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Machine learning-based radiomics score improves prognostic prediction accuracy of stage II/III gastric cancer: A multi-cohort study

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 345-356页

作者： ying-hao Xiang Huan Mou Bo Qu Hui-Rong Sun Department of General Surgery Lichuan People's HospitalEnshi 445400Hubei ProvinceChina

BACKGROUND Although accurately evaluating the overall survival(OS)of gastric cancer patients remains difficult,radiomics is considered an important option for studying *** To develop a robust and unbiased biomarker for predicting OS using machine learning and computed tomography(CT)image *** This study included 181 stage II/III gastric cancer patients,141 from Lichuan People's Hospital,and 40 from the Cancer Imaging Archive(TCIA).Primary tumors in the preoperative unenhanced CT images were outlined as regions of interest(ROI),and approximately 1700 radiomics features were extracted from each *** skeletal muscle index(SMI)and skeletal muscle density(SMD)were measured using CT images from the lower margin of the third lumbar *** the least absolute shrinkage and selection operator regression with 5-fold cross-validation,36 radiomics features were identified as important predictors,and the OS-associated CT image radiomics score(OACRS)was cal-culated for each patient using these important *** Patients with a high OACRS had a poorer prognosis than those with a low OACRS score(P<0.05)and those in the TCIA *** and multivariate analyses revealed that OACRS was a risk factor[RR=3.023(1.896-4.365),P<0.001]independent of SMI,SMD,and pathological ***,OACRS outperformed SMI and SMD and could improve OS prediction(P<0.05).CONCLUSION A novel biomarker based on machine learning and radiomics was developed that exhibited exceptional OS discrimination potential.

关键词： Radiomics Machine learning Gastric cancer Skeletal muscle density Skeletal muscle index

One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide(NIPAM) in Water

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Chinese Journal of Polymer Science 2024年第1期42卷 1-6,I0004页

作者： Zi-Shan Li Jing Lyu Bei Qiu ying-hao Li Ruth Foley Ri-Jian Song Melissa Johnson Qiang Geng Wen-Xin Wang Institute of Precision Medicine(AUST-IPM) Anhui University of Science and TechnologyHuainan 232001China Charles Institute of Dermatology School of MedicineUniversity College DublinDublin D04 V1W8Ireland

Copper(0)-mediated reversible-deactivation radical polymerization(Cu(0)-mediated RDRP) of the water-soluble monomer Nisopropylacrylamide(NIPAM) has been challenging with the problems of high dispersity, poor control over the molecular weights(MWs) or complex or multi reaction steps, etc. In this work, we report the well-controlled polymerization of NIPAM in water via a facile one-pot and one-step Cu(0)-mediated RDRP. The results of this approach show that the key for kicking off the Cu(0)-mediated NIPAM RDRPs is to ensure sufficient Cu~I at the very beginning, and the key to achieve a well-controlled chain growth is to provide adequate deactivation strength during the polymerization process. For NIPAM, which has a high propagation rate constant, the deactivation control can be effectively enhanced by extra adding deactivator(i.e., Cu~II) to the system. Moreover, a low reaction temperature(4 ℃) is necessary in the controlled synthesis of higher MW poly(Nisopropylacrylamide)(PNIPAM) to avoid the compromise in control caused by the phase transition from its lower critical solution temperature(LCST). Through this new kinetically controlled strategy, PNIPAMs with well-defined structure, narrow molecular weight distributions(MWDs) and varied MWs were successfully achieved.

关键词： Cu(0)-mediated RDRP N-isopropylacrylamide Propagation Deactivation Reaction parameters

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中哈跨界河流合作:进程、机遇与深化路径

新疆大学学报（哲学社会科学版） 2024年第1期52卷 63-71页

作者：郝少英西北政法大学经济法学院陕西西安710063

中哈跨界河流合作机制以联合委员会为平台,在水文信息交换、水质保护、水量分配、水利工程合作等方面取得突出成果,中哈两国政治关系的提升、环委会的积极配合及“一带一路”倡议相关政策的支持是推进中哈跨界河流合作的主要因素;同时,... 详细信息

中哈跨界河流合作机制以联合委员会为平台,在水文信息交换、水质保护、水量分配、水利工程合作等方面取得突出成果,中哈两国政治关系的提升、环委会的积极配合及“一带一路”倡议相关政策的支持是推进中哈跨界河流合作的主要因素;同时,中哈跨界河流合作机制也面临一系列挑战;制定切实有效的水资源分配规则,深化跨界河流环保合作,重视跨界含水层条约的签订,构建系统的跨界水合作制度以及多元化的水争端解决方法体系,并提升国际话语权引导国际舆论等是应对挑战,实现中哈跨界水资源可持续利用的关键。

关键词：中哈跨界河流联合委员会合作机制

抗阻运动提升老年人下肢肌肉力量及功能状态的网状Meta分析

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中国循证医学杂志 2024年第2期24卷 175-182页

