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Estimation of plasma parameters of X-pinch with time-resolved x-ray spectroscopy

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Matter and Radiation at Extremes 2023年第3期8卷 34-46页

作者： Seunggi Ham Jonghyeon Ryu Hakmin lee Sungbin Park Y.-C.Ghim Y.S.Hwang Kyoung-Jae Chung Department of Energy Systems Engineering Seoul National UniversitySeoul 08826South Korea Department of Nuclear and Quantum Engineering KAISTDaejeon 34141South Korea

We estimate the parameters of a Cu plasma generated by an X-pinch by comparing experimentally measured x-rays with synthetic data.A filtered absolute extreme ultraviolet diode array is used to measure time-resolved x-ray spectra with a spectral resolution of∼1 keV in the energy range of 1–10 *** synthetic spectra of Cu plasmas with different electron temperatures,electron densities,and fast electron fractions are calculated using the FLYCHK *** quantitative comparison with the measured spectrum,two x-ray power ratios with three different spectral ranges are *** observe three x-ray bursts in X-pinch experiments with two Cu wires conducted on the SNU X-pinch at a current rise rate of∼0.2 ka/*** of the spectra reveals that the first burst comprises x-rays emitted by hot spots and electron beams,with characteristics similar to those observed in other *** second and third bursts are both generated by longlived electron beams formed after the neck structure has been completely *** the second burst,the formation of the electron beam is accompanied by an increase in the electron density of the background ***,the long-lived electron beams generate the additional strong x-ray bursts while maintaining a plasma channel in the central region of the ***,they emit many hard x-rays(HXRs),enabling the SNU X-pinch to be used as an HXR *** study confirms that the generation of long-lived electron beams is crucial to the dynamics of X-pinches and the generation of strong HXRs.

关键词： resolved parameters absolute

Effects of Lewis and karlovitz numbers on transport equations for turbulent kinetic energy and enstrophy

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Acta Mechanica Sinica 2022年第7期38卷 29-44,I0001页

作者： Hsu-Chew lee Xiaoyu Liu Peng Dai Zheng Chen Abouelmagd Abdelsamie Minping Wan Guangdong Provincial Key Laboratory of Turbulence Research and Applications Department of Mechanics and Aerospace EngineeringSouthern University of Science and TechnologyShenzhen518055China Department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing100871China Laboratory of Fluid Dynamics and Technical Flows University of Magdeburg“Otto von Guericke”Magdeburg39106Germany National Center for Applied Mathematics Shenzhen Shenzhen518055China

A three-dimensional Direct numerical simulation(DNS)with complex chemistry was employed to examine the statistical behavior of turbulent kinetic energy(TKE)and enstrophy transport equations in hydrogen(Lewis number(Le)≈0.4)and dodecane(Le≈4.2)*** karlovitz(ka)numbers ranged from 4 to 150,involving both the thin and broken reaction *** analyses of TKE and enstrophy transport equations are performed,and scaling terms in the literature are *** to thin reaction zone flames,viscous dissipation term appears to be the most important term in the TKE balance,while viscous dissipation and vortex-stretching terms are the dominant terms in the enstrophy transport equation at high ka *** velocity-pressure gradient and the mean velocity dilatation in the TKE transport equation and the dilatation term in enstrophy budget are found to be affected by the *** scaling estimations for those terms affected by Le are proposed in this work to account for the Le effects spanning different combustion *** work confirmed that Kolmogorov’s first hypothesis is not valid for low ka number flames investigated in this study,where the vortex stretching and viscous dissipation terms cannot be scaled with local dissipation and *** sufficiently high ka number flames,the vorticity can be scaled with the Kolmogorov time scale,and the mean enstrophy value approaches homogeneous,isotropic,non-reacting turbulence flow,but lower Le fuels require much higher ka number to achieve that.

