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Colorectal carcinogenesis-update and perspectives

World Journal of Gastroenterology 2014年第48期20卷 18151-18164页

作者： hans Raskov hans-christian Pommergaard Jakob Burcharth Jacob Rosenberg Speciall?gecentret ved Diakonissestiftelsen 2000 Frederiksberg Denmark Department of Surgery Herlev Hospital University of Copenhagen DK-2730 Herlev Denmark

Colorectal cancer(CRC)is a very common malignancy in the Western World and despite advances in surgery,chemotherapy and screening,it is still the second leading cause of cancer deaths in this part of the *** factors are found important in the development of CRC including colonocyte metbolism,high risk luminal environment,inflammation,as well as lifestyle factors such as diet,tobacco,and alchohol *** recent years focus has turned towards the genetics and molecular biology of CRC and several interesting and promising correlations and pathways have been *** major genetic pathways of CRC are the Chromosome Instability Pathway representing the pathway of sporadic CRC through the K-ras,APC,and P53 mutations,and the Microsatellite Instability Pathway representing the pathway of he re di t ar y non-polyposis c olon c anc e r t hrough mutations in mismatch repair *** identify early cancers,screening programs have been initiated,and the leading strategy has been the use of faecal occult blood testing followed by colonoscopy in positive *** the treatment of colorectal cancer,significant advances have been made in the recent *** molecular targets of CRC include at least two important cell surface receptors:the epidermal growth factorreceptor and the vascular endothelial growth factor *** genetic and molecular knowledge of CRC has widen the scientific and clinical perspectives of diagnosing and ***,despite significant advances in the understanding and treatment of CRC,results from targeted therapy are still not *** studies will determine the role for this new treatment modality.

关键词： Colorectal carcinogenesis Risk factors Microbiology Genetics Diet Microbiome Inflammation

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Rationality of quotients by linear actions of affine groups

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Science China Mathematics 2011年第8期54卷 1521-1532页

作者： BOGOMOLOV Fedor BHNING christian GRAF VON BOTHMER hans-christian Department of Mathematics Courant Institute of Mathematical Sciences New York University Mathematisches Institut University of Gottingen

LetG = SLn(C)Cn be the (special) affine group. In this paper we study the representation theory of G and in particular the question of rationality for V/G, where V is a generically free G-representation. We show that the answer to this question is positive (Theorem 6.1) if the dimension of V is sufficiently large and V is indecomposable. We explicitly characterize two-step extensions 0 → S → V → Q → 0, with completely reducible S and Q, whose rationality cannot be obtained by the methods presented here (Theorem 5.3).

关键词： rationality linear group quotients affine groups

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Single and multiple stressor effect of road deicers and Cu on Atlantic salmon (Salmo salar) alevins from hatching till swim-up

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Journal of Environmental Sciences 2018年第4期30卷 368-378页

作者： Urma Mahrosh BjФrn Olav Rosseland Brit Salbu hans-christian Teien Nortuegian Uniuersity of Life Sciences Department of Environmental Sciences N-1432 As Norway National University of Sciences and Technology H-12 Islamabad Pakistan Norwegian University of Life Sciences Department of Ecology and Natural Resource Management N-1432 As Norway

Road salts are frequently used for deicing of roads in the Nordic countries. During snow-melt, the road run-off containing high concentrations of road salt and various metals such as Cu remobilized from sand, silt and dust may negatively influence organisms in downstream receiving water bodies. The present work focuses on the impact of road salt（NaCl） and Cu, separately and in mixtures on Atlantic salmon alevins from hatching till swim-up. The results showed that high road salt concentrations could induce a series of negative effects in alevins such as reduced growth, deformities, delayed swim-up and mortality. For alevins exposed to all tested road salt concentrations（100–1000 mg/L）,mortality was significantly higher compared to control. In exposure to Cu solutions（5–20 μg Cu/L）, no effects on growth, morphology, swim-up or mortality of alevins compared to control were observed. In mixture solutions（road salt and Cu）, ultrafiltration of the exposure water demonstrated that only 20%–40% of Cu was present as positively charged low molecular mass（LMM） Cu species assumed to be bioavailable. When exposed to road salt and Cu mixtures, negative effects in alevins such as reduced growth, deformities,delayed swim-up and mortality were observed. The overall results indicated that the road salt application could seriously affect sensitive life stages of Atlantic salmon, and application of road salt should be avoided during the late winter–early spring period.

