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基于社区的气候变化适应方法与高海拔Garhwal喜马拉雅山脉Bhagirathi地区的生计安全

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Journal of Resources and Ecology 2024年第1期15卷 197-203页

作者： Shoryabh SRIVASTAVA Bindhy Wasini PANDEY Virender singh negi 德里大学经济学院地理系印度德里110007 德里大学莎希德·巴加特·辛格学院地理系(E) 印度德里110017

位于Garhwal喜马拉雅山的Bhagirathi(HA-BV)谷地是一个生态和文化重要性极高的地区,但当地居民的生计容易受到气候变化的影响。基于社区的气候变化适应方法(CB-CCA)已成为一种增强地方社区的经济和社会福祉重要策略,并提高了社区发展的... 详细信息

位于Garhwal喜马拉雅山的Bhagirathi(HA-BV)谷地是一个生态和文化重要性极高的地区,但当地居民的生计容易受到气候变化的影响。基于社区的气候变化适应方法(CB-CCA)已成为一种增强地方社区的经济和社会福祉重要策略,并提高了社区发展的韧性。本文旨在研究HA-BV地区的CB-CCA和生计保障计划,关注应对气候变化所面临挑战的策略。研究认为优先考虑适应该地区崎岖的地形和恶劣的天气条件的可持续生计选择至关重要。例如,与山谷独特的土壤和气候动态相适应,推广温室种植和农林复合种植等替代农业,可能会带来较好的结果;此外,鼓励养蜂、手工艺和生态旅游等替代生计途径不仅可以创收,还能保护该地区的自然环境。为了鼓励当地居民实施这些环境友好的生计措施,政府和利益相关者需要进行战略性投资,基础设施的完善(包括道路建设和电力供应)可为经济增长创造良好的条件。研究结果可为喜马拉雅山地区的可持续发展做出贡献,为类似情境下未来构建气候韧性和保障生计的努力提供参考。

关键词： Bhagirathi谷基于社区的方法气候变化适应生计保障 Garhwal喜马拉雅山

Effects of irregularity and initial stresses on the dynamic response of viscoelastic half-space due to a moving load

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Acta Mechanica Solida Sinica 2017年第3期30卷 306-317页

作者： A.K. singh A. Das A. Lakshman A. negi A. Chattopadhyay Department of Applied Mathematics Indian Institute of Technology (Indian School of Mines) Dhanbad 826004 Jharkhand India

The present article deals with the stresses developed in an initially stressed irregular viscoelastic half-space clue to a load moving with a constant velocity at a rough free surface. Expressions for normal and shear stresses are obtained in closed form. The substantial effects of influence parameters, viz., depth （from the free surface）, irregularity factor, maximum depth of irregularity, viscoelastic parameter, horizontal and vertical initial stresses, and frictional coefficient, on normal and shear stresses are investigated. Moreover, comparative study is carried out for three different cases of irregularity, viz., rectangular irregularity, parabolic irregulariW and no irregularity, which is manifested through graphs.

关键词： Viscoelastic Irregularity Moving load Frictional coefficient Stresses

A new flavone C-glucoside from Glycosmis arborea(Rutaceae)

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Chinese Chemical Letters 2010年第12期21卷 1443-1445页

作者： Rajni Kant Sharma Sushma Semwal Devendra singh negi Department of Chemistry HNB Garhwal Central University SrinagarUttarakhandIndia Department of Chemistry University of Cape TownCape TownRondebosch 7701South Africa

A new C-glycosyl flavone 7,4＇-dihydroxy-5-methoxyflavone-6-C-β-D-glucopyranoside 1 has been isolated and characterized form ethanolic extract of leaves part of Glycosmis *** structure of compound was verified by mea... 详细信息

关键词： Glycosmis arborea Rutaceae Flavone C-glucoside

Ethnobotanical and Indigenous Knowledge of Important Plants in East Hararghe, Eastern Ethiopia

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Journal of Mountain Science 2015年第6期12卷 1521-1533页

作者： Laxman singh KANDARI Tripti negi Ashok Kumar THAKUR Eshetu YILMA Department of Forestry Himgiri Zee University Don Paramedical college and Hospital School of Plant Science College of Agriculture and Environmental Sciences Haramaya University

An ethnobotanical study was conducted in East Hararghe, Ethiopia to identify and investigate the use of various plants by the traditional healers and communities engaged in domestic, pesticide and medicinal use. A total of 78 species were observed to be used by the local inhabitants in the region for the treatments of various ailments. Out of these, herbs constitute 49% followed by trees(36%) and shrubs only 15%. However, most frequently used plant parts were leaf and aerial parts(20) followed by seed(13), fruit(12), other parts(10), rhizome(7) and bark(1). Most of the plants were found to be used for medicinal, aromatic and food flavouring(spices, condiments) purposes. Out of 78 species recorded in the present study, 11 were reported to cure stomachache, seven for cold, cough and respiratory problem, six for diarrhoea and five species were found capable of curing fever. Fabaceae was the largest family contributing to medicinal plant use with seven species followed by Solanaceae, Myrtaceae,(5 spp.), and Zingiberaceae, Asteraceae, Liliaceae(4 spp. each). Some of the important plants utilized for taking care of variety of ailments are Azadirachta indica, Brassica nigra, Balanites aegyptiaca, Maytenus ovatus, Rosmarinus officinalis and Trigonella foenum graecum. Most of these medicinal and aromatic plants(MAPs) play a significant role in the household economy and were observed to be very popular among the people. Unpopular plants were left out of the study. This study provides useful and basic information on usage of different plants for conducting further studies aimed at conservation and documentation of traditional medicine system and economic welfare of rural peoples of the East Hararghe, Ethiopia. It also revealed that indigenous practices contributed to sustainable management of plants.