关键词： Direct numerical simulations Turbulent premixed flames Lewis number Complex chemistry

Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field

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Bioactive Materials 2023年第4期22卷 312-324页

作者： Yucong Li Linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl Sien Lin Liming Bian Wayne Yuk-Wai lee Gang Li Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region Research&Clinical Affairs Orthofix Medical Inc.LewisvilleTXUSA Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong Special Administrative Region Innovation Centre for Advanced Interdisciplinary Medicine Key Laboratory of Biological Targeting DiagnosisTherapy and Rehabilitation of Guangdong Higher Education InstitutesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhenPR China School of Biomedical Sciences and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhouPR China Department of Orthopaedics and Traumatology SH Ho Scoliosis Research LaboratoryJoint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing UniversityThe Chinese University of Hong KongHong Kong Special Administrative Region

Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged *** is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix *** have been made to seek suitable scaffolds for cartilage tissue *** Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing *** time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage ***,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid *** granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical *** electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic *** treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue *** we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue *** this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were *** treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in *** of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy r

关键词： Supramolecular hydrogels Pulsed electromagnetic field Cartilage tissue engineering Mesenchymal stem cells Chondrogenesis

Experimental Verification to Estimate Ground Thermal Conductivity Using Spiral Coil Type Ground Heat Exchangers

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Journal of Civil Engineering and Architecture 2014年第4期8卷 425-429页

作者： Seok Yoon Min Jun Kim Gyu Hyun Go Seung Rae lee Department of Civil and Environmental Engineering Korean Advanced Institute of Science and Technology (KA1ST) Daejeon305-701 South Korea

This paper presents an experimental study on the evaluation of thermal response of a spiral coil type GHE （ground heat exchanger）. This GHE was installed on partially saturated landfill ground that was composed of silt and clay in the runway area of Incheon International airport. TRT （thermal response test） was conducted for more than 65 hours under continuous operation conditions. Ground thermal conductivity was derived based on line source theory, which has usually been found to be appropriate for line type GHEs such as U, W and 2U types. A reasonable method to derive ground thermal conductivity using the infinite line source theory for a spiral coil type GHE was introduced. Ground thermal conductivity from the TRT using spiral coil type GHE was compared with those from the analytical equivalent model of ground thermal conductivity.

关键词： Ground thermal conductivity ground heat exchanger thermal response test spiral coil.

O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repair

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Bioactive Materials 2023年第10期28卷 255-272页

作者： Yucong Li Linlong Li Ming Wang Boguang Yang Baozhen Huang Shanshan Bai Xiaoting Zhang Nan Hou Haixing Wang Zhengmeng Yang Chong Tang Ye Li Wayne Yuk-Wai lee Lu Feng Micky D.Tortorella Gang Li Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region of China Musculoskeletal Research Laboratory Department of Orthopaedics&TraumatologyFaculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region of China The CUHK-ACC Space Medicine Centre on Health Maintenance of Musculoskeletal System The Chinese University of Hong Kong Shenzhen Research InstituteShenzhenPR China Department of Orthopaedics Peking University Shougang HospitalBeijingPR China Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong Special Administrative Region of China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina

Lacking self-repair abilities,injuries to articular cartilage can lead to cartilage degeneration and ultimately result in *** engineering based on functional bioactive scaffolds are emerging as promising approaches for articular cartilage regeneration and *** the use of cell-laden scaffolds prior to implantation can regenerate and repair cartilage lesions to some extent,these approaches are still restricted by limited cell sources,excessive costs,risks of disease transmission and complex manufacturing *** approaches through the recruitment of endogenous cells offer great promise for in situ articular cartilage *** this study,we propose an endogenous stem cell recruitment strategy for cartilage *** on an injectable,adhesive and self-healable o-alg-THAM/gel hydrogel system as scaffolds and a biophysio-enhanced bioactive microspheres engineered based on hBMSCs secretion during chondrogenic differentiation as bioactive supplement,the as proposed functional material effectively and specifically recruit endogenous stem cells for cartilage repair,providing new insights into in situ articular cartilage regeneration.