关键词： Road deicers Copper Atlantic salmon Alevins Biological effects

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Phosphorus accumulation and leaching risk of greenhouse vegetable soils in Southeast China

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Pedosphere 2021年第5期31卷 683-693页

作者： Yusef KIANPOOR KALKHAJEH Biao HUANG Helle SORENSEN Peter EHOLM hans christian BhansEN Anhui Province Key Laboratory of Farmland Ecological Conservation and Pollution Prevention School of Resources and EnvironmentAnhui Agricultural UniversityHefei 230036(China) Department of Plant and Environmental Sciences University of CopenhagenThorvaldsensvej 40Frederiksberg DK-1871 C(Denmark) Key Laboratory of Soil Environment and Pollution Remediation Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) Sino-Danish Center for Education and Research(SDC) Beijing 101408(China) Data Science Lab Department of Mathematical SciencesUniversity of CopenhagenUniversitetsparken 5DK-2100 Copenhagen East(Denmark)

Over-fertilization has caused significant phosphorus(P)accumulation in Chinese greenhouse vegetable production(GVP)*** study,for the first time,quantified profile P accumulation directly from soil P measurements,as well as subsoil P immobilization,in three alkaline coarse-textured GVP soil profiles with 5(S5),15(S15),and 30(S30)years of cultivation in Tongshan,Southeast *** each profile,soil samples were collected at depths of 0-10(topsoil),10-20,20-40,40-60,60-80,and 80-100 *** accumulation was estimated from the difference in P contents between topsoil and parent material(60-100 cm subsoil).Phosphorus mobility was assessed from measurements of water-soluble P concentration(P_(Sol)).Finally,P sorption isotherms were produced using a batch sorption experiment and fitted using a modified Langmuir *** total P contents of 1980(S5),3190(S15),and 2330(S30)mg kg^(-1) were measured in the topsoils versus lower total P content of approximately 600 mg kg^(-1) in the 80-100 cm ***,topsoil PSol values were very high,varying from 6.4 to 17.0 mg L^(-1).The estimated annual P accumulations in the topsoils were 397(S5),212(S15),and 78(S30)kg ha^(-1) year^(-1).Sorption isotherms demonstrated the dominance of P desorption in highly P-saturated topsoils,whereas the amount of adsorbed P increased in the 80-100 cm subsoils with slightly larger P adsorption *** total P adsorption capacity of the 80-100 cm subsoils at a solution P concentration of0.5 mg L^(-1) was 15.7(S5),8.7(S15),and 6.5(S30)kg ha^(-1),demonstrating that subsoils were unable to secure P concentrations in leaching water below 0.5 mg L^(-1) because of their insufficient P-binding capacity.

关键词： greenhouse vegetable production Langmuir model P adsorption capacity P desorption P immobilization P mobility subsoil topsoil

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基于卷积神经网络感知功能的极端场景生成方法

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同济大学学报（自然科学版） 2022年第S01期50卷 119-127页

作者： Kun GAO hans-christian REUSS 斯图加特汽车工程与车辆发动机研究所(FKFS) 德国斯图加特70569 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

近年来,基于卷积神经网络深度学习的感知算法在自动驾驶车辆环境感知系统中发挥着越来越重要的作用。由于在神经网络训练过程中,训练数据无法覆盖所有极端场景,因此如何保证基于深度学习的感知算法在极端场景下的安全性和可靠性,仍是一... 详细信息

近年来,基于卷积神经网络深度学习的感知算法在自动驾驶车辆环境感知系统中发挥着越来越重要的作用。由于在神经网络训练过程中,训练数据无法覆盖所有极端场景,因此如何保证基于深度学习的感知算法在极端场景下的安全性和可靠性,仍是一个亟待解决的问题。传统的基于真实行驶里程的验证方法,在获取极端场景数据上危险性高,经济性差,因此很难检验驾驶功能在极端场景下的性能。基于虚拟场景的仿真验证方法,虽然可以通过设置场景参数来生成大量测试场景,但是通过简单的参数组合并不能有效的生成极端场景。本文展示了一种在虚拟环境中生成极端场景的方法,用于训练和测试基于深度卷积神经网络的车道线识别算法。首先将场景特征用参数进行表示,然后使用deep Q-learning强化学习的方法,来生成极端场景的参数组合。通过与随机组合以及成对组合场景参数的方法进行对比,可以看出该基于强化学习的场景生成方法可以更有效地生成极端场景,因此可提高自动驾驶感知功能的测试效率,同时可为卷积神经网络提供更多的极端场景训练数据。

关键词：自动驾驶极端场景卷积神经网络强化学习

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基于MPSoC平台的自动驾驶车辆故障运行控制

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同济大学学报（自然科学版） 2022年第S01期50卷 151-155页

作者： Dennis NIEDBALLA hans-christian REUSS 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

在德国联邦研发项目UNICARagil中,开发了一个ECU,作为UNICARagil新颖的大脑架构的一部分。应用所谓的脑干部件,通过面向服务的架构,对全自动驾驶车辆进行安全关键的实时控制。本文介绍了该设备的硬件架构和基本软件架构,并列举了一些安... 详细信息

