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Mesenteric ischemia with intrasplenic gas:A case report

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World Journal of Clinical Cases 2025年第7期13卷 52-56页

作者： Hsiang-Yu Tsang Chee-Chien Yong hao-ping Wang Department of Surgery Kaohsiung Chang Gung Memorial HospitalKaohsiung 833401Taiwan

BACKGROUND Acute mesenteric ischemia is a life-threatening *** gas is an extremely rare finding in such *** SUMMARY We report a case of a 79-year-old woman with a history of end-stage renal disease on hemodialysis for approximately 20 years,type 2 diabetes mellitus,and atrial fibrillation who presented with two days of epigastric pain.A computed tomography scan of the abdomen revealed intraperitoneal free air and significant intrasplenic *** revealed diffuse intestinal gangrene,and acute superior mesenteric ischemia was *** patient died within 24 hours owing to profound *** Intrasplenic gas is an extremely rare finding on computed tomography imaging in cases of acute mesenteric ischemia.

关键词： Acute mesenteric ischemia Spleen Hepatic portal venous gas Pneumatosis cystoides intestinalis Prognosis Case report

A better parameter in predicting insulin resistance:Obesity plus elevated alanine aminotransferase

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World Journal of Gastroenterology 2009年第44期15卷 5598-5603页

作者： ping-hao then Jong-Dar Chen Yu-Cheng Lin Department of family practice Lo-Sheng Sanatorium Department of Health Taipei County 242 Taiwan China Department of family medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan China Department of Occupational Medicine Tao- Yuan General Hospital Department of Health Tao-Yuan 330 Taiwan China

AIM:To investigate the association of obesity and elevated alanine aminotransferase with insulin resistance and compare these factors with metabolic syndrome. METHODS:We enrolled a total of 1308 male workers aged from 22 to 63 *** was extracted from the workers'periodic health check-ups in *** cases were from the community of northern Taiwan. This was a cross-sectional observational study from July to September in *** grouped all cases into four groups,based on the quartile of homeostasis model *** top fourth quartile group was defined as the group with insulin *** performed multivariate logistic regression analysis for the odds ratio of the risk factors for insulin resistance. RESULTS:Compared with metabolic syndrome,the coexistence of both factors had a 4.3-fold(95%CI: 2.7-6.8)increased risk,which was more than metabolic syndrome with a 3.6-fold(95%CI:2.6-5.0)increased *** two factors had a synergistic *** synergistic index of obesity and elevated alanine aminotransferase(ALT)was 2.1(95%CI:1.01-4.3).CONCLUSION:Obesity and elevated ALT are associatedwith insulin *** effects are synergistic. Coexistence of them is better than metabolic syndrome in predicting insulin resistance.

关键词： Alanine aminotransferase Transaminase Overweight Obesity Insulin resistance

Role of Nitric Oxide Dependence on Nitric Oxide Synthase-like Activity in the Water Stress Signaling of Maize Seedling

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Journal of Integrative Plant Biology 2008年第4期50卷 435-442页

作者： Gang-ping hao Yu Xing Jian-Hua Zhang Department of Biological Science Taishan Medical University Taian 271000 China Department of Biology Hong Kong Baptist University Hong Kong China

Nitric oxide （NO） has been known as an important signal in plant antioxidative defense but its production and roles in water stress are less known. The present study investigated whether NO dependence on a NO synthase-like （NOS） activity is involved in the signaling of drought-induced protective responses in maize seedlings. NOS activity, rate of NO release and drought responses were analyzed when NO donor sodium nitroprusside （SNP）, NO scavenger c-PTIO （2-（4-carboxyphenyl）- 4,4,5,5-tetramethylimidazoline-l-oxyl-3-oxide） and NOS inhibitor L-NAME （NG-nitro-L-arginine methyl ester） were applied to both detached maize leaves and whole plants. Both NOS activity and the rate of NO release increased substantially under dehydration stress. The high NOS activity induced by c-PTIO as NO scavenger and NO accumulation inhibited by NOS inhibitor L-NAME in dehydration-treated maize seedlings indicated that most NO production under water deficit stress may be generated from NOS-like activity. After dehydration stress for 3 h, detached maize leaves pretreated with NO donor SNP maintained more water content than that of control leaves pretreated with water. This result was consistent with the decrease in the transpiration rate of SNP-treated leaves subjected to drought treatment for 3 h. Membrane permeability, a cell injury index, was lower in SNP-treated maize leaves under dehydration stress for 4 h when compared with the control leaves. Also, superoxide dismutase （SOD） activity of SNP combined drought treatment maize leaves was higher than that of drought treatment alone, indicating that exogenous NO treatment alleviated the water loss and oxidative damage of maize leaves under water deficit stress. When c-PTIO as a specific NO scavenger was applied, the effects of applied SNP were overridden. Treatment with L-NAME on leaves also led to higher membrane permeability, higher transpiration rate and lower SOD activities than those of control leaves, indicating that NOS-like activity

关键词： anti-oxidative defense maize (Zea mays) nitric oxide nitric oxide synthase signal transduction water stress.