作者：郝莹陈卓西北师范大学体育学院兰州730070

目的系统评价抗阻运动干预与老年人下肢肌肉力量及功能提升的剂量-效应关系。方法计算机检索EBSCO、PubMed、Web of Science、CNKI、VIP和WanFang Data数据库,搜集关于抗阻运动对老年人下肢肌肉力量及功能影响的随机对照试验(RCT),检索... 详细信息

目的系统评价抗阻运动干预与老年人下肢肌肉力量及功能提升的剂量-效应关系。方法计算机检索EBSCO、PubMed、Web of Science、CNKI、VIP和WanFang Data数据库,搜集关于抗阻运动对老年人下肢肌肉力量及功能影响的随机对照试验(RCT),检索时限均从建库至2022年7月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4和Stata 15.0软件进行网状Meta分析。结果共纳入32个RCT,总样本量1594人。网状Meta分析结果显示,强度50%~70%1RM、周期8~12周、频率3~4次/周、时间30~45分钟、间歇1.1~2分钟的抗阻运动干预效果最佳。结论抗阻运动改善老年人下肢肌肉力量及功能的最佳选择为中等运动强度(50%~70%1RM)、持续8~12周、每周运动3~4次、每次运动时间30~45分钟、组间间歇1.1~2分钟。

关键词：老年人抗阻运动下肢肌肉力量下肢肌肉功能剂量-效应关系网状Meta分析

Giant retroperitoneal hemolymphangioma:A case report and review of literature

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World Journal of Clinical Cases 2024年第22期12卷 5258-5262页

作者： Yi-Kai Wang ying-hao Liu Wei-Bing Shuang Department of Urology The First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

BACKGROUND Hemolymphangioma is a very rare benign tumor in clinical practice caused by abnormalities of the *** clinical features are often atypical,and it is easy to miss and *** the time of nuclear magnetic T1 is significantly reduced,the diagnosis of hemangioma should be ***,we report this case in the hope of raising clinicians'awareness of the *** SUMMARY A 37-year-old man presented with a giant retroperitoneal *** tomography and magnetic resonance imaging indicated the possibility of a large perirenal lymphatic *** postoperative pathological diagnosis is retroperitoneal *** patient underwent surgical excision after adequate *** postoperative recovery was smooth and there were no *** was no recurrence during half a year of *** This case reiterates that large retroperitoneal cystic masses with significantly shortened nuclear T1 time should be considered *** clinical basis and experience for the diagnosis and treatment of these diseases is necessary.

关键词： Hemolymphangioma Retroperitoneal tumor Surgical excision Magnetic resonance imaging Case report

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通孔球壳胞元结构压缩力学性能

材料导报 2024年第9期38卷 220-225页

作者：牛克心余为郝颖燕山大学河北省重型装备与大型结构力学可靠性重点实验室河北秦皇岛066004

球壳胞元结构作为一种新型轻质功能材料,在航空航天、交通运输等领域有着广阔的应用前景。本工作通过实验和数值模拟的方法对简单堆积的通孔球壳胞元结构受压缩时的力学性能进行了研究,得出其名义应力-应变曲线,分析了结构的有效弹性模... 详细信息

球壳胞元结构作为一种新型轻质功能材料,在航空航天、交通运输等领域有着广阔的应用前景。本工作通过实验和数值模拟的方法对简单堆积的通孔球壳胞元结构受压缩时的力学性能进行了研究,得出其名义应力-应变曲线,分析了结构的有效弹性模量、屈服极限、平台应力、比吸能等性能随球壳壁厚和球心距变化的规律。结果表明,部分球壳胞元结构在压缩过程中出现屈曲现象,并翻转形成塑性铰,从而增强结构的承载能力。球壳胞元结构的有效弹性模量、屈服极限随着球心距增大呈先增加后减小的规律,其平台应力和比吸能随着球心距增大而增加。综合各项数据可得,球壳胞元结构的球心距大于等于18.0 mm是更理想的结构形式。

关键词：球壳胞元结构压缩实验数值模拟有效弹性模量比吸能

Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffold

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Asian Journal of Andrology 2024年第3期26卷 260-267页

作者： Yu-Zhuo Chen Yi-Hong Zhou Min-Bo Yan Ming Xiao Biao Liu ying-hao Yin Xiao-Li Tan Yong-Quan Huang Yu-Hong Lin Ting Xie Jia-Li Tian Qi Wang Jian-ying Li Zi-Zhou Meng Zheng Li Emily Xing Yu-Xin Tang Ya-Wei Li Zhong-Zhen Su Liang-Yu Zhao Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Andrology the Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of ReproductiveMedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Cedars-Sinai Medical Center Los AngelesCA 90024USA

