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Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

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Research 2024年第1期2023卷 763-778页

作者： Qing Liu Qiaoyun Long Jiayu Zhao Wenjie Wu Zexin Lin Wei Sun Ping Gu Tuo Deng Kerry Martin Loomes Donghai Wu Alice P.S.Kong Jingying Zhou Alfred S.Cheng hannah xiaoyan hui School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina China-New Zealand Joint Laboratory on Biomedicine and Health Chinese Academy of SciencesGuangzhouChina Department of Endocrinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of Diabetes Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina School of Biological Sciences and Maurice Wilkins Centre University of AucklandAucklandNew Zealand Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Adipose browning has demonstrated therapeutic potentials in several ***,by conducting transcriptomic profiling at the single-cell and single-nucleus resolution,we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue(iWAT)at thermoneutrality or chronic cold *** major nonimmune cells within the iWAT,including adipose stem and progenitor cells(ASPCs),mature adipocytes,endothelial cells,Schwann cells,and smooth muscle cells,were recovered,allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown *** findings also unravel the existence of subpopulations in mature adipocytes,ASPCs,and endothelial cells,as well as new insights on their interconversion and reprogramming in response to *** adipocyte subpopulation competent of major histocompatibility complex class Ⅱ(MHCⅡ)antigen presentation is ***,a subcluster of ASPC with CD74 expression was identified as the precursor of this MHCⅡ^(+)*** adipocytes are transdifferented from preexisting lipid generating adipocytes,which exhibit developmental trajectory from de novo differentiation of amphiregulin cells(Aregs).Two distinct immune-like endothelial subpopulations are present in iWAT and are responsive to *** data reveal fundamental changes during cold-evoked adipose browning.

关键词： evoked programming generating

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Single-nucleus RNA sequencing reveals heterogeneity among multiple white adipose tissue depots

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Life Metabolism 2023年第6期2卷 58-73页

作者： Limin Xie Wanyu Hu Haowei Zhang Yujin Ding Qin Zeng Xiyan Liao Dandan Wang Wanqin Xie hannah xiaoyan hui Tuo Deng National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Key Laboratory of Diabetes Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China The First Affiliated Hospital Department of OrthopedicsHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China NHC Key Laboratory of Birth Defect for Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410028China School of Biomedical Sciences The Chinese University of Hong KongHong Kong 999077China Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China

Regardless of its anatomical site,adipose tissue shares a common energy-storage role but exhibits distinctive *** the cellular and molecular heterogeneity of white adipose tissue(WAT)is crucial for comprehending its function and ***,existing single-nucleus RNA sequencing(snRNA-seq)studies of adipose tissue heterogeneity have examined only one or two *** this study,we employed snRNA-seq to test five representative depots including inguinal,epididymal,mesenteric,perirenal,and pericardial adipose tissues in mice under physiological *** analyzing the contents of main cell catego-ries and gene profiles of various depots,we identified their distinctive physiological *** cells and fibro-adipogenic progenitor cells(FAPs)showed dramatic differences among WAT depots,while adipocytes seemed to be *** heightened presence of regulatory macrophages and B cells in pericardial adipose tissues implied their potential contribution to the preservation of coronary vascular ***,the selective aggregation of pericytes within mesenteric adipose tissue was likely associated with the maintenance of intestinal barrier *** a combination of RNA sequencing and snRNA-seq analysis,the major subpopulations of FAPs derived from these depots determined the site characteristics of FAPs to a certain *** work estab-lishes a systematic and reliable foundation for investigating the heterogeneity of WAT depots and elucidating the unique roles these depots play in coordinating the function of adjacent organs.

关键词： white adipose tissue adipose tissue heterogeneity adipocyte subpopulations snRNA-seq

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Efficacy of exercise rehabilitation for managing patients with Alzheimer's disease

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Neural Regeneration Research 2024年第10期19卷 2175-2188页

作者： Dan Li Jinning Jia Haibo Zeng xiaoyan Zhong hui Chen Chenju Yi Department of Pathology The First Affiliated Hospital of Gannan Medical UniversityGanzhouJiangxi ProvinceChina Department of Pathology Huichang County People’s HospitalGanzhouJiangxi ProvinceChina School of Life Sciences Faculty of ScienceUniversity of Technology SydneyUltimoNSWAustralia Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdong ProvinceChina Shenzhen Key Laboratory of Chinese Medicine Active Substance Screening and Translational Research ShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Function and Disease GuangzhouGuangdong ProvinceChina

Alzheimer's disease(AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low-and middle-income countries.