关键词： Ethnobotany Medicinal plants Primary health care Traditional knowledge East Hararghe

Impact of source and drain contact thickness on the performance of organic thin film transistors

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Journal of Semiconductors 2014年第12期35卷 21-27页

作者： Poornima Mittal Y.S.negi R.K.singh Department of Electronics & Communication Engineering Graphic Era UniversityDehradun–248002 India Department of Electronics & Communication Engineering Uttarakhand Technical UniversityDehradun–248002 India Department of Polymer and Process Engineering Indian Institute of Technology Roorkee–246776 India

This paper analyzes the impact of source（ts） and drain（td） contact thicknesses on top contact（TC） and bottom contact（BC） organic thin film transistors（OTFTs） with a gate in the bottom, using a benchmarked industry standard Atlas 2-D numerical device simulator. The parameters including drive current（Ids）, mobility（μ）, threshold voltage（Vt）and current on-off ratio（ION/IOFF） are analyzed from the device physics point of view on different electrode thicknesses, ranging from infinitesimal to 50 nm, for both top and bottom contact structures. Observations demonstrate that the performance of the BC structure is more affected by scaling of ts=din comparison to its counterpart. In the linear region, the mobility is almost constant at all the values of ts=dfor both structures. However,an increment of 18% and 83% in saturation region mobility is found for TC andBC structures, respectively with scaling down ts=dfrom 50–0 nm. Besides this, the current on-off ratio increases more sharply in the BC *** analysis simplifies a number of issues related to the design and fabrication of organic material based devices and circuits.

关键词： contact thickness organic semiconductor organic thin film transistor bottom contact top contact structure

Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1041-1057页

作者： Samreen Khan Abhishek Kumar Rai Anjali singh Saudan singh Basant Kumar Dubey Raj Kishori Lal Arvind singh negi Nicholas Birse Prabodh Kumar Trivedi Christopher T.Elliott Ratnasekhar Ch Metabolomics Lab Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Crop Production&Protection Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Academy of Council of Scientific and Industrial Research(ACSIR) Ghaziabad201002India Department of Biotechnology Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Genetics and Plant Breeding Department Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India Department of Phytochemistry Council of Scientific and Industrial Research(CSIR)-Central Institute of Medicinal and Aromatic Plants(CIMAP)Lucknow226015India School of Biological Sciences Queen's UniversityBelfastBT95DLUK

Herbal medicines are popular natural medicines that have been used for *** use of alternative medicines continues to expand rapidly across the *** World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications,as their therapeutic potential varies between different geographic origins,plant species,and *** of herbal medicines based on a limited number of secondary metabolites is not an ideal *** quality should be considered based on a complete metabolic profile,as their pharmacological activity is not due to a few specific secondary metabolites but rather a larger group of bioactive compounds.A holistic and integrative approach using rapid and nondestructive analytical strategies for the screening of herbal medicines is required for robust *** this study,a rapid and effective quality assessment system for geographical traceability,species,and variety-specific authenticity of the widely used natural medicines turmeric,Ocimum,and Withania somnifera was investigated using Fourier transform near-infrared(FT-NIR)spectroscopy-based metabolic *** different geographical origins of turmeric,five different Ocimum species,and three different varieties of roots and leaves of Withania somnifera were studied with the aid of machine learning *** good discrimination(R^(2)>0.98,Q^(2)>0.97,and accuracy=1.0)with sensitivity and specificity of 100%was achieved using this metabolic fingerprinting *** study demonstrated that FT-NIR-based rapid metabolic fingerprinting can be used as a robust analytical method to authenticate several important medicinal herbs.

关键词： Rapid metabolic fingerprinting Natural medicines FT-NIR Chemometric models

Prospects of diagnostic and prognostic biomarkers of pyometra in canine

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Asian pacific Journal of Reproduction 2020年第4期9卷 166-173页

作者： Laishram Kipjen singh Manas Kumar Patra Girish Kumar Mishra Abhishek Chandra Saxena Ujjwal Kumar De Sanjay Kumar singh harendra Kumar Krishnaswamy Narayanan Animal Reproduction Division Indian Veterinary Research InstituteIzatnagarU.P.243122India Animal Reproduction Gynaecology and Obstetrics Division ICAR-National Dairy Research InstituteKarnal-132001India Department of Veterinary Gynaecology andObstetrics College of Veterinary Sciences and Animal HusbandryAnjoraDurg(C.G.)India Referral Veterinary Polyclinic ICAR-Indian Veterinary Research InstituteIzatnagarU.P.243122India ICAR-Indian Veterinary Reseach Institute HebbalBangaluru 560024India

