A better parameter in predicting insulin resistance:Obesity plus elevated alanine aminotransferase

作     者：Ping-Hao then Jong-Dar Chen Yu-Cheng Lin 

作者机构：Department of family practice Lo-Sheng Sanatorium Department of Health Taipei County 242 Taiwan China Department of family medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan China Department of Occupational Medicine Tao- Yuan General Hospital Department of Health Tao-Yuan 330 Taiwan China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第44期

页      面：5598-5603页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 082803[工学-农业生物环境与能源工程] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0828[工学-农业工程] 0804[工学-仪器科学与技术] 

主　　题：Alanine aminotransferase Transaminase Overweight Obesity Insulin resistance 

摘      要：AIM:To investigate the association of obesity and elevated alanine aminotransferase with insulin resistance and compare these factors with metabolic syndrome. METHODS:We enrolled a total of 1308 male workers aged from 22 to 63 *** was extracted from the workers periodic health check-ups in *** cases were from the community of northern Taiwan. This was a cross-sectional observational study from July to September in *** grouped all cases into four groups,based on the quartile of homeostasis model *** top fourth quartile group was defined as the group with insulin *** performed multivariate logistic regression analysis for the odds ratio of the risk factors for insulin resistance. RESULTS:Compared with metabolic syndrome,the coexistence of both factors had a 4.3-fold(95%CI: 2.7-6.8)increased risk,which was more than metabolic syndrome with a 3.6-fold(95%CI:2.6-5.0)increased *** two factors had a synergistic *** synergistic index of obesity and elevated alanine aminotransferase(ALT)was 2.1(95%CI:1.01-4.3).CONCLUSION:Obesity and elevated ALT are associatedwith insulin *** effects are synergistic. Coexistence of them is better than metabolic syndrome in predicting insulin resistance.