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Tuning ge.atin-base. hydroge. towards bioadhe.ive.ocular tissue.e.gine.ring applications

Bioactive.Mate.ials 2021年第11期6卷 3947-3961页

作者： Sina Sharifi Mohammad Mirazul Islam hannah Sharifi Rakibul Islam Darre.l Koza Fe.isa Re.e.-Orte.a David Alba-Molina Pe. H.Nilsson Clae. H.Dohlman Tom e.rik Mollne. Jame. Chodosh Migue. Gonzale.-Andrade. Massachuse.ts e.e.and e.r and Sche.e.s e.e.Re.e.rch Institute Department of OphthalmologyHarvard Medical SchoolBostonMAUSA De.artme.t of Immunology Oslo University HospitalRikshospitaletUniversity of OsloOsloNorway De.artme.t of Physical Scie.ce. Eastern Connecticut State UniversityWillimanticCTUSA Linnae.s Ce.te. for Biomate.ials Che.istry Linnaeus UniversityKalmarSweden Re.e.rch Laboratory Nordland HospitalBodøNorway Ce.tre.of Mole.ular Inflammation Re.e.rch Norwegian University of Science and TechnologyTrondheimNorway Maimonide. Biome.ical Re.e.rch Institute.of Cordoba(IMIBIC) Department of OphthalmologyReina Sofia University Hospital and University of CordobaCordobaSpain Faculty of He.lth Scie.ce. K.G.Jebsen TRECUniversity of TromsøNorway

Ge.atin base. adhe.ive. have.be.n use. in the.last de.ade. in diffe.e.t biome.ical applications due.to the.e.ce.le.t biocompatibility,e.sy proce.sability,transpare.cy,non-toxicity,and re.sonable.me.hanical prope.tie. to mimic the.e.trace.lular matrix(e.M).Ge.atin adhe.ive. can be.e.sily tune. to gain diffe.e.t viscoe.astic and me.hanical prope.tie. that facilitate.its ocular *** he.e.n grafte. glycidyl me.hacrylate.on the.ge.atin backbone.with a simple.che.ical modification of the.pre.ursor,utilizing e.oxide.ring-ope.ing re.ctions and visible.*** che.ical modification allows the.obtaining of an e.astic prote.n-base. hydroge.(Ge.GYM)with e.ce.le.t biomime.ic prope.tie.,approaching those.of the.native.*** can be.modulate. to be.stre.che. up to 4 time. its initial le.gth and withstand high te.sile.stre.se. up to 1.95 MPa with compre.sive.strains as high as 80%compare. to Ge.atin-me.hacryloyl(Ge.MA),the.most studie. de.ivative.of ge.atin use. as a *** is also highly biocompatible.and supports ce.lular adhe.ion,prolife.ation,and migration in both 2 and 3-dime.sional *** characte.istics along with its supe. adhe.ion to biological tissue. such as corne.,aorta,he.rt,muscle.kidne.,live.,and sple.n sugge.t wide.pre.d applications of this hydroge. in many biome.ical are.s such as transplantation,tissue.adhe.ive.wound dre.sing,bioprinting,and drug and ce.l de.ive.y.

关键词： Natural-base. hydroge. Ge.atin Biocompatible Biomime.ic Bioadhe.ive Corne.

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二级污水处理系统优化技术

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山西建筑 1988年第3期 35-48页

作者： Chl-Chung Tang A.M.ASCe.e.downey Brill Jr. J.T.Pfe.fe. Me.be.s 王军太原工业大学

已经表明优化法对解决活性污泥和污水处理系统的综合模型是有效的。现在提出一种新的解析法,它的优点是可专门适用于处理系统的特殊结构。专设了一个液体子系统和一个污泥子系统可以解决一系列的子问题。进而要求各种解能协调一致。同... 详细信息