关键词： Alzheimer's disease cerebrovascular function cognitive function epigenetic regulation exercise hippocampal neurogenesis mitochondria neuroinflammation neuronal plasticity

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Unveiling size-fluorescence correlation of organic nanoparticles and its use in nanoparticle size determination

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Aggregate 2024年第1期5卷 331-336页

作者： Wu-Jie Guo Shixiang Ma hui Wang Lu Qiao Lei Chen Chenyu Hong Bin Liu xiaoyan Zheng hui-Qing Peng State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion MaterialsKey Laboratory of Medicinal Molecule Science and Pharmaceutics Engineering of Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijingChina

Quantitatively establishing the correlation between nanoparticle size and fluorescence is essential for understanding the behavior and functionality of fluorescent nanoparticles(FNPs).However,such exploration focusing on organic FNPs has not been achieved to ***,we employ the use of supramolecular polymeric FNPs prepared from tetraphenylethylene-based bis-ureidopyrimidinone monomers(bis-UPys)to relate the size to the fluorescence of organic *** an equal concentration of bis-UPys,a logarithmic relationship between them is built with a correlation coefficient higher than *** calculations indicate that variations in fluorescence intensity among FNPs of different sizes are attributed to the distinct molecular packing environments at the surface and within the interior of the *** leads to different nonradiative decay rates of the embedded and exposed bis-UPys and thereby changes the overall fluorescence quantum yield of nanoparticles due to their different specific surface *** established fluorescence intensity-size correlation possesses fine universality and reliability,and it is successfully utilized to estimate the sizes of other nanoparticles,including those in highly diluted dispersions of *** work paves a new way for the simple and real-time determination of nanoparticle sizes and offers an attractive paradigm to optimize nanoparticle functionalities by the size effect.

关键词： aggregation-induced emission fluorescence detection fluorescent nanoparticle nanoparticle size supramolecular polymer

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A Latent Class Analysis of Lifestyle Patterns in Relation to Depressive Symptoms Among Adolescents—Jiangsu Province,China,2022

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China CDC weekly 2024年第40期6卷 1028-1032,I0001页

作者： Linyuan Lai Xin Wang Ying Li Yan Wang hui Xue xiaoyan Ni Yifan Chen Lijun Fan Jie Yang Wei Du School of Public Health Southeast UniversityNanjing CityJiangsu ProvinceChina Department of Child and Adolescent Health Promotion Jiangsu Provincial Center for Disease Control and PreventionNanjing CityJiangsu ProvinceChina

What is already known about this topic?Interventions aimed at modifying lifestyle behaviors can effectively reduce the risk of depression among *** lifestyle behaviors tend to be interconnected;thus,changes to one behavior can often lead to changes in others,usually occurring *** is added by this report?Adolescents from Jiangsu Province displayed distinct lifestyle patterns,with those engaging in multiple specific behaviors,such as excessive consumption of sugar-sweetened beverages and prolonged screen time,showing increased odds of *** are the implications for public health practice?Early implementation of anti-depression interventions in adolescents should be advocated and prioritized,particularly targeting multiple high-risk lifestyles.

关键词： sugar Jiangsu lifestyle

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N-doped graphene quantum dot-decorated N-TiO2/P-doped porous hollow g-C_(3)N_(4) nanotube composite photocatalysts for antibiotic photodegradation and H2 production

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 165-178页

作者： Jingshu Yuan Yao Zhang xiaoyan Zhang Junjie Zhang Shen’gen Zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Xi’an Fanyi University Xi’an 710105China Shunde Graduate School of University of Science and Technology Beijing Foshan 528399China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao SAR 820000China