Ex vivo tissue culture of the human corpus cavernosum(cc)can be used to explore the tissue structural changes and complex signaling *** present,artificial Cc-like tissues based on acellular or three-dimensional(3D)-printed scaffolds are used to solve the scarcity of primary penis tissue ***,inconvenience and high costs limit the wide application of such ***,we describe a simple,fast,and economical method of constructing artificial CC-like *** Cc fibroblasts(FBs),endothelial cells(ECs),and smooth muscle cells(SMCs)were expanded in vitro and mixed with Matrigel in specific proportions.A large number of bubbles were formed in the mixture by vortexing combined with pipette blowing,creating a porous,spongy,and spatial *** Cc FBs produced a variety of signaling factors,showed multidirectional differentiation potential,and grew in a 3D grid in Matrigel,which is necessary for CC-like tissue to maintain a porous structure as a cell *** the C-like tissue,ECs covered the surface of the lumen,and SMCs were located inside the trabeculae,similar to the structure of the primary *** cell components remained stable for 3 days in vitro,but the EC content decreased on the 7th ***/integrated(WNT)signaling activation led to lumen atrophy and increased tissue fibrosis in CC-like tissue,inducing the same changes in characteristics as in the primary *** study describes a preparation method for human artificial cC-like tissue that may provide an improved experimental platform for exploring the function and structure of the cC and conducting drug screening for erectile dysfunction therapy.

关键词： artificial tissue corpus cavernosum ex vivo fibroblasts

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公路隧道装配式仰拱接头变形破坏规律

中国公路学报 2024年第7期37卷 58-69页

作者：王迎超徐杭雷雅婷周鑫郝英中国矿业大学深地工程智能建造与健康运维全国重点实验室江苏徐州221116 中国矿业大学力学与土木工程学院江苏徐州221116

接头部位是公路隧道装配式仰拱受力最薄弱的部位,研究接头的力学性能意义重大。首先,预制仰拱采用弯螺栓连接,通过室内试验研究不同轴力分级加载过程中接缝张开量、竖向位移、接头附近表面混凝土应变等变化规律。然后,建立装配式仰拱接... 详细信息

接头部位是公路隧道装配式仰拱受力最薄弱的部位,研究接头的力学性能意义重大。首先,预制仰拱采用弯螺栓连接,通过室内试验研究不同轴力分级加载过程中接缝张开量、竖向位移、接头附近表面混凝土应变等变化规律。然后,建立装配式仰拱接头的三维精细化有限元模型,模拟接头连接形式及接触状态,研究不同轴力-弯矩组合荷载作用下装配式仰拱接头变形、竖向位移以及混凝土应力发展规律。研究结果表明:室内试验和数值模拟获得的弯螺栓抗弯性能具有很好的一致性,且接头破坏过程特征也基本一致,即从接缝靠近施力侧压紧,到对侧张开,再到接头靠近施力侧表面混凝土先产生裂缝,紧接着侧面裂缝斜向上方发展逐渐贯通至顶面,混凝土压坏,最终接头破坏;接缝最大张开量和接头转角随着弯矩的增大,先线性增大后曲线形增大;轴力相同时,接头抗弯刚度随弯矩增加而减小;弯矩一定时,接头抗弯刚度随轴力增加而增加。研究成果可为公路隧道装配式仰拱接头设计及力学性能分析提供参考。

关键词：隧道工程装配式仰拱模型试验破坏特征接头转角

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基于数据集蒸馏的光伏发电功率超短期预测

中国电机工程学报 2024年第13期44卷 5196-5207,I0015页

作者：郑珂王丽婕郝颖王勃北京信息科技大学自动化学院北京市海淀区100192 中国电力科学研究院有限公司北京市海淀区100192

云是影响太阳直接辐射变化的主要因素,由于各类云的透光率不同,导致到达光伏电站的太阳辐射会随之产生波动。为解决各类云遮挡下的光伏发电功率波动大、预测模型个数多的问题,提出一种基于卫星云图和数据集蒸馏的光伏发电功率超短期预... 详细信息

云是影响太阳直接辐射变化的主要因素,由于各类云的透光率不同,导致到达光伏电站的太阳辐射会随之产生波动。为解决各类云遮挡下的光伏发电功率波动大、预测模型个数多的问题,提出一种基于卫星云图和数据集蒸馏的光伏发电功率超短期预测模型。首先,基于待测场站上方的历史云图,采用Farneback光流法预测出云图;然后,根据卫星云分类标签数据建立各类云的样本库,利用数据集蒸馏算法训练样本库得到云类判别图,将预测云图与云类判别图匹配计算,获得云类聚合匹配特征;最后,利用上述特征、云量特征以及数值天气预报数据建立长短期记忆网络模型,对光伏发电功率进行超短期预测。利用某光伏电站数据进行验证,结果显示,该文所提模型能准确描述云层的各项特征,有效提升光伏功率预测精度。

关键词：数据集蒸馏卫星云图云分类光流法超短期光伏功率预测

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