensive examination of resection or biopsy specimens is crucial for an accurate ***,there is no standard treatment for cHCC-CCA,and surgery is the *** hepatectomy with lymphadenectomy is among the recommended surgical *** role of liver transplantation in the management of cHCC-CCA is still *** chemoembolization may be effective for unresectable cHCC-CCA,particularly for hypervascular ***,the available evidence does not support systemic therapy for advanced *** prognosis of cHCC-CCA is generally poor,and there is no established staging *** research is needed to better understand the histogenesis and clinical management of *** review provides an overview of the current literature on cHCC-CCA with a focus on its clinical characteristics,pathological diagnosis,and management.

关键词： Combined hepatocellular-cholangiocarcinoma Clinical characteristics Imaging characteristics Pathological diagnosis Treatment

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PARTICLE-BASED TRANSPARENT FUSED VISUALIZATION APPLIED TO MEDICAL VOLUME DATA

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International Journal of Modeling, Simulation, and Scientific Computing 2013年第S01期4卷 104-114页

作者： KYOKO hasegawa SAORI OJIMA YOSHIYUKI SHIMOKUBO SUSUMU NAKATA KOZABURO HACHIMURA SATOSHI TANAKA College of Information Science and Engineering Ritsumeikan University Noji Higashi 1-1-1 KusatsuShiga525-8577Japan Graduate School of Science and Engineering Ritsumeikan University Noji Higashi 1-1-1 KusatsuShiga525-8577Japan

This paper proposes a method to create 3D fusion images,such as volume–volume,volume–surface,and surface–surface *** method is based on the particle-based rendering,which uses tiny particles as rendering *** method can create natural and comprehensible 3D fusion images simply by merging particles prepared for each element to be ***,the method does not require particle sorting along the line of sight to realize right depth *** apply our method to realize comprehensible visualization of medical volume data.

关键词： Particle-based rendering fused visualization stochastic particle generation.

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Effects of Earth's curvature and radial heterogeneity in dislocation studies:Case studies of the 2008 Wenchuan earthquake and the 2004 Sumatra earthquake

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Earthquake Science 2010年第4期23卷 301-308页

作者： Guangyu Fu Wenke Sun Yoichi Fukuda Shanghua Gao Takashi hasegawa Institute of Earthquake Science China Earthquake Administration Beijing 100036 China Department of Geophysics Graduate School of Science Kyoto University Kyoto 606-8502 Japan Laboratory of Computational Geoclynamics Graduate University of Chinese Academy of Sciences Beijing 100049 China

Recently, effects of Earth＇s curvature and radial heterogeneity on coseismic deformations are often investi- gated based on the 2004 Sumatra earthquake. However, such effects are strongly related to earthquake types. As a low dip angle event, the 2004 Sumatra earthquake is not a good seismic case for such a topic since the effects for moderate dip angle events are much bigger. In this study, the half-space and spherical dislocation theories are used, respectively, to calculate co- seismic displacements caused by the 2008 Wenchuan earthquake and the 2004 Sumatra earthquake. Effects of Earth＇s curva- ture and stratification are investigated through the discrepancies of results calculated using the two dislocation theories. Re- sults show that the effects of Earth＇s curvature and stratification for the 2008 Wenchuan earthquake are much larger than those for the 2004 Sumatra earthquake. Ignoring the effects will cause errors up to 100%-200% in far field displacements for a moderate dip angle event like the 2008 Wenchuan earthquake. Such great effects are much bigger than those conclusions of previous studies. Besides, comparison with observations verifies that spherical dislocation theories yield better results than half-space ones in far fields.

关键词： coseismic displacement dislocation theory Earth model

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In-process monitoring in laser grooving with line-shaped femtosecond pulses using optical coherence tomography

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Light(Advanced Manufacturing) 2022年第3期3卷 150-159页

作者： Satoshi hasegawa Masatoshi Fujimoto Toshihisa Atsumi Yoshio Hayasaki Center for Optical Research and Education Utsunomiya University7-1-2 YotoUtsunomiya 321-8585Japan Hamamatsu Photonics K.K. 5000 HirakuchiHamakita-kuHamamatsu 434-8601Japan

A line-shaped beam is useful for increasing the processing speed in laser grooving and *** laser grooving,depth control of the processed structure is important for performing precise *** this paper,in-process monitoring of the depth of a structure formed by femtosecond laser processing with a line-shaped beam using swept-source optical coherence tomography(SS-OCT)was *** the evaluation of the SS-OCT system,the depth resolution,measurement accuracy,and axial measurable range were 15.8μm,±2.5μm and 5.3 mm,*** laser grooving,the structural shape and the distribution of deposited debris were successfully *** measured depth agreed well with the depth obtained using a laser confocal *** proposed method will be effective for precise laser processing with feedback control of the laser parameters based on in-process monitoring of the processed structure.