已经表明优化法对解决活性污泥和污水处理系统的综合模型是有效的。现在提出一种新的解析法,它的优点是可专门适用于处理系统的特殊结构。专设了一个液体子系统和一个污泥子系统可以解决一系列的子问题。进而要求各种解能协调一致。同时给出了为处理同等约束而设立的一个广泛应用的非线性编程算法(GRGZ)和一个几何编程算法(1GGP)。已表明每种方法对一试题都会得到满意的解答,而它们的计算要求都相似。前一种方法最清楚地表明是趋于经济有效的而且有几个解,第三种方法最为便当。不同方法的适用性很重要,因为刘于某种特殊情况,也许某种方法就比其他方法更适合,特别是当模型已经变更或扩展时更有差别。

关键词：污水处理系统固体成分消化池消化水池废水处理设备活性污泥浓缩池固体浓度污泥处理上清液水力停留时间滤出液优化技术

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A phase.1b randomize. clinical trial of CT1812 to me.sure.Aβoligome. displace.e.t in Alzhe.me.’s dise.se.using an indwe.ling CSF cathe.e.

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Translational Ne.rode.e.e.ation 2023年第1期12卷 568-571页

作者： Ke.sie.M.LaBarbe.a Yve.te.I.She.ine.Nicholas J.Izzo Carla M.Yue.e.Lora Waybright Raymond Yurko hannah M.e.wards Woodrow D.Gardine. Kaj Ble.now He.rik Ze.te.be.g Anne.Börje.son-Hanson Roge. Morgan Charle. S.Davis Robe.t J.Gutte.dorf Lon S.Schne.de. Ste.e. De.osky Harry Le.ine.III Michae. Grundman Anthony O.Caggiano John R.Cirrito Susan M.Catalano Mary e.Hamby Cognition The.ape.tics Inc. PittsburghPAUSA Unive.sity of Pe.nsylvania PhiladelphiaUSA Washington Unive.sity St.LouisUSA Unive.sity of Gothe.burg MölndalSweden De.artme.t of Psychiatry and Ne.roche.istry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden Clinical Ne.roche.istry Laboratory Sahlgrenska University HospitalMölndalSweden De.artme.t of Ne.rode.e.e.ative.Dise.se UCL Institute of NeurologyQueen SquareLondonUK UK De.e.tia Re.e.rch Institute.at UCL LondonUK Hong Kong Ce.te. for Ne.rode.e.e.ative.Dise.se. Clear Water BayHong KongChina Wisconsin Alzhe.me.’s Dise.se.Re.e.rch Ce.te. University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWIUSA Karolinska Unive.sity Hospital StockholmSweden Me.SurgPI LLCRaleighNCUSA CSD Biostatistics Inc.Oro ValleyAZUSA Aclairo Pharmace.tical De.e.opme.t Group IncViennaVAUSA Ke.k School of Me.icine.of USC Los AngelesCAUSA McKnight Brain Institute University of FloridaGainesvilleFLUSA Sande.s-Brown Ce.te. on Aging University of KentuckyLexingtonKYUSA Global R&D Partne.s LLCSan DiegoCAUSA De.artme.t of Ne.roscie.ce. University of CaliforniaSan DiegoUSA

Trial Re.istration:May 11th,2018 *** Ide.tifie.:NCT03522129 https://clini caltr ***/ct2/show/*** the.apie. for Alzhe.me.’s dise.se.AD)targe. a wide.range.of me.hanisms,ye. promising dis-e.se.modifying the.apie. re.ain a huge.unme. *** e.ide.ce.indicate. that the.oligome.ic form of amyloid-be.a(Aβ)is a toxic spe.ie. contributing to AD through synaptic damage.and ne.ronal toxicity[1].

关键词： Alzhe.me. Aβ damage

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Comparative.e.ficacy of gypsy moth(Le.idopte.a:e.e.idae.e.tomopathoge.s on transge.ic blight-tole.ant and wild-type.Ame.ican,Chine.e.and hybrid che.tnuts(Fagale.:Fagace.e.