Recent Advances of Porous Solids for Ultradilute CO_(2) Capture

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Chemical Research in Chinese Universities 2022年第1期38卷 18-30页

作者： LIU Ru-Shuai XU Shuang hao Guang-ping LU An-Hui State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion Carbon ResourcesSchool of Chemical EngineeringDalian University of TechnologyDalian 116024P.R.China

The urgency of dealing with global climate change caused by greenhouse gas(GHG) emissions is increasing as the carbon dioxide(CO_(2)) concentration in the atmosphere has reached a record high value of 416 ppm(parts per million). Technologies that remove CO_(2) from the surrounding air(direct air capture, DAC) could result in negative carbon emissions, and thus attracts increasing attention. The steady technical progress in adsorption-based CO_(2) separation greatly advanced the DAC, which largely relies on advanced sorbent materials. This review focuses on the latest development of porous solids for air capture;first discussed the main types of sorbents for air capture, which include porous carbons, zeolites, silica materials, and metal-organic frameworks(MOFs), particularly their modified counterparts. Then, we evaluated their performances, including uptake and selectivity under dry and humid CO_(2) streams for practical DAC application. Finally, a brief outlook on remaining challenges and potential directions for future DAC development is given.

关键词： Direct air capture Porous carbon CO_(2)capture Porous solid Adsorption

Adaptive Fuzzy Dynamic Surface Control for Uncertain Nonlinear Systems

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International Journal of Automation and computing 2009年第4期6卷 385-390页

作者： Xiao-Yuan Luo Zhi-hao Zhu Xin-ping Guan Institute of Electrical Engineering Yanshan University Qinhuangdao 066004 PRC

In this paper, a robust adaptive fuzzy dynamic surface control for a class of uncertain nonlinear systems is proposed. A novel adaptive fuzzy dynamic surface model is built to approximate the uncertain nonlinear functions by only one fuzzy logic system. The approximation capability of this model is proved and the model is implemented to solve the problem that too many approximators are used in the controller design of uncertain nonlinear systems. The shortage of ＂explosion of complexity＂ in backstepping design procedure is overcome by using the proposed dynamic surface control method. It is proved by constructing appropriate Lyapunov candidates that all signals of closed-loop systems are semi-globally uniformly ultimate bounded. Also, this novel controller stabilizes the states of uncertain nonlinear systems faster than the adaptive sliding mode controller （SMC）. Two simulation examples are provided to illustrate the effectiveness of the control approach proposed in this paper.

关键词： Uncertain nonlinear systems fuzzy logic system dynamic surface control backstepping design

Effect of Delay on the Synchronization of Weakly Coupled Neurons via Excitatory Chemical Synapses

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Effect of Delay on the Synchronization of Weakly Coupled Neu...

Cumulative Coulomb Failure Stress Change in the Basin- range Region of West Beijing and Its Effect on Strong Earthquakes

第25届中国控制与决策会议

作者： ping hao Ruixue Li Yanqiu Che Chunxiao Han Tianjin Key Laboratory of Information Sensing & Intelligent Control Tianjin University of Technology and Education Institute of Semiconductors Chinese Academy of Sciences

ISBN: (纸本)9781467355322

Excitatory chemical coupling connections are ubiquitous in neuronal system. In this paper, we investigate the effect of conduction time delays on synchronization properties of weakly coupled Morris-Lecar neuronal oscillators via excitatory chemical synapses. We first reduce the complex neuronal dynamics to a simple phase model by means of phase-model reduction method. Then we examine the roles of time delays extensively on the synchronization properties by bifurcation analysis and numerical simulation. Finally, we identify the existence and the stability of various phase- locked states, including in-phase, anti-phase and out-of-phase synchronization states.