Exclusive responsiveness to ultraviolet light (~3.2 eV) and high photogenerated charge recombination rate are the two primary drawbacks of pure TiO_(2). We combined N-doped graphene quantum dots (N-GQDs), morphology regulation, and heterojunction construction strategies to synthesize N-GQD/N-doped TiO_(2)/P-doped porous hollow g-C_(3)N_(4) nanotube (PCN) composite photocatalysts (denoted as G-TPCN). The optimal sample (G-TPCN doped with 0.1wt% N-GQD, denoted as 0.1% G-TPCN) exhibits significantly enhanced photoabsorption, which is attributed to the change in bandgap caused by elemental doping (P and N), the improved light-harvesting resulting from the tube structure, and the upconversion effect of N-GQDs. In addition, the internal charge separation and transfer capability of0.1% G-TPCN are dramatically boosted, and its carrier concentration is 3.7, 2.3, and 1.9 times that of N-TiO_(2), PCN, and N-TiO_(2)/PCN(TPCN-1), respectively. This phenomenon is attributed to the formation of Z-scheme heterojunction between N-TiO_(2) and PCNs, the excellent electron conduction ability of N-GQDs, and the short transfer distance caused by the porous nanotube structure. Compared with those of N-TiO_(2), PCNs, and TPCN-1, the H2 production activity of 0.1%G-TPCN under visible light is enhanced by 12.4, 2.3, and 1.4times, respectively, and its ciprofloxacin (CIP) degradation rate is increased by 7.9, 5.7, and 2.9 times, respectively. The optimized performance benefits from excellent photoresponsiveness and improved carrier separation and migration efficiencies. Finally, the photocatalytic mechanism of 0.1% G-TPCN and five possible degradation pathways of CIP are proposed. This study clarifies the mechanism of multiple modification strategies to synergistically improve the photocatalytic performance of 0.1% G-TPCN and provides a potential strategy for rationally designing novel photocatalysts for environmental remediation and solar energy conversion.

关键词： N-doped TiO_(2) N-doped graphene quantum dots P-doped g-C_(3)N_(4) porous hollow nanotube heterojunction photocatalysis

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结合梯度提升树算法与可解释机器学习模型SHAP的抑郁症影响因素研究

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数据分析与知识发现 2024年第3期8卷 41-52页

作者：聂卉吴晓燕中山大学信息管理学院广州510275

【目的】本研究旨在探讨构建抑郁严重度预测模型及其解释性问题,通过分析互联网用户生成的内容,进一步发展抑郁症风险预测研究,从而提高抑郁症自动检测模型的可靠性和实用性。【方法】通过收集“好大夫在线”平台上的抑郁症医疗咨询文... 详细信息

【目的】本研究旨在探讨构建抑郁严重度预测模型及其解释性问题,通过分析互联网用户生成的内容,进一步发展抑郁症风险预测研究,从而提高抑郁症自动检测模型的可靠性和实用性。【方法】通过收集“好大夫在线”平台上的抑郁症医疗咨询文本记录,构建了一个语料库。利用心理学词典,从中提取了患者的心理特征,并采用梯度提升树算法预测患者的病情,同时引入可解释机器学习方法SHAP解读模型,借助SHAP独特的可视化图表剖析患者年龄、性别、认知、情感、感知、社会家庭及个人得失与抑郁症发生之间的复杂关系。【结果】抑郁症患者心理状态能反馈患者病况,利用从患者问诊记录中提取的心理特征能够有效检测重度抑郁,准确率达到86%。可解释机器学习模型SHAP解释了模型的预测结果,揭示出患者各层面心理特征对抑郁症发生产生的多重效应。【局限】受语料集所限,仅利用单次问诊记录对抑郁程度做预测;而模型特征基于心理学词典,更多与抑郁症发生风险有关的要素可纳入建模考虑中。【结论】影响抑郁症产生及发展的因素复杂。个体差异致使各项特征对于疾病预测产生不同效应。构建抑郁症的自动诊断模型,不仅要关注模型的精准度,更需增强对模型预测的理解。

关键词：抑郁症预测在线用户生成内容可解释机器学习梯度提升树算法

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Qingchang suppositry(清肠栓)induced remission in patients with mild-to-moderate ulcerative proctitis:a multicenter,prospective,randomized,parallel-controlled clinical trial

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Journal of Traditional Chinese Medicine 2024年第1期44卷 156-162页

作者： DAI Xiaoling ZHANG Anming LIN hui SHI Bei REN Yi WEN Hongzhu FEI xiaoyan LIN Jiang Department of Gastroenterology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Gastroenterology Shanghai Putuo Traditional Chinese Medicine hospitalShanghai 200063China Department of Protocology Shanghai Tianshan Traditional Chinese Medicine hospitalShanghai 200050China