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Inse.t Scie.ce 2020年第5期27卷 1067-1078页

作者： Aaron J.Brown Andre. e.Ne.house.William A.Powe.l Dylan Parry De.artme.t of e.vironme.tal and Fore.t Biology College of Environmental Science and ForestryState University of New YorkSyracuseNY13210USA

Ame.ican che.tnut(Castane. de.tata[Marsh.]Borkh.)was once.the.dominant hardwood spe.ie. in e.ste.n North Ame.ica be.ore.an e.otic fungal pathoge.,Cryphone.-tria parasitica(Murrill)Barr,functionally e.iminate. it across its *** promising approach toward re.toring Ame.ican che.tnut to natural fore.ts is de.e.opme.t of blight-tole.ant tre.s using ge.e.ic ***,transformation and re.ate. proce.se. can re.ult in une.pe.te. and uninte.de. phe.otypic change.,pote.tially alte.ing e.ologi-cal *** asse.s uninte.de. tritrophic impacts of transge.ic Ame.ican che.tnut on plant he.bivore.inte.actions,gypsy moth(Lymantria dispar L.)cate.pillars we.e.fe. le.f disks e.cise. from two transge.ic e.e.ts,Darling 54 and Darling 58,and four control Ame.ican che.tnut *** disks we.e.pre.iously tre.te. with an LDso dose.of e.the. the.spe.e.-spe.ific Lymantria dispar multiple.nucle.polyhe.rovirus(LdMNPV)or the.ge.e.alist pathoge. Bacillus thuringie.sis ***(Btk).Mortality was quantifie. and compare. to wate. blank *** ge.otype.had a strong e.e.t on the.e.ficacie. of both *** mortality from Btk-tre.te. foliage.from only one.transge.ic e.e.t,Darling 54,diffe.e. from its isoge.ic proge.itor,e.lis l,but was similar to an unre.late. wild-type.Ame.ican che.tnut *** e.ficacy was unaffe.te. by ge.e.ic *** sugge.t that although ge.e.ic modification of tre.s may affe.t inte.actions with othe. nontarge. organisms,this may be.due.to inse.tion e.fe.ts,and varia-tion amnon diMte.e.t ge.vtype.(wle.he. uasge.c ul wild-typc)iupaults a gie.lci change.in re.ponse.than transge.e.pre.e.ce.

关键词： Bacillus thuringie.sis LdMNPV nontarge. re.toration tri-trophic unin-te.de. e.fe.ts

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莫奈名画的天文解读

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中国国家天文 2014年第2期8卷 94-101页

作者： Donald W.Olson Russe.l L.Doe.che. Laura e.Briqht hannah N.Re.nolds Ava G.Pope.郭晓博(译)

一个天文研究团队确定了莫奈的一幅最美画作绘于何时何地。

关键词：天文解读名画

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Mole.ular and e.ide.iologic characte.ization of Wilms tumor from Baghdad, Iraq

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World Journal of Pe.iatrics 2018年第6期14卷 585-593页

作者： hannah M.Phe.ps Mazin F.Al-Jadiry Natasha M.Corbitt Jane.e.M.Pie.ce.Bingshan Li Qiang We. Raina R.Flore. He.nan Corre. Ste.ania Uccini Haydar Frangoul Ade. R.Alsaadawi Safaa A.F.Al-Badri Amir F.Al-Darraji Raghad M.Al-Sae.d Salma A.Al-Hadad Harold N.LovvornⅢ Vande.bilt Unive.sity School of Me.icine 2215 Garland AvenueNashvilleTN 37232-9780USA Oncology Unit Children’s Welfare Teaching HospitalBaghdad University Medical CityBaghdadIraq De.artme.t of P e.iatric Surge.y Vanderbilt University Medical CenterNashvilleUSA De.artme.t of Mole.ular Physiology and Bioph ysics Vanderbilt University School of MedicineNashvilleUSA Division of P e.iatric Pathology Vanderbilt University Medical CenterNashvilleUSA De.artme.t of Clinical and Mole.ular Me.icine Sapienza UniversityRomeItaly Division of P e.iatric He.atology and Oncology Vanderbilt University Medical CenterNashvilleUSA De.artme.t of P athology Baghdad University Medical CityBaghdadIraq Oncology Unit Children’s Welfare Teaching HospitalWasit University College of MedicineWasitIraq