关键词： Optical coherence tomography Computer-generated hologram Femtosecond laser processing In-process monitoring

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Natural regression of fibrosis in chronic hepatitis B

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World Journal of Gastroenterology 2016年第24期22卷 5459-5466页

作者： Shogo Ohkoshi Haruka Hirono Kazuhiko Watanabe Katsuhiko hasegawa Kenya Kamimura Masahiko Yano Department of Internal Medicine School of Life Dentistry at Niigata The Nippon Dental University Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

The fibrosis of liver cirrhosis was considered to be irreversible before the anti-viral drugs showed that it is reversible when they lead to continuous suppression of viral replication and inflammation. However, several reports previously showed that fibrosis of type B liver cirrhosis was almost completely absorbed after the natural remission of chronic inflammation. This phenomenon might not be limited to exceptional patients, but rather occur commonly, considering the dynamic clinical features of chronic hepatitis B(CHB), where inactive carrier stage normally follows aggravation of hepatitis and progression of fibrosis at the time of HBe Ag seroconversion. Thus, fibrosis levels of CHB as a hepatocellular carcinoma(HCC)-surveillance marker, particularly those of the inactive stage, could be underestimated, because some of them might have been(pre)cirrhotic in the past and recovered with the natural regression of fibrosis. We argue that cirrhosisinduced HCC mechanisms, rather than direct action of viral genome, may be more common than generally considered in CHB patients. This may have some impact on reconsidering the surveillance rationale for HCC in CHB, from where advanced HCCs tended to be missed. In addition, a molecular marker to assess the cancer-prone characteristics of the liver will definitely be needed to resolve the issue.

关键词： Chronic hepatitis B Cirrhosis Spontaneous remission Regression of fibrosis Occult hepatitis B infection Hepatocellular carcinoma surveillance of hepatitis B virus

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Optimal treatment strategies for hepatic portal venous gas:A retrospective assessment

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World Journal of Gastroenterology 2020年第14期26卷 1628-1637页

作者： Masanori Gonda Tatsuya Osuga Yoshihiro Ikura Kazunori hasegawa Kentaro Kawasaki Takatoshi Nakashima Department of Gastroenterology Takatsuki General HospitalTakatsuki 5691192Japan Department of Pathology Takatsuki General HospitalTakatsuki 5691192Japan Department of Surgery Takatsuki General HospitalTakatsuki 5691192Japan

BACKGROUND Hepatic portal venous gas(HPVG)generally indicates poor prognoses in patients with serious intestinal *** surgical removal of the damaged portion is effective,some patients can recover with conservative *** To establish an optimal treatment strategy for HPVG,we attempted to generate computed tomography(CT)-based criteria for determining surgical indication,and explored reliable prognostic factors in non-surgical *** Thirty-four cases of HPVG(patients aged 34-99 years)were *** for surgery had been determined mainly by CT findings(***-air,embolism,lack of contrast enhancement of the intestinal wall,and intestinal pneumatosis).The clinical data,including treatment outcomes,were analyzed separately for the surgical cases and non-surgical *** Laparotomy was performed in eight cases(surgical cases).Seven patients(87.5%)survived but one(12.5%)*** each case,severe intestinal damage was confirmed during surgery,and the necrotic portion,if present,was ***-occlusive mesenteric ischemia was the most common cause(n=4).Twentysix cases were treated conservatively(non-surgical cases).Surgical treatments had been required for twelve but were abandoned because of the patients’poor general ***,however,three(25%)of the twelve inoperable patients *** remaining 14 of the 26 cases were diagnosed originally as being sufficiently cured by conservative treatments,and only one patient(7%)*** analyses of the fatal(n=10)and recovery(n=16)cases revealed that ascites,peritoneal irritation signs,and shock were significantly more frequent in the fatal *** mortality was 90%if two or all of these three clinical findings were *** HPVG related to intestinal necrosis requires surgery,and our CT-based criteria are probably useful to determine the surgical *** non-surgical cases,ascites,peritoneal irritation signs and shock were closely associated

关键词： Hepatic portal venous gas Surgical treatment Conservative treatment Computed tomography Intestinal necrosis Prognostic factor

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Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea

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World Journal of Clinical Cases 2021年第19期9卷 5112-5125页

作者： Haruka Hirono Kazuhiko Watanabe Katsuhiko hasegawa Masaki Kohno Shuji Terai Shogo Ohkoshi Department of Internal Medicine The Nippon Dental University School of Life Dentistry at NiigataNiigata 951-8580Japan The Center for Dental Sleep Medicine The Nippon Dental University Niigata HospitalNiigata 951-8580Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan

BACKGROUND Obstructive sleep apnea(OSA)has been suggested as an independent risk factor for nonalcoholic fatty liver disease(NAFLD),and continuous positive airway pressure(CPAP)is the first-line therapy for *** To clarify the efficacy of effective CPAP therapy on NAFLD of OSA patients by serum markers and transient elastography(TE)using FibroScan®(Echosens,Paris,France).METHODS We prospectively enrolled 123 consecutive patients with OSA who met the indications for *** fibrosis and steatosis were assessed using *** and after 6 mo of CPAP therapy,serum markers and TE were assessed for all *** mean usage rate of CPAP therapy for 6 mo was arbitrarily calculated in each patient and expressed as“mean compliance index”(m-CI).RESULTS In 50 OSA patients with NAFLD,both aspartate aminotransferase(AST)and alanine aminotransferase(ALT)levels were significantly decreased after 6 mo of CPAP *** analysis showed that decreased body weight(BW),decreased body mass index(BMI),decreased AST level,decreased hemoglobin A1c,and high m-CI were significantly related with improved ALT *** multivariate regression model adjusted for quantities of BW change during 6 mo of CPAP therapy,high m-CI tended to improve ALT level(P=0.051).All 17 OSA patients with NAFLD,high m-CI and no BMI changes showed significant improvements in AST and ALT ***,no significant changes in TE data or serum fibrosis markers were *** Some NAFLD could be associated with chronic intermittent hypoxia due to OSA independent of BW *** those cases,adequate reoxygenation from effective CPAP therapy may improve NAFLD.

关键词： Nonalcoholic fatty liver disease Obstructive sleep apnea Continuous positive airway pressure Chronic intermittent hypoxia Transient elastography

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Myringoplasty: A comparison of inlay and underlay techniques

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Journal of Otology 2024年第2期19卷 72-76页

作者： Hisashi Sugimoto Akiko Tamori Miyako Hatano Hiroki hasegawa Tomokazu Yoshizaki Department of Otolaryngology-Head and Neck Surgery Kanazawa University Graduate School of Medical ScienceKanazawaJapan

Purpose:Myringoplasty aims to improve hearing and prevent otorrhea,making graft uptake rates and hearing crucial *** study analyzed the factors associated with unsuccessful graft uptake and hearing improvement to guide the selection of optimal surgical approaches for ***:We retrospectively reviewed 56 ears with chronic otitis *** patients were followed up for>6 months after tympanic membrane closure *** compared the underlay method using the transcanal approach with the inlay method using the retroauricular approach for myringoplasty in patients with chronic otitis *** underlay and inlay methods were used for 23 and 33 ears,*** primary outcomes were graft uptake rate and hearing ***,factors such as the location of tympanic membrane perforation,patient age,and the degree of mastoid development were ***:The perforation rate was high when the transcanal underlay method was employed to repair perforations in the anterior inferior *** the underlay and inlay methods significantly improved ***,the success rate of the inlay method was *** the cases performed using the inlay method,outcomes tended to be poorer in older age *** were no significant differences in surgical success rates related to mastoid ***:The inlay method using the retroauricular approach is a favorable option for repairing perforations involving the anterior inferior ***,older patients presented lower rates of hearing improvement when the inlay method was used.

关键词： Myringoplasty Chronic otitis media Underlay method Inlay method

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Ultrafast laser processing of materials: from science to industry

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Light(Science & Applications) 2016年第1期5卷 548-561页

作者： Mangirdas Malinauskas Albertas Žukauskas Satoshi hasegawa Yoshio Hayasaki Vygantas Mizeikis Ričardas Buividas Saulius Juodkazis Laser Research Centre Department of Quantum ElectronicsPhysics FacultyVilnius UniversitySaulėtekio Ave.10LT-10223 VilniusLithuania Center for Optical Research and Education(CORE) Utsunomiya University7-1-2 YotoUtsunomiya 321-8585Japan Research Institute of Electronics Shizuoka University3-5-3-1 JohokuNaka-kuHamamatsu 432-8561Japan Centre for Micro-Photonics Faculty of ScienceEngineering and TechnologySwinburne University of TechnologyHawthornVIC 3122Australia Melbourne Centre for Nanofabrication ANFF151 Wellington RoadClaytonVIC 3168Australia Center of Nanotechnology King Abdulaziz UniversityJeddah 21589Saudi Arabia

Processing of materials by ultrashort laser pulses has evolved significantly over the last decade and is starting to reveal its scientific,technological and industrial *** ultrafast laser manufacturing,optical energy of tightly focused femtosecond or picosecond laser pulses can be delivered to precisely defined positions in the bulk of materials via two-/multi-photon excitation on a timescale much faster than thermal energy exchange between photoexcited electrons and lattice *** of photoionization and thermal processes with the highest precision,inducing local photomodification in sub-100-nm-sized regions has been ***-of-the-art ultrashort laser processing techniques exploit high 0.1–1μm spatial resolution and almost unrestricted three-dimensional structuring *** pulse duration,spatiotemporal chirp,phase front tilt and polarization allow control of photomodification via uniquely wide parameter *** opto-electrical/mechanical technologies have enabled laser processing speeds approaching meters-per-second,leading to a fast lab-to-fab *** key aspects and latest achievements are reviewed with an emphasis on the fundamental relation between spatial resolution and total fabrication *** biomedical applications implementing micrometer feature precision over centimeter-scale scaffolds and photonic wire bonding in telecommunications are highlighted.

关键词： biomedical applications direct laser writing functional microdevices material processing nonlinear light–matter interaction 3D structuring ultrashort laser pulses

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