在德国联邦研发项目UNICARagil中,开发了一个ECU,作为UNICARagil新颖的大脑架构的一部分。应用所谓的脑干部件,通过面向服务的架构,对全自动驾驶车辆进行安全关键的实时控制。本文介绍了该设备的硬件架构和基本软件架构,并列举了一些安全措施。重点是MPSoC和OS配置、ECU的更新过程和启动过程。回退实例系统可以保护它免受引导加载程序、内核或根文件系统以及开发过程中和应用现场中的严重错误的影响。最后,列举了设备在车辆环境中的功能。在众多的科学内容出版物和社交媒体上,笔者展示了以使用脑干为核心部件的车辆通过试验场的测试情况。

关键词： MPSoC 故障运行嵌入式实时系统 UNICARagil PetaLinux

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基于ISO 26262安全要求的汽车电子电气架构优化模型

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同济大学学报（自然科学版） 2022年第S01期50卷 247-251页

作者： Dorsa ZAHERI hans⁃christian REUSS 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

在开发汽车电子电气(E/E)架构时,考虑安全要求是实现未来技术(如自动驾驶)的先决条件之一。按照ISO 26262标准,安全分析必须在产品开发生命周期的早期阶段进行,以检测设计缺陷并采取行动改善设计。本文提出了一种基于模型的方法,在汽车... 详细信息

在开发汽车电子电气(E/E)架构时,考虑安全要求是实现未来技术(如自动驾驶)的先决条件之一。按照ISO 26262标准,安全分析必须在产品开发生命周期的早期阶段进行,以检测设计缺陷并采取行动改善设计。本文提出了一种基于模型的方法,在汽车E/E架构的设计阶段解决符合ISO 26262的安全要求;同时,基于这些要求,提取了一组与安全相关的约束条件,并通过整数线性规划(ILP)模型将这些约束用于E/E架构的优化。

关键词：汽车电子电气电子电气架构优化模型安全要求 ISO 26262标准

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The effects of artificial surface temperature on mechanical properties and player kinematics during landing and acceleration

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Journal of Sport and Health Science 2016年第3期5卷 355-360页

作者： Laura Charalambous hans christian von Lieres und Wilkau Wolfgang Potthast Gareth Irwin Department of Sport Science and Physical Activity University of Bedfordshire Cardiff School of Sport Cardiff Metropolitan University Institute of Biomechanics and Orthopaedics German Sport University Cologne

Background: Artificial turf is considered a feasible global alternative to natural turf by many sports governing bodies. Consequently, its ability to provide a safe and consistent playing surface regardless of climate becomes essential. The aims of this study were to determine the effects of artificial surface temperature on:(1) mechanical properties of the turf and(2) the kinematics of a turf-sport related ***: Two identical artificial turf pitches were tested: one with a cold surface temperature(1.8°C–2.4°C) and one with a warm surface temperature(14.5°C–15.2°C). Mechanical testing was performed to measure the surface properties. Four amateur soccer players performed a hurdle jump to sprint acceleration movement, with data(contact time, step length and hip, knee and ankle kinematics) collected using CODASport(200 Hz).Results: The temperature difference had a significant influence on the mechanical properties of the artificial turf, including force absorption,energy restitution, rotational resistance, and the height where the head injury criterion was met. Both step length(p = 0.008) and contact time(p = 0.002) of the initial step after the landing were significantly longer on the warm surface. In addition, significant range of motion and joint angular velocity differences were ***: These findings highlight different demands placed on players due to the surface temperature and suggest a need for coaches,practitioners, and sports governing bodies to be aware of these differences.

关键词： Artificial turf Biomechanics Rugby Soccer Temperature

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基于机器学习的车队数据分析

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同济大学学报（自然科学版） 2021年第S01期49卷 186-193页

作者： EBEL André RIEMER Thomas REUSS hans-christian Research Institute of Automotive Engineering and Vehicle Engines Stuttgart(FKFS) 德国斯图加特70569 Institute of Automotive Engineering(IFS) University of Stuttgart德国斯图加特70569

为了增强新一代车辆的功能和安全性,收集了大量的车辆行驶历史数据,利用机器学习方法创建基于规则的计算模型,以检测车队中的故障车辆。详细介绍了模型的设计步骤,并通过低压电池的电气故障测试进行该方法的有效性验证。分析结果可供后... 详细信息

为了增强新一代车辆的功能和安全性,收集了大量的车辆行驶历史数据,利用机器学习方法创建基于规则的计算模型,以检测车队中的故障车辆。详细介绍了模型的设计步骤,并通过低压电池的电气故障测试进行该方法的有效性验证。分析结果可供后续车型台架测试参考。

关键词：车队数据机器学习规则学习测试条件

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Karl Blossfeldt, 1865 - 1932

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作者： Adam hans christian. Metzger Rainer.

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