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Unraveling the mechanism of action of Shangxia liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan hao liang Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Elastic Behavior of Polymer Chains

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Chinese Journal of Chemical Physics 2008年第5期21卷 463-468页

作者： Teng Lu Tao Chen hao-jun liang Hefei National Laboratory for Physical Sciences at Microscale Department of Polymer Science andEngineering University of Science and Technology of China Hefei 230025 China

The elastic behavior of the polymer chain was investigated in a three-dimensional off-lattice model. We sample more than 109 conformations of each kind of polymer chain by using a Monte Carlo algorithm, then analyze them with the non-Gaussian theory of rubberlike elasticity, and end with a statistical study. Through observing the effect of the chain flexibility and the stretching ratio on the mean-square end-to-end distance, the average energy, the average Helmholtz free energy, the elastic force, the contribution of energy to the elastic force, and the entropy contribution to elastic force of the polymer chain, we find that a rigid polymer chain is much easier to stretch than a flexible polymer chain. Also, a rigid polymer chain will become difficult to stretch only at a quite high stretching ratio because of the effect of the entropy contribution. These results of our simulation calculation may explain some of the macroscopic phenomena of polymer and biomacromolecular elasticity.

关键词： Monte Carlo algorithm Three-dimensional off-lattice model Elastic behavior Polymer

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Factors Affecting Polymer Translocation Through a Nanopore in a Membrane

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Chinese Journal of Chemical Physics 2008年第3期21卷 275-280页

作者： Tao Chen Teng Lu hao-iun liang Hefei National Laboratory for Physical Sciences at Microscale Department of Polymer Science andEnEineerinE University of Science and Technology of China Hefei 230025 China

Monte Carlo simulations were used to study the translocation of a flexible polymer through a pore in a membrane, assuming an attractive interaction between the monomers and the membrane on the trans side of the membrane and no interaction on the cis side. For the case T〈Tc （the temperature corresponding to the minimum in the translocation time τ）, the value of τdecreases with increasing temperature, whereas for T〉Tc, τ increases with increasing temperature. The translocation time depends on the absorbed energy uo in a nontrivial way. The value of τ increases initially upon increasing uo before it begins to decrease. The variation of the translocation time with respect to the solvent quality was also studied. It showed that there is a transition, as the solvent quality improves from ＂poor＂ to ＂good＂： when εAB〈εc （the interaction energy corresponding to the minimum in τ）, τdecreases with increasing the value of εAB; when εAB〉εc, τincreases with increasing εAB- When the chain length was changed, it was found that when the absorbed energy uo was greater than uc,τ was proportional to N1.602; for uo〈uc, τ∝N2.248. As the solvent quality improved from ＂poor＂ to ＂good,＂ the translocation probability increased initially before becoming stable.

关键词： Monte Carlo simulation Translocation time Absorbed energy Solvent quality

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A time and charge measurement board for muon tomography of high-Z materials

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Nuclear Science and Techniques 2017年第3期28卷 104-108页

作者： Shi-Tao Xiang hao liang State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China

In this paper, a versatile time and charge measurement(MQT) board for muon tomography is described in detail. For time measurement, the general-purpose timeto-digital converter(TDC) chip TDC-GP2 is employed,while for charge measurement, digitization plus numerical integration in field programmable gate array is *** tests demonstrate that the total 32 channels of two MQT boards have a time resolution of superior than100 ps, with excellent linearity for time and charge measurement.

关键词： Time and charge measurement Generalpurpose time-to-digital converter (TDC-GP2) Muon tomography

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CAPABILITY OF DNA-FUELED MOLECULAR MACHINE IN TUNING ASSOCIATION RATE OF DNA-FUNCTIONALIZED GOLD NANOPARTICLES

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Chinese Journal of Polymer Science 2013年第9期31卷 1183-1183,1184-1189页

作者： Ting-jie Song hao-jun liang CAS Key Laboratory of Soft Matter Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Department of Polymer Science and Engineering University of Science and Technology of China

The capability of our newly developed DNA-machine-driven strategy in tuning the association rate of DNA- AuNPs was compared with that of linker-addition strategy which has potential practical applications in different fields. The new established strategy shows its superiority to the linker-addition strategy in tuning the association rate of DNA-AuNPs in both pre-incubation treatment and non-incubation treatment conditions since its two components （a complex and a catalyst- oligonucleotide） can be individually optimized to make the machine run at an optimal rate. This strategy will provide a more convenient and flexible option in designing an oligonucleotide detection system and building a complex and versatile device.

关键词： Assembly DNA Enhancing Kinetics Nanoparticle.

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Three-dimensionally ordered macro-porous Pt/TiO_2 catalyst used for water-gas shift reaction

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Journal of Natural Gas Chemistry 2008年第4期17卷 403-408页

作者： hao liang Yuan Zhang Yuan Liu Department of Catalysis Science and Technology School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Three-dimensionally ordered macro-porous （3DOM） Pt/TiO2 catalysts were prepared by template and impregnation methods, and the resultant samples were characterized by using TG-DTA, XRD, SEM, TEM, and TPR techniques. The catalytic performance for water-gas shift （WGS） reaction was tested, and the influences of some conditions, such as reduction temperature of catalysts, the amount of Pt loadings and space velocity on catalytic performance were investigated. It was shown that Pt particles were homogeneously dispersed on 3DOM TiO2. The reduction of TiO2 surface was important for the catalytic performance. The activity test results showed that the 3DOM Pt/TiO2 catalysts exhibited very good catalytic performance for WGS reaction even at high space velocity, which was owing to the better mass transfer of 3DOM porous structure besides the high intrinsic activity of Pt/TiO2.

