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First immunohistochemical evidence of human tendon repair following stem cell injection: A case report and review of literature

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World Journal of Stem Cells 2021年第7期13卷 944-970页

作者： Eckhard Alt Ralf Rothoerl Matthias Hoppert hans-georg Frank Tobias Wuerfel Christopher Alt Christoph Schmitz Chairman of the Board Isarklinikum MunichMunich 80331Germany Department of Spine Surgery Isarklinikum MunichMunich 80331Germany Department for Orthopedics and Trauma Surgery Isarklinikum MunichMunich 80331Germany Chair of Neuroanatomy Institute of AnatomyFaculty of MedicineLMU MunichMunich 80336Germany Director of Science and Research InGeneron GmbHMunich 80331Germany

BACKGROUND Current clinical treatment options for symptomatic,partial-thickness rotator cuff tear(sPTRCT)offer only limited potential for true tissue healing and improvement of clinical *** animal models,injections of adult stem cells isolated from adipose tissue into tendon injuries evidenced histological regeneration of tendon ***,it is unclear whether such beneficial effects could also be observed in a human tendon treated with fresh,uncultured,autologous,adipose derived regenerative cells(UA-ADRCs).A specific challenge in this regard is that UA-ADRCs cannot be labeled and,thus,not unequivocally identified in the host ***,histological regeneration of injured human tendons after injection of UA-ADRCs must be assessed using comprehensive,immunohistochemical and microscopic analysis of biopsies taken from the treated tendon a few weeks after injection of *** SUMMARY A 66-year-old patient suffered from sPTRCT affecting the right supraspinatus and infraspinatus tendon,caused by a bicycle *** day 18 post injury[day 16 post magnetic resonance imaging(MRI)examination]approximately 100 g of abdominal adipose tissue was harvested by liposuction,from which approximately 75×10^(6) UA-ADRCs were isolated within 2 ***,UA-ADRCs were injected(controlled by biplanar X-ray imaging)adjacent to the injured supraspinatus tendon immediately after *** fast clinical recovery,a follow-up MRI examination 2.5 mo post treatment indicated the need for open revision of the injured infraspinatus tendon,which had not been treated with *** this operation,a biopsy was taken from the supraspinatus tendon at the position of the injury.A comprehensive,immunohistochemical and microscopic analysis of the biopsy(comprising 13 antibodies)was indicative of newly formed tendon *** Injection of UA-ADRCs can result in regeneration of injured human tendons by formation of new tendon tissue.

关键词： Stem cells Partial-thickness rotator cuff tear Tendon regeneration Adipose derived regenerative cells Cell-based therapy at point of care Case report

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CO_2 mitigation potential in farmland of China by altering current organic matter amendment pattern

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Science China Earth Sciences 2010年第9期53卷 1351-1357,1407-1417页

作者： CADISCH georg Institute of Plant Production and Agroecology in the Tropics and Subtropics University of Hohenheim

The estimation of the global warming mitigation potential in terrestrial ecosystems is of great importance for decision makers to adopt measures to increase soil organic carbon (SOC) as well as to reduce greenhouse gas (GHGs) emissions. In this paper, we compiled data published in peer-reviewed journals, and conducted a holistic analysis of the effects of organic matter amendment on soil organic carbon sequestration, methane (CH4) and nitrous oxide (N2O) emissions in paddy and upland systems. Results showed that organic matter amendment increased soil organic carbon content, and apparent conversion rate of organic matter carbon to soil organic carbon in paddies was constant, while that in uplands decreased along with amendment years at 25 years time scale. Organic matter amendment during the rice season led to large CH4-C emissions, e.g on average 99.5 g CH4-C per kg organic carbon input under intermittent flood conditions, and 191.7 g CH4-C per kg organic carbon input under continuous flood conditions, respectively. By alteration of organic matter amendment from rice season to off-rice upland crop season, estimated CH4-C emissions in China could be cut by 3.5 Tg yr-1, accounting for 63% of current CH4-C emissions (5.5 Tg). If organic matter amendment percentage was increased from current 30% to future 50% of organic matter production and by alteration of organic matter amendment from rice season to off-rice upland crop season, the equivalent CO2-C mitigation potential in farmland of China would be 49.2 Tg yr-1 at the 10th year organic matter amendment and 36.0 Tg yr-1 at the 30th year amendment. These findings are important not only for China but also for the other rice production countries to increase farmland global warming mitigation.