Background Wilms tumor (WT) is the.most common childhood kidne. cance. worldwide. ye. its incide.ce.and clinical be.avior vary according to race.and acce.s to ade.uate.he.lthcare.re.ource.. To guide.and stre.mline.the.apy in the.war-torn and re.ource.constraine. city of Baghdad, Iraq, we.conducte. a first-e.e. mole.ular analysis of 20 WT spe.ime.s to characte.ize.the.biological fe.ture. of this le.hal dise.se.within this challe.ge. population. Me.hods Ne.t-ge.e.ation se.ue.cing of te. targe. ge.e. associate. with WT de.e.opme.t and tre.tme.t re.istance.(WT1, CTNNB1, WTX, IGF2, CITe.1, SIX2, p53, N-MYC, CRABP2, and TOP2A) was comple.e.. Immunohistoche.istry was pe.forme. for 6 marke. prote.ns of WT (WT1, CTNNB1, NCAM, CITe.1, SIX2, and p53). Patie.t outcome. we.e.compile.. Re.ults Mutations we.e.de.e.te. in pre.iously de.cribe. WT 'hot spots' (e.g., WT1 and CTNNB1) as we.l as nove. loci that may be.unique.to the.Iraqi population. Immunohistoche.istry showe. e.pre.sion domains most typical of blaste.al-pre.ominant WT. Re.arkably, de.pite.the.challe.ge. facing familie. and care.provide.s, only one.child, with combine. WT1 and CTNNB1 mutations, was confirme. de.d from dise.se. Me.ian clinical follow-up was 40.5 months (range.6–78 months). Conclusions The.e.data sugge.t that WT biology within a population of Iraqi childre. manife.ts fe.ture. both similar to and unique.from dise.se.variants in othe. re.ions of the.world. The.e.obse.vations will he.p to risk stratify WT patie.ts living in this difficult e.vironme.t to more.or le.s inte.sive.the.apie. and to focus tre.tme.t on ce.l-spe.ific targe.s.

关键词： Iraq Low- and middle.income countrie. Ne.t-ge.e.ation se.ue.cing Pe.iatric cance. Wilms tumor

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Sharpe.ing e.itte. localization in front of a tune. mirror

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Light(Scie.ce.& Applications) 2018年第1期7卷 71-78页

作者： hannah S.He.l Be.jamin Schre.be. Ralph Götz Monika e.me.ling Marie.Christine.Dabauvalle.Ge.rg Krohne.Sve. Höfling Martin Kamp Markus Saue. Katrin G.He.nze Rudolf Virchow Ce.te. Research Center for Experimental BiomedicineUniversity of WürzburgJosef-Schneider-Str.297080 WürzburgGermany De.artme.t of Biote.hnology and Biophysics BiozentrumUniversity of WürzburgAm Hubland97074 WürzburgGermany Te.hnische.Physik Physikalisches Institut and Wilhelm Conrad Röntgen-Center for Complex Material SystemsUniversity of WürzburgAm Hubland97074 WürzburgGermany Division of e.e.tron Microscopy BiozentrumUniversity of WürzburgAm Hubland97074 WürzburgGermany SUPA School of Physics and AstronomyUniversity of St AndrewsSt Andrews KY169SSUK

Single.mole.ule.localization microscopy(SMLM)aims for maximize. pre.ision and a high signal-to-noise.*** fe.ture. can be.provide. by placing the.e.itte. in front of a me.al-die.e.tric nanocoating that acts as a tune. mirror2–***,we.de.onstrate.that a highe. photon yie.d at a lowe. background on biocompatible.me.al-die.e.tric nanocoatings substantially improve. SMLM pe.formance.and incre.se. the.localization pre.ision by up to a factor of *** re.olution improve.e.t re.ie. sole.y on e.sy-to-fabricate.nanocoatings on standard glass cove.slips and is spe.trally and spatially tunable.by the.laye. de.ign and wave.e.gth,as e.pe.ime.tally de.onstrate. for dual-color SMLM in ce.ls.

关键词： e.itte. mirror tunable

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Mole.ular Characte.ization of e.te.de. Spe.trum <i>β</i>-Lactamase.Ge.e. in Clinical <i>e. coli</i>Isolate.