关键词： three-dimensionally ordered macro-porous water-gas shift platinum titania

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Damage and fracture mechanism of 6063 aluminum alloy under three kinds of stress states

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Rare Metals 2008年第1期27卷 64-69页

作者： ZHU hao ZHU liang CHEN Jianhong Key Laboratory of the Ministry of Education of China for Nonferrous Metal Alloys Lanzhou University of Technology Lanzhou 730050 China

To study the damage and fracture mechanism of 6063 aluminum alloy under different stress states,three kinds of representative triaxial stress states have been adopted,namely smooth tensile,notch tensile,and pure *** results of the study indicate the *** the notch tensile test,a relatively higher stress triaxiality appears in the root of the *** the applied loading increasing,the volume fraction of microvoids in the root of the notch increases *** it reaches the critical volume fraction of microvoids,the specimen *** the pure shear test,the stress triaxiality almost equals to zero,and there is almost no microvoids but a shear band at the center of the butterfly *** shear band results from nonuniform deformation constantly under the shear *** stress concentration,cracks are produced within the shear band and are later *** the equivalent plastic strain reaches the critical value（equivalent plastic fracture strain）,the butterfly specimen *** the smooth tensile test,the stress triaxiality in the gauge of the specimen remains constant at ***,the volume of microvoids of the smooth tensile test is less than that of the notch tensile test and the smooth specimen fractures due to shearing between *** G-T-N damage model and Johnson-Cook model are used to simulate the notch tensile and shear test,*** simulated engineering stress-strain curves fit the measured engineering stress-strain curves very *** addition,the empirical damage evolution equation for the notch specimen is obtained from the experimental data and FEM simulations.

关键词： 6063 aluminum alloy damage mechanism fracture mechanism G-T-N model Johnson-Cook model

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On Sullivan's Conjecture on Cycles in 4-free and 5-free Digraphs

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Acta Mathematica Sinica,English Series 2013年第1期29卷 53-64页

作者： hao liang Jun Ming XU Department of Mathematics Southwestern University of Finance and Economics School of Mathematical Sciences University of Science and Technology of China Wentsun Wu Key Laboratory of CAS

For a simple digraph G, let β（G） be the size of the smallest subset X E（G） such that G - X has no directed cycles, and let γ（G） be the number of unordered pairs of nonadjacent vertices in G. A digraph G is called k-free if G has no directed cycles of length at most k. This paper proves that β（G） ≤ 0.3819γ（G） if G is a 4-free digraph, and β（G） ≤ 0.2679γ（G） if G is a 5-free digraph. These improve the results of Sullivan in 2008.

关键词： Digraph directed cycle

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Laser-Induced Electron Fresnel Diffraction in Tunneling and Over-Barrier Ionization

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Chinese Physics Letters 2022年第4期39卷 17-21页

作者： Lei Geng hao liang liang-You Peng State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Quantum Matter Beijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Beijing Academy of Quantum Information Sciences Beijing 100193China

Photoelectron momentum distribution in strong-field ionization has a variety of structures that reveal the complicated dynamics of this ***,we identified a low-energy interference structure in the case of a super-intense extreme ultraviolet(XUV)laser pulse and attributed it to the laser-induced electron Fresnel *** structure is determined by the laser-induced electron displacement[Geng et ***.A104(2021)L021102].In the present work,we find that the Fresnel diffraction picture also appears in the tunneling and over-barrier regime of ionization by short ***,the electron displacement is now induced by the electric field component of the laser pulse rather than the magnetic field component in the case of the super-intense XUV *** corresponding modifications to our quantum and semiclassical models,we find that the same physical mechanism of the Fresnel diffraction governs the low-energy interference structures along the laser *** results predicted by the two models agree well with the accurate results from the numerical solution to the time-dependent Schr¨odinger equation.

关键词： equation process Fresnel

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Quasi-periodically Forced Logistic Map with Weak Liouvillean Frequency

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2411-2435页

作者： Jin hao liang Lin Lin FU Department of Applied Mathematics Nanjing Forestry UniversityNanjing 210037P.R.China School of Mathematics and Statistics Shaoguan UniversityShaoguan 512005P.R.China

Consider a class of quasi-periodically forced logistic maps T×[0,1]■:(θ,x)→(θ+ω,c(θ)x(1-x))(T=R/Z),whereωis an irrational frequency and c(θ)is a specific bimodal *** prove that under weak Liouvillean condition on frequency,the strange non-chaotic attractor occurs with negative Lyapunov *** extends the result in[Bjerklov,CMP,2009].

关键词： Quasi-periodically forced logistic map strange non-chaotic attractor weak Liouvillean frequency Lyapunov exponent

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