关键词： climate change global warming radiative forcing SOC GHGs CH4 N2O

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Metallic debris from metal-on-metal total hip arthroplasty regulates periprosthetic tissues

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World Journal of Orthopedics 2014年第5期5卷 660-666页

作者： Christoph H Lohmann Gurpal Singh hans-georg Willert Gottfried H Buchhorn Department of Orthopaedic Surgery Otto-von-Guericke University University Orthopaedics Hand and Reconstructive Microsurgery Cluster National University Health System Department of Orthopaedics University Hospital Goettingen

The era of metal-on-metal(MoM) total hip arthroplasty has left the orthopaedic community with valuable insights and lessons on periprosthetic tissue reactions to metallic debris. Various terms have been used to describe the tissue reactions. Sometimes the nomenclature can be confusing. We present a review of the concepts introduced by Willert and Semlitsch in 1977,along with further developments made in the understanding of periprosthetic tissue reactions to metallic debris. We propose that periprosthetic tissue reactions be thought of as(1) gross(metallosis, necrosis, cyst formation and pseudotumour);(2) histological(macrophage-dominated, lymphocyte-dominated or mixed);and(3) molecular(expression of inflammatory mediators and cytokines such as interleukin-6 and tumor necrosis factor-alpha). Taper corrosion and modularity are discussed, along with future research directions to elucidate the antigen-presenting pathways and materi-al-specific biomarkers which may allow early detection and intervention in a patient with adverse periprosthetic tissue reactions to metal wear debris.

关键词： Periprosthetic tissue response Metal-on-Metal Total hip arthroplasty Metal debris Lymphocytedominated Macrophage-dominated Taper corrosion Modularity

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NO<sub>2</sub>Excited State Properties Revisited: An Effect of Extra Compactified Dimensions

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Journal of Modern Physics 2017年第11期8卷 1749-1761页

作者： hans-georg Weber Heinrich-Hertz-Institut Einsteinufer 37 Berlin Germany Sudetenstr. 16 Amorbach Germany

Experiments on NO2 reveal a substructure underlying the optically excited isolated hyperfine structure (hfs) levels of the molecule. This substructure is seen in a change of the symmetry of the excited molecule and is represented by the two “states” and of a hfs-level. Optical excitation induces a transition from the ground state of the molecule to the excited state . However, the molecule evolves from to in a time τ0 ≈ 3 μs. Both and have the radiative lifetime τR ≈ 40 μs, but and differ in the degree of polarization of the fluorescence light. Zeeman coherence in the magnetic sublevels is conserved in the transition →, and optical coherence of and is able to affect (inversion effect) the transition →. This substructure, which is not caused by collisions with baryonic matter or by intramolecular dynamics in the molecule, contradicts our knowledge on an isolated hfs-level. We describe the experimental results using the assumption of extra dimensions with a compactification space of the size of the molecule, in which dark matter affects the nuclei by gravity. In , all nuclei of NO2 are confined in a single compactification space, and in , the two O nuclei of NO2 are in two different compactification spaces. Whereas and represent stable configurations of the nuclei,represents an unstable configuration because the vibrational motion in shifts one of the two O nuclei periodically off the common compactification space, enabling dark matter interaction to stimulate the transition →with the rate (τ0)−1. We revisit experimental results, which were not understood before, and we give a consistent description of these results based on the above assumption.