关键词： Time delays Synchronization Chemical synapses Bifurcation

来源： cnki会议评论

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Earthquake Research in China 2016年第4期30卷 513-525页

作者： Chen Dan hao ping Institute of Earthquake Science CEA

Since 231 B. C.,a total of 15 M6.0 - 7.5 earthquakes have been recorded in the west Beijing basin-range tectonic region( 38.3°- 41.5° E,112°- 116.2° N),a region mainly under the action of tensional normal faulting. In this paper,we calculate the Coulomb stress change of each earthquake and the cumulative Coulomb stress change,and on this basis we analyze the stress triggering of strong earthquakes. The research shows that there are 10 of 14 earthquakes that occurred in the trigger zones,in which the Coulomb stress change is positive,and the trigger rate is 71%. The positive areas of cumulative Coulomb stress change caused by these 15 earthquakes are: middle of northern Liulengshan fault,Northern Huaizhuo basin fault,Xinbaoan-Shacheng fault,Sangganhe fault and Southern Yuxian basin fault. This necessarily increases the seismic risk of these faults and can be used as a reference for future seismic risk analysis in this area.

关键词： West Beijing basin-range tectonic region Cumulative Coulomb stress change Seismic risk

Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo

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Chinese Journal of Natural Medicines 2016年第11期14卷 865-870页

作者： WANG Jing WANG Hong PENG Ying WANG Guang-Ji hao Hai-ping Key Lab of Drug Metabolism & Pharmacokinetics State Key Laboratory of Natural Medicines China Pharmaceutical University

Isochlorogenic acid A(ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually used in combination with other medicines in the clinic. However, little is known about the regulatory effects of ICQA on drug-metabolizing enzymes and the herb-drug interactions. In the present study, we evaluated the inhibitory potentials of ICQA on CYP1A2, CYP2C9,CYP2C19, CYP3A4, CYP2D6, and CYP2E1 in vitro based on a cocktail approach. The P450 and UGT activities in mice treated with ICQA for a prolonged period were also determined. Our results demonstrated that ICQA exhibited a weak inhibitory effect on CYP2C9 in human liver microsomes with IC_(50) being 57.25 μmol·L^(-1) and Ki being 26.77 μmol·L^(-1). In addition, ICQA inhibited UGT1A6 activity by 25%, in the mice treated with ICQA(i.p.) at 30 mg·kg^(-1)for 14 d, compared with the control group. Moreover, ICQA showed no mechanism-based inhibition on CYP2C9 or UGT1A6. In conclusion, our results further confirm a safe use of ICQA in clinical practice.

关键词： Isochlorogenic acid A P450 UGT Herb-drug interaction

Effects of diammonium glycyrrhizinate on hepatic and intestinal UDP-Glucuronosyltransferases in rats: Implication in herb-drug interactions

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Chinese Journal of Natural Medicines 2016年第7期14卷 534-540页

作者： LI Fei-Yan XIE hao WENG Lin WANG Hong CAO Li-Juan hao Hai-ping WANG Guang-Ji State Key Laboratory of Natural Medicines Key Laboratory of Drug Metabolism and Pharmacokinetics China Pharmaceutical University Department of Good Clinical Practice Zhejiang Cancer Hospital

Glycyrrhizin is a major bioactive component of liquorice, which exerts multiple biochemical and pharmacological activities and is frequently used in combination with other drugs in the clinic. Mycophenolate mofetil(MMF), an immunosuppressant widely used in transplant patients, is metabolized by UDP-glucuronyltransferases(UGTs). Although significant evidence supports that glycyrrhizin could interact with the cytochrome P450s(CYPs), few studies have addressed its effects on UGTs. The present study aimed at investigating the regulatory effects of diammonium glycyrrhizinate(GLN) on UGTs in vitro and in vivo. We found that long-term administration of GLN in rats induced overall metabolism of MMF, which might be due to the induction of UGT1A protein expression. Hepatic UGT1A activity and UGT1A mRNA and protein expression were significantly increased in GLN-treated rats. UGT1A expression levels were also increased in the intestine, contradicting with the observed decrease in intestinal UGT1A activities. This phenomenon may be attributed to different concentrations of glycyrrhetinic acid(GA) in liver and intestine and the inhibitory effects of GA on UGT1A activity. In conclusion, our study revealed that GLN had multiple effects on the expression and activities of UGT1A isoforms, providing a basis for a better understanding of interactions between GLN and other drugs.

关键词： Diammonium glycyrrhizinate UDP-glucuronosyltransferase Sprague-Dawley rat Drug-drug interaction