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Journal of Biome.ical Scie.ce.and e.gine.ring 2014年第5期7卷 276-285页

作者： Jame. Chibue.e.Igwe.Josiah Ade.ola Onaolapo Mohamme. Kachallah Amose.Nworie.hannah Oluwake.i Oladipo Be.trice.Onyiye.Ojie.o Obadiah Dauda e.ose.Se.i e.un Ade.oye.Mojirayo Titilayo Durowaiye.Ale. Uwadie.wu Akpa Inimfon Akaninye.e.Ibanga De.artme.t of Me.ical Biote.hnology National Biotechnology Development Agency Abuja Nigeria De.artme.t of Me.ical Laboratory Scie.ce Ebonyi State University Abakaliki Nigeria De.artme.t of Pharmace.tical Microbiology University of Ibadan Ibadan Nigeria De.artme.t of Pharmace.tics and Pharmace.tical Microbiology Ahmadu Bello University Zaria Nigeria De.artme.t of Pharmace.tics and Pharmace.tical Microbiology University of Maiduguri Maiduguri Nigeria

e.te.de. Spe.trum Be.a-Lactamase. (e.BLs) e.coding ge.e. (Te., SHV and OXA) we.e.amplifie. from multidrug re.istance.e. coli. The.multidrug re.istance.e. coli isolate. from diffe.e.t clinical source. we.e.docume.te. to be.plasmid e.code. and re.istance.against β-lactam and ce.halosporin. Conve.tional laboratory analysis showe. that se.e.ty pe.ce.t (70%) of the.se.e.te. multidrug re.istant clinical isolate. we.e.e.BLs positive. showing a ≥5 mm incre.se.in zone.diame.e. for e.the. antibiotics compare. to its zone.whe. te.te. alone. The.antibiotic susce.tibility re.ult showe. that 100% of the.isolate. we.e.re.istant to amoxicillin-clavulanic acid, amoxicillin, ce.uroxime.and ampicillin-sulbactam while.90% of the.isolate. we.e.re.istant to ce.tazidine.and te.racycline. 80% to ofloxacin, 70% to ce.triazon, nalidixic acid, ce.ale.in, 60% to ciprofloxacin, 50% to nitrofurantoin, 40% to chloramphe.icol and 20% to ge.tamicine. The.multiple. PCR with prime.s Te. (931bp), SHV (868), OXA-2 (478), aac(3)-IIa (900) and rmtA (634), which are.ge.e. re.ponsible.for e.te.de. spe.trum β-lactamase.and aminoglycoside.re.istance.in e. coli shows that: isolate.W15 comprise. of thre. (3) re.istant ge.e. which corre.ponds with Te. re.olving as a 931 base.pair, SHV 868 base.pair, and a 478 bp indicating OXA-2 that is faint probably indicating a low conce.tration of the.ge.e. Isolate.B2 comprise. single.re.istant ge.e. which is inte.pre.e. as OXA-2 with 478 base.pair while.isolate.URO2, U64 and S45 comprise. of two re.istance.ge.e. which re.olve.as 868 and 478 base.pair indicating SHV and OXA-2 re.pe.tive.y. Howe.e., isolate. S57, U58 and B7 showe. no ge.e.amplification de.pite.the.various de.re. of re.istance.in MIC and antibiotic susce.tibility profile.te.t obtaine. with conve.tional de.e.tion analysis. We.assume.that the.r re.istant ge.e. are.not code. for by the.prime.s use. in this study as the.e.isolate. are.like.y to contain othe. re.istant ge.e., which are.also e.pre.se. at a mole.ula

关键词： e.BLs Te. SHV OXA Multidrug Re.istant e. coli

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Cross-scale.mode.ing of surface.te.pe.ature.and tre. se.dling e.tablishme.t in mountain landscape.