OBJECTIVE:To evaluate the efficacy and safety of Qingchang suppository(清肠栓,QCS),a preparation of Chinese herbal medicine,in the induction of remission in patients with mild-to-moderate ulcerative proctitis(UP).METHODS:We performed a multicenter,prospective,randomized,parallel-controlled trial to evaluate the efficacy of QCS induction therapy in 140 adult patients with mild-to-moderate UP and TCM syndrome of dampness-heat in large *** patients were randomized to receive QCS(study group)or Salicylazosulfapyridine(SASP)suppository(control group)one piece each time,twice a day,per anum for 12 *** score and main symptoms score were evaluated at weeks 0,2,4,8 and 12,rectosigmoidscopy was taken at weeks 0,4,8 and 12,Geboes score,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and safety indexes were assessed at weeks 0 and *** primary efficacy endpoint is clinical remission rate,the secondary efficacy endpoints are clinical response rate,mucosa healing rate,Geboes score,the remission rates of the main symptoms,the median day to the remission of the symptom,***:There were no statistical difference in the clinical remission rates,the clinical response rates,the mucosa healing rates,Geboes score,ESR and CRP between the two *** remission rates of tenesmus and anal burning sensation of the study group were significantly higher than those of the control group(76.5%vs 25.0%,P=0.009;74.51%vs 29.63%,P=0.003).The median day to the remission of purulent bloody stool of the study group was significantly less than that of control group[11(1,64)vs 19(2,67),P=0.007].The patients receiving QCS had a significantly higher mucosa healing rate at week 4 than the patients receiving SASP suppository(71.42%vs 52.85%,P=0.023).No adverse event occurred in the study group while the adverse events incidence of the control group was 5.7%(P=0.049).CONCLUSIONS:QCS could induce the remission of UP as effectively and safely as SASP suppository,and was superio

关键词： ulcerative proctitis salicylazosulfapyridine suppository Qingchang suppositry randomized controlled trial

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以“中国之智”蓄势“中国之治”:档案馆赋能廉政智库发展路径研究

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山西档案 2024年第3期 12-18页

作者：郑慧余晓彦广西民族大学研究生院南宁530006 广西民族大学管理学院南宁530006

党的二十大提出以“中国之治”推进国家治理体系和治理能力现代化的目标,需要档案馆参与廉政智库建设,汇聚反腐治理的数据之智、政治之智、社会之智、文明之智,助力将“中国之智”的反腐智慧方案转化为“中国之治”的治理效能。在此基础... 详细信息

党的二十大提出以“中国之治”推进国家治理体系和治理能力现代化的目标,需要档案馆参与廉政智库建设,汇聚反腐治理的数据之智、政治之智、社会之智、文明之智,助力将“中国之智”的反腐智慧方案转化为“中国之治”的治理效能。在此基础上,针对我国廉政智库当前面临信息“汇”而乏“质”、机构“联”而不“通”、成果“用”而无“效”的内外困境,提出发挥档案馆职能,加大资源建设;跨界交流合作,增强技术创新;满足党政需求,重构社会监督等现实路径,以期为新时代高质量推动腐败治理体系和治理能力现代化、促进清廉建设相关工作和研究提供参考。

关键词：档案馆廉政智库档案治理现代化治国理政

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Pathogens of first-episode pulmonary infection in 141 children with chronic granulomatous disease

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Chinese Medical Journal 2024年第4期137卷 502-504页

作者： hui Liu Shunying Zhao Haiming Yang Jinrong Liu hui Xu Xiaolei Tang Yuelin Shen xiaoyan Zhang Xiaohui Wen Yuhong Zhao Ping Chu huimin Li Department of Second Respiratory Medicine National Clinical Research Center for Respiratory DiseasesBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Office of Scientific Research Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China

To the Editor:Chronic granulomatous disease(CGD)is an inherited primary immunodeficiency disease characterized by recurrent life-threatening bacterial or fungal infection and tissue granuloma formation.^([1])Pulmonary infection is the most frequent manifestation,affecting nearly 80%of patients,[2]and remains the major cause of morbidity and mortality in patients with *** of the pathogenic microorganisms responsible for first-episode pulmonary infection provide information on the spectrum of infection in patients with CGD,help guide the empirical choice of antibiotics or antifungal therapy,and contribute to the early identification and management of *** is the commonest causative agent of pulmonary infection,but the distribution of other pathogens varies among countries.^([2–5])Few studies have investigated the etiology of pulmonary infection in CGD in a large cohort in China.

关键词： granuloma infection mortality

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