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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langerscheidt hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Enhancing Immune Responses for Cancer Therapy

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Cellular & Molecular Immunology 2007年第3期4卷 173-184页

作者： hans j Stauss Department of Immunology and Molecular Pathology University College London Hampstead Campus Royal Free Hospital Rowland Hill Street London NW3 2PF United Kingdom

Although the immune system possesses the means to respond to cancer, it often fails to control the spread of malignancy. Nonetheless, equipping endogenous immunity to release a strong antitumor response has significant advantages over conventional therapies. This review explores some of the options available to accomplish this, focusing first on vaccinations with tumor antigens to stimulate the immune system and empower stronger antitumor responses. We then compare and contrast the so-far limited clinical success of vaccination with the well-documented curative potential of adoptive therapy using T lymphocytes transfer. Finally, we highlight novel approaches using T call receptor （TCR） gene transfer strategy to exploit allogeneic T cell repertoires in conjunction with receptors selected in vitro for defined MHC/peptide combinations, as a basis for antigen-specific gene therapy of cancers. Cellular ＆ Molecular Immunology.

关键词： tumor antigen vaccination adoptive immunotherapy T cell receptor gene transfer TCR gene therapy

Anisotropic plastic deformation behavior of as-extruded ZK60 magnesium alloy at room temperature

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Science China(Technological Sciences) 2009年第1期52卷 161-165页

作者： hans j R Department of Materials Science and Engineering Norwegian University of Science and Technology

The anisotropic plastic deformation behavior of as-extruded ZK60 magnesium alloy at room tempera-ture (RT) was investigated by compressive and tensile testing in different directions, i.e. the loading axis oriented at 0°, 45° and 90° to the extrusion direction. The relationship between texture and plastic deformation behavior were examined. The results show that the extruded ZK60 alloy exhibits a strong ring fiber texture. The mechanical properties are strongly orientation dependent. In tension testing, the 0° specimen exhibited higher yield strength and lower elongation. In compression testing, however, ZK60 alloy exhibited almost the same yield strength in three directions. The anisotropic plastic defor-mation behavior is due to strong fiber texture and the lower symmetry of the hexagonal close packed (hcp) structure of ZK60 alloy. The correlation between texture and mechanical behaviour offers the possibility to improve the mechanical properties of magnesium alloy by optimization of the material production process.

关键词： anisotropic plastic deformation behavior ZK60 Mg alloy texture mechanical property

High-resolution Induan-Olenekian boundary sequence in Chaohu, Anhui Province

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Science China Earth Sciences 2005年第3期48卷 291-297页

作者： hans j. hansen Geological Institute Copenhagen University Oster Voldgade 10 DK-1350 Copenhage Denmark

The West Pingdingshan Section in Chaohu, Southeast China’s Anhui Province is one of the potential GSSP candidates for the Induan-Olenekian boundary. Extensive study has been done on the Induan-Olenekian boundary strata at the section to meet the requirements of defining the GSSP precisely. This paper focuses on the boundary strata at the section to present a review of the main results achieved in recent years. The Induan-Olenekian boundary strata here cover an interval of about four meters at the West Pingdingshan Section, in which the key indices of defining the boundary and the chief transitional processes of some parameters at the boundary are included. The relationship between the boundaries defined by ammonoids and by conodonts is well clarified at the section. The magnetic polarity analysis shows that the boundary interval belongs to a normal polarity zone. Both the carbonate and organic carbon isotopes com- positions experienced a significant conversion in the boundary interval.

关键词： Lower Triassic, Induan-Olenekian boundary, GSSP, candidate, Chaohu of China.

Recycling of automotive aluminum

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Transactions of Nonferrous Metals Society of China 2010年第11期20卷 2057-2063页

作者： jirang CUI hans j.ROVEN Department of Materials Science and Engineering Norwegian University of Science and Technology(NTNU)

With the global warming of concern,the secondary aluminum stream is becoming an even more important component of aluminum production and is attractive because of its economic and environmental *** this work,recycling of automotive aluminum is reviewed to highlight environmental benefits of aluminum recycling,use of aluminum alloys in automotive applications,automotive recycling process,and new technologies in aluminum scrap *** survey shows that newly developed techniques such as laser induced breakdown spectroscopy(LIBS) and solid state recycling provide promising alternatives in aluminum scrap *** with conventional remelting and subsequent refinement,solid state recycling utilizing compression and extrusion at room or moderate temperature can result in significant energy savings and higher metal yield.

关键词： recycling automotive aluminum sorting mechanical separation solid state recycling

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Micromechanical investigation of granular ratcheting using a discrete model of polygonal particles

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Particuology 2008年第6期6卷 390-403页

作者： Fernando Alonso-Marroquín hans B. Mhlhaus hans j. Herrmann Earth Systems Science Computational Centre & School of Physical Sciences The University of Queensland Earth Systems Science Computational Centre The University of Queensland Institut fr Baustoffe ETH-HenggerbergZrich

We use a two-dimensional model of polygonal particles to investigate granular ratcheting. Ratcheting is a long-term response of granular materials under cyclic loading, where the same amount of permanent deformation is accumulated after each cycle. We report on ratcheting for low frequencies and extremely small loading amplitudes. The evolution of the sub-network of sliding contacts allows us to understand the micromechanics of ratcheting. We show that the contact network evolves almost periodically under cyclic loading as the sub-network of the sliding contacts reaches different stages of anisotropy in each cycle. Sliding contacts lead to a monotonic accumulation of permanent deformation per cycle in each particle. The distribution of these deformations appears to be correlated in form of vortices inside the granular assembly.

关键词： Granular systems Dynamics and kinematics of rigid bodies Molecular dynamics methods

From Single Droplet to Column Design

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Tsinghua Science and Technology 2006年第2期11卷 212-216页

作者： hans-jrg Bart Institute of Thermal Process Engineering TU Kaiserslautern D-67653 Kaiserslautern Germany

The technique state to design counter-current extraction columns is based on the performance of pilot plant experiments. The modelling is then either with the equilibrium or dispersion model, whereas in the latter the dispersion coefficient accounts for all hydrodynamic non-idealities. A new approach uses single droplet experiments to obtain the basic laws and functions governing droplet breakage, coalescence, relative velocity, and axial dispersion when using droplet populance balance models （DPBM）. The hydrodynamics simulation results show that the mean Sauter diameter, hold-up, and concentration profiles could be well predicted, which promotes the use of DPBM models for further applications in industrial scale.

关键词： single droplet column design countercurrent extraction droplet populance balance model