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e.ological Proce.se. 2013年第1期2卷 313-327页

作者： John R Dingman Lynn C Swe.t Ian McCullough Frank W Davis Alan Flint Jane. Franklin Lorraine.e.Flint e.rth Re.e.rch Institute University of California Santa BarbaraSanta BarbaraCA 93106USA U.S.Ge.logical Surve. California Water Science CenterSacramentoCA 95819USA Bre. School of e.vironme.tal Scie.ce.Manage.e.t University of California Santa BarbaraSanta BarbaraCA93106USA School of Ge.graphical Scie.ce. and Urban Planning Arizona State UniversityTempeAZ85287USA

Introduction:e.timating surface.te.pe.ature.from above.ground fie.d me.sure.e.ts is important for unde.standing the.comple. landscape.patte.ns of plant se.dling survival and e.tablishme.t,proce.se. which occur at he.ghts of only se.e.al ***,future.climate.mode.s pre.ict te.pe.ature.at 2 m above.ground,le.ving ground-surface.microclimate.not we.l ***:Using a ne.work of fie.d te.pe.ature.se.sors and climate.mode.s,a ground-surface.te.pe.ature.me.hod was use. to e.timate.microclimate.variability of minimum and maximum *** lapse.rate. we.e.de.ive. from fie.d te.pe.ature.se.sors and distribute. across the.landscape.capturing diffe.e.ce. in solar radiation and cold air drainage. mode.e. at a 30-m spatial ***:The.surface.te.pe.ature.e.timation me.hod use. for this analysis succe.sfully e.timate. minimum surface.te.pe.ature. on north-facing,south-facing,valle.,and ridge.ine.topographic se.tings,and whe. compare. to me.sure. te.pe.ature. yie.de. an R2 of 0.88,0.80,0.88,and 0.80,*** surface.te.pe.ature. ge.e.ally had slightly more.spatial variability than minimum surface.te.pe.ature.,re.ulting in R2 value. of 0.86,0.77,0.72,and 0.79 for north-facing,south-facing,valle.,and ridge.ine.topographic ***-Poisson re.re.sions pre.icting re.ruitme.t of Que.cus ke.loggii(black oak)se.dlings from te.pe.ature.variable. we.e.significantly improve. using the.e.e.timate. of surface.te.pe.ature.compare. to air te.pe.ature.mode.e. at 2 ***:Pre.icting minimum and maximum ground-surface.te.pe.ature. using a downscale. climate.mode. couple. with te.pe.ature.lapse.rate. e.timate. from fie.d me.sure.e.ts provide. a me.hod for mode.ing te.pe.ature.e.fe.ts on plant *** me.hods could be.applie. to improve.proje.tions of spe.ie.’range.shifts unde. climate.*** of comple. topography can provide.intricate.microclimate. that may allow spe.ie. to re.istribute.locally as climate

关键词： Black oak Climate.change Ge.e.alize. line.r mode.s Microclimate Topography Spatial scale Surface.te.pe.ature

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足月臀先露妊娠行剖宫产术及阴道分娩术2年后产妇结局分析:足月臀先露国际随机试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 19-19页

作者： hannah M.e. Whyte.H. hannah W.J. 朱晓明

This study was unde.take. to compare.mate.nal outcome. at2ye.rs postpartum afte. planne. ce.are.n se.tion and planne. vaginal birth for the.single.ton fe.us in bre.ch pre.se.tation at *** se.e.te. ce.te.rs in the.Te.m Bre.ch Trial,mothe.s comple.e. a structur e. que.tionnaire.at 2or more.ye.rs postpartumto de.e.mine.t he.r he.lth in the.pre.vious 3to 6months.A total of 917of 1159(79.1%)mothe.s from 85ce.te.s comple.e. a f ollow -up que.tion-naire.at 2ye.rs *** we.re.no diffe.e.ce. be.we.n groups in bre.st fe.ding,re.lationship with child or partne.,pain,subse.ue.t pre.nancy,incontine.ce.de.pre.sion,urinary,me.strual or se.ual proble.s,fatigue.or distre.sing me.orie. of the.birth *** ce.are.n se.tion was associate. with a highe. risk of con-stipation(P =.02).Mate.nal outcome. at 2ye.rs post-partum are.similar afte. planne. ce.are.n se.tion and planne. vaginal birth for the.single.ton bre.ch fe.us at te.m.

关键词：臀先露剖宫产术阴道分娩随机试验单胎妊娠母乳喂养大小便失禁记忆方面试验中心问卷调查

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