关键词： Extra Dimensions Compactification Space Dark Matter Molecular Physics

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Towards engineering a portable platform for laparoscopic pre-training in virtual reality with haptic feedback

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虚拟现实与智能硬件（中英文） 2024年第2期6卷 83-99页

作者： hans-georg ENKLER Wolfgang KUNERT Stefan PFEFFER Kai-Jonas BOCK Steffen AXT Jonas JOHANNINK Christoph REICH Furtwangen University 78120 FurtwangenGermany University Hospital and Faculty of Medicine Tuebingen 72076 TuebingenGermany

Background Laparoscopic surgery is a surgical technique in which special instruments are inserted through small incision holes inside the *** some time,efforts have been made to improve surgical pre training through practical exercises on abstracted and reduced *** The authors strive for a portable,easy to use and cost-effective Virtual Reality-based(VR)laparoscopic pre-training platform and therefore address the question of how such a system has to be designed to achieve the quality of today's gold standard using real tissue *** VR controllers are limited regarding haptic *** haptic feedback is necessary or at least beneficial for laparoscopic surgery training,the platform to be developed consists of a newly designed prototype laparoscopic VR controller with haptic feedback,a commercially available head-mounted display,a VR environment for simulating a laparoscopic surgery,and a training *** To take full advantage of benefits such as repeatability and cost-effectiveness of VR-based training,the system shall not require a tissue sample for haptic *** is currently calculated and visually displayed to the user in the VR *** the prototype controller,a first axis was provided with perceptible feedback for test *** of the prototype VR controllers can be combined to simulate a typical both-handed use case,e.g.,laparoscopic suturing.A Unity based VR prototype allows the execution of simple standard *** The first prototype enables full operation of a virtual laparoscopic instrument in *** addition,the simulation can compute simple interaction *** challenges lie in a realistic real-time tissue simulation and calculation of forces for the haptic *** weaknesses were identified in the first hardware prototype,which will be improved in subsequent *** degrees of freedom of the controller are to be provided with haptic *** make forces t

关键词： Laparoscopic surgery Training Virtual reality Controller Haptic feedback Kinesthetic skills

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Zinc Fingers, TAL Effectors, or Cas9-Based DNA Binding Proteins： What＇s Best for Targeting Desired Genome Loci？

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Molecular Plant 2013年第5期6卷 1384-1387页

作者： Annett strauβ Thomas Lahaye Faculty of Biology Institute of Genetics Ludwig-Maximilians-University Munich Grolβhaderner Straβe 2-4 D-82152 Martinsried Germany

ZINC FINGER- AND TAL EFFECTOR- BASED DNA BINDING PROTEINSProgrammable DNA binding proteins （PDPs） that selectively bind user-defined nucleotide sequences can navigate protein domains to any desired target within the genome. Different functional domains can be fused to PDPs to achieve （1） acti- vation or repression of transcription, （2） nicking or cleavage of DNA, or （3） modification or removal of epigenetic marks at the targeted genome spot. Given their broad applicabil- ity, the development of highly specific, easy-to-use PDPs has been a holy grail of biotechnology since the determination of the 3-D structure of zinc fingers （ZFs） bound to DNA in 1991 （Pavletich and Pabo, 1991）. This structure suggested that tandemly arranged ZFs act as functionally independ- ent modules with each finger binding three bases. However, the combination of fingers with experimentally defined base specificities into arrays revealed that ZFs are not function- ally independent. Instead, they were found to behave in a context-dependent, and often unpredictable fashion requir- ing iterative cycles of selection to get ZF arrays with desired specificity （Joung and Sander, 2013）.

关键词： DNA结合蛋白基因组 TAL 锌指期望基础蛋白质结构域用户自定义

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Yield Improvement and Advanced Defect Control——Driving Forces for Modeling of Bulk Crystal Growth

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Journal of Rare Earths 2006年第z1期24卷 200-207页

作者： georg Mueller Jochen Friedrich Crystal Growth Laboratory University Erlangen-Nürnberg (WW6) and Fraunhofer Institute of Integrated Systems and Device Technology (IISB) Martensstrasse 7 D-91058 Erlangen Germany Crystal Growth Laboratory University Erlangen-Nürnberg (WW6) and Fraunhofer Institute of Integrated Systems and Device Technology (IISB) Martensstrasse 7 D-91058 Erlangen Germany

Yield improvement and advanced defect control can be identified as the driving forces for modeling of industrial bulk crystal growth. Yield improvement is mainly achieved by upscaling of the whole crystal growth apparatus and increased processing windows with more tolerances for parameter variations. Advanced defect control means on one hand a reduction of the number of deficient crystal defects and on the other hand the formation of beneficial crystal defects with a uniform distribution and well defined concentrations in the whole crystal. This "defect engineering" relates to the whole crystal growth process as well as the following cooling and optional annealing processes, respectively. These topics were illustrated in the paper by examples of modeling and experimental results of bulk growth of silicon (Si), gallium arsenide (GaAs), indium phosphide (InP) and calcium fluoride (CaF2). These examples also involve the state of the art of modeling of the most important melt growth techniques, crystal pulling (Czochralski methods) and vertical gradient freeze (Bridgman-type methods).

关键词： yield improvement advanced defect control crystal growth

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RESILIENCE 2.0： COMPUTER-AIDED DISASTER MANAGEMENT

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Journal of Systems Science and Systems Engineering 2017年第3期26卷 321-335页

作者： Gerhard Chroust georg Aumayr Institute for Telecooperation Johannes Kepler University Linz Austria Johanniter Osterreich Ausbildung und Forschung Vienna Austria

Many factors （larger population, more dependency on technology, more human-caused interference in the natural systems and equilibria, climate changes,... ） contribute to the seemingly growing number and severity of disasters. Additional exaggeration is generated by public media. As a consequence Disaster Prevention and Disaster Management must be given increased attention. The ultimate goal of Disaster Management is resilience of the affected system and thus the adequate and acceptable survival of the affected population. We discuss system behavior in the case of an assault or disturbance： from being fragile （loss of their functionality due to the assault） to being resilient （having the capacity ... of bouncing back to dynamic stability after a disturbance）, or even antifragile （being able to ＂learn＂ so as to improve disaster resilience）. Resilience 2. 0 identifies a new paradigm： modem Information and Communication Technologies （ICT） are employed as a basis for enabling and improving resilience of a system. ICT provide the basis for sufficient preparation before an assault, for quick recognition of, and for effective, efficient reactions to disasters. Only the coordinated intra- and interphase deployment of ICT promises sufficient success and can bring resilience to currently as yet fragile systems. We discuss stressors （time and performance pressure, physical and psychological stress on personnel） and problems due to damaged ICT-platforms and communication infrastructure. The basic message is that computer-aided Disaster Management is able to offers a new level of reactivity： Resilience 2.0.

关键词： Disaster vulnerability resilience human reaction hazard threat systemic reaction

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Die Einzige und die Zweite

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德语人文研究 2001年第5期 4-5页

作者： Botho strauβ

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On the Connection Between the Spectral Difference Method and the Discontinuous Galerkin Method

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Communications in Computational Physics 2011年第4期9卷 1071-1080页

作者： georg May Aachen Institute for Advanced Study in Computational Engineering Sciences RWTH Aachen UniversitySchinkelstr.252062 AachenGermany

In this short note we present a derivation of the Spectral Difference Scheme from a Discontinuous Galerkin(DG)discretization of a nonlinear conservation *** allows interpretation of the Spectral Difference Scheme as a particular discretization under the quadrature-free nodal DG ***,it enables identification of the key differences between the Spectral Difference Scheme and standard nodal DG schemes.

关键词： Spectral difference method discontinuous Galerkin method hyperbolic conservation laws quadrature-free schemes nodal schemes

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