关键词： Bioactive hydrogels Solidified secretome Adhesive hydrogels Acellular functional scaffold Cartilage repair

Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome

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Traditional Medicine Research 2022年第3期7卷 44-54页

作者： Leanne lee Leung Jing Xie Ya-Cun Chen kar-Ho Lam Hei Wan Su-Lan Yu Tzi-Bun Ng George Pak-Heng Leung Jin Yu Ren-Min Yao Shu-Jia Sun Sydney Chi-Wai Tang Hai-Yong Chen Jia Zhao Zhang-Jin Zhang Calvin kai-Fai lee kalin Yan-Bo Zhang Li-Xing Lao Yun Feng Xiang Lin Wei Meng School of Chinese Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Workstation for Training and Research(Hong Kong Branch) Distinguished Professor Yu Jin Gynaecology of Chinese Medicine&Integrative MedicineHong Kong 999077China Shanghai Taikuntang Chinese Medicine Hospital Shanghai 200023China Department of Medicine Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong 999077China Virginia University of Integrative Medicine Virginia 22031USA Department of Ophthalmology Peking University Third HospitalBeijing 100191China Workstation of Zhu Nansun National Master of Chinese MedicineHong Kong Branch of Zhu’s School of Gynaecology of Chinese Medicine from ShanghaiHong Kong 999077China

Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing ***,PCOS patients have decreased pregnancy rates and clomiphene citrate *** traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with ***,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been ***:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established *** serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was ***:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with *** serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(Pkaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also cl

关键词： polycystic ovary syndrome traditional Chinese medicine ovulation Kun-Tai-1A seahorse endocrine disease

Application of Cellulose Nanofibril as a Wet-end Additive in Papermaking:A Brief Review

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Paper And Biomaterials 2020年第2期5卷 76-84页

作者： Guihua Yang Guangrui Ma Ming He Xinxiang Ji Hye Jung Youn Hak Lae lee Jiachuan Chen State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology(Shandong Academy of Sciences)Ji'nanShangdong Province250353China Department of Forest Sciences Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National University1 Gwanak-roGwanak-guSeoul08826South Korea

Recently,cellulose nanofibril(CNF)has emerged as a promising,sustainable reinforcement with outstanding potential in material *** to the properties of CNF,it has been explored in food,cosmetic,and pharmaceutical applications,as well as in industrial applications such as paints,drill muds,packaging,and *** application of CNF in papermaking is expected to be implemented in the near future to broaden the commercial market of *** studies and patents have reported on the manufacturing,properties,and applications of *** present paper focuses on the recent progresses in the application of CNF as a wet-end additive in papermaking.

关键词： cellulose nanofibril papermaking wet-end additive dewatering

Supramolecular encapsulation of a Rho kinase inhibitor by cucurbit[7]uril

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Supramolecular encapsulation of a Rho kinase inhibitor by cu...

Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction

全国第十八届大环化学暨第十届超分子化学学术讨论会

作者： Hang Yin Linmin Chen Simon M.Y.lee Ruibing Wang State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau

Fasudil,a Rho kinase(ROCK)inhibitor that has shown a great potential in protection of the central nervous system by promoting neurite outgrowth,is encapsulated by cucurbit[7]uril(CB[7])in 1:1 stoichiometry with the binding affinity of 2.2(±0.12)×13 M and 4.28(±0.21)×10 M under physiological and acidic conditions,respectively.A p ka shift of 2.91 of the guest drug

关键词： Cucurbituril Rho kinase inhibitor Host-guest interaction

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Cellular & Molecular Immunology 2010年第4期7卷 263-270页

作者： Anna hing-Yee Law Davy Chun-Wai lee Kwok-Yung Yuen Malik Peiris Allan Sik-Yin Lau Cytokine Biology Group Department of Paediatrics and Adolescent MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Historically,influenza pandemics have arisen from avian influenza *** influenza viruses H5N1 and H9N2 are potential pandemic *** of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%,which has been attributed to dysregulation of the cytokine *** macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 *** mechanisms underlying this cytokine and chemokine hyperinduction are not fully *** the present study,we demonstrate that autophagy,a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents,plays a role in cytokine *** is induced to a greater extent by H9N2/G1,in association with cytokine hyperinduction,compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 *** 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene,Atg5,we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-a expression in primary human blood *** results provide new insights into the pathogenic mechanisms of avian influenza viruses.

关键词： autophagy CXCL10 influenza interferon