Pyometra is one of the most common uterine pathologies of intact bitch at middle to advanced age. In the early stages, the disease shows subtle changes, making diagnosis a challenge. In contrast, at later stages, it manifests as potentially life-threatening systemic inflammatory response syndrome. Ultrasonographic examination of the uterus aids in the diagnosis, although it has limitation in ascertaining the clinical severity of pyometra. Moreover, differentiation of cystic endometrial hyperplasia from pyometra could not be discerned with greater accuracy. Therefore, false negative diagnosis of pyometra patients leads to development of systemic inflammatory response, which delays administration of therapies and results in deaths during early course of treatment. Further, indiscriminate use of broad-spectrum antimicrobials at higher dose in false positive cases considerably contributes to the rising pool of drug resistant pathogens, thereby increasing the risk of case fatality due to sepsis in a long-term. Monitoring the circulating pro-inflammatory cytokines, acute phase proteins, endotoxin, growth factors and inflammatory mediators is the current trend in pyometra research, especially for developing diagnostic and prognostic biomarkers. The present review deals with the prospects of developing diagnostic and prognostic biomarkers in the canine pyometra.

关键词： Pyometra Systemic inflammatory response Acute-phase proteins Prostaglandin F metabolite Canine

Gold Nanoparticles: Synthesis and Effect on Viability of Human Non-Small Lung Cancer Cells

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Advances in Materials Physics and Chemistry 2021年第9期11卷 145-153页

作者： Rakesh Sharma Yuvraj singh negi Innovations and Solutions Amity University and Florida State University Research Foundation Tallahassee USA Indian Institute of Technology Roorkee Saharanpur Campus Saharanpur India

Gold nanoparticles recently showed great interest for many uses including food, drug and medical applications. The algae Undaria sp. well known as wakame in South Asia are considered to be large edible brown algae. It provides nutritious source of dietary fiber, vitamin Bs and mineral. The present study aimed to investigate the use of Undaria sp. for green synthesis of metallic gold nanoparticles. The synthesized nanoparticles were characterized for physicochemical properties including size measurement and tested in vitro for their effect on viability of human non-small lung cancer H-460 cell line using the MTT assay. From the results, brown algae were able to chemically form nanoparticles with chloroauric acid solution possibly due to the sulphated polysaccharides found in algae. The particle sizes were found to be approximately 10 nm. The gold nanoparticles stabilized by the algae could decrease the cancer cell viability. However, the properties and biological activity of nanoparticles seemed to depend upon reaction time and temperature. Conclusively, gold nanoparticles synthesized and stabilized by the algae could decrease the cancer cell viability, thus indicating the potential of such nanoparticles for further study for anticancer activity.

关键词： Brown Algae Undaria sp. Gold Nanoparticles MTT Assay Non-Small Lung Cancer Cells

Effect of COVID-19 pandemic on blood transfusion service:an experience from a regional blood transfusion center

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Blood Science 2023年第3期5卷 209-217页

作者： Sanjay K.Thakur Anil K.Sinha Dinesh K.negi Sompal singh PhD Research Scholar P.G.Department of ZoologyVeer Kunwar Singh UniversityAraBihar 802301India Dean Faculty of Science and Head P.G.Department of Zoology Veer Kunwar Singh UniversityAraBihar 802301India Former CMO In charge Department of RBTCHindu Rao HospitalDelhi 110007India Specialist Pathologist Head Department of Regional Blood Transfusion Centre and Department of PathologyHindu Rao HospitalDelhi 110007India

The unforeseen and uncertain life-threatening situation of the COVID-19 pandemic dramatically affected all areas of the human daily work *** study was designed to assess the impact of the COVID-19 pandemic on blood transfusion services and discuss the adopted confrontation measures for uninterrupted blood supply during the pandemic *** data on blood donation,blood component preparation,and issue from January 2019 to December 2022 were collected from the inventory registers of the RBTC,Delhi,*** to the non-pandemic year 2019,during the year 2020,all variables decreased *** observed maximum decrease in variables such as blood collection(–79.16%)in the month of October,blood issue(–71.61%)in the month of August,random donor platelets(RDP)preparation(–98.09%)in the month of October,RDP issue(–86.08%)in the month of September,fresh frozen plasma(FFP)preparation(–100%)in the month of October,and FFP issue(–96.08%)in the month of July with an annual decrease of–45.52%,–42.87%,–33.00%,–59.79%,–40.98%,and–54.48%,respectively,as compared to year *** to year 2020,in year 2021,the annual increase in blood collection,blood issue,FFP preparation,FFP issue,RDP preparation,and RDP issue was+50.20%,+21.68%,+65.31%,+78.52%,+116.23%,and+213.30%,*** study results show that the COVID-19 pandemic has significantly affected blood transfusion services at our blood *** adopted coping strategies to maintain the safe and uninterrupted blood transfusion chain at our blood bank gave us lessons for future preparedness if faced with a similar situation.

关键词： Blood bank inventory Blood components Blood recipients Blood transfusion COVID-19 pandemic