First immunohistochemical evidence of human tendon repair following stem cell injection: A case report and review of literature
作者机构：Chairman of the BoardIsarklinikum MunichMunich 80331Germany Department of Spine SurgeryIsarklinikum MunichMunich 80331Germany Department for Orthopedics and Trauma SurgeryIsarklinikum MunichMunich 80331Germany Chair of NeuroanatomyInstitute of AnatomyFaculty of MedicineLMU MunichMunich 80336Germany Director of Science and ResearchInGeneron GmbHMunich 80331Germany
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第7期
页 面：944-970页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
主 题：Stem cells Partial-thickness rotator cuff tear Tendon regeneration Adipose derived regenerative cells Cell-based therapy at point of care Case report
摘 要：BACKGROUND Current clinical treatment options for symptomatic,partial-thickness rotator cuff tear(sPTRCT)offer only limited potential for true tissue healing and improvement of clinical *** animal models,injections of adult stem cells isolated from adipose tissue into tendon injuries evidenced histological regeneration of tendon ***,it is unclear whether such beneficial effects could also be observed in a human tendon treated with fresh,uncultured,autologous,adipose derived regenerative cells(UA-ADRCs).A specific challenge in this regard is that UA-ADRCs cannot be labeled and,thus,not unequivocally identified in the host ***,histological regeneration of injured human tendons after injection of UA-ADRCs must be assessed using comprehensive,immunohistochemical and microscopic analysis of biopsies taken from the treated tendon a few weeks after injection of *** SUMMARY A 66-year-old patient suffered from sPTRCT affecting the right supraspinatus and infraspinatus tendon,caused by a bicycle *** day 18 post injury[day 16 post magnetic resonance imaging(MRI)examination]approximately 100 g of abdominal adipose tissue was harvested by liposuction,from which approximately 75×10^(6) UA-ADRCs were isolated within 2 ***,UA-ADRCs were injected(controlled by biplanar X-ray imaging)adjacent to the injured supraspinatus tendon immediately after *** fast clinical recovery,a follow-up MRI examination 2.5 mo post treatment indicated the need for open revision of the injured infraspinatus tendon,which had not been treated with *** this operation,a biopsy was taken from the supraspinatus tendon at the position of the injury.A comprehensive,immunohistochemical and microscopic analysis of the biopsy(comprising 13 antibodies)was indicative of newly formed tendon *** Injection of UA-ADRCs can result in regeneration of injured human tendons by formation of new tendon tissue.
维